Synthesis and evaluation of inhibitors of cytochrome P450 3A (CYP3A) for pharmacokinetic enhancement of drugs

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 18, 2009, Pages 5444-5448

  Flentge, Charles A ^a   Randolph, John T ^a   Huang, Peggy P ^a   Klein, Larry L ^a   Marsh, Kennan C ^b   Harlan, John E ^c   Kempf, Dale J ^a  

^a ABBOTT LABORATORIES   (United States)

^b Exploratory Science ^*  (United States)

^c Structural Biology (D R46Y)   (United States)

Author keywords

Cytochrome P450 3A; Lopinavir; Ritonavir

Indexed keywords

CYTOCHROME P450 3A; CYTOCHROME P450 3A4; IMIDAZOLE DERIVATIVE; LOPINAVIR; OXAZOLE DERIVATIVE; PROTEINASE INHIBITOR; PYRAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; RITONAVIR; THIAZOLE DERIVATIVE; THIOPHENE DERIVATIVE;

AREA UNDER THE CURVE; ARTICLE; DOG; DRUG BLOOD LEVEL; DRUG DESIGN; DRUG METABOLISM; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; IN VITRO STUDY; NONHUMAN; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANIMALS; CYTOCHROME P-450 CYP3A; DOGS; DRUG DESIGN; DRUG INTERACTIONS; HIV PROTEASE INHIBITORS; HUMANS; PYRIMIDINONES; RITONAVIR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 69049094210     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.07.118     Document Type: Article

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