Artificial sweeteners and the risk of gastric, pancreatic, and endometrial cancers in Italy

Cancer Epidemiology Biomarkers and Prevention

Volumn 18, Issue 8, 2009, Pages 2235-2238

  Bosetti, Cristina ^a   Gallus, Silvano ^a   Talamini, Renato ^c   Montella, Maurizio ^d   Franceschi, Silvia ^e   Negri, Eva ^a   La Vecchia, Carlo ^a,b  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^d NATIONAL CANCER INSTITUTE   (Italy)

^e INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTAME; SACCHARIN; SWEETENING AGENT;

ADULT; AGED; ARTICLE; CALORIC INTAKE; CANCER INCIDENCE; CANCER RISK; CONTROLLED STUDY; ENDOMETRIUM CANCER; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; ITALY; MAJOR CLINICAL STUDY; MALE; PANCREAS CANCER; PRIORITY JOURNAL; STOMACH CANCER;

ADULT; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; ITALY; MALE; MIDDLE AGED; ODDS RATIO; PANCREATIC NEOPLASMS; RISK FACTORS; STOMACH NEOPLASMS; SWEETENING AGENTS;

EID: 68949090137     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: 10.1158/1055-9965.EPI-09-0365     Document Type: Article

References (40)

1. Weihrauch MR, Diehl V. Artificial sweeteners - do they bear a carcinogenic risk? Ann Oncol 2004;15:1460-5.
2. Armstrong B, Doll R. Bladder cancer mortality in diabetics in relation to saccharin consumption and smoking habits. Br J Prev Soc Med 1975;29:73-81.
3. Howe GR, Burch JD, Miller AB, et al. Artificial sweeteners and human bladder cancer. Lancet 1977;2:578-81.
4. Andreatta MM, Munoz SE, Lantieri MJ, Eynard AR, Navarro A. Artificial sweetener consumption and urinary tract tumors in Cordoba, Argentina. Prev Med 2008;47:136-9.
5. Simon D, Yen S, Cole P. Coffee drinking and cancer of the lower urinary tract. J Natl Cancer Inst 1975;54:587-91.
6. Wynder EL, Goldsmith R. The epidemiology of bladder cancer: a second look. Cancer 1977;40:1246-68.
7. Wynder EL, Stellman SD. Artificial sweetener use and bladder cancer: a case-control study. Science 1980;207:1214-6.
8. Cartwright RA, Adib R, Glashan R, Gray BK. The epidemiology of bladder cancer in West Yorkshire. A preliminary report on non-occupational aetiologies. Carcinogenesis 1981;2:343-7.
9. Hoover RN, Strasser PH. Artificial sweeteners and human bladder cancer. Preliminary results. Lancet 1980;1:837-40.
10. Morrison AS, Buring JE. Artificial sweeteners and cancer of the lower urinary tract. N Engl J Med 1980;302:537-41.
11. Piper JM, Matanoski GM, Tonascia J. Bladder cancer in young women. Am J Epidemiol 1986;123:1033-42.
12. Sturgeon SR, Hartge P, Silverman DT, et al. Associations between bladder cancer risk factors and tumor stage and grade at diagnosis. Epidemiology 1994;5:218-25.
13. Capen CC, Dybing E, Rice JM, Wilbourn JD. Species differences in thyroid, kidney and urinary bladder carcinogenesis. IARC Scientific Publ. No.147. IARC Scientific Publ. No.147. Lyon, France: International Agency for Research on Cancer; 1999.
14. National Toxicology Program USDoHaHS. Toxicity studies of aspartame (CAS No.22839-47-0) in FVB/N-TgN(v-Ha-ras)Led(Tg.AC) hemizygous mice and carcinogenicity studies of aspartame in B6.129-Trp53tm1Brd(N5) haploinsufficient mice. NTP Techincal Report (NIH Publication No. 03-4459) 2003.
15. Soffritti M, Belpoggi F, Degli Esposti D, Lambertini L, Tibaldi E, Rigano A. First experimental demonstration of the multipotential carcinogenic effects of aspartame administered in the feed to Sprague-Dawley rats. Environ Health Perspect 2006;114:379-85.
16. Soffritti M, Belpoggi F, Tibaldi E, Esposti DD, Lauriola M. Life-span exposure to low doses of aspartame beginning during prenatal life increases cancer effects in rats. Environ Health Perspect 2007;115: 1293-7.
17. The European Food Safety Authority. Opinion of the scientific panel AFC related to new long-term carcinogenicity study on aspartame. EFSA Journal 2006;356:1-44.
