Heterogeneous expression of the adhesion receptor CD226 on murine NK and T cells and its function in NK-mediated killing of immature dendritic cells

Journal of Leukocyte Biology

Volumn 86, Issue 1, 2009, Pages 91-101

  Seth, Sebastian ^a   Georgoudaki, Anna Maria ^b   Chambers, Benedict J ^b   Qiu, Quan ^a   Kremmer, Elisabeth ^c   Maier, Michael K ^a   Czeloth, Niklas ^a   Ravens, Inga ^a   Foerster, Reinhold ^a   Bernhardt, Günter ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

Antibodies; CD155; Depletion; DNAM 1; Splice variant

Indexed keywords

ADHESION RECEPTOR CD226; CD226 MONOCLONAL ANTIBODY; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; NATURAL KILLER CELL RECEPTOR; UNCLASSIFIED DRUG; CD226 ANTIGEN; POLIOVIRUS RECEPTOR; T LYMPHOCYTE ANTIGEN; VIRUS RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD8+ T LYMPHOCYTE; CELL FUNCTION; CELL KILLING; CELL MATURATION; CELL TYPE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; EMBRYO; HUMAN; HUMAN CELL; MOUSE; NATURAL KILLER T CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRECURSOR; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; T LYMPHOCYTE; TARGET CELL; ANIMAL; BINDING SITE; CYTOLOGY; CYTOTOXICITY; GENE EXPRESSION REGULATION; IMMUNOLOGY; METABOLISM; NATURAL KILLER CELL; PROTEIN BINDING;

MURINAE; MUS;

ANIMALS; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; BINDING SITES; CYTOTOXICITY, IMMUNOLOGIC; DENDRITIC CELLS; GENE EXPRESSION REGULATION; KILLER CELLS, NATURAL; MICE; PROTEIN BINDING; RECEPTORS, VIRUS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 68849120512     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.1208745     Document Type: Article

References (44)

