What is the risk of orofacial clefts from lamotrigine exposure during pregnancy?

Neurology

Volumn 71, Issue 10, 2008, Pages 706-707

  Meador, Kimford J ^a   Penovich, Patricia ^b  

^a UNIVERSITY OF FLORIDA   (United States)

^b MINNESOTA EPILEPSY GROUP   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LAMOTRIGINE; ANTICONVULSIVE AGENT; TRIAZINE DERIVATIVE;

CLEFT FACE; CLEFT PALATE; DOSE RESPONSE; EDITORIAL; FETUS RISK; HIGH RISK INFANT; HUMAN; MONOTHERAPY; PRENATAL EXPOSURE; PRIORITY JOURNAL; REGISTER; RISK ASSESSMENT; SEIZURE; TERATOGENICITY; CHEMICALLY INDUCED DISORDER; CLEFT LIP; EPILEPSY; FEMALE; NOTE; PREGNANCY; RISK;

ANTICONVULSANTS; CLEFT LIP; EPILEPSY; FEMALE; HUMANS; PREGNANCY; RISK; TRIAZINES;

EID: 54049093670     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/01.wnl.0000324945.24036.a1     Document Type: Editorial

References (7)

1. Bren L. Frances Oldham Kelsey: FDA medical reviewer leaves her mark on history. FDA Consumer, US Food and Drug Administration, 2001-02-28. Available at: http://www.fda.gov/fdac/features/2001/201-kelsey.html.
2. Tomson T, Battino D. Teratogenicity of antiepileptic drugs: state of the art: review. Curr Opin Neurol 2005;18:135-140.
3. Holmes LB, Baldwin EJ, Smith CR, et al. Increased frequency of isolated cleft palate in infants exposed to lamotrigine during pregnancy. Neurology 2008;70: 2152-2158.
4. Dolk H, Jentink J, Loane M, Morris J, De Jong-van den Berg LTW, on behalf of the EUROCAT Antiepileptic Drug Working Group. Does lamotrigine use in pregnancy increase orofacial cleft risk relative to other malformations? Neurology 2008;71:714-722.
5. Cunnington M, Tennis P, and the International Lamotrigine Pregnancy Registry Scientific Advisory Committee. Lamotrigine and the risk of malformations in pregnancy. Neurology 2005;64:955-960.
6. Morrow J, Russell A, Guthrie E, Parsons L, et al. Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry 2006;77:193-198.
7. Finnell RH, Nau H, Yerby MS. General principles: Teratogenicity of antiepileptic drugs. In: Levy RH, Mattson RH, Meldrum BS, eds. Antiepileptic Drugs. 4th ed. New York, Raven Press, 1995:209-230.