CD4+ CD25+ Foxp3- T-regulatory cells produce both gamma interferon and interleukin-10 during acute severe murine spotted fever rickettsiosis

Infection and Immunity

Volumn 77, Issue 9, 2009, Pages 3838-3849

  Fang, Rong ^a   Ismail, Nahed ^a,b   Shelite, Thomas ^a   Walker, David H ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b MEHARRY MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

ACUTE DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD LEVEL; BOUTONNEUSE FEVER; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; FLOW CYTOMETRY; IMMUNITY; IMMUNOSTIMULATION; LIVER; LUNG; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; RICKETTSIA CONORII; RICKETTSIOSIS; SPLEEN; SPLEEN CELL; SPOTTED FEVER RICKETTSIOSIS; TH1 CELL;

ACUTE DISEASE; ANIMALS; BOUTONNEUSE FEVER; CD4-POSITIVE T-LYMPHOCYTES; FORKHEAD TRANSCRIPTION FACTORS; IMMUNE TOLERANCE; INTERFERON-GAMMA; INTERLEUKIN-10; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C3H; RICKETTSIA CONORII; T-LYMPHOCYTES, REGULATORY;

EID: 69049101186     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00349-09     Document Type: Article

References (50)

1. - Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis. J. Exp. Med. 204:285-297.
2. Battaglia, M., S. Gregori, R. Bacchetta, and M. G. Roncarolo. 2006. Tr1 cells: from discovery to their clinical application. Semin. Immunol. 18:120-127.
3. Belkaid, Y., and B. T. Rouse. 2005. Natural regulatory T cells in infectious disease. Nat. Immunol. 6:353-360.
4. + regulatory T cells are dependent on CTLA-4 expression. Eur. J. Immunol. 34:3485-3496.
5. + regulatory T lymphocytes in hepatitis C virus infection. Hepatology 40:1062-1071.
6. Cillari, E., S. Milano, P. D'Agostino, F. Arcoleo, G. Stassi, A. Galluzzo, P. Richiusa, C. Giordano, P. Quartararo, P. Colletti, G. Gambino, C. Mocciaro, A. Spinelli, G. Vitale, and S. Mansueto. 1996. Depression of CD4 T cell subsets and alteration in cytokine profile in boutonneuse fever. J. Infect. Dis. 174:1051-1057.
7. de Sousa, R., N. Ismail, S. D. Nobrega, A. França, M. Amaro, M. Anes, J. Poças, R. Coelho, J. Torgal, F. Bacellar, and D. H. Walker. 2007. Intralesional expression of mRNA of interferon-gamma, tumor necrosis factor-alpha, interleukin-10, nitric oxide synthase, indoleamine-2,3- dioxygenase, and RANTES is a major immune effector in Mediterranean spotted fever rickettsiosis. J. Infect. Dis. 196:770-781.
8. Dumler, J. S., and D. H. Walker. 2005. Rocky Mountain spotted fever - changing ecology and persisting virulence. N. Engl. J. Med. 353:551-553.
9. + T cells during Listeria monocytogenes infection. J. Immunol. 182:3032-3038.
10. Fang, R., N. Ismail, L. Soong, V. L. Popov, T. Whitworth, D. H. Bouyer, and D. H. Walker. 2007. Differential interaction of dendritic cells with Rickettsia conorii: impact on host susceptibility to murine spotted fever rickettsiosis. Infect. Immun. 75:3112-3123.
11. Feng, H., V. L. Popov, G. Yuoh, and D. H. Walker. 1997. Role of T lymphocyte subsets in immunity to spotted fever group rickettsiae. J. Immunol. 158:5314-5320.
12. Feng, H. M., V. L. Popov, and D. H. Walker. 1994. Depletion of gamma interferon and tumor necrosis factor alpha in mice with Rickettsia conorii-infected endothelium: impairment of rickettsicidal nitric oxide production resulting in fatal, overwhelming rickettsial disease. Infect. Immun. 62:1952-1960.
13. Feng, H. M., and D. H. Walker. 1993. Interferon-gamma and tumor necrosis factor-alpha exert their antirickettsial effect via induction of synthesis of nitric oxide. Am. J. Pathol. 143:1016-1023.
14. Feng, H. M., and D. H. Walker. 2000. Mechanisms of intracellular killing of Rickettsia conorii in infected human endothelial cells, hepatocytes, and macrophages. Infect. Immun. 68:6729-6736.
15. Fontenot, J. D., J. P. Rasmussen, L. M. Williams, J. L. Dooley, A. G. Farr, and A. Y. Rudensky. 2005. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 22:329-341.
16. + T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha. J. Immunol. 157:798-805.
17. + T cell clones producing both interferon-gamma and interleukin-10 predominate in bronchoalveolar lavages of active pulmonary tuberculosis patients. Clin. Immunol. 92:224-234.
18. Hanson, B. A., C. L. Wisseman, Jr., A. Waddell, and D. J. Silverman. 1981. Some characteristics of heavy and light bands of Rickettsia prowazekii on Renografin gradients. Infect. Immun. 34:596-604.
19. Hubert, P., N. Jacobs, J. H. Caberg, J. Boniver, and P. Delvenne. 2007. The cross-talk between dendritic and regulatory T cells: good or evil? J. Leukoc. Biol. 82:781-794.
20. - Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection. J. Exp. Med. 204:273-283.