1. Shibuya, A., Campbell, D., Hannum, C., Yssel, H., Franz-Bacon, K., McClanahan, T., Kitamura, T., Nicholl, J., Sutherland, G. R., Lanier, L. L., Phillips, J. H. (1996) DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes. Immunity 4, 573-581. (Pubitemid 26233311)
2. Shibuya, K., Lanier, L. L., Phillips, J. H., Ochs, H. D., Shimizu, K., Nakayama, E., Nakauchi, H., Shibuya, A. (1999) Physical and functional association of LFA-1 with DNAM-1 adhesion molecule. Immunity 11, 615-623.
3. Shirakawa, J., Shibuya, K., Shibuya, A. (2005) Requirement of the serine at residue 329 for lipid raft recruitment of DNAM-1 (CD226). Int. Immunol. 17, 217-223. (Pubitemid 40372644)
4. Shibuya, K., Shirakawa, J., Kameyama, T., Honda, S., Tahara-Hanaoka, S., Miyamoto, A., Onodera, M., Sumida, T., Nakauchi, H., Miyoshi, H., Shibuya, A. (2003) CD226 (DNAM-1) is involved in lymphocyte function-associated antigen 1 costimulatory signal for naive T cell differentiation and proliferation. J. Exp. Med. 198, 1829-1839. (Pubitemid 38032116)
5. Reymond, N., Imbert, A. M., Devilard, E., Fabre, S., Chabannon, C., Xerri, L., Farnarier, C., Cantoni, C., Bottino, C., Moretta, A., Dubreuil, P., Lopez, M. (2004) DNAM-1 and PVR regulate monocyte migration through endothelial junctions. J. Exp. Med. 199, 1331-1341. (Pubitemid 38685725)
6. Bottino, C., Castriconi, R., Moretta, L., Moretta, A. (2005) Cellular ligands of activating NK receptors. Trends Immunol. 26, 221-226.
7. Pende, D., Castriconi, R., Romagnani, P., Spaggiari, G. M., Marcenaro, S., Dondero, A., Lazzeri, E., Lasagni, L., Martini, S., Rivera, P., Capobianco, A., Moretta, L., Moretta, A., Bottino, C. (2006) Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction. Blood 107, 2030-2036. (Pubitemid 43289387)
8. Mendelsohn, C. L., Wimmer, E., Racaniello, V. R. (1989) Cellular receptor for poliovirus: molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily. Cell 56, 855-865. (Pubitemid 19082521)
9. Eberle, F., Dubreuil, P., Mattei, M. G., Devilard, E., Lopez, M. (1995) The human PRR2 gene, related to the human poliovirus receptor gene (PVR), is the true homolog of the murine MPH gene. Gene 159, 267-272.
10. Takai, Y., Irie, K., Shimizu, K., Sakisaka, T., Ikeda, W. (2003) Nectins and nectin-like molecules: roles in cell adhesion, migration, and polarization. Cancer Sci. 94, 655-667. (Pubitemid 37160921)
11. Du Pasquier, L., Zucchetti, I., De Santis, R. (2004) Immunoglobulin superfamily receptors in protochordates: before RAG time. Immunol. Rev. 198, 233-248. (Pubitemid 38406947)
12. Fuchs, A., Cella, M., Giurisato, E., Shaw, A. S., Colonna, M. (2004) Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155). J. Immunol. 172, 3994-3998. (Pubitemid 38375210)
13. Meyer, D., Seth, S., Albrecht, J., Maier, M. K., du Pasquier, L., Ravens, I., Dreyer, L., Burger, R., Gramatzki, M., Schwinzer, R., Kremmer, E., Foerster, R., Bernhardt, G. (2008) CD96 interaction with CD155 via its first Ig-like domain is modulated by alternative splicing or mutations in distal Ig-like domains. J. Biol. Chem. 284, 2235-2244.
14. Mueller, S., Wimmer, E. (2003) Recruitment of Nectin-3 to cell-cell junctions through trans-heterophilic interaction with CD155, a vitronectin and poliovirus receptor that localizes to α(v)β3 integrin-containing membrane microdomains. J. Biol. Chem. 278, 31251-31260. (Pubitemid 36994642)
15. Ikeda, W., Kakunaga, S., Takekuni, K., Shingai, T., Satoh, K., Morimoto, K., Takeuchi, M., Imai, T., Takai, Y. (2004) Nectin-like molecule-5/Tage4 enhances cell migration in an integrin-dependent, Nectin-3-independent manner. J. Biol. Chem. 279, 18015-18025. (Pubitemid 38560571)
16. Ogita, H., Takai, Y. (2006) Nectins and nectin-like molecules: roles in cell adhesion, polarization, movement, and proliferation. IUBMB Life 58, 334-343. (Pubitemid 43880026)
17. Sakamoto, Y., Ogita, H., Komura, H., Takai, Y. (2008) Involvement of nectin in inactivation of integrin {α}v 3 after the establishment of cell-cell adhesion. J. Biol. Chem. 283, 496-505.
18. Maier, M. K., Seth, S., Czeloth, N., Qiu, Q., Ravens, I., Kremmer, E., Ebel, M., Muller, W., Pabst, O., Förster, R., Bernhardt, G. (2007) The adhesion receptor CD155 determines the magnitude of humoral immune responses against orally ingested antigens. Eur. J. Immunol. 37, 2214-2225. (Pubitemid 47250214)
19. Erickson, B. M., Thompson, N. L., Hixson, D. C. (2006) Tightly regulated induction of the adhesion molecule necl-5/CD155 during rat liver regeneration and acute liver injury. Hepatology 43, 325-334.
20. Castriconi, R., Dondero, A., Corrias, M. V., Lanino, E., Pende, D., Moretta, L., Bottino, C., Moretta, A. (2004) Natural killer cell-mediated killing of freshly isolated neuroblastoma cells: critical role of DNAX accessory molecule-1-poliovirus receptor interaction. Cancer Res. 64, 9180-9184. (Pubitemid 39665534)
21. Tomasec, P., Wang, E. C., Davison, A. J., Vojtesek, B., Armstrong, M., Griffin, C., McSharry, B. P., Morris, R. J., Llewellyn-Lacey, S., Rickards, C., Nomoto, A., Sinzger, C., Wilkinson, G. W. (2005) Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141. Nat. Immunol. 6, 181-188. (Pubitemid 40268199)
