Low level nose-only exposure to the nerve agent soman: Toxicokinetics of soman stereoisomers and cholinesterase inhibition in atropinized guinea pigs

Toxicology and Applied Pharmacology

Volumn 153, Issue 2, 1998, Pages 179-185

  Benschop, Hendrik P ^a   Trap, Henk C ^a   Spruit, Helma E T ^a   Van Der Wiel, Herma J ^a   Langenberg, Jan P ^a   De Jong, Leo P A ^a  

^a TNO   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ATROPINE; CARBOXYLESTERASE; CHOLINESTERASE; SOMAN;

ANIMAL CELL; ARTICLE; BLOOD LEVEL; ENZYME INHIBITION; EXPOSURE; GUINEA PIG; INHALATION; MALE; NEUROTOXICITY; NONHUMAN; STEREOISOMERISM; TOXICOKINETICS;

EID: 0032443820     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1998.8490     Document Type: Article

References (31)

1. Ballantyne, B. Marrs, T. C. 1992, Clinical and Experimental Toxicology of Organophosphates and Carbamates, 380, Butterworth Heinemann, Oxford.
2. Benschop H. P., Bijleveld E. C., Otto M. F., Degenhardt C. E. A. M., Van Helden H. P. M., De Jong L. P. A. Stabilization and gas chromatographic analysis of the four stereoisomers of 1,2,2-trimethylpropyl methylphosphonofluoridate (soman) in rat blood. Anal. Biochem. 151:1985;242-253.
3. Benschop H. P., De Jong L. P. A. Toxicokinetics of soman: Species variation and stereospecificity in elimination pathways. Neurosci. Biobehav. Rev. 15:1991;73-77.
4. Benschop H. P., Konings C. A. G., Van Genderen J., De Jong L. P. A. Isolation, anticholinesterase properties, and acute toxicity in mice of the four stereoisomers of soman. Toxicol. Appl. Pharmacol. 90:1984;61-64.
5. Brackett D. W. Armageddon in Tokyo. 1996;Weatherhill, New York, Tokyo.
6. Central Intelligence Agency, 1997, Modeling the Chemical Warfare Agent Release at the Khamisiyah Pit, www.gulflink.osd.mil/cia_092297/.
7. Croddy E. Urban terrorism-chemical warfare in Japan. Jane's Intelligence Rev. November:1995;520-523.
8. Due A. H., Trap H. C., Van der Wiel H. J., Benschop H. P. The effect of pretreatment with CBDP on the toxicokinetics of soman stereoisomers in rats and guinea pigs. Arch. Toxicol. 67:1993;706-711.
9. Duffy F. H., Burchfiel J. L. Long term effects of the organophosphate sarin on EEGs in monkeys and humans. Neurotoxicology. 1:1980;667-690.
10. Ember, L. 1996, Probe of troops' exposure to chemical arms failed, Chem. Eng. News, Sept. 23, 40, 41.
11. Jacobson K. H., Christensen M. K., DeArmon I. A., Oberst F. W. Studies of chronic exposures of dogs to GB (isopropyl methylphosphonofluoridate) vapor. Arch. Ind. Health. 19:1959;5-10.
12. Johnson C. D., Russell R. L. A rapid, simple radiometric assay for cholinesterase, suitable for multiple determinations. Anal. Biochem. 64:1975;229-238.
13. Langenberg J. P., Spruit W. E. T., Van der Wiel H. J., Trap H. C., Helmich R. B., Bergers W. W. A., Van Helden H. P. M., Benschop H. P. Inhalation toxicokinetics of soman stereoisomers in the atropinized guinea pig with nose-only exposure to soman vapor. Toxicol. Appl. Pharmacol. 151:1998;79-87.
14. Langenberg J. P., Van Dijk C., Sweeney R. E., Maxwell D. M., De Jong L. P. A., Benschop H. P. Development of a physiologically based model for the toxicokinetics of C(±)P(±)-soman in the atropinized guinea pig. Arch. Toxicol. 71:1997;320-331.
15. McNamara, B. P. Leitnaker, F. 1971, Toxicological basis for emission of GB into the environment. AD-914271 (NTIS).
16. Moylan-Jones R. J., Price Thomas D. Cyclopentolate in treatment of sarin miosis. Br. J. Pharmacol. 48:1973;309-313.
17. Nakajima T., Sato S., Morita H., Yanagisawa N. Sarin poisoning of a rescue team in the Matsumoto incident in Japan. Occup. Environ. Med. 54:1997;697-701.
18. National Research Council (Committee on Toxicology), 1985, Possible long-term effects of short term exposure to chemical agents.
19. e, Toxicologist, 147, March 10-14, 1996.
20. Nozaki H., Hori S., Shinozawa S., Fujishima S., Takuma K., Sagoh M., Kimura H., Ohki T., Suzuki M., Aikawa N. Secondary exposure of medical staff to sarin vapor in the emergency room. Intensive Care Med. 21:1995;1032-1035.
21. Oberst F. W., Koon W. S., Christensen M. K., Crook J. W., Cresthull B. S., Freeman G. Retention of inhaled sarin vapor and its effect on red blood cell cholinesterase activity in man. Clin. Pharmacol. Ther. 9:1968;421-427.
22. Okudera H., Morita H., Iwashita H., Shibata T., Otagiri T., Kobayashi S., Yanagisawa N. Unexpected nerve gas exposure in the city of Matsumoto: Report of rescue activity in the first sarin gas terrorism. Am. J. Emerg. Med. 15:1997;527-528.
23. Okumura T., Takasu N., Ishimatsu S., Miyanoka S., Mitsuhashi A., Kumada K., Hinohara S. Report on 640 victims of the Tokyo subway attack. Ann. Emerg. Med. 28:1996;129-135.
24. Polhuijs M., Langenberg J. P., Benschop H. P. New method for retrospective detection of exposure to organophosphate anticholinesterases: Application to alleged sarin victims of Japanese terrorists. Toxicol. Appl. Pharmacol. 146:1997;156-161.
25. Reed C. J. Drug metabolism in the nasal cavity: Relevance to toxicology. Drug Metab. Rev. 25:1993;173-205.
26. e, Toxicologist, 148, March 10-14, 1996.
27. Rubin L. S., Goldberg M. N. Effect of sarin on dark adaptation in man: Threshold changes. J. Appl. Physiol. 11:1957;439-444.
28. Stephens R., Spurgeon A., Calvert I. A., Beach J., Levy L. S., Berry H., Harrington J. M. Neuropsychological effects of long-term exposure to organophosphates in sheep dip. Lancet. 345:1995;1135-1139.
29. Sterri S. H., Fonnum F. Carboxylesterase - the soman scavenger in rodents; heterogeneity and hormonal influence. Enzymes Hydrolysing Organophosphorus Compounds. 1989;Ellis Horwood, Chichester. p. 155-164.
30. 14. Biochem. Pharmacol. 34:1985;2779-2785.
31. Suzuki J., Kohno T., Tsukagosi M., Furuhata T., Yamazaki K. Eighteen cases exposed to sarin in Matsumoto, Japan. Intern. Med. 36:1997;466-470.