-
1
-
-
0028032894
-
Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1
-
Tamemoto H, Kadowaki T, Tobe K, Yagi T, Sakura H, Hayakawa T, Terauchi Y, Ueki K, Kahuragi Y, Satoh S, Sekihara H, Yoshioka S, Horikoshi H, Furuta Y, Ikawa Y, Kasuga M, Yazaki Y, Aizawa S: Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature 1994;372:182-186.
-
(1994)
Nature
, vol.372
, pp. 182-186
-
-
Tamemoto, H.1
Kadowaki, T.2
Tobe, K.3
Yagi, T.4
Sakura, H.5
Hayakawa, T.6
Terauchi, Y.7
Ueki, K.8
Kahuragi, Y.9
Satoh, S.10
Sekihara, H.11
Yoshioka, S.12
Horikoshi, H.13
Furuta, Y.14
Ikawa, Y.15
Kasuga, M.16
Yazaki, Y.17
Aizawa, S.18
-
2
-
-
0030961962
-
Development of non-insulin-dependent diabetes mellitus in double knockout mice with disruption of insulin receptor substrate-1 and β cell glucokinnse genes. Genetic reconstruction of diabetes as a polygenic disease
-
Terauchi Y, Iwamoto K, Tamemoto H, Komeda K, Ishii C, Kanazawa Y, Asanuma N, Aizawa I, Akanuma Y, Yasuda K, Kodama T, Tobe K, Yazaki Y, Kadowaki T: Development of non-insulin-dependent diabetes mellitus in double knockout mice with disruption of insulin receptor substrate-1 and β cell glucokinnse genes. Genetic reconstruction of diabetes as a polygenic disease. J Clin Invest 1997;99:861-866.
-
(1997)
J Clin Invest
, vol.99
, pp. 861-866
-
-
Terauchi, Y.1
Iwamoto, K.2
Tamemoto, H.3
Komeda, K.4
Ishii, C.5
Kanazawa, Y.6
Asanuma, N.7
Aizawa, I.8
Akanuma, Y.9
Yasuda, K.10
Kodama, T.11
Tobe, K.12
Yazaki, Y.13
Kadowaki, T.14
-
3
-
-
0038155702
-
Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles
-
Brüning J, Winnay J, Bonner-Weir S, Taylor SI, Accili D, Kahn CR: Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell 1997;88: 561-572.
-
(1997)
Cell
, vol.88
, pp. 561-572
-
-
Brüning, J.1
Winnay, J.2
Bonner-Weir, S.3
Taylor, S.I.4
Accili, D.5
Kahn, C.R.6
-
4
-
-
0027367546
-
Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus
-
Almind K, Bjorbaek C, Vestergaard H, Hansen T, Echwald S, Pedersen O: Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus. Lancet 1993;342:828-832.
-
(1993)
Lancet
, vol.342
, pp. 828-832
-
-
Almind, K.1
Bjorbaek, C.2
Vestergaard, H.3
Hansen, T.4
Echwald, S.5
Pedersen, O.6
-
5
-
-
0027422281
-
Insulin receptor substrate (IRS-1) gene polymorphisms in French NIDDM families
-
Hager J, Zouali H, Velho G, Froguel P: Insulin receptor substrate (IRS-1) gene polymorphisms in French NIDDM families. Lancet 1993;342: 1430.
-
(1993)
Lancet
, vol.342
, pp. 1430
-
-
Hager, J.1
Zouali, H.2
Velho, G.3
Froguel, P.4
-
6
-
-
0028557255
-
Variant sequence of insulin receptor substrate-1 in patients with noninsulin-dependent diabetes mellitus
-
Imai Y, Fusco A, Suzuki Y, Lesniak MA, D'Alfonzo R, Sesti G, Bertori A, Lauro R, Accili D, Taylor SI: Variant sequence of insulin receptor substrate-1 in patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1994;79:1655-1658.
