The first line of therapy in a girl with juvenile myoclonic epilepsy: Should it be valproate or a new agent?

Epilepsia

Volumn 50, Issue SUPPL. 8, 2009, Pages 16-20

  Montouris, Georgia ^a   Abou Khalil, Bassel ^b  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Antiepileptic drugs; First line therapy; Juvenile myoclonic epilepsy; Lamotrigine; Levetiracetam; Topiramate; Valproate; Zonisamide

Indexed keywords

ANTICONVULSIVE AGENT; ETIRACETAM; LAMOTRIGINE; PLACEBO; TOPIRAMATE; VALPROIC ACID; ZONISAMIDE;

BIRTH DEFECT; CLEFT LIP FACE PALATE; CLINICAL TRIAL; CONGENITAL MALFORMATION; CONTROLLED STUDY; DISEASE CONTROL; EVIDENCE BASED MEDICINE; FEMALE; HAIR LOSS; HUMAN; JUVENILE; LIVER TOXICITY; MYOCLONUS EPILEPSY; PREGNANCY; PRIMARY HEALTH CARE; PRIORITY JOURNAL; REVIEW; SIDE EFFECT; TERATOGENICITY; TONIC CLONIC SEIZURE; TREATMENT PLANNING; TREMOR; WEIGHT GAIN;

ANTICONVULSANTS; CONGENITAL ABNORMALITIES; DELAYED-ACTION PREPARATIONS; DRUG DESIGN; EPILEPSY, GENERALIZED; FEMALE; FRUCTOSE; HUMANS; ISOXAZOLES; MALE; MYOCLONIC EPILEPSY, JUVENILE; PIRACETAM; PREGNANCY; RISK ASSESSMENT; TREATMENT OUTCOME; TRIAZINES; VALPROIC ACID; WEIGHT GAIN;

EID: 68949200959     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2009.02230.x     Document Type: Review

References (53)

