[76Br]BMK-I-152, a non-peptide analogue for PET imaging of corticotropin-releasing hormone type 1 receptor (CRHR1)

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 52, Issue 9, 2009, Pages 394-400

  Lang, L ^a   Ma, Y ^a   Kim, B M ^b   Jagoda, E M ^a   Rice, K C ^b   Szajek, L P ^c   Contoreggi, C ^b   Gold, P W ^d   Chrousos, G P ^e   Eckelman, W C ^f   Kiesewettera, D O ^a  

^a NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING   (United States)

^b NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^e UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^f Molecular Tracer LLC   (United States)

Author keywords

Bromine 76; Corticotropin releasing hormone; CRH; PET; Radiobromination

Indexed keywords

BROMINE; PLANTS (BOTANY); RADIOACTIVITY;

BROMINE-76; CORTICOTROPIN-RELEASING HORMONE; CRH; HIGH AFFINITY; MENTAL HEALTH; PEPTIDE ANALOGS; PET IMAGING; RADIOBROMINATION; REACTION CONDITIONS; RECEPTOR ANTAGONISTS;

ISOMERS;

2,6 DIMETHOXY 4 HYDROXYBENZALDEHYDE; 8 (2,4 DICHLOROPHENYL) 4 [2 METHOXY 1 (METHOXYMETHYL)ETHYLAMINO] 2,7 DIMETHYLPYRAZOLO[1,5 A][1,3,5]TRIAZINE; ACETONITRILE; AMMONIUM HYDROXIDE; ANTALARMIN; BENZALDEHYDE DERIVATIVE; BMK I 152; BROMIDE; BROMINE 76; BUTYL[2,5 DIMETHYL 7 (2,4,6 TRIMETHYLPHENYL) 7H PYRROLO[2,3 D]PYRIMIDIN 4 YL]ETHYLAMINE; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; HORMONE RECEPTOR BLOCKING AGENT; MJL 1 109 2; ORGANOTIN COMPOUND; RADIOPHARMACEUTICAL AGENT; TRIFLUOROACETIC ACID; UNCLASSIFIED DRUG; WATER; [8 (3 BROMO 2,6 DIMETHOXYPHENYL) 2,7 DIMETHYLPYRAZOLO[1,5 A][1,3,5]TRIAZIN 4 YL]BIS(2 METHOXYETHYL)AMINE BR 76; [8 (4 BROMO 2,6 DIMETHOXYPHENYL) 2,7 DIMETHYLPYRAZOLO[1,5 A][1,3,5]TRIAZIN 4 YL] N,N BIS(2 METHOXYETHYL)AMINE BR 76;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BROMINATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ISOMERISM; ISOTOPE LABELING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RADIOBROMINATION; RADIOCHEMISTRY; STRUCTURE ACTIVITY RELATION; TEMPERATURE SENSITIVITY;

EID: 68949164947     PISSN: 03624803     EISSN: 10991344     Source Type: Journal    
DOI: 10.1002/jlcr.1616     Document Type: Article

References (15)

1. W. Vale, J. Spiess, C. Rivier, J. Rivier, Science 1981, 213, 1394-1397.
2. J. D. Bremner, J. Licinio, A. Darnell, J. H. Krystal, M. J. Owens, S. M. Southwick, C. B. Nemeroff, D. S. Charney, Am. J. Psychiatry 1997, 154, 624-629.
3. C. B. Nemeroff, E. Widerlov, G. Bissette, H. Walleus, I. Karlsson, K. Eklund, C. D. Kilts, P. T. Loosen, W. Vale, Science 1984, 226, 1342-1344.
4. M. J. Owens, C. B. Nemeroff, Pharmacol. Rev. 1991, 43, 425-473.
5. A. J. Dunn, C. W. Berridge, Brain Res. Rev. 1990, 15, 71-100.
6. G. F. Koob, Biol. Psychiatry 1999, 46, 1167-1180.
7. L. Arborelius, M. J. Owens, P. M. Plotsky, C. B. Nemeroff, J. Endocrinol. 1999, 160, 1-12.
8. D. E. Grigoriadis, R. G. Struble, D. L. Price, E. B. De Souza, Neuropharmacology 1989, 28, 761-764.
9. E. Jagoda, C. Contoreggi, M. Lee, C. K. Kao, L. P. Szajek, S. Listwk, P. Gold, G. Chrousos, E. Greiner, B. M. Kim, A. E. Jacobson, K. C. Rice, W. C. Eckelman, J. Med. Chem. 2003, 46, 3559-3562.
10. L.-W. Hsin, E. L. Webster, G. P. Chrousos, P. W. Gold, W. C. Eckelman, C. Contoreggi, K. C. Rice, Bioorg. Med. Chem. Lett. 2000, 10, 707-710.
11. L. Martarello, C. D. Kilts, T. D. Ely, M. J. Owens, C. B. Nemeroff, M. Camp, M. M. Goodman, Nucl. Med. Biol. 2001, 28, 187-195.
12. G. M. Sullivan, R. V. Parsey, J. S. D. Kumar, V. Arango, S. A. Kassir, Y. Huang, N. R. Simpson, R. L. Van Heertum, J. J. Mann, Nucl. Med. Biol. 2007, 34, 353-362.
13. A. M. Van Leusen, P. G. Oomkes, Synth. Commun. 1980, 10, 399-403.
14. L. He, P. J. Gilligan, R. Zaczek, L. W. Fitzgerald, J. McElroy, H.-S. L. Shen, J. A. Saye, N. H. Kalin, S. Shelton, D. Christ, G. Trainor, P. Hartig, J. Med. Chem. 2000, 43, 449-456.
15. L. P. Szajek, C. H. K. Kao, D. O. Kiesewetter, M. B. Sassaman, L. Lang, P. Plascjak, W. C. Eckelman, Radiochim. Acta 2004, 92, 291-295.