Chronic equol administration attenuates the antioxidant defense system and causes apoptosis in the mouse brain

Food and Chemical Toxicology

Volumn 47, Issue 8, 2009, Pages 1779-1784

  Choi, Eun Jeong ^a  

^a Duksung Women's University   (South Korea)

Author keywords

Antioxidant; Apoptosis; Equol; In vivo; Neurotoxicity

Indexed keywords

ANTIOXIDANT; CATALASE; EQUOL; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; LIPID; PROTEIN P53; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN TISSUE; CHRONIC DRUG ADMINISTRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; IN VITRO STUDY; INHIBITION KINETICS; LIPID PEROXIDATION; MOUSE; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PROTEIN INDUCTION;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BRAIN; CASPASE 3; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; GLUTATHIONE; HEPATOCYTES; IMMUNOBLOTTING; ISOFLAVONES; LIPID PEROXIDATION; MICE; MICE, INBRED ICR; NEURONS; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

MUS;

EID: 68649113055     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2009.04.036     Document Type: Article

References (54)

1. Adams Jr. J.D., Klaidman L.K., Odunze I.N., Shen H.C., and Miller C.A. Alzheimer's and Parkinson's disease. Brain levels of glutathione, glutathione disulfide, and vitamin E. Mol. Chem. Neuropathol. 14 (1991) 213-226
2. Aebi H. Catalase in vitro. Meth. Enzymol. 105 (1984) 121-126
3. Agarwal M.L., Agarwal A., Taylor W.R., and Stark G.R. p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts. Proc. Natl. Acad. Sci. USA 92 (1995) 8493-8497
4. Aldini G., Dalle-Donne I., Facino R.M., Milzani A., and Carini M. Intervention strategies to inhibit protein carbonylation by lipoxidation-derived reactive carbonyls. Med. Res. Rev. 27 (2007) 817-868
5. Ansari M.A., Joshi G., Huang Q., Opii W.O., Abdul H.M., Sultana R., and Butterfield D.A. In vivo administration of D609 leads to protection of subsequently isolated gerbil brain mitochondria subjected to in vitro oxidative stress induced by amyloid β-peptide and other oxidative stressors: relevance to Alzheimer's disease and other oxidative stress-related neurodegenerative disorders. Free Radic. Biol. Med. 41 (2006) 1694-1703
6. Bai F., Matsui T., Ohtani-Fujita N., Matsukawa Y., Ding Y., and Sakai T. Promoter activation and following induction of the p21/WAF1 gene by flavone is involved in G1 phase arrest in A549 lung adenocarcinoma cells. FEBS Lett. 437 (1998) 61-64
7. Bharath S., Hsu M., Kaur D., Rajagopalan S., and Andersen J.K. Glutathione, iron and Parkinson's disease. Biochem. Pharmacol. 64 (2002) 1037-1048
8. Bonilla E. Huntington disease. Invest. Clin. 41 (2000) 117-141
9. Bors W., Michel C., and Stettmaier K. Antioxidant effects of flavonoids. Biofactors 6 (1997) 399-402
10. Cao G., Sofic E., and Prior R.L. Antioxidant and prooxidant behavior of flavonoids: structure-activity relationships. Free Radic. Biol. Med. 22 (1997) 749-760
11. Carlberg I., and Mannervik B. Glutathione reductase. Meth. Enzymol. 113 (1985) 484-490
12. Choi E.J. The prooxidant, rather than antioxidant, acts of daidzein in vivo and in vitro: daidzein suppresses glutathione metabolism. Eur. J. Pharmacol. 542 (2006) 162-169
13. Choi E.J., and Kim T. Equol induced apoptosis via cell cycle arrest in human breast cancer MDA-MB-453 but not MCF-7 cells. Mol. Med. Rep. 1 (2008) 239-244
14. Choi E.J., and Lee B.H. Evidence for genistein mediated cytotoxicity and apoptosis in rat brain. Life Sci. 75 (2004) 499-509
