Nonsteroidal anti-inflammatory drugs in orthopaedics

Journal of Bone and Joint Surgery

Volumn 91, Issue 8, 2009, Pages 2020-2027

  Abdul Hadi, Omar ^a   Parvizi, Javad ^b   Austin, Matthew S ^b   Viscusi, Eugene ^c   Einhorn, Thomas ^d  

^a SOUTHERN OREGON ORTHOPEDICS   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c THOMAS JEFFERSON UNIVERSITY HOSPITAL   (United States)

^d BOSTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; INDOMETACIN; INTERLEUKIN 1; INTERLEUKIN 11; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 6; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; ROFECOXIB; TUMOR NECROSIS FACTOR ALPHA; CYCLOOXYGENASE 2 INHIBITOR; PROSTAGLANDIN;

ANGIOGENESIS; BONE GROWTH; BONE REMODELING; CELL PROLIFERATION; CONFERENCE PAPER; DRUG MECHANISM; FEMUR FRACTURE; FRACTURE HEALING; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; SPINE FUSION; ARTICLE; BONE REGENERATION; DRUG EFFECT; HUMAN; MUSCULOSKELETAL DISEASE; PAIN; PATHOPHYSIOLOGY; PHYSIOLOGY; PROSTHESIS FAILURE; WOUND HEALING;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYCLOOXYGENASE 2 INHIBITORS; FRACTURE HEALING; HUMANS; MUSCULOSKELETAL DISEASES; OSSEOINTEGRATION; PAIN; PROSTAGLANDINS; PROSTHESIS FAILURE; SPINAL FUSION; WOUND HEALING;

EID: 68349159265     PISSN: 00219355     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (74)

1. Singh G, Ramey DR, Morfeld D, Fries JF. Comparative toxicity of non-steroidal anti-inflammatory agents. Pharmacol Ther. 1994;62:175-191 (Pubitemid 24234863)
2. Seidenberg AB, An YH. Is there an inhibitory effect of COX-2 inhibitors on bone healing? Pharmacol Res. 2004;50:151-156
3. Pirmohamed M, James S, Meakin S, Green C, Scott AK, Walley TJ, Farrar K, Park BK, Breckenridge AM. Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients. BMJ. 2004;329:15-19 (Pubitemid 38869995)
4. Riew KD, Long J, Rhee J, Lewis S, Kuklo T, Kim YJ, Yukawa Y, Zhu Y. Time-dependent inhibitory effects of indomethacin on spinal fusion. J Bone Joint Surg Am. 2003;85:632-634 (Pubitemid 36538710)
5. Sun JS, Tsuang YH, Lin FH, Liu HC, Tsai CZ, Chang WH. Bone defect healing enhanced by ultrasound stimulation: an in vitro tissue culture model. J Biomed Mater Res. 1999;46:253-261 (Pubitemid 129513749)
6. Radi ZA, Khan NK. Effects of cyclooxygenase inhibition on bone, tendon, and ligament healing. Inflamm Res. 2005;54:358-366
7. Sato Y, Tsuboi R, Lyons R, Moses H, Rifkin DB. Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulating system. J Cell Biol. 1990;111:757-763 (Pubitemid 20239886)
8. Suzawa T, Miyaura C, Inada M, Maruyama T, Sugimoto Y, Ushikubi F, Ichikawa A, Narumiya S, Suda T. The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: an analysis using specific agonists for the respective EPs. Endocrinology. 2000;141:1554-1559 (Pubitemid 32269125)
9. Burke A, Smyth EM, FitzGerald GA. Analgesic-antipyretic and antiinflammatory agents; pharmacotherapy of gout. In: Brunton LL, Lazo JS, Parker KL, editors. Goodman and Gilman's the pharmacological basis of therapeutics. 11th ed. New York: McGraw-Hill; 2005. p 671-716.
10. Herschman HR, Fletcher BS, Kujubu DA. TIS10, a mitogen-inducible glucocorticoid-inhibited gene that encodes a second prostaglandin synthase/cyclooxygenase enzyme. J Lipid Mediat. 1993;6:89-99.