-
(1994)
J Clin Endocrinol Metab
, vol.79
, pp. 1655-1658
-
-
Imai, Y.1
Fusco, A.2
Suzuki, Y.3
Lesniak, M.A.4
D'Alfonzo, R.5
Sesti, G.6
Bertori, A.7
Lauro, R.8
Accili, D.9
Taylor, S.I.10
-
7
-
-
0028058980
-
Molecular scanning of the glycogen synthase and insulin receptor substrate-1 genes in Japanese subjects with non-insulin-dependent diabetes mellitus
-
Shimokawa K. Kadowaki H, Sakura H, Otabe S, Hagura R, Kosaka K, Yazaki Y, Akanuma Y, Kadowaki T: Molecular scanning of the glycogen synthase and insulin receptor substrate-1 genes in Japanese subjects with non-insulin-dependent diabetes mellitus. Biochem Biophys Res Commun 1994;202:463-469.
-
(1994)
Biochem Biophys Res Commun
, vol.202
, pp. 463-469
-
-
Shimokawa, K.1
Kadowaki, H.2
Sakura, H.3
Otabe, S.4
Hagura, R.5
Kosaka, K.6
Yazaki, Y.7
Akanuma, Y.8
Kadowaki, T.9
-
8
-
-
0027994029
-
Insulin receptor substrate-1 variants in non-insulin-dependent diabetes
-
Laakso M, Malkki M, Kekäläinen P, Kuusisto J, Deeb S: Insulin receptor substrate-1 variants in non-insulin-dependent diabetes. J Clin Invest 1994;94:1141-1146.
-
(1994)
J Clin Invest
, vol.94
, pp. 1141-1146
-
-
Laakso, M.1
Malkki, M.2
Kekäläinen, P.3
Kuusisto, J.4
Deeb, S.5
-
9
-
-
0028912848
-
Insulin receptor substrate-1 gene mutations in NIDDM: Implications for the study of polygenic disease
-
Hitman GA, Hawrami K, McCarthy MI, Viswanathan M, Snehalatha C, Ramachandran A, Tuomilehto J, Tuomilehto-Wolf E, Nissinen A, Pedersen O: Insulin receptor substrate-1 gene mutations in NIDDM: implications for the study of polygenic disease. Diabetologia 1995; 38:481-486.
-
(1995)
Diabetologia
, vol.38
, pp. 481-486
-
-
Hitman, G.A.1
Hawrami, K.2
McCarthy, M.I.3
Viswanathan, M.4
Snehalatha, C.5
Ramachandran, A.6
Tuomilehto, J.7
Tuomilehto-Wolf, E.8
Nissinen, A.9
Pedersen, O.10
-
10
-
-
0029118510
-
Insulin resistance: Interactions between obesity and a common variant of insulin receptor substrate-1
-
Clausen JO, Hansen T, Bjørbaek C, Echwald SM, Urhammer SA, Rasmussen S, Andersen CB, Hansen L, Almind K, Winther K, Haraldsdòttir J, Borch-Johnson K, Pedersen O: Insulin resistance: Interactions between obesity and a common variant of insulin receptor substrate-1. Lancet 1995;346:397-402.
-
(1995)
Lancet
, vol.346
, pp. 397-402
-
-
Clausen, J.O.1
Hansen, T.2
Bjørbaek, C.3
Echwald, S.M.4
Urhammer, S.A.5
Rasmussen, S.6
Andersen, C.B.7
Hansen, L.8
Almind, K.9
Winther, K.10
Haraldsdòttir, J.11
Borch-Johnson, K.12
Pedersen, O.13
-
11
-
-
0029071130
-
Insulin receptor substrate-1 gene and cardiovascular risk factors in NIDDM
-
Grant PJ, Stickland MH, Mansfield MW: Insulin receptor substrate-1 gene and cardiovascular risk factors in NIDDM. Lancet 1995;346: 841-842.
-
(1995)
Lancet
, vol.346
, pp. 841-842
-
-
Grant, P.J.1
Stickland, M.H.2
Mansfield, M.W.3
-
12
-
-
0029114157
-
Amino acid polymorphisms of the insulin receptor substrate-1 in japanese noninsulin-dependent diabetes mellitus
-
Mori H. Hashiramoto M, Kishimoto M, Kasuga M: Amino acid polymorphisms of the insulin receptor substrate-1 in Japanese noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1995;80:2822-2826.