22. Gilfillan, S., Chan, C. J., Cella, M., Haynes, N. M., Rapaport, A. S., Boles, K. S., Andrews, D. M., Smyth, M. J., Colonna, M. (2008) DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors. J. Exp. Med. 205, 2965-2973.
23. Iguchi-Manaka, A., Kai, H., Yamashita, Y., Shibata, K., Tahara-Hanaoka, S., Honda, S., Yasui, T., Kikutani, H., Shibuya, K., Shibuya, A. (2008) Accelerated tumor growth in mice deficient in DNAM-1 receptor. J. Exp. Med. 205, 2959-2964.
24. Tahara-Hanaoka, S., Miyamoto, A., Hara, A., Honda, S., Shibuya, K., Shibuya, A. (2005) Identification and characterization of murine DNAM-1 (CD226) and its poliovirus receptor family ligands. Biochem. Biophys. Res. Commun. 329, 996-1000. (Pubitemid 40341375)
25. Dardalhon, V., Schubart, A. S., Reddy, J., Meyers, J. H., Monney, L., Sabatos, C. A., Ahuja, R., Nguyen, K., Freeman, G. J., Greenfield, E. A., Sobel, R. A., Kuchroo, V. K. (2005) CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions. J. Immunol. 175, 1558-1565. (Pubitemid 41023057)
26. Seth, S., Maier, M. K., Qiu, Q., Ravens, I., Kremmer, E., Forster, R., Bernhardt, G. (2007) The murine pan T cell marker CD96 is an adhesion receptor for CD155 and Nectin-1. Biochem. Biophys. Res. Commun. 364, 959-965. (Pubitemid 350087894)
27. Rousseaux, J., Rousseaux-Prevost, R., Bazin, H. (1983) Optimal conditions for the preparation of Fab and F(ab′)2 fragments from monoclonal IgG of different rat IgG subclasses. J. Immunol. Methods 64, 141-146. (Pubitemid 14241101)
28. Czeloth, N., Bernhardt, G., Hofmann, F., Genth, H., Forster, R. (2005) Sphingosine-1-phosphate mediates migration of mature dendritic cells. J. Immunol. 175, 2960-2967. (Pubitemid 41170513)
29. Hollyoake, M., Campbell, R. D., Aguado, B. (2005) NKp30 (NCR3) is a pseudogene in 12 inbred and wild mouse strains, but an expressed gene in Mus caroli. Mol. Biol. Evol. 22, 1661-1672. (Pubitemid 41373577)
30. Porritt, H. E., Rumfelt, L. L., Tabrizifard, S., Schmitt, T. M., Zuniga-Pflucker, J. C., Petrie, H. T. (2004) Heterogeneity among DN1 prothymocytes reveals multiple progenitors with different capacities to generate T cell and non-T cell lineages. Immunity 20, 735-745. (Pubitemid 38757443)
31. Ehl, S., Nuesch, R., Tanaka, T., Myasaka, M., Hengartner, H., Zinkernagel, R. (1996) A comparison of efficacy and specificity of three NK depleting antibodies. J. Immunol. Methods 199, 149-153. (Pubitemid 26412944)
32. Hayakawa, Y., Smyth, M. J. (2006) CD27 dissects mature NK cells into two subsets with distinct responsiveness and migratory capacity. J. Immunol. 176, 1517-1524. (Pubitemid 43134295)
33. Lanier, L. L. (2005) NK cell recognition. Annu. Rev. Immunol. 23, 225-274.
34. Persson, C. M., Assarsson, E., Vahlne, G., Brodin, P., Chambers, B. J. (2008) Critical role of Qa1b in the protection of mature dendritic cells from NK cell-mediated killing. Scand. J. Immunol. 67, 30-36. (Pubitemid 350209583)
35. Hayday, A. C., Pennington, D. J. (2007) Key factors in the organized chaos of early T cell development. Nat. Immunol. 8, 137-144. (Pubitemid 46152644)
36. Sprent, J., Kishimoto, H. (2002) The thymus and negative selection. Immunol. Rev. 185, 126-135.
37. Revilla, C., Gonzalez, A. L., Conde, C., Lopez-Hoyos, M., Merino, J. (1997) Treatment with anti-LFA-1 α monoclonal antibody selectively interferes with the maturation of CD4- 8+ thymocytes. Immunology 90, 550-556. (Pubitemid 27142178)
38. Link, A., Vogt, T. K., Favre, S., Britschgi, M. R., Acha-Orbea, H., Hinz, B., Cyster, J. G., Luther, S. A. (2007) Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells. Nat. Immunol. 8, 1255-1265. (Pubitemid 350011765)
39. Bryceson, Y. T., Long, E. O. (2008) Line of attack: NK cell specificity and integration of signals. Curr. Opin. Immunol. 20, 344-352.
40. Moretta, L., Bottino, C., Pende, D., Vitale, M., Mingari, M. C., Moretta, A. (2005) Human natural killer cells: molecular mechanisms controlling NK cell activation and tumor cell lysis. Immunol. Lett. 100, 7-13. (Pubitemid 41262028)
41. Sivori, S., Pende, D., Bottino, C., Marcenaro, E., Pessino, A., Biassoni, R., Moretta, L., Moretta, A. (1999) NKp46 is the major triggering receptor involved in the natural cytotoxicity of fresh or cultured human NK cells. Correlation between surface density of NKp46 and natural cytotoxicity against autologous, allogeneic or xenogeneic target cells. Eur. J. Immunol. 29, 1656-1666. (Pubitemid 29224471)
42. Parham, P. (2008) The genetic and evolutionary balances in human NK cell receptor diversity. Semin. Immunol. 20, 311-316.
43. Vance, R. E., Jamieson, A. M., Cado, D., Raulet, D. H. (2002) Implications of CD94 deficiency and monoallelic NKG2A expression for natural killer cell development and repertoire formation. Proc. Natl. Acad. Sci. USA 99, 868-873. (Pubitemid 34106602)
44. Hayakawa, Y., Screpanti, V., Yagita, H., Grandien, A., Ljunggren, H. G., Smyth, M. J., Chambers, B. J. (2004) NK cell TRAIL eliminates immature dendritic cells in vivo and limits dendritic cell vaccination efficacy. J. Immunol. 172, 123-129. (Pubitemid 38020463)