IRS1 G972R polymorphism and type 2 diabetes: A paradigm for the difficult ascertainment of the contribution to disease susceptibility of 'low-frequency-low-risk' variants

Diabetologia

Volumn 52, Issue 9, 2009, Pages 1852-1857

  Morini, E ^a   Prudente, S ^a   Succurro, E ^b   Chandalia, M ^c   Zhang, Y Y ^d,e   Mammarella, S ^f   Pellegrini, F ^a,g   Powers, C ^d   Proto, V ^a   Dallapiccola, B ^a   Cama, A ^f   Sesti, G ^b   Abate, N ^c   Doria, A ^a,d,e   Trischitta, V ^a,h  

^a CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^b UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^c UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^d JOSLIN DIABETES CENTER   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f UNIVERSITY OF CHIETI   (Italy)

^g G d'Annunzio University Foundation ^*  (Italy)

^h SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Age at type 2 diabetes diagnosis; Genetics of type 2 diabetes; Insulin secretion; Insulin signalling; Meta analysis

Indexed keywords

ARGININE; GLYCINE; INSULIN RECEPTOR SUBSTRATE 1;

ARTICLE; CLINICAL TRIAL; CONFIDENCE INTERVAL; DISEASE PREDISPOSITION; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC POLYMORPHISM; HUMAN; IRS 1 GENE; NON INSULIN DEPENDENT DIABETES MELLITUS; ONSET AGE; PRIORITY JOURNAL; PROTEIN VARIANT; RISK FACTOR; STATISTICAL ANALYSIS;

AGE OF ONSET; AMINO ACID SUBSTITUTION; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; DNA; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HUMANS; INSULIN RECEPTOR SUBSTRATE PROTEINS; META-ANALYSIS AS TOPIC; ODDS RATIO; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; REFERENCE VALUES; SAMPLE SIZE;

EID: 68449104737     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-009-1426-4     Document Type: Article

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