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A potential function of KIR2DL4 in promoting neo-vascularization during early pregnancy is revealed in this study. KIR2DL4 signals for a pro-inflammatory/pro-angionenic response of resting cells from endosomes, into which it has internalized its ligand, soluble HLA-G.
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As previously demonstrated in mice, these results show that NK cells lacking inhibitory receptors for MHC class I are found in circulation but are functionally hyporesponsive. Together with data from animal models, these data reveal the impact of inhibitory receptor-MHC class I interactions on the potency of individual NK cells.
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Unexpectedly, mouse NK cells do not mount effective responses unless stimulated by dendritic cells trans-presenting IL-15. The data reveal a requirement for priming of NK cells, analogous to T cell responses.
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