18. Magnuson BA, Burdock GA, Doull J, et al. Aspartame: a safety evaluation based on current use levels, regulations, and toxicological and epidemiological studies. Crit Rev Toxicol 2007;37:629-727.
19. Olney JW, Farber NB, Spitznagel E, Robins LN. Increasing brain tumor rates: is there a link to aspartame? J Neuropathol Exp Neurol 1996;55:1115-23.
20. Trichopoulos D. Response to Schwartz GR. Aspartame and breast and other cancers. West J Med 1999;171:301.
21. Gurney JG, Pogoda JM, Holly EA, Hecht SS, Preston-Martin S. Aspartame consumption in relation to childhood brain tumor risk: results from a case-control study. J Natl Cancer Inst 1997;89:1072-4.
22. Bunin GR, Kushi LH, Gallagher PR, Rorke-Adams LB, McBride ML, Cnaan A. Maternal diet during pregnancy and its association with medulloblastoma in children: a children's oncology group study (United States). Cancer Causes Control 2005;16:877-91.
23. Hardell L, Dreifaldt AC. Breast-feeding duration and the risk of malignant diseases in childhood in Sweden. Eur J Clin Nutr 2001;55:179-85.
24. Lim U, Subar AF, Mouw T, et al. Consumption of aspartame-containing beverages and incidence of hematopoietic and brain malignancies. Cancer Epidemiol Biomarkers Prev 2006;15:1654-9.
25. Ewertz M, Gill C. Dietary factors and breast-cancer risk in Denmark. Int J Cancer 1990;46:779-84.
26. Goodman MT, Morgenstern H, Wynder EL. A case-control study of factors affecting the development of renal cell cancer. Am J Epidemiol 1986;124:926-41.
27. Asal NR, Risser DR, Kadamani S, Geyer JR, Lee ET, Cherng N. Risk factors in renal cell carcinoma: I. Methodology, demographics, tobacco, beverage use, and obesity. Cancer Detect Prev 1988;11:359-77.
28. Gallus S, Scotti L, Negri E, et al. Artificial sweeteners and cancer risk in a network of case-control studies. Ann Oncol 2007;18:40-4.
29. Lucenteforte E, Scita V, Bosetti C, Bertuccio P, Negri E, La Vecchia C. Food groups and alcoholic beverages and the risk of stomach cancer: a case-control study in Italy. Nutr Cancer 2008;60:577-84.
30. Bravi F, Scotti L, Bosetti C, et al. Food groups and endometrial cancer risk: a case-control study from Italy. Am J Obstet Gynecol 2009;200:293 e1-7.
31. Decarli A, Franceschi S, Ferraroni M, et al. Validation of a food-frequency questionnaire to assess dietary intakes in cancer studies in Italy. Results for specific nutrients. Ann Epidemiol 1996;6:110-8.
32. Franceschi S, Negri E, Salvini S, et al. Reproducibility of an Italian food frequency questionnaire for cancer studies: results for specific food items. Eur J Cancer 1993;29A:2298-305.
33. Salvini S, Parpinel M, Gnagnarella P, Maisonneuve P, Turrini A. Banca di composizione degli alimenti per studi epidemiologici in Italia. Milano, Italia: Istituto Europeo di Oncologia; 1998.
34. Gnagnarella P, Parpinel M, Salvini S, Franceschi S, Palli D, Boyle P. The update of the Italian food composition database. J Food Comp Analysis 2004;17:509-22.
35. Breslow NE, Day NE. Statistical methods in cancer research. Vol. I. The analysis of case-control studies. Lyon, France: IARC; 1980.
36. La Vecchia C, Negri E, Franceschi S, D'Avanzo B, Boyle P. A case-control study of diabetes mellitus and cancer risk. Br J Cancer 1994; 70:950-3.
37. Michaud DS. Epidemiology of pancreatic cancer. Minerva Chir 2004; 59:99-111.
38. La Vecchia C, Bosetti C, Negri E, Franceschi S. Refined sugar intake and the risk of gastric cancer. Int J Cancer 1998;78:130-1.
39. Bao Y, Stolzenberg-Solomon R, Jiao L, et al. Added sugar and sugar-sweetened foods and beverages and the risk of pancreatic cancer in the National Institutes of Health-AARP Diet and Health Study. Am J Clin Nutr 2008;88:431-40.
40. Arcella D, Le Donne C, Piccinelli R, Leclercq C. Dietary estimated intake of intense sweeteners by Italian teenagers. Present levels and projections derived from the INRAN-RM-2001 food survey. Food Chem Toxicol 2004;42:677-85.