15. Choi E.J., Chee K.M., and Lee B.H. Anti- and prooxidant effects of chronic quercetin administration in rats. Eur. J. Pharmacol. 482 (2003) 281-285
16. Cooke G.M. A review of the animal models used to investigate the health benefits of soy isoflavones. J. AOAC Int. 89 (2006) 1215-1227
17. Cooper A.J.L. Glutathione in the brain: disorders of glutathione metabolism. In: The Molecular and Genetic Basis of Neurological Disease (1997), Butterworth-Heinemann, Boston pp. 1195-1230
18. Cruz-Aguado R., Turner L.F., Diaz C.M., and Pinero J. Nerve growth factor and striatal glutathione metabolism in a rat model of Huntington's disease. Restor. Neurol. Neurosci. 17 (2000) 217-221
19. Dajas F., Rivera-Megret F., Blasina F., Arredondo F., Abin-Carriquiry J.A., Costa G., Echeverry C., Lafon L., Heizen H., Ferreira M., and Morquio A. Neuroprotection by flavonoids. Braz. J. Med. Biol. Res. 36 (2003) 1613-1620
20. Flohé L., and Günzler W.A. Assays of glutathione peroxidase. Meth. Enzymol. 105 (1984) 114-121
21. Fridovich I. Superoxide radical and superoxide dismutases. Annu. Rev. Biochem. 64 (1995) 97-112
22. - ·), superoxide dismutases, and related matters. J. Biol. Chem 272 (1997) 18515-18517
23. Galati G., Sabzevari O., Wilson J.X., and O'Brien P.J. Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics. Toxicology 177 (2002) 91-104
24. Hirrlinger J., Schulz J.B., and Dringen R. Effects of dopamine on the glutathione metabolism of cultured astroglial cells: implications for Parkinson's disease. J. Neurochem. 82 (2002) 458-467
25. Hissin P.J., and Hilf R. A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal. Biochem. 74 (1976) 214-226
26. Ho Y.S., Magnenat J.L., Bronson R.T., Cao J., Gargano M., Sugawara M., and Funk C.D. Mice deficient in cellular glutathione peroxidase develop normally and show no increased sensitivity to hyperoxia. J. Biol. Chem. 272 (1997) 16644-16651
27. Ho Y.S., Swenson L., Derewenda U., Serre L., Wei Y., Dauter Z., Hattori M., Adachi T., Aoki J., Arai H., Inoue K., and Derewenda Z.S. Brain acetylhydrolase that inactivates platelet-activating factor is a G-protein-like trimer. Nature 385 (1997) 89-93
28. Hwang J., Wang J., Morazzoni P., Hodis H.N., and Sevanian A. The phytoestrogen equol increases nitric oxide availability by inhibiting superoxide production: an antioxidant mechanism for cell-mediated LDL modification. Free Radic. Biol. Med. 34 (2003) 1271-1282
29. Jin Y., Wu H., Cohen E.M., Wei J., Jin H., Prentice H., and Wu J.Y. Genistein and daidzein induce neurotoxicity at high concentrations in primary rat neuronal cultures. J. Biomed. Sci. 14 (2007) 275-284
30. Kandaswami C., and Middleton Jr. E. Free radical scavenging and antioxidant activity of plant flavonoids. Adv. Exp. Med. Biol. 366 (1994) 351-376
31. Lepik D., Jaks V., Kadaja L., Värv S., and Maimets T. Electroporation and carrier DNA cause p53 activation, cell cycle arrest, and apoptosis. Anal. Biochem. 318 (2003) 52-59
32. Li N., Liu J.H., Zhang J., and Yu B.Y. Comparative evaluation of cytotoxicity and antioxidative activity of 20 flavonoids. J. Agric. Food Chem. 56 (2008) 3876-3883
33. Marklund S., and Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur. J. Biochem. 47 (1974) 469-474
34. Mitchell J.H., Gardner P.T., McPhail D.B., Morrice P.C., Collins A.R., and Duthie G.G. Antioxidant efficacy of phytoestrogens in chemical and biological model systems. Arch. Biochem. Biophys. 360 (1998) 142-148
