Early experience and results of bone graft enriched with autologous platelet gel for recalcitrant nonunions of lower extremity

Journal of Trauma

Volumn 63, Issue 3, 2007, Pages 655-661

  Chiang, Chao Ching ^a   Su, Chen Yao ^a   Huang, Ching Kuei ^a   Chen, Wei Ming ^a   Chen, Tain Hsiung ^a   Tzeng, Yun Hsuan ^b  

^a CHENG HSIN GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Autologous platelet gel; Femur; Recalcitrant nonunion; Tibia

Indexed keywords

ADULT; AGED; ARTICLE; AUTOTRANSPLANTATION; BONE TRANSPLANTATION; FEASIBILITY STUDY; FEMALE; FEMUR FRACTURE; FRACTURE HEALING; FRACTURE NONUNION; GEL; HUMAN; INTERNAL FIXATOR; MALE; METHODOLOGY; MIDDLE AGED; OSTEOSYNTHESIS; POSTOPERATIVE COMPLICATION; PROSPECTIVE STUDY; RADIOGRAPHY; THROMBOCYTE; TIBIA FRACTURE; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; BLOOD PLATELETS; BONE TRANSPLANTATION; FEASIBILITY STUDIES; FEMALE; FEMORAL FRACTURES; FRACTURE FIXATION, INTERNAL; FRACTURE HEALING; FRACTURES, UNUNITED; GELS; HUMANS; INTERNAL FIXATORS; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDIES; TIBIAL FRACTURES; TRANSPLANTATION, AUTOLOGOUS; TREATMENT OUTCOME;

EID: 38449110529     PISSN: 00225282     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ta.0000219937.51190.37     Document Type: Article

References (32)

1. Einhorn TA. Enhancement of fracture-healing. J Bone Joint Surg Am. 1995;77:940-956.
2. Ring D, Barrick WT, Jupiter JB. Recalcitrant nonunion. Clin Orthop. 1997;340:181-189.
3. Babhulkar S, P and e K, Babbulkar S. Nonunion of the diaphysis of long bones. Clin Orthop. 2005;431:50-56.
4. Zaslav KR, Meinhard BP. Management of resistant pseudoarthrosis of long bones. Clin Orthop. 1988;233:234-242.
5. Ross R, Raines EW, Bowen-Pope DF. The biology of platelet derived growth factor. Cell. 1986;46:155-169.
6. Roberts AB, Spron MB. Physiological actions and clinical applications of transforming growth factor-beta (TGF-beta). Growth Factors. 1995;8:1-9.
7. 3 integrin, osteopontin, and thrombin. Am J Pathol. 1996;149:293-305.
8. Marx RE, Carlson ER, Schimmele SR. Platelet rich plasma: growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radio Endod. 1998;85:638-646.
9. Henderson JL, Cupp CL, Ross EV, et al. The effect of autologous platelet gel on wound healing. Ear Nose Throat J. 2003;82:598-602.
10. Kim SG, Chung CH, Kim YK, et al. Use of particular dentin-plaster of Paris combination with/without platelet-rich plasma in the treatment of bone defect around implants. Int J Oral Maxillofac Implants. 2002;17:86-94.
11. Zechner W, Tangl S, Tepper G, et al. Influence of platelet-rich plasma on osseous healing of dental implants: a histologic and histomorphometric study in minipigs. Int J Oral Maxillofac Implants. 2003;18:15-22.
12. Fennis JP, Stoelinga PJ, Jansen JA. M and ibular reconstruction: a histological and histomorphometric study on the use of autogenous scaffold, particulate cortico-cancellous bone grafts and platelet rich plasma in goats. Int J Oral Maxillofac Surg. 2004;33:48-55.
13. Aghaloo TL, Moy PK, Freymiller EG. Evaluation of platelet-rich plasma in combination with anorganic bovine bone in the rabbit cranium: a pilot study. Int J Oral Maxillofac Implants. 2004;19:59-65.
14. Man D, Plosker H, Winland-Brown JE. The use of autologous platelet rich plasma (platelet gel) and autologous platelet-poor plasma (fibrin-glue) in cosmetic surgery. Plast Reconstr Surg. 2001;107:229-237.
15. Gravlee GP. Effectiveness of intraoperative autologous whole blood and platelet-rich plasma in cardiac surgery. Ann Acad Med Singapore. 1994;23 (Suppl 6):65-70.
16. Valbonesi M, Carlier P, Florio G, et al. Intraoperative blood salvage (IOBS) in cardiac and vascular surgery. Int J Artif Organs. 1995;18:130-135.
17. Oba J, Aoki H, Yoshida T, et al. Mitral valve replacement in patient with idiopathic thrombocytopenia purpura. Jpn J Thorac Cardiovasc Surg. 2000;48:129-131.
18. Soffer E, Ouhayoun JP, Anagnostou F. Fibrin sealants and platelet preparations in bone and periodontal healing. Oral Surg Oral Med Oral Pathol Oral Radio Endod. 2003;95:521-528.
19. Tozum TF, Demiralp B. Platelet-rich plasma: a promising innovation in dentistry. J Can Dent Assoc. 2003;69:664.
20. Babbush CA, Kevy SV, Jacobson MS. An in vitro and in vivo evaluation of autologous platelet concentrate in oral reconstruction. Implant Dent. 2003;12:24-34.
21. Su CY, Chiang CC, Lai WF, et al. Platelet-derived growth factor-AB and transforming growth factor-β1 in platelet gels activated by single-donor human thrombin. Transfusion. 2004;44:945.
22. Ware JE, Snow KK, Kosinski KK, et al. SF-36 Health Survey: Manual and Interpretation Guide. Boston, Lincoln: The Health Assessment Lab and QualityMetric, Inc.; 1996.
23. Rodriguez-Merchan EC, Forriol F. Nonunion: general principles and experimental data. Clin Orthop. 2004;419:4-12.
24. Jain AK, Sinha S. Infected nonunion of the long bones. Clin Orthop. 2005;431:57-65.
25. Bohler J. An approach to non-union of fractures. Surg Annu. 1982;14:299-315.
26. Perry CR. Bone repair techniques, bone graft, and bone graft substitutes. Clin Orthop. 1999;360:71-86.
27. Gonzalez del PJ, Bartolome del VE, Grana GL, et al. Free vascularized fibular grafts have a high union rate in atrophic nonunions. Clin Orthop. 2004;419:38-45.
28. Lind M. Growth factor stimulation of bone healing. Effects on osteoblasts, osteotomies, and implant fixation. Acta Orthop Sc and. 1998;283 (Suppl):2-37.
29. Marx RE. Platelet rich plasma: a source of multiple autogenous growth factors for bone grafts. In: Lynch SE, Genco RJ, Marx RE, eds. Tissue Engineering: Applications in Maxillofacial Surgery and Periodontics. Hanover, IL: Quintessence Publishing; 1999:71-82.
30. Martinez-Gonzales JM, Cano-Sanchez J, Gonzalo-Lafuente JC, et al. Do ambulatory use platelet-rich plasma (PRP) concentrates present risks? Med Oral. 2002;7:375-390.
31. Christie RJ, Carrington L, Alving B. Postoperative bleeding induced by topical bovine thrombin: report of two cases. Surgery. 1997;121:708-710.
32. Rapaport SI, Zivelin A, Minow RA, et al. Clinical significance of antibodies to bovine and human thrombin and factor V after surgical use of bovine thrombin. Am J Clin Pathol. 1992;97:84-91.