Interaction of exposure concentration and duration in determining acute toxic effects of sarin vapor in rats

Toxicological Sciences

Volumn 66, Issue 2, 2002, Pages 176-184

  Mioduszewski, R ^a   Manthei, J ^a   Way, R ^a   Burnett, D ^a   Gaviola, B ^a   Muse, W ^a   Thomson, S ^a   Sommerville, D ^a   Crosier, R ^a  

^a EDGEWOOD CHEMICAL BIOLOGICAL CENTER   (United States)

Author keywords

Cholinesterase; Exposure concentration; Inhalation; LC50; LCT50; Lethality; Miosis; Mydriasis; Rat; Sarin

Indexed keywords

CHOLINESTERASE; SARIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL INTERACTION; CLINICAL FEATURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; INHALATION; LC 50; LETHALITY; MALE; MIOSIS; MODEL; NONHUMAN; PREDICTION; PROBABILITY; RAT; RAT STRAIN; SENSITIVITY ANALYSIS; SEX DIFFERENCE; TIME; VAPOR;

ACETYLCHOLINESTERASE; ACUTE TOXICITY TESTS; ADMINISTRATION, INHALATION; ANIMALS; BUTYRYLCHOLINESTERASE; CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; FEMALE; LETHAL DOSE 50; MALE; MIOSIS; MODELS, BIOLOGICAL; RATS; RATS, SPRAGUE-DAWLEY; SARIN; SEX FACTORS; TIME FACTORS;

ANIMALIA; HABER;

EID: 0036204587     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/66.2.176     Document Type: Article

References (25)

1. The method of probits
2. A comparative assessment of the vapour toxicities of GB, GD, GF, T.2132, T.2137 and T.2146 to male and female rats
3. Importance of aliesterase as a detoxification mechanism for soman (pinacolyl methyl phosphonoflouridate) in mice
4. Pseudocholinesterase of mammalian plasma, physiochemical properties and organophosphate inhibition in eleven species
5. A new rapid colormetric determination of acetylcholinesterase activity
6. Iso-OMPA induced potentiation of soman toxicity in rats correlates with the inhibition of serum carboxylesterases
7. Zur geschichte des gaskrieges
8. Identification of human plasma cholinesterase variants in 6688 individuals using biochemical analysis
9. Pharmacology of organophosphates
10. The effect of carboxylesterase inhibition on interspecies difference in soman toxicity
11. The effects of blood flow and detoxification on in vivo cholinesterase inhibition by soman in rats
12. Designs and operational characteristics of inhalation exposure equipment
13. Sex and the response to G agents
14. Haber's rule: A special case in a family of curves relating concentration and duration of exposure to a fixed level of response for a given endpoint
15. ECBC Low Level Operational Toxicology Program: Phase I-inhalation toxicity of sarin vapor in rats as a function of exposure concentration and duration
16. Generation, sampling and analysis of Sarin (GB) vapor for inhalation studies
17. Review of Acute Human-Toxicity Estimates For Selected Chemical-Warfare Agents
18. Subchronic neurotoxicity screening studies with six organophosphate insecticides: An assessment of behavior and morphology relative to cholinesterase inhibition
19. Clinical considerations in nerve agent intoxication
20. Efficacy of antidotes against soman poisoning in female physostigmine-protected rats
21. Carboxylesterase-the soman scavenger in rodents; heterogeneity and hormonal influence
22. A radiochemical assay method for carboxylesterase, and comparison of enzyme activity towards the substrates methyl[1-14c]butyrate and 4-nitrophenyl butyrate
23. Concentration-time mortality response relationship of irritant and systemically acting vapours and gases
24. A non-linear dose-response model with an application to the reconstruction of the human mortality response surface from acute inhalation toxicity with Sarin