Design, synthesis and analgesic properties of novel conformationally-restricted N-acylhydrazones (NAH)

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 17, 2009, Pages 4963-4966

  Kümmerle, Arthur E ^a,b   Vieira, Marina M ^a   Schmitt, Martine ^b   Miranda, Ana L P ^a   Fraga, Carlos A M ^a   Bourguignon, Jean Jacques ^b   Barreiro, Eliezer J ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b Faculté de Pharmacie   (France)

Author keywords

Analgesic; Conformational restriction; N Acylhydrazones

Indexed keywords

1,2,4 TRIAZOLO[4,3 B]PYRIDAZINE; BENZO[1,2 D]DIAZEPIN 1 ONE; HETEROCYCLIC COMPOUND; HYDRAZONE DERIVATIVE; INDOMETACIN; N ACYLHYDRAZONE DERIVATIVE; PARACETAMOL; PHTHALAZINONE DERIVATIVE; PYRAZOLE; QUINAZOLIN 4(3H) ONE DERIVATIVE; QUINAZOLINE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CONFORMATION; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; MOUSE; NONHUMAN; POLYMERIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS;

ANALGESICS; ANIMALS; DRUG DESIGN; HYDRAZONES; MICE; MOLECULAR CONFORMATION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 68349146235     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.07.075     Document Type: Article

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