-
(1995)
J Clin Endocrinol Metab
, vol.80
, pp. 2822-2826
-
-
Mori, H.1
Hashiramoto, M.2
Kishimoto, M.3
Kasuga, M.4
-
13
-
-
0029968888
-
Relationship between insulin sensitivity and insulin receptor substrate-1 mutations in non-diabetic relatives of NIDDM families
-
Armstrong M, Haldane F, Avery PJ, Mitcheson J. Stewart MW, Turnbull DM, Walker M: Relationship between insulin sensitivity and insulin receptor substrate-1 mutations in non-diabetic relatives of NIDDM families. Diabet Med 1996;13:341-345.
-
(1996)
Diabet Med
, vol.13
, pp. 341-345
-
-
Armstrong, M.1
Haldane, F.2
Avery, P.J.3
Mitcheson, J.4
Stewart, M.W.5
Turnbull, D.M.6
Walker, M.7
-
14
-
-
0030000562
-
Codon 972 polymorphism in the insulin receptor substrate-1 gene, obesity, and risk of noninsulin-dependent diabetes mellitus
-
Sigal RJ, Doria A, Warram JH, Krolewski AS: Codon 972 polymorphism in the insulin receptor substrate-1 gene, obesity, and risk of noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1996;81:1657-1659.
-
(1996)
J Clin Endocrinol Metab
, vol.81
, pp. 1657-1659
-
-
Sigal, R.J.1
Doria, A.2
Warram, J.H.3
Krolewski, A.S.4
-
15
-
-
0029666050
-
No association between the Gly971Arg variant of the insulin receptor substrate 1 gene and NIDDM in the taiwanese population
-
Chuang LM, Lai CS, Yen JI, Wu HP, Tai TY, Lin BJ: No association between the Gly971Arg variant of the insulin receptor substrate 1 gene and NIDDM in the Taiwanese population. Diabetes Care 1996;19:446-449.
-
(1996)
Diabetes Care
, vol.19
, pp. 446-449
-
-
Chuang, L.M.1
Lai, C.S.2
Yen, J.I.3
Wu, H.P.4
Tai, T.Y.5
Lin, B.J.6
-
16
-
-
0029857775
-
UKPDS 19: Heterogeneity in NIDDM: Separate contributions of IRS-1 and β3-adrenergic-receptor mutations to insulin resistance and obesity respectively with no evidence for glycogen synthase gene mutations
-
Zhang Y, Wat N, Stratton IM, Warren-Perry MG, Orho M, Groop L. Turner RC: UKPDS 19: Heterogeneity in NIDDM: Separate contributions of IRS-1 and β3-adrenergic-receptor mutations to insulin resistance and obesity respectively with no evidence for glycogen synthase gene mutations. Diabetologia 1996;39: 1505-1511.
-
(1996)
Diabetologia
, vol.39
, pp. 1505-1511
-
-
Zhang, Y.1
Wat, N.2
Stratton, I.M.3
Warren-Perry, M.G.4
Orho, M.5
Groop, L.6
Turner, R.C.7
-
17
-
-
9244256729
-
Molecular scanning of insulin receptor substrate-1 (IRS-1) gene in Japanese patients with NIDDM: Identification of five novel polymorphisms
-
Ura S, Araki E, Kishikawa H, Shirotani T, Todaka M, Isami S, Shimoda Sm Yoshimura R, Matsuda K, Motoyoshi S, Miyamura N, Kahn CR, Shichiri M: Molecular scanning of insulin receptor substrate-1 (IRS-1) gene in Japanese patients with NIDDM: Identification of five novel polymorphisms. Diabetologia 1996;39: 600-608.
-
(1996)
Diabetologia
, vol.39
, pp. 600-608
-
-
Ura, S.1
Araki, E.2
Kishikawa, H.3
Shirotani, T.4
Todaka, M.5
Isami, S.6
Shimoda, S.7
Yoshimura, R.8
Matsuda, K.9
Motoyoshi, S.10
Miyamura, N.11
Kahn, C.R.12
Shichiri, M.13
-
18
-
-
0031735456
-
Codon 972 polymorphism of the insulin receptor substrate-1 gene in impaired glucose tolerance and late-onset NIDDM
-
Yamada K, Yuan X, Ishiyama S, Shoji S, Kohno S, Koyama K, Koyanagi A, Koyama W, Nonaka K: Codon 972 polymorphism of the insulin receptor substrate-1 gene in impaired glucose tolerance and late-onset NIDDM. Diabetes Care 1998;21:753-756.