1. Alfradique I, Vasconcelos MM 2007) Juvenile myoclonic epilepsy. Arq Neuropsiquiatr 65 : 1266 1271.
2. Arroyo S, Dodson WE, Privitera MD, Glauser TA, Naritoku DK, Dlugos DJ, Wang S, Schwabe SK, Twyman RE 2005) Randomized dose-controlled study of topiramate as first-line therapy in epilepsy. Acta Neurol Scand 112 : 214 222.
3. Bergey GK 2005) Evidence-based treatment of idiopathic generalized epilepsies with new antiepileptic drugs. Epilepsia 46 (Suppl 9 161 168.
4. Berkovic SF, Knowlton RC, Leroy RF, Schiemann J, Falter U 2007) Placebo-controlled study of levetiracetam in idiopathic generalized epilepsy. Neurology 69 : 1751 1760.
5. Biraben A, Allain H, Scarabin JM, Schuck S, Edan G 2000) Exacerbation of juvenile myoclonic epilepsy with lamotrigine. Neurology 55 : 1758.
6. Biton V, Montouris GD, Ritter F, Riviello JJ, Reife R, Lim P, Pledger G 1999) A randomized, placebo-controlled study of topiramate in primary generalized tonic-clonic seizures. Topiramate YTC Study Group. Neurology 52 : 1330 1337.
7. Biton V, Mirza W, Montouris G, Vuong A, Hammer AE, Barrett PS 2001) Weight change associated with valproate and lamotrigine monotherapy in patients with epilepsy. Neurology 56 : 172 177.
8. Biton V, Bourgeois BF 2005) Topiramate in patients with juvenile myoclonic epilepsy. Arch Neurol 62 : 1705 1708.
9. Biton V, Sackellares JC, Vuong A, Hammer AE, Barrett PS, Messenheimer JA 2005) Double-blind, placebo-controlled study of lamotrigine in primary generalized tonic-clonic seizures. Neurology 65 : 1737 1743.
10. Buchanan N 1996) The use of lamotrigine in juvenile myoclonic epilepsy. Seizure 5 : 149 151.
11. Calleja S, Salas-Puig J, Ribacoba R, Lahoz CH 2001) Evolution of juvenile myoclonic epilepsy treated from the outset with sodium valproate. Seizure 10 : 424 427.
12. Cohen J 2003) Levetiracetam monotherapy for primary generalised epilepsy. Seizure 12 : 150 153.
13. Coppola G, Auricchio G, Federico R, Carotenuto M, Pascotto A 2004) Lamotrigine versus valproic acid as first-line monotherapy in newly diagnosed typical absence seizures: an open-label, randomized, parallel-group study. Epilepsia 45 : 1049 1053.
14. Crespel A, Genton P, Berramdane M, Coubes P, Monicard C, Baldy-Moulinier M, Gelisse P 2005) Lamotrigine associated with exacerbation or de novo myoclonus in idiopathic generalized epilepsies. Neurology 65 : 762 764.
15. Cross JH 2002) Topiramate monotherapy for childhood absence seizures: an open label pilot study. Seizure 11 : 406 410.
16. Cunnington M, Tennis P 2005) Lamotrigine and the risk of malformations in pregnancy. Neurology 64 : 955 960.
17. daSousa PS, Araujo Filho GM, Garzon E, Sakamoto AC, Yacubian EM 2005) Topiramate for the treatment of juvenile myoclonic epilepsy. Arq Neuropsiquiatr 63 : 733 737.
18. Delgado-Escueta AV, Enrile-Bacsal F 1984) Juvenile myoclonic epilepsy of Janz. Neurology 34 : 285 294.
19. Dolk H, Jentink J, Loane M, Morris J, de Jong-van den Berg LT 2008) Does lamotrigine use in pregnancy increase orofacial cleft risk relative to other malformations? Neurology 71 : 714 722.
20. Faught E 2004) Treatment of refractory primary generalized epilepsy. Rev Neurol Dis 1 (Suppl 1 S34 43.
21. Freitag FG, Collins SD, Carlson HA, Goldstein J, Saper J, Silberstein S, Mathew N, Winner PK, Deaton R, Sommerville K 2002) A randomized trial of divalproex sodium extended-release tablets in migraine prophylaxis. Neurology 58 : 1652 1659.
22. Holmes LB, Baldwin EJ, Smith CR, Habecker E, Glassman L, Wong SL, Wyszynski DF 2008) Increased frequency of isolated cleft palate in infants exposed to lamotrigine during pregnancy. Neurology 70 : 2152 2158.
23. Hunt S, Craig J, Russell A, Guthrie E, Parsons L, Robertson I, Waddell R, Irwin B, Morrison PJ, Morrow J 2006) Levetiracetam in pregnancy: preliminary experience from the UK Epilepsy and Pregnancy Register. Neurology 67 : 1876 1879.
24. Hunt S, Russell A, Smithson WH, Parsons L, Robertson I, Waddell R, Irwin B, Morrison PJ, Morrow J, Craig J 2008) Topiramate in pregnancy: preliminary experience from the UK Epilepsy and Pregnancy Register. Neurology 71 : 272 276.
25. Isojarvi JI, Tauboll E, Herzog AG 2005) Effect of antiepileptic drugs on reproductive endocrine function in individuals with epilepsy. CNS Drugs 19 : 207 223.
26. Janz D 1985) Epilepsy with impulsive petit mal (juvenile myoclonic epilepsy). Acta Neurol Scand 72 : 449 459.
27. Kondo T, Kaneko S, Amano Y, Egawa I 1996) Preliminary report on teratogenic effects of zonisamide in the offspring of treated women with epilepsy. Epilepsia 37 : 1242 1244.
28. Kothare SV, Valencia I, Khurana DS, Hardison H, Melvin JJ, Legido A 2004) Efficacy and tolerability of zonisamide in juvenile myoclonic epilepsy. Epileptic Disord 6 : 267 270.
