The pilus-induced Ca2+ flux triggers lysosome exocytosis and increases the amount of Lamp1 accessible to Neisseria IgA1 protease

Cellular Microbiology

Volumn 3, Issue 4, 2001, Pages 265-275

  Ayala, B Patricia ^a   Vasquez, Brandi ^a   Clary, Susan ^a   Tainer, John A ^b   Rodland, Karin ^c   So, Magdalene ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; IMMUNOGLOBULIN A1; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MEMBRANE PROTEIN; PORIN; PROTEINASE; UNCLASSIFIED DRUG; IGA SPECIFIC SERINE ENDOPEPTIDASE; IGA-SPECIFIC SERINE ENDOPEPTIDASE; LEUKOCYTE ANTIGEN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN; SERINE PROTEINASE;

ARTICLE; BACTERIUM ADHERENCE; BACTERIUM PILUS; CALCIUM TRANSPORT; CELL PH; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; ENZYME RELEASE; EPITHELIUM CELL; EXOCYTOSIS; GRAM NEGATIVE INFECTION; HUMAN; HUMAN CELL; HYDROLYSIS; LYSOSOME; NEISSERIA GONORRHOEAE; NEISSERIA MENINGITIDIS; NONHUMAN; PATHOGENICITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; STEADY STATE; CELL LINE; ENZYMOLOGY; EPITHELIUM; FIMBRIA; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MICROBIOLOGY; NEISSERIA; PHYSIOLOGY;

BACTERIA (MICROORGANISMS); NEGIBACTERIA; NEISSERIA; NEISSERIA GONORRHOEAE; NEISSERIA MENINGITIDIS;

ANTIGENS, CD; CALCIUM; CELL LINE; EPITHELIUM; EXOCYTOSIS; FIMBRIAE, BACTERIAL; HUMANS; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 1; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; LYSOSOMES; MEMBRANE GLYCOPROTEINS; NEISSERIA; SERINE ENDOPEPTIDASES;

EID: 0034744582     PISSN: 14625814     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1462-5822.2001.00112.x     Document Type: Article

References (52)

1. Biosynthetic transport of a major lysosomal membrane glycoprotein, Lamp-1: Convergence of biosynthetic and endocytic pathways occurs at three distinctive points
2. Infection of epithelial cells by pathogenic Neisseriae reduces the levels of multiple lysosomal constituents
3. Etiology, manifestation, and therapy of acute epididymitis: Prospective study of 50 cases
4. Studies on gonococcus infection. XVII. IgA1-cleaving protease in vaginal washings from women with gonorrhea
5. Alteration of epithelial cell transferrin-homeostasis by Neisseriae meningitidis and Neisseria gonorrhoeae
6. Gonococcal infection: A model of molecular pathogenesis
7. Construction of isogenic gonococci with variable porin structure: Effects on susceptibility to human serum and antibiotics
8. The lysosomal membrane glycoprotein Lamp-1 is transported to lysosomes by two alternative pathways
9. Isolation and characterization of human lysosomal membrane glycoproteins, h-lamp1 and h-lamp-2
10. Identification of two lysosomal membrane glycoproteins
11. 2+-triggers massive exocytosis in Chinese hamster ovary cells
12. 2+
13. Catecholamine section from digitonin-treated adrenal medullary chromaffin cells
14. Immunobiology of purified recombinant outer membrane porin protein I of Neisseria gonorrhoeae
15. Partial duplication in the 'hinge' region of IgA1 myeloma proteins
16. Characterization of the cation-independent mannose 6-phosphate receptor-enriched prelysosomal compartment in NRK cells
17. The lysosomal/phagosomal membrane protein h-lamp1 is a target of the IgA1 protease of Neisseria gonorrhoeae
18. Evaluation of immunoglobulin A1 (IgA1) protease and IgA1 protease-inhibitory activity in human female genital infection with Neisseria gonorrhoeae
19. Lysosomes
20. Gonococcal infections
21. Effects of the immunoglobulin A1 protease on Neisseria gonorrhoeae trafficking across polarized T84 epithelial monolayers
22. Isolation of Neisseria gonorrhoeae mutants that show enhanced trafficking across polarized T84 epithelial monolayers
23. A Neisseria gonorrhoeae immunoglobulin A1 protease mutant is infectious in the human/challenge model of urethral infection
24. Cell signaling by the type IV pili of pathogenic Neisseria
25. Multiple and diverse forms of regulated exocytosis in wild type and defective PC12 cells
26. Etiology of acute epididymitis presenting in a venereal disease clinic
27. The Neisseria type 2 IgA1 protease cleaves LAMP1 and promotes survival of bacteria within epithelial cells
28. - gonococci and meningococci to epithelial cells elicits cortical actin rearrangements and clustering of tyrosine-phosphorylated proteins
29. Traversal of a polarized epithelium by pathogenic Neisseriae: Facilitation by type IV pili and maintenance of epithelial barrier function
30. Neisserial porin (PorB) causes rapid calcium influx in target cells and induces apoptosis by the activation of cysteine proteases
31. Antigenic variation of pilin regulates adhesion of Neisseria meningitidis to human epithelial cells
32. Biochemical purification and crystallographic characterization of the fiber-forming protein pilin from Neisseria gonorrhoeae
33. Neisseria gonorrhoeae and Neisseria meningitidis: Extracellular enzyme cleaves human immunoglobulin A
34. Cell surface labelling of CFTR in T84 cells
35. Interaction of Neisseria meningitidis with a polarized monolayer of epithelial cells
36. Gonococcal invasion of epithelial cells driven by P.IA, a bacterial ion channel with GTP binding properties
37. Modulation of RNA expression by intracellular calcium
38. 3 formation, intracellular calcium mobilization and microfilament rearrangement in host cells
39. Host cell invasion by trypanosomes requires lysosome and microtubule/kinesis-mediated transport
40. 2+ -regulated exocytic vesicles in fibroblasts and epithelial cells
41. 2+ -dependent exocytosis of lysosomes and lysosomes-mediated cell invasion by trypanosomes
42. Modulation of Neisseria porin (PorB) by cytosolic ATP/GTP of target cells: Parallels between pathogen accommodation and mitochondrial endosymbiosis
43. 2+ depletion from granules inhibits exocytosis
44. Antigenic variation of gonococcal pilus involves assembly of separated silent gene segments
45. Proteolysis of bacterial membrane proteins by Neisseria gonorrhoeae type 2 immunoglobulin A1 protease
46. Serological classification of Neisseria gonorrhoeae with monoclonal antibodies
47. Molecular cloning of cDNAs encoding lampA, a human lysosomal membrane glycoprotein with apparent Mr=120,000
48. Opa binding to cellular CD66 receptors mediates the transcellular traversal of Neisseria gonorrhoeae across polarized T84 epithelial cell monolayers
49. Distinct saturable pathway for the endocytosis of different tyrosine motifs
50. Fate of the major outer membrane protein P.IA in early and late events of gonococcal infection of epithelial cells
51. Multiple kinetics components of exocytosis distinguished by neurotoxin sensitivity