Insulin inhibits myocardial ischemia-induced apoptosis and alleviates chronic adverse changes in post-ischemic cardiac structure and function

Apoptosis

Volumn 14, Issue 9, 2009, Pages 1050-1060

  Xing, Wenjuan ^a   Yan, Wenjun ^a   Fu, Feng ^a   Jin, Yulan ^b   Ji, Lele ^a   Liu, Wenchong ^a   Wang, Li ^a   Lv, Anlin ^a   Duan, Yunyan ^a   Zhang, Jun ^a   Zhang, Haifeng ^a   Gao, Feng ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b NORTH CHINA COAL MEDICAL COLLEGE   (China)

Author keywords

Apoptosis; Cardiac function; Insulin; Myocardial ischemia; Remodeling

Indexed keywords

4 [4 (4 FLUOROPHENYL) 5 (2 METHOXY 4 PYRIMIDINYL) 1 IMIDAZOLYL]CYCLOHEXANOL; CASPASE 3; CREATINE KINASE; INSULIN; LACTATE DEHYDROGENASE; SODIUM CHLORIDE; WORTMANNIN;

ADVERSE OUTCOME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTERY OCCLUSION; ARTICLE; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; CREATININE BLOOD LEVEL; DRUG INHIBITION; ECHOCARDIOGRAPHY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HEART FUNCTION; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE SIZE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART SURGERY; HEART VENTRICLE SEPTUM; INSULIN TREATMENT; LACTATE DEHYDROGENASE BLOOD LEVEL; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; APOPTOSIS; CREATINE KINASE; HEART FUNCTION TESTS; INSULIN; L-LACTATE DEHYDROGENASE; MALE; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; MYOCARDIUM; MYOCYTES, CARDIAC; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; VENTRICULAR FUNCTION, LEFT;

RATTUS;

EID: 68349130477     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-009-0378-y     Document Type: Article

References (39)

1. F Fath-Ordoubadi KJ Beatt 1997 Glucose-insulin-potassium therapy for treatment of acute myocardial infarction: an overview of randomized placebo-controlled trials Circulation 96 1152 1156
2. K Malmberg 1997 Prospective randomised study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus. DIGAMI (diabetes mellitus, insulin glucose infusion in acute myocardial infarction) study group BMJ 314 1512 1515
3. R Diaz EA Paolasso LS Piegas CD Tajer MG Moreno R Corvalan 1998 Metabolic modulation of acute myocardial infarction. The ECLA (estudios cardiologicos latinoamerica) collaborative group Circulation 98 2227 2234
4. F Gao E Gao TL Yue EH Ohlstein BL Lopez TA Christopher 2002 Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation Circulation 105 1497 1502 10.1161/01.CIR.0000012529.00367.0F (Pubitemid 34263284)
5. HF Zhang Q Fan XX Qian BL Lopez TA Christopher XL Ma 2004 Role of insulin in the anti-apoptotic effect of glucose-insulin-potassium in rabbits with acute myocardial ischemia and reperfusion Apoptosis 9 777 783 10.1023/B:APPT. 0000045796.58715.82 (Pubitemid 40941206)
6. TA Duhamel NS Dhalla 2007 New insights into the causes of heart failure Drug Discov Today Dis Mech 4 175 184 10.1016/j.ddmec.2007.12.001 (Pubitemid 351980419)
7. BA French CM Kramer 2007 Mechanisms of post-infarct left ventricular remodeling Drug Discov Today Dis Mech 4 185 196 10.1016/j.ddmec.2007.12.006
8. X Guo HK Saini J Wang SK Gupta RK Goyal NS Dhalla 2005 Prevention of remodeling in congestive heart failure due to myocardial infarction by blockade of the renin-angiotensin system Expert Rev Cardiovasc Ther 3 717 732 10.1586/14779072.3.4.717 (Pubitemid 41086827)
9. I Shiojima M Yefremashvili Z Luo Y Kureishi A Takahashi J Tao 2002 Akt signaling mediates postnatal heart growth in response to insulin and nutritional status J Biol Chem 277 37670 37677 10.1074/jbc.M204572200
10. RA Gottlieb KO Burleson RA Kloner BM Babior RL Engler 1994 Reperfusion injury induces apoptosis in rabbit cardiomyocytes J Clin Invest 94 1621 1628 10.1172/JCI117504
11. D Wencker M Chandra K Nguyen W Miao S Garantziotis SM Factor 2003 A mechanistic role for cardiac myocyte apoptosis in heart failure J Clin Invest 111 1497 1504 10.1172/JCI17664
12. A Baldi A Abbate R Bussani G Patti R Melfi A Angelini 2002 Apoptosis and post-infarction left ventricular remodeling J Mol Cell Cardiol 34 165 174 10.1006/jmcc.2001.1498 (Pubitemid 35222826)
13. G Olivetti F Quaini R Sala C Lagrasta D Corradi E Bonacina 1996 Acute myocardial infarction in humans is associated with activation of programmed myocyte cell death in the surviving portion of the heart J Mol Cell Cardiol 28 2005 2016 10.1006/jmcc.1996.0193 (Pubitemid 26340560)
14. A Abbate GG Biondi-Zoccai R Bussani A Dobrina D Camilot F Feroce 2003 Increased myocardial apoptosis in patients with unfavorable left ventricular remodeling and early symptomatic post-infarction heart failure J Am Coll Cardiol 41 753 760 10.1016/S0735-1097(02)02959-5 (Pubitemid 36308381)
15. L Matturri J Milei DR Grana AM Lavezzi 2002 Characterization of myocardial hypertrophy by DNA content, PCNA expression and apoptotic index Int J Cardiol 82 33 39 10.1016/S0167-5273(01)00578-2 (Pubitemid 34084914)
16. G Condorelli C Morisco G Stassi A Notte F Farina G Sgaramella 1999 Increased cardiomyocyte apoptosis and changes in proapoptotic and antiapoptotic genes bax and bcl-2 during left ventricular adaptations to chronic pressure overload in the rat Circulation 99 3071 3078
17. F Gao L Tao W Yan E Gao HR Liu BL Lopez 2004 Early anti-apoptosis treatment reduces myocardial infarct size after a prolonged reperfusion Apoptosis 9 553 559 10.1023/B:APPT.0000038035.75845.ab (Pubitemid 39158631)
18. QJ Zhang QX Li HF Zhang KR Zhang WY Guo HC Wang 2007 Swim training sensitizes myocardial response to insulin: role of Akt-dependent eNOS activation Cardiovasc Res 75 369 380 10.1016/j.cardiores.2007.04.015 (Pubitemid 46961927)
19. FN Salloum A Abbate A Das JE Houser CA Mudrick IZ Qureshi 2008 Sildenafil (Viagra) attenuates ischemic cardiomyopathy and improves left ventricular function in mice Am J Physiol Heart Circ Physiol 294 H1398 H1406 10.1152/ajpheart.91438.2007
20. LE Teichholz T Kreulen MV Herman R Gorlin 1976 Problems in echocardiographic volume determinations: echocardiographic-angiographic correlations in the presence of absence of asynergy Am J Cardiol 37 7 11
21. R Diaz A Goyal SR Mehta R Afzal D Xavier P Pais 2007 Glucose-insulin- potassium therapy in patients with ST-segment elevation myocardial infarction JAMA 298 2399 2405 10.1001/jama.298.20.2399 (Pubitemid 350190781)
22. H Su X Sun H Ma HF Zhang QJ Yu C Huang 2007 Acute hyperglycemia exacerbates myocardial