11. Masferrer JL, Zweifel BS, Seibert K, Needleman P. Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice. J Clin Invest. 1990;86:1375-1379 (Pubitemid 20370450)
12. Min YK, Rao Y, Okada Y, Raisz LG, Pilbeam CC. Regulation of prostaglandin G/H synthase-2 expression by interleukin-1 in human osteoblast-like cells. J Bone Miner Res. 1998;13:1066-1075 (Pubitemid 28311774)
13. Tokushima T, Sato T, Morita I, Murota S. Involvement of prostaglandin endoperoxide H synthase-2 in osteoclast formation induced by parathyroid hormone. Adv Exp Med Biol. 1997;433:307-309 (Pubitemid 28231837)
14. Tai H, Miyaura C, Pilbeam CC, Tamura T, Ohsugi Y, Koishihara Y, Kubodera N, Kawaguchi H, Raisz LG, Suda T. Transcriptional induction of cyclooxygenase-2 in osteoblasts is involved in interleukin-6-induced osteoclast formation. Endocrinology. 1997;138:2372-2379 (Pubitemid 27215239)
15. Kotake S, Udagawa N, Takahashi N, Matsuzaki K, Itoh K, Ishiyama S, Saito S, Inoue K, Kamatani N, Gillespie MT, Martin TJ, Suda T. IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest. 1999;103:1345-1352 (Pubitemid 29218305)
16. Morinaga Y, Fujita N, Ohishi K, Zhang Y, Tsuruo T. Suppression of interleukin-11-mediated bone resorption by cyclooxygenases inhibitors. J Cell Physiol. 1998;175:247-254 (Pubitemid 28198204)
17. Kawaguchi H, Pilbeam CC, Harrison JR, Raisz LG. The role of prostaglandins in the regulation of bone metabolism. Clin Orthop Relat Res. 1995;313:36-46.
18. Zhang X, Morham SG, Langenbach R, Young DA, Xing L, Boyce BF, Puzas EJ, Rosier RN, O'Keefe RJ, Schwarz EM. Evidence for a direct role of cyclooxygenase 2 in implant wear debris-induced osteolysis. J Bone Miner Res. 2001;16:660-670 (Pubitemid 32230594)
19. Botting R, Ayoub SS. COX-3 and the mechanism of action of paracetamol/acetaminophen. Prostaglandins Leukot Essent Fatty Acids. 2005;72:85-87
20. Snipes JA, Kis B, Shelness GS, Hewett JA, Busija DW. Cloning and characterization of cyclooxygenase-1b (putative cyclooxygenase-3) in rat. J Pharmacol Exp Ther. 2005;313:668-676 (Pubitemid 40604167)
21. Ke HZ, Shen VW, Qi H, Crawford DT, Wu DD, Liang XG, Chidsey-Frink KL, Pirie CM, Simmons HA, Thompson DD. Prostaglandin E2 increases bone strength in intact rats and in ovariectomized rats with established osteopenia. Bone. 1998;23:249-255 (Pubitemid 28434669)
22. Yang RS, Liu TK, Lin-Shiau SY. Increased bone growth by local prostaglandin E2 in rats. Calcif Tissue Int. 1993;52:57-61. (Pubitemid 23086271)