-
(1998)
Diabetes Care
, vol.21
, pp. 753-756
-
-
Yamada, K.1
Yuan, X.2
Ishiyama, S.3
Shoji, S.4
Kohno, S.5
Koyama, K.6
Koyanagi, A.7
Koyama, W.8
Nonaka, K.9
-
19
-
-
0029893417
-
A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insuling signaling. Evidence from transfection studies
-
Almind K, Inoue G, Pedersen O, Kahn CR: A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insuling signaling. Evidence from transfection studies. J Clin Invest 1996;97:2569-2575.
-
(1996)
J Clin Invest
, vol.97
, pp. 2569-2575
-
-
Almind, K.1
Inoue, G.2
Pedersen, O.3
Kahn, C.R.4
-
20
-
-
0030917640
-
Impact of natural IRS-1 mutations on insulin signals, mutations of IRS-1 in the PTB domain and near sh2 protein binding sites result in impaired function at different steps of IRS-1 signaling
-
Yoshimura R, Araki E, Ura S, Todaka M, Tsuruzoc K, Furukawa N, Motoshima H, Yoshizato K, Kaneko K, Matsuda K, Kishikawa H, Shichiri M: Impact of natural IRS-1 mutations on insulin signals, mutations of IRS-1 in the PTB domain and near SH2 protein binding sites result in impaired function at different steps of IRS-1 signaling. Diabetes 1997;46: 929-936.
-
(1997)
Diabetes
, vol.46
, pp. 929-936
-
-
Yoshimura, R.1
Araki, E.2
Ura, S.3
Todaka, M.4
Tsuruzoc, K.5
Furukawa, N.6
Motoshima, H.7
Yoshizato, K.8
Kaneko, K.9
Matsuda, K.10
Kishikawa, H.11
Shichiri, M.12
-
21
-
-
0018520840
-
Glucose clamp technique: A method for quantifying insulin secretion and resistance
-
DeFronzo RA, Tobin JD, Andres R: Glucose clamp technique: A method for quantifying insulin secretion and resistance. Am J Physiol 1979;237:E214-E223.
-
(1979)
Am J Physiol
, vol.237
-
-
DeFronzo, R.A.1
Tobin, J.D.2
Andres, R.3
-
22
-
-
0021813187
-
Homeostasis model assessment: Insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man
-
Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC: Homeostasis model assessment: Insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28:412-419.
-
(1985)
Diabetologia
, vol.28
, pp. 412-419
-
-
Matthews, D.R.1
Hosker, J.P.2
Rudenski, A.S.3
Naylor, B.A.4
Treacher, D.F.5
Turner, R.C.6
-
23
-
-
0028032895
-
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
-
Araki E, Lipes MA, Patti ME, Brüning JC, Haag B 3rd, Johnson RS, Kahn CR: Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature 1994;372:186-190.
-
(1994)
Nature
, vol.372
, pp. 186-190
-
-
Araki, E.1
Lipes, M.A.2
Patti, M.E.3
Brüning, J.C.4
Haag B. III5
Johnson, R.S.6
Kahn, C.R.7
-
24
-
-
0028810236
-
4PS/Insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice
-
Patti ME, Sun XJ, Bru7die;ning JC, Araki E, Lipes MA, White MF, Kahn CR: 4PS/Insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice. J Biol Chem 1995;270:24670-24673.
-
(1995)
J Biol Chem
, vol.270
, pp. 24670-24673
-
-
Patti, M.E.1
Sun, X.J.2
Brüning, J.C.3
Araki, E.4
Lipes, M.A.5
White, M.F.6
Kahn, C.R.7
-
25
-
-
0030890580
-
Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus
-
Rondinone CM, Wang L-M, Lonnroth P, Wesslau C, Pierce JH, Smith U: Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci USA 1996;94:4171-4175.
-
(1996)
Proc Natl Acad Sci USA
, vol.94
, pp. 4171-4175
-
-
Rondinone, C.M.1
Wang, L.-M.2
Lonnroth, P.3
Wesslau, C.4
Pierce, J.H.5
Smith, U.6
|