29. Krauss GL, Betts T, Abou-Khalil B, Gergey G, Yarrow H, Miller A 2003) Levetiracetam treatment of idiopathic generalised epilepsy. Seizure 12 : 617 620.
30. Labate A, Colosimo E, Gambardella A, Leggio U, Ambrosio R, Quattrone A 2006) Levetiracetam in patients with generalised epilepsy and myoclonic seizures: an open label study. Seizure 15 : 214 218.
31. Levisohn PM, Holland KD 2007) Topiramate or valproate in patients with juvenile myoclonic epilepsy: a randomized open-label comparison. Epilepsy Behav 10 : 547 552.
32. Marson AG, Al-Kharusi AM, Alwaidh M, Appleton R, Baker GA, Chadwick DW, Cramp C, Cockerell OC, Cooper PN, Doughty J, Eaton B, Gamble C, Goulding PJ, Howell SJ, Hughes A, Jackson M, Jacoby A, Kellett M, Lawson GR, Leach JP, Nicolaides P, Roberts R, Shackley P, Shen J, Smith DF, Smith PE, Smith CT, Vanoli A, Williamson PR 2007) The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial. Lancet 369 : 1016 1026.
33. Meador KJ, Penovich P 2008) What is the risk of orofacial clefts from lamotrigine exposure during pregnancy? Neurology 71 : 706 707.
34. Meador K, Reynolds MW, Crean S, Fahrbach K, Probst C 2008a) Pregnancy outcomes in women with epilepsy: a systematic review and meta-analysis of published pregnancy registries and cohorts. Epilepsy Res 81 : 1 13.
35. Meador KJ, Baker GA, Browning N, Clayton-Smith J, Combs-Cantre D, Cohen M, Kalayjian L, Kanner A, Liporace J, Pennell P, Privitera M, Loring D 2008b) Neurodevelopmental effects of fetal antiepileptic drug exposure: 3 year old cognitive outcomes. Epilepsia 49 : 489.
36. Mikati MA, Holmes GL 1997) Lamotrigine in absence and primary generalized epilepsies. J Child Neurol 12 (Suppl 1 S29 37.
37. Montouris G 2007) Importance of monotherapy in women across the reproductive cycle. Neurology 69 : S10 16.
38. Morris GL, Hammer AE, Kustra RP, Messenheimer JA 2004) Lamotrigine for patients with juvenile myoclonic epilepsy following prior treatment with valproate: results of an open-label study. Epilepsy Behav 5 : 509 512.
39. Nicolson A, Appleton RE, Chadwick DW, Smith DF 2004) The relationship between treatment with valproate, lamotrigine, and topiramate and the prognosis of the idiopathic generalised epilepsies. J Neurol Neurosurg Psychiatry 75 : 75 79.
40. Noachtar S, Andermann E, Meyvisch P, Andermann F, Gough WB, Schiemann-Delgado J 2008) Levetiracetam for the treatment of idiopathic generalized epilepsy with myoclonic seizures. Neurology 70 : 607 616.
41. Prasad A, Kuzniecky RI, Knowlton RC, Welty TE, Martin RC, Mendez M, Faught RE 2003) Evolving antiepileptic drug treatment in juvenile myoclonic epilepsy. Arch Neurol 60 : 1100 1105.
42. Privitera MD, Brodie MJ, Mattson RH, Chadwick DW, Neto W, Wang S 2003) Topiramate, carbamazepine and valproate monotherapy: double-blind comparison in newly diagnosed epilepsy. Acta Neurol Scand 107 : 165 175.
43. Quality Standards Subcommittee of the American Academy of Neurology 1998) Practice parameter: management issues for women with epilepsy (summary statement). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 51 : 944 948.
44. Sharpe DV, Patel AD, Abou-Khalil B, Fenichel GM 2008) Levetiracetam monotherapy in juvenile myoclonic epilepsy. Seizure 17 : 64 68.
45. Specchio LM, Gambardella A, Giallonardo AT, Michelucci R, Specchio N, Boero G, La Neve A 2006) Open label, long-term, pragmatic study on levetiracetam in the treatment of juvenile myoclonic epilepsy. Epilepsy Res 71 : 32 39.
46. Sullivan JE, Dlugos DJ 2004) Idiopathic generalized epilepsy. Curr Treat Options Neurol 6 : 231 242.
47. Vajda FJ, O'Brien TJ, Hitchcock A, Graham J, Cook M, Lander C, Eadie MJ 2004) Critical relationship between sodium valproate dose and human teratogenicity: results of the Australian register of anti-epileptic drugs in pregnancy. J Clin Neurosci 11 : 854 858.
48. Vajda FJ, Hitchcock A, Graham J, Solinas C, O'Brien TJ, Lander CM, Eadie MJ 2006) Foetal malformations and seizure control: 52 months data of the Australian Pregnancy Registry. Eur J Neurol 13 : 645 654.
49. Verrotti A, Cerminara C, Coppola G, Franzoni E, Parisi P, Iannetti P, Aloisi P, Tozzi E, Cusmai R, Vigevano F, Chiarelli F, Curatolo P 2008a) Levetiracetam in juvenile myoclonic epilepsy: long-term efficacy in newly diagnosed adolescents. Dev Med Child Neurol 50 : 29 32.
50. Verrotti A, Cerminara C, Domizio S, Mohn A, Franzoni E, Coppola G, Zamponi N, Parisi P, Iannetti P, Curatolo P 2008b) Levetiracetam in absence epilepsy. Dev Med Child Neurol 50 : 850 853.
51. Wheless JW 2000) Use of topiramate in childhood generalized seizure disorders. J Child Neurol 15 (Suppl 1 S7 13.
52. Wilfong A, Schultz R 2005) Zonisamide for absence seizures. Epilepsy Res 64 : 31 34.
53. Yerby MS, Leavitt A, Erickson DM, McCormick KB, Loewenson RB, Sells CJ, Benedetti TJ 1992) Antiepileptics and the development of congenital anomalies. Neurology 42 : 132 140.