23. Jee WS, Ma YF. The in vivo anabolic actions of prostaglandins in bone. Bone. 1997;21:297-304.
24. Dekel S, Lenthall G, Francis MJ. Release of prostaglandins from bone and muscle after tibial fracture. An experimental study in rabbits. J Bone Joint Surg Br. 1981;63:185-189 (Pubitemid 11098763)
25. Elves MW, Bayley I, Roylance PJ. The effect of indomethacin upon experimental fractures in the rat. Acta Orthop Scand. 1982;53:35-41. (Pubitemid 12184149)
26. Keller J, Klamer A, Bak B, Suder P. Effect of local prostaglandin E2 on fracture callus in rabbits. Acta Orthop Scand. 1993;64:59-63. (Pubitemid 23092305)
27. Sudmann E, Dregelid E, Bessesen A, Morland J. Inhibition of fracture healing by indomethacin in rats. Eur J Clin Invest. 1979;9:333-339 (Pubitemid 10142421)
28. Li M, Healy DR, Li Y, Simmons HA, Crawford DT, Ke HZ, Pan LC, Brown TA, Thompson DD. Osteopenia and impaired fracture healing in aged EP4 receptor knockout mice. Bone. 2005;37:46-54. (Pubitemid 40848417)
29. Allen HL, Wase A, Bear WT. Indomethacin and aspirin: effect of nonsteroidal anti-inflammatory agents on the rate of fracture repair in the rat. Acta Orthop Scand. 1980;51:595-600. (Pubitemid 10090468)
30. Huo MH, Troiano NW, Pelker RR, Gundberg CM, Friedlaender GE. The influence of ibuprofen on fracture repair: biomechanical, biochemical, histologic, and histomorphometric parameters in rats. J Orthop Res. 1991;9:383-390
31. Altman RD, Latta LL, Keer R, Renfree K, Hornicek FJ, Banovac K. Effect of nonsteroidal antiinflammatory drugs on fracture healing: a laboratory study in rats. J Orthop Trauma. 1995;9:392-400.
32. Glassman SD, Rose SM, Dimar JR, Puno RM, Campbell MJ, Johnson JR. The effect of postoperative nonsteroidal anti-inflammatory drug administration on spinal fusion. Spine. 1998;23:834-838
33. Giannoudis PV, Macdonald DA, Matthews SJ, Smith RM, Furlong AJ, De BP. Nonunion of the femoral diaphysis. The influence of reaming and non-steroidal anti-inflammatory drugs. J Bone Joint Surg Br. 2000;82:655-658
34. Dumont AS, Verma S, Dumont RJ, Hurlbert RJ. Nonsteroidal anti-inflammatory drugs and bone metabolism in spinal fusion surgery: a pharmacological quandary. J Pharmacol Toxicol Methods. 2000;43:31-39 (Pubitemid 30946907)
35. Gerstenfeld LC, Thiede M, Seibert K, Mielke C, Phippard D, Svagr B, Cullinane D, Einhorn TA. Differential inhibition of fracture healing by non-selective and cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs. J Orthop Res. 2003;21:670-675 (Pubitemid 36763489)
36. Goodman SB, Ma T, Genovese M, Lane SR. COX-2 selective inhibitors and bone. Int J Immunopathol Pharmacol. 2003;16:201-205
37. Brown KM, Saunders MM, Kirsch T, Donahue HJ, Reid JS. Effect of COX-2-specific inhibition on fracture-healing in the rat femur. J Bone Joint Surg Am. 2004;86:116-123 (Pubitemid 38057344)
38. Gerstenfeld LC, Al-Ghawas M, Alkhiary YM, Cullinane DM, Krall EA, Fitch JL, Webb EG, Thiede MA, Einhorn TA. Selective and nonselective cyclooxygenase-2 inhibitors and experimental fracture-healing. Reversibility of effects after short-term treatment. J Bone Joint Surg Am. 2007;89:114-125 (Pubitemid 46059150)
39. Simon AM, Manigrasso MB, O'Connor JP. Cyclooxygenase 2 function is essential for bone fracture healing. J Bone Miner Res. 2002;17:963-976 (Pubitemid 34535133)
40. Goodman S, Ma T, Trindade M, Ikenoue T, Matsuura I, Wong N, Fox N, Genovese M, Regula D, Smith RL. COX-2 selective NSAID decreases bone ingrowth in vivo. J Orthop Res. 2002;20:1164-1169 (Pubitemid 35363972)
41. Simon AM, O'Connor JP. Dose and time-dependent effects of cyclooxygenase-2 inhibition on fracture-healing. J Bone Joint Surg Am. 2007;89:500-511 (Pubitemid 46365350)