21. + regulatory T cells restrain pathogenic responses during Leishmania amazonensis infection. J. Immunol. 174:7147- 7153.
22. Kursar, M., M. Koch, H. W. Mittrücker, G. Nouailles, K. Bonhagen, T. Kamradt, and S. H. Kaufmann. 2007. Cutting edge: regulatory T cells prevent efficient clearance of Mycobacterium tuberculosis. J. Immunol. 178:2661-2665.
23. high regulatory T cells in acute dengue infection. J. Exp. Med. 205:979-985.
24. Lund, J. M., L. Hsing, T. T. Pham, and A. Y. Rudensky. 2008. Coordination of early protective immunity to viral infection by regulatory T cells. Science 320:1220-1224.
25. high regulatory T cells suppress memory T-cell responses to H. pylori in infected individuals. Infect. Immun. 71:1755-1762.
26. Mansueto, P., G. Vitale, G. Di Lorenzo, F. Arcoleo, S. Mansueto, and E. Cillari. 2008. Immunology of human rickettsial diseases. J. Biol. Regul. Homeost. Agents 22:131-139.
27. Mills, K. H. 2004. Regulatory T cells: friend or foe in immunity to infection? Nat. Rev. Immunol. 4:841-855.
28. Murphy, M. L., S. E. Cotterell, P. M. Gorak, C. R. Engwerda, and P. M. Kaye. 1998. Blockade of CTLA-4 enhances host resistance to the intracellular pathogen, Leishmania donovani. J. Immunol. 161:4153-4160.
29. National Research Council. 1996. Guide for the care and use of laboratory animals. National Academy Press, Washington, DC.
30. Ortega, G., R. J. Robb, E. M. Shevach, and T. R. Malek. 1984. The murine IL 2 receptor. I. Monoclonal antibodies that define distinct functional epitopes on activated T cells and react with activated B cells. J. Immunol. 133:1970-1975.
31. Pohl-Koppe, A., K. E. Balashov, A. C. Steere, E. L. Logigian, and D. A. Hafler. 1998. Identification of a T cell subset capable of both IFN-gamma and IL-10 secretion in patients with chronic Borrelia burgdorferi infection. J. Immunol. 160:1804-1810.
32. + T cells anergic and suppressive. Immunology 120:447-455.
33. Roncarolo, M. G., S. Gregori, M. Battaglia, R. Bacchetta, K. Fleischhauer, and M. K. Levings. 2006. Interleukin-10-secreting type 1 regulatory T cells in rodents and humans. Immunol. Rev. 212:28-50.
34. + regulatory T cells in immunological tolerance to self and non-self. Nat. Immunol. 6:345-352.
35. Sansom, D. M., and L. S. Walker. 2006. The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatory T-cell biology. Immunol. Rev. 212:131-148.
36. + regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J. Exp. Med. 201:723-735.
37. Shevach, E. M. 2006. From vanilla to 28 flavors: Multiple varieties of T regulatory cells. Immunity 25:195-201.
38. + regulatory T cells. Immunol. Rev. 212:60-73.
39. Smith, P., C. M. Walsh, N. E. Mangan, R. E. Fallon, J. R. Sayers, A. N. McKenzie, and P. G. Fallon. 2004. Schistosoma mansoni worms induce anergy of T cells via selective up-regulation of programmed death ligand 1 on macrophages. J. Immunol. 173:1240-1248.
40. Stock, P., O. Akbari, G. Berry, G. J. Freeman, R. H. Dekruyff, and D. T. Umetsu. 2004. Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity. Nat. Immunol. 5:1149-1156.
41. Tarleton, R. L. 1988. Trypanosoma cruzi-induced suppression of IL-2 production. I. Evidence for the presence of IL-2-producing cells. J. Immunol. 140:2763-2768.
42. Tarleton, R. L. 1988. Trypanosoma cruzi-induced suppression of IL-2 production. II. Evidence for a role for suppressor cells. J. Immunol. 140:2769-2773.
43. Trinchieri, G. 2001. Regulatory role of T cells producing both interferon gamma and interleukin 10 in persistent infection. J. Exp. Med. 194:F53-F57.
44. Valbuena, G., W. Bradford, and D. H. Walker. 2003. Expression analysis of the T-cell-targeting chemokines CXCL9 and CXCL10 in mice and humans with endothelial infections caused by rickettsiae of the spotted fever group. Am. J. Pathol. 163:1357-1369.
45. + regulatory T cells. J. Immunol. 172:5986-5993.
46. Walker, D. H., and N. Ismail. 2008. Emerging and re-emerging rickettsioses: endothelial cell infection and early disease events. Nat. Rev. Microbiol. 6:375-386.
47. Walker, D. H., J. P. Olano, and H. M. Feng. 2001. Critical role of cytotoxic T lymphocytes in immune clearance of rickettsial infection. Infect. Immun. 69:1841-1846.
48. Walker, D. H., V. L. Popov, J. Wen, and H. M. Feng. 1994. Rickettsia conorii infection of C3H/HeN mice. A model of endothelial-target rickettsiosis. Lab. Investig. 70:358-368.
49. + regulatory T cell responses during Friend retrovirus infection. Eur. J. Immunol. 36:2658-2670.
50. Zheng, Y., C. N. Manzotti, M. Liu, F. Burke, K. I. Mead, and D. M. Sansom. 2004. CD86 and CD80 differentially modulate the suppressive function of human regulatory T cells. J. Immunol. 172:2778-2784.