35. Moreira P.I., Siedlak S.L., Aliev G., Zhu X., Cash A.D., Smith M.A., and Perry G. Oxidative stress mechanisms and potential therapeutics in Alzheimer disease. J. Neural Transm. 112 (2005) 921-932
36. Niculescu III A.B., Chen X., Smeets M., Hengst L., Prives C., and Reed S.I. Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol. Cell. Biol. 18 (1998) 629-643
37. Nunomura A., Moreira P.I., Lee H.G., Zhu X., Castellani R.J., Smith M.A., and Perry G. Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases. CNS Neurol. Disord. Drug Targets 6 (2007) 411-423
38. Oakes S.A., Lin S.S., and Bassik M.C. The control of endoplasmic reticulum-initiated apoptosis by the BCL-2 family of proteins. Curr. Mol. Med. 6 (2006) 99-109
39. Ohkawa H., Ohishi N., and Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95 (1979) 351-358
40. Okayasu H., Ishihara M., Satoh K., and Sakagami H. Cytotoxic activity of vitamins K1, K2 and K3 against human oral tumor cell lines. Anticancer Res. 21 (2001) 2387-2392
41. Palozza P., Serini S., Di Nicuolo F., Piccioni E., and Calviello G. Prooxidant effects of β-carotene in cultured cells. Mol. Aspects Med. 24 (2003) 353-362
42. Park M., Chae H.D., Yun J., Jung M., Kim Y.S., Kim S.H., Han M.H., and Shin D.Y. Constitutive activation of cyclin B1-associated cdc2 kinase overrides p53-mediated G2-M arrest. Cancer Res. 60 (2000) 542-545
43. Ross J.A., and Kasum C.M. Dietary flavonoids: bioavailability, metabolic effects, and safety. Annu. Rev. Nutr. 22 (2002) 19-34
44. Rüfer C.E., and Kulling S.E. Antioxidant activity of isoflavones and their major metabolites using different in vitro assays. J. Agric. Food Chem. 54 (2006) 2926-2931
45. Seglen P.O. Preparation of isolated rat liver cells. In: Prescott D.M. (Ed). Methods of Cell Biology, vol. 13 (1976), Academic Press, New York 29-83
46. Setchell K.D., Brown N.M., and Lydeking-Olsen E. The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavones. J. Nutr. 132 (2002) 3577-3584
47. Sian J., Dexter D.T., Lees A.J., Daniel S., Agid Y., Javoy-Agid F., Jenner P., and Marsden C.D. Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia. Ann. Neurol. 36 (1994) 348-355
48. Tafazoli S., Wright J.S., and O'Brien P.J. Prooxidant and antioxidant activity of vitamin E analogues and troglitazone. Chem. Res. Toxicol. 18 (2005) 1567-1574
49. van Delft M.F., and Huang D.C. How the Bcl-2 family of proteins interact to regulate apoptosis. Cell Res. 16 (2006) 203-213
50. Watała C., Budziejewska A., and Jóźwiak Z. Alloxan-induced alterations in composition and dynamics of red blood cell membranes. I. Effect of alloxan on intact red blood cells and isolated erythrocyte membranes. Biochem. Pharmacol. 38 (1989) 1793-1798
51. Yoshino M., Haneda M., Naruse M., and Murakami K. Prooxidant activity of flavonoids: copper-dependent strand breaks and the formation of 8-hydroxy-2′-deoxyguanosine in DNA. Mol. Genet. Metab. 68 (1999) 468-472
52. Youdim K.A., Spencer J.P., Schroeter H., and Rice-Evans C. Dietary flavonoids as potential neuroprotectants. Biol. Chem. 383 (2002) 503-519
53. Yuan J.P., Wang J.H., and Liu X. Metabolism of dietary soy isoflavones to equol by human intestinal microflora - implications for health. Mol. Nutr. Food Res. 51 (2007) 765-781
54. Zhu Y., Carvey P.M., and Ling Z. Age-related changes in glutathione and glutathione-related enzymes in rat brain. Brain Res. 1090 (2006) 35-44