42. Krischak GD, Augat P, Blakytny R, Claes L, Kinzl L, Beck A. The non-steroidal anti-inflammatory drug diclofenac reduces appearance of osteoblasts in bone defect healing in rats. Arch Orthop Trauma Surg. 2007;127:453-458
43. Murnaghan M, Li G, Marsh DR. Nonsteroidal anti-inflammatory drug-induced fracture nonunion: an inhibition of angiogenesis? J Bone Joint Surg Am. 2006;88 Suppl 3:140-147
44. Anderson GD, Hauser SD, McGarity KL, Bremer ME, Isakson PC, Gregory SA. Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis. J Clin Invest. 1996;97:2672-2679
45. Bergenstock M, Min W, Simon AM, Sabatino C, O'Connor JP. A comparison between the effects of acetaminophen and celecoxib on bone fracture healing in rats. J Orthop Trauma. 2005;19:717-723 (Pubitemid 44378210)
46. Burd TA, Hughes MS, Anglen JO. Heterotopic ossification prophylaxis with indomethacin increases the risk of long-bone nonunion. J Bone Joint Surg Br. 2003;85:700-705
47. Van Staa TP, Leufkens HG, Cooper C. Use of nonsteroidal anti-inflammatory drugs and risk of fractures. Bone. 2000;27:563-568 (Pubitemid 30738625)
48. Vestergaard P, Rejnmark L, Mosekilde L. Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis. Calcif Tissue Int. 2006;79:84-94. (Pubitemid 44306165)
49. Adolphson P, Abbaszadegan H, Jonsson U, Dalen N, Sjoberg HE, Kalen S. No effects of piroxicam on osteopenia and recovery after Colles' fracture. A randomized, double-blind, placebo-controlled, prospective trial. Arch Orthop Trauma Surg. 1993;112:127-130
50. Bhattacharyya T, Levin R, Vrahas MS, Solomon DH. Nonsteroidal antiinflammatory drugs and non-union of humeral shaft fractures. Arthritis Rheum. 2005;53:364-367 (Pubitemid 40799874)
51. Boden SD. Overview of the biology of lumbar spine fusion and principles for selecting a bone graft substitute. Spine. 2002;27(16 Suppl 1):S26-31.
52. Dimar JR 2nd, Ante WA, Zhang YP, Glassman SD. The effects of nonsteroidal anti-inflammatory drugs on posterior spinal fusions in the rat. Spine. 1996;21:1870-1876
53. Martin GJ Jr, Boden SD, Titus L. Recombinant human bone morphogenetic protein-2 overcomes the inhibitory effect of ketorolac, a nonsteroidal anti-inflammatory drug (NSAID), on posterolateral lumbar intertransverse process spine fusion. Spine. 1999;24:2188-2194 (Pubitemid 29518020)
54. Bo J, Sudmann E, Marton PF. Effect of indomethacin on fracture healing in rats. Acta Orthop Scand. 1976;47:588-599 (Pubitemid 8018946)
55. Keller J, Bunger C, Andreassen TT, Bak B, Lucht U. Bone repair inhibited by indomethacin. Effects on bone metabolism and strength of rabbit osteotomies. Acta Orthop Scand. 1987;58:379-383
56. Lindholm TS, Tornkvist H. Inhibitory effect on bone formation and calcification exerted by the anti-inflammatory drug ibuprofen. An experimental study on adult rat with fracture. Scand J Rheumatol. 1981;10:38-42. (Pubitemid 11114040)
57. Sudmann E, Bang G. Indomethacin-induced inhibition of haversian remodelling in rabbits. Acta Orthop Scand. 1979;50(6 Pt 1):621-627 (Pubitemid 10162502)
58. Boden SD, Schimandle JH, Hutton WC. An experimental lumbar intertransverse process spinal fusion model. Radiographic, histologic, and biomechanical healing characteristics. Spine. 1995;20:412-420
59. Deguchi M, Rapoff AJ, Zdeblick TA. Posterolateral fusion for isthmic spondylolisthesis in adults: analysis of fusion rate and clinical results. J Spinal Disord. 1998;11:459-464 (Pubitemid 29024381)
60. Long J, Lewis S, Kuklo T, Zhu Y, Riew KD. The effect of cyclooxygenase-2 inhibitors on spinal fusion. J Bone Joint Surg Am. 2002;84:1763-1768 (Pubitemid 35176467)
61. Trancik T, Mills W, Vinson N. The effect of indomethacin, aspirin, and ibuprofen on bone in-growth into a porous-coated implant. Clin Orthop Relat Res. 1989;249:113-121 (Pubitemid 20199761)
62. Keller JC, Trancik TM, Young FA, St Mary E. Effects of indomethacin on bone ingrowth. J Orthop Res. 1989;7:28-34.
63. Cook SD, Barrack RL, Dalton JE, Thomas KA, Brown TD. Effects of indomethacin on biologic fixation of porous-coated titanium implants. J Arthroplasty. 1995;10:351-358
64. Hukkanen M, Corbett SA, Batten J, Konttinen YT, McCarthy ID, Maclouf J, Santavirta S, Hughes SP, Polak JM. Aseptic loosening of total hip replacement. Macrophage expression of inducible nitric oxide synthase and cyclo-oxygenase-2, together with peroxynitrite formation, as a possible mechanism for early prosthesis failure. J Bone Joint Surg Br. 1997;79:467-474 (Pubitemid 27232254)
65. Bukata SV, Gelinas J, Wei X, Rosier RN, Puzas JE, Zhang X, Schwarz EM, Song XY, Griswold DE, O'Keefe RJ. PGE2 and IL-6 production by fibroblasts in response to titanium wear debris particles is mediated through a Cox-2 dependent pathway. J Orthop Res. 2004;22:6-12. (Pubitemid 38035439)
66. Vogel HG. Mechanical and chemical properties of various connective tissue organs in rats as influenced by non-steroidal antirheumatic drugs. Connect Tissue Res. 1977;5:91-95
67. Forslund C, Bylander B, Aspenberg P. Indomethacin and celecoxib improve tendon healing in rats. Acta Orthop Scand. 2003;74:465-469 (Pubitemid 37108468)
68. Lu K, Liang CL, Chen HJ, Chen SD, Hsu HC, Chen YC, Hsu FF, Cho CL. Nuclear factor-kappaB-regulated cyclooxygenase-2 expression in surgery-associated paraspinal muscle injury in rats. J Neurosurg. 2003;98(2 Suppl):181-187 (Pubitemid 36356186)
69. Elder CL, Dahners LE, Weinhold PS. A cyclooxygenase-2 inhibitor impairs ligament healing in the rat. Am J Sports Med. 2001;29:801-805
70. Hanson CA, Weinhold PS, Afshari HM, Dahners LE. The effect of analgesic agents on the healing rat medial collateral ligament. Am J Sports Med. 2005;33:674-679 (Pubitemid 40593762)
71. Bogatov VB, Weinhold P, Dahners LE. The influence of a cyclooxygenase-1 inhibitor on injured and uninjured ligaments in the rat. Am J Sports Med. 2003;31:574-576 (Pubitemid 36875390)
72. Ferry ST, Dahners LE, Afshari HM, Weinhold PS. The effects of common anti-inflammatory drugs on the healing rat patellar tendon. Am J Sports Med. 2007;35:1326-1333
73. Gierer P, Mittlmeier T, Bordel R, Schaser KD, Gradl G, Vollmar B. Selective cyclooxygenase-2 inhibition reverses microcirculatory and inflammatory sequelae of closed soft-tissue trauma in an animal model. J Bone Joint Surg Am. 2005;87:153-160 (Pubitemid 40094152)
74. Cohen DB, Kawamura S, Ehteshami JR, Rodeo SA. Indomethacin and celecoxib impair rotator cuff tendon-to-bone healing. Am J Sports Med. 2006;34:362-369 (Pubitemid 43260571)