Preliminary report on teratogenic effects of zonisamide in the offspring of treated women with epilepsy

Epilepsia

Volumn 37, Issue 12, 1996, Pages 1242-1244

  Kondo, Tsuyoshi ^a   Kaneko, Sunao ^a   Amano, Yoshiyuki ^b   Egawa, Isao ^c  

^a HIROSAKI UNIVERSITY   (Japan)

^b Iwata Municipal General Hospital   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

Epilepsy; Polypharmacy; Pregnancy; Teratogenicity; Zonisamide

Indexed keywords

ZONISAMIDE;

ANENCEPHALUS; ANTICONVULSANT THERAPY; ARTICLE; CLINICAL ARTICLE; CONGENITAL MALFORMATION; EPILEPSY; HEART ATRIUM SEPTUM DEFECT; HUMAN; NEWBORN; PREGNANCY; PRIORITY JOURNAL; RISK ASSESSMENT; TERATOGENESIS;

EID: 0029807973     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1528-1157.1996.tb00560.x     Document Type: Article

References (8)

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2. Kaneko S, Otani K, Kondo T, et al. Malformation in infants of mothers with epilepsy receiving antiepileptic drugs. Neurology 1992;42(suppl 5):68-74.
3. Oguni H, Hayashi K, Fukuyama Y, et al. Phase III study of a new antiepileptic AD-810, zonisamide in childhood epilepsy. Jpn J Pediatr 1988;41:439-50 (in Japanese).
4. Schmidt D, Jacob R, Loiseau P, et al. Zonisamide for add-on treatment of refractory partial epilepsy: a European double blind trial. Epilepsy Res 1993;15:67-73.
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6. Terada Y, Fukagawa S, Shigematsu K, Mukumoto K, Nishimura K, Ohnishi K. Reproduction studies of zonisamide. (4) Teratogenicity studies in mice, dogs, and monkeys. Jpn Pharmacol Ther 1987;15:4435-51 (in Japanese).
7. Kaneko S, Otani K, Fukushima Y, et al. Teratogenicity of antiepileptic drugs: analysis of possible risk factors. Epilepsia 1988;29:459-67.
8. Kaneko S, Kondo T. Antiepileptic agents and birth defects. Incidence, mechanisms and prevention. CNS Drugs 1995;3:41-55.