The value added by measuring myocardial contractility 'in vivo' in safety pharmacological profiling of drug candidates

Journal of Pharmacological and Toxicological Methods

Volumn 56, Issue 2, 2007, Pages 203-211

  Markert, Michael ^a   Klumpp, Anja ^a   Trautmann, Thomas ^a   Mayer, Karin ^a   Stubhan, Miriam ^a   Guth, Brian ^a  

^a BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

Conscious dog; Contractility; Force frequency relationship; Methods; Telemetry

Indexed keywords

BETA 1 ADRENERGIC RECEPTOR; BUPRENORPHINE; DUPHAMOX; PIMOBENDAN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AORTA PRESSURE; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BODY TEMPERATURE; COMPUTER PROGRAM; DOG; DRUG SAFETY; DRUG SCREENING; ELECTROCARDIOGRAM; ENZYME ACTIVATION; FEMALE; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE CONTRACTILITY; HEART RATE; IN VIVO STUDY; INFORMATION PROCESSING; MALE; NONHUMAN; RHESUS MONKEY; SIGNAL DETECTION; SWINE; TELEMETRY;

ADMINISTRATION, ORAL; ANIMALS; BLOOD PRESSURE; CARDIOTONIC AGENTS; DOGS; DRUG EVALUATION, PRECLINICAL; ELECTROCARDIOGRAPHY; FEMALE; HEART RATE; HUMANS; MACACA FASCICULARIS; MALE; MYOCARDIAL CONTRACTION; PYRIDAZINES; REPRODUCIBILITY OF RESULTS; SIGNAL PROCESSING, COMPUTER-ASSISTED; SPECIES SPECIFICITY; SWINE; SWINE, MINIATURE; TELEMETRY; VENTRICULAR FUNCTION, LEFT;

ANIMALIA; CANIS FAMILIARIS; MACACA FASCICULARIS; MACACA MULATTA; PRIMATES; SUIDAE;

EID: 34548523478     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2007.03.004     Document Type: Article

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