Increasing brain tumor rates: Is there a link to aspartame?

Journal of Neuropathology and Experimental Neurology

Volumn 55, Issue 11, 1996, Pages 1115-1123

  Olney, John W ^a   Farber, Nuri B ^a   Spitznagel, Edward ^a   Robins, Lee N ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aspartame; Brain tumors; Human; Increased incidence; Increased malignancy; Mutagenesis

Indexed keywords

ASPARTAME;

ARTICLE; BRAIN TUMOR; CANCER INCIDENCE; CANCER RISK; CONTROLLED STUDY; HUMAN; MAJOR CLINICAL STUDY; MUTAGENESIS; PRIORITY JOURNAL; UNITED STATES;

EID: 0029851769     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005072-199611000-00002     Document Type: Article

References (25)

1. Davis DL, Ahlbom A, Hoel D, Percy C. Is brain cancer mortality increasing in industrial countries? Am J Indust Med 1991;19:421-31
2. Greig NH, Ries LG, Yancik R, Rapoport, SI. Increasing annual incidence of primary malignant brain tumors in the elderly. J Natl Cancer Inst 1990;82:1621-23
3. Mao Y, Desmeules M, Semenciw RM, Hill G, Gaudette L, Wigle DT. Increasing brain cancer rates in Canada. Can Med Assoc J 1991;145:1583-90
4. Levi F, La Vecchia C. Trends in brain cancer. Lancet 1989;2:917
5. Kurland LT, Schoenberg BS, Annegers JF, Okazaki H, Molgaard C. Brain tumors in the chemical industry. Ann NY Acad Sci 1982;381: 6-16
6. Alexander V. Brain tumor risk among United States nuclear workers. Occup Med 1991;6(4):695-711
7. Demers PA, Heyer NJ, Rosenstock L. Mortality among firefighters from three northwestern United States cities. Brit J Indust Med 1992;49:664-70
8. Brownson RC, Reif, JS, Chang JC, Davis JR. An analysis of occupational risks for brain cancer. Am J Pub Health 1990;80:169-72
9. Thomas TL, Waxweiler RJ. Brain tumors and occupational risk factors. Scand J Work Environ Health 1986;12:1-15
10. Hagmar L, Akesson B, Nielsen J, Andersson C, Linden K, Attewell R, Moller T. Mortality and cancer morbidity in workers exposed to low levels of vinyl chloride monomer at a polyvinyl chloride processing plant. Am J Indust Med 1990;17:553-65
11. Savitz DA, Loomis DP. Magnetic field exposure in relation to leukemia and brain cancer mortality among electric utility workers. Am J Epidemiol 1995;141:123-34
12. Heath CW. Electromagnetic field exposure and cancer: A review of epidemiologic evidence. CA 1996;46:29-45
13. Roberts HJ. Does aspartame cause human brain cancer? J Advancement Med 1991;4:231-41
14. Nauta Walle JH, Lampert Peter W, Young Vernon. Aspartame: Decision of the public board of inquiry (FDA Docket No. 75F-0355.) Available through US Government Printing Office, see Federal Register 1980;45:69558
15. Hayes AH. Aspartame: Commissioner's final decision, Federal Register 1991;46:38284-38308
16. Shephard SE, Wakabayashi K, Nagao M. Mutagenic activity of peptides and the artificial sweetener aspartame after nitrosation. Fd Chem Toxic 1993;31:323-29
17. Kosary CL, Ries LAG, Miller BA, Hankey BF, Harras A, Edwards BK, eds. SEER cancer statistics review, 1973-1992. Bethesda, MD: NIH Publications, 1995
18. Nelson J, Tsukada Y, Schoenfeld D, Fulling K, Lamarche J, Peress N. Necrosis as a prognostic criterion in malignant supratentorial, astrocytic gliomas. Cancer 1983;52:550-54
19. Wrensch M, Bondy, ML, Wiencke J, Yost M. Environmental risk factors for primary malignant brain tumors: A review. J Neuro Oncol 1993;17:47-64
20. Inskip PD, Linet MS, Heineman EF. Etiology of brain tumors in adults. Epidemiologic Reviews 1995;17:382-414
21. Study E33-34 in Master File 134 on aspartame, on file at the FDA Hearing Clerk's Office
22. Bigner DD, JA Swenberg JA. Experimental tumors of the central nervous system. Upjohn Company, Kalamazoo, Michigan, 1977
23. Druckrey H, Ivankovic S, Preussmann R. Teratogenic and carcinogenic effects in the offspring after a single injection of ethylnitrosourea to pregnant rats. Nature 1966;210:1378-79
24. Wechsler W, Kleihues P, Matsumoto S, Zulch KJ, Ivankovic S, Preussmann R, Druckrey H. Pathology of experimental neurogenic tumors chemically induced during prenatal and postnatal life. Ann NY Acad Sci 1969;159:360-480
25. Swenberg JA, Koestner A, Wechsler W, Denlinger RH. Quantitative aspects of transplacental tumor induction with ethylnitrosourea in rats. Cancer Res 1972;32:2656-60