A simple method for accurate endotracheal placement of an intubation tube in guinea pigs to assess lung injury following chemical exposure

Toxicology Mechanisms and Methods

Volumn 17, Issue 7, 2007, Pages 385-392

  Nambiar, M P ^a,b   Gordon, R K ^a   Moran, T S ^c   Richards, S M ^c   Sciuto, A M ^c  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^c US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

Author keywords

Chemical Warfare Agents; Guinea Pigs; Inhalation Exposure; Intubation; Pulmonary Toxicity; Respiratory System; Trachea

Indexed keywords

MEDETOMIDINE; TELAZOL;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOTRACHEAL INTUBATION; GUINEA PIG; HISTOPATHOLOGY; LUNG INJURY; LUNG TOXICITY; MALE; NONHUMAN; OTOSCOPY; PRIORITY JOURNAL; VOCAL CORD;

ANIMALIA; CAVIA; MUS; RATTUS;

EID: 34548449860     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.1080/15376510601094131     Document Type: Article

References (44)

1. Allon, N., Rabinovitz, I., Manistersky, E., Weissman, B. A., and Grauer, E. 2005. Acute and long-lasting cardiac changes following a single whole-body exposure to sarin vapor in rats. Toxicol. Sci. 87:385-390.
2. Allon, N., Raveh, L., Gilat, E., Cohen, E., Grunwald, J., and Ashani, Y. 1998. Prophylaxis against soman inhalation toxicity in guinea pigs by pretreatment alone with human serum butyrylcholinesterase. Toxicol. Sci. 43:121-128.
3. Anthony, J. S., Haley, M., Manthei, J., Way, R., Burnett, D., Gaviola, B., Sommerville, D., Crosier, R., Mioduszewski, R., Thomson, S., Crouse, C., and Matson, K. 2004. Inhalation toxicity of Cyclosarin (GF) vapor in rats as a function of exposure concentration and duration: potency comparison to sarin (GB). Inhal. Toxicol. 16:103-111.
4. Anzueto, A., deLemos, R. A., Seidenfeld, J., Moore, G., Hamil, H., Johnson, D., and Jenkinson, S. G. 1990. Acute inhalation toxicity of soman and sarin in baboons. Fundam. Appl. Toxicol. 14:676-687.
5. Bajgar, J., Sevelova, L., Krejcova, G., Fusek, J., Vachek, J., Kassa, J., Herink, J., de Jong, L. P., and Benschop, H. 2004a. Biochemical effects of low level exposure to soman vapour. Cent. Eur. J. Public Health 12(Suppl):S4-S7.
6. Bajgar, J., Sevelova, L., Krejcova, G., Fusek, J., Vachek, J., Kassa, J., Herink, J., de Jong, L. P., and Benschop, H. P. 2004b. Biochemical and behavioral effects of soman vapors in low concentrations. Inhal. Toxicol. 16:497-507.
7. Benschop, H. P., Trap, H. C., Spruit, H. E., Van DerWiel, H. J., Langenberg, J. P., and de Jong, L. P. 1998. Low level nose-only exposure to the nerve agent soman: toxicokinetics of soman stereoisomers and cholinesterase inhibition in atropinized guinea pigs. Toxicol. Appl. Pharmacol. 153:179-185.
8. Bide, R. W., and Risk, D. J. 2004. Inhalation toxicity in mice exposed to sarin (GB) for 20-720 min. J. Appl. Toxicol. 24:459-467.
9. Blouin, A., and Cormier, Y. 1987. Endotracheal intubation in guinea pigs by direct laryngoscopy. Lab. Anim. Sci. 37:244-245.
10. Buchanan, K. C., Burge, R. R., and Ruble, G. R. 1998. Evaluation of injectable anesthetics for major surgical procedures in guinea pigs. Contemp. Top. Lab. Anim. Sci. 37:58-63.
11. Caranto, G. R., Waibel, K. H., Asher, J. M., Larrison, R. W., Brecht, K. M., Schutz, M. B., Raveh, L., Ashani, Y., Wolfe, A. D., and Maxwell, D. M. 1994. Amplification of the effectiveness of acetylcholinesterase for detoxification of organophosphorus compounds by bis-quaternary oximes. Biochem. Pharmacol. 47:347-357.
12. Cohan, S. L., Pohlmann, J. L., Mikszewski, J., and O'Doherty, D. S. 1976. The pharmacokinetics of pyridostigmine. Neurology 26:536-539.
13. Costa, D. L., Lehmann, J. R., Harold, W. M., and Drew, R. T. 1986. Transoral tracheal intubation of rodents using a fiberoptic laryngoscope. Lab. Anim. Sci. 36:256-261.
14. Dacre, J. C., and Goldman, M. 1996. Toxicology and pharmacology of the chemical warfare agent sulfur mustard. Pharmacol. Rev. 48:289-326.
15. DeLorenzo, R. A. 2001. Exposed. Signs, symptoms & EMS management of nerve-agent poisoning. JEMS. 26:48-57.
16. Driscoll, K. E., Costa, D. L., Hatch, G., Henderson, R., Oberdorster, G., Salem, H., and Schlesinger, R. B. 2000. Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: uses and limitations. Toxicol. Sci. 55:24-35.
17. Holstege, C. P., Kirk, M., and Sidell, F. R. 1997. Chemical warfare. Nerve agent poisoning. Crit. Care Clin. 13:923-942.
18. Jimmerson, V. R., Shih, T. M., Maxwell, D. M., Kaminskis, A., and Mailman, R. B. 1989a. The effect of 2-(o-cresyl)-4H-1:3:2-benzodioxaphosphorin- 2-oxide on tissue cholinesterase and carboxylesterase activities of the rat. Fundam. Appl. Toxicol. 13:568-575.
19. Jimmerson, V. R., Shih, T. M., Maxwell, D. M., and Mailman, R. B. 1989b. Cresylbenzodioxaphosphorin oxide pretreatment alters soman-induced toxicity and inhibition of tissue cholinesterase activity of the rat. Toxicol. Lett. 48:93-103.
20. Kadivar, H., and Adams, S. C. 1991. Treatment of chemical and biological warfare injuries: insights derived from the 1984 Iraqi attack on Majnoon Island. Mil. Med. 156:171-177.
21. Karalliedde, L., Gauci, C. A., and Carter, M. 1991. Chemical weapons. BMJ. 302:474.
22. Kramer, K., Grimbergen, J. A., van Iperen, D. J., van Altena, K., Voss, H. P., and Bast, A. 1998. Oral endotracheal intubation of guineapigs. Lab. Anim. 32:162-164.
23. Kujime, K., and Natelson, B. H. 1981. A method of endotracheal intubation of guinea pigs (Cavia porcellus). Lab. Anim. Sci. 31:715-716.
24. Levy, A., Chapman, S., Cohen, G., Raveh, L., Rabinovitz, I., Manistersky, E., Kapon, Y., Allon, N., and Gilat, E. 2004. Protection and inflammatory markers following exposure of guinea pigs to sarin vapour: comparative efficacy of three oximes. J. Appl. Toxicol. 24:501-504.
25. Lizio, R., Westhof, A., Lehr, C. M., and Klenner, T. 2001. Oral endotracheal intubation of rats for intratracheal instillation and aerosol drug delivery. Lab. Anim. 35:257-260.
26. Logan, T. P., Millard, C. B., Shutz, M., Schulz, S. M., Lee, R. B., and Bongiovanni, R. 1999. Cutaneous uptake of 14C-HD vapor by the hairless guinea pig. Drug Chem. Toxicol. 22:375-387.
27. MacIntyre, N. R. 2001. Intratracheal catheters as drug delivery systems. Respir. Care 46:193-197.
28. Masuda, N., Takatsu, M., Morinari, H., and Ozawa, T. 1995. Sarin poisoning in Tokyo subway. Lancet 345:1446.
29. Mauderly, J. L. 1977. Bronchopulmonary lavage of small laboratory animals. Lab. Anim. Sci. 27:255-261.
30. Maxwell, D. M., and Brecht, K. M. 1991. The role of carboxylesterase in species variation of oxime protection against soman. Neurosci. Biobehav. Rev. 15:135-139.
31. Maxwell, D. M., and Brecht, K. M. 2001. Carboxylesterase: specificity and spontaneous reactivation of an endogenous scavenger for organophosphorus compounds. J. Appl. Toxicol. 21(Suppl 1):S103-S107.
32. Maxwell, D. M., Brecht, K. M., and O'Neill, B. L. 1987. The effect of carboxylesterase inhibition on interspecies differences in soman toxicity. Toxicol. Lett. 39:35-42.
33. Nambiar, M. P., Wright, B. S., Smith, K. B., Moran, S. T., Richards, S. M., Gordon, R. K., and Sciuto, A. M. 2006. Development of a microinstillation model of inhalation exposure to assess lung injury following exposure to toxic chemicals and nerve agents. Toxicol. Mech. Meth. 16:295-300.
34. Niven, A. S., and Roop, S. A. 2004. Inhalational exposure to nerve agents. Respir. Care Clin. N. Am. 10:59-74.
35. Okumura, T., Takasu, N., Ishimatsu, S., Miyanoki, S., Mitsuhashi, A., Kumada, K., Tanaka, K., and Hinohara, S. 1996. Report on 640 victims of the Tokyo subway sarin attack. Ann. Emerg. Med. 28:129-135.
36. Ray, R., III, Clark, O. E., Ford, K. W., Knight, K. R., Harris, L. W., and Broomfield, C. A. 1991. A novel tertiary pyridostigmine derivative [3-(N,N-dimethylcarbamyloxy)-1-methyl-delta 3-tetrahydropyridine]: anticholinesterase properties and efficacy against soman. Fundam. Appl. Toxicol. 16:267-274.
37. Saffiotti, U., Cefis, F., and Kolb, L. H. 1968. Amethod for the experimental induction of bronchogenic carcinoma. Cancer Res. 28:104-124.
38. Shih, T., Jr., McDonough, J. H., and Koplovitz, I. 1999. Anticonvulsants for soman-induced seizure activity. J. Biomed. Sci. 6:86-96.
39. Tremblay, G., Gagnon, L., and Cormier, Y. 1990. Sequential bronchoalveolar lavages by endotracheal intubation in guineapigs. Lab. Anim. 24:63-67.
40. Turner, M. A., Thomas, P., and Sheridan, D. J. 1992. An improved method for direct laryngeal intubation in the guineapig. Lab. Anim. 26:25-28.
41. van Helden, H. P., Kuijpers, W. C., and Diemel, R. V. 2004a. Asthmalike symptoms following intratracheal exposure of guinea pigs to sulfur mustard aerosol: therapeutic efficacy of exogenous lung surfactant curosurf and salbutamol. Inhal. Toxicol. 16:537-548.
42. van Helden, H. P., Trap, H. C., Kuijpers, W. C., Oostdijk, J. P., Benschop, H. P., and Langenberg, J. P. 2004b. Low-level exposure of guinea pigs and marmosets to sarin vapour in air: lowest-observable-adverse-effect level (LOAEL) for miosis. J. Appl. Toxicol. 24:59-68.
43. Wiener, S. L. 1996. Strategies for the prevention of a successful biological warfare aerosol attack. Mil. Med. 161:251-256.
44. Wright, B. S., Rezk, P. E., Graham, J. R., Steele, K. E., Gordon, R. K., Sciuto, A. M., and Nambiar, M. P. 2006. Acute lung injury following inhalation exposure to nerve agent VX in guinea pigs. Inhal. Toxicol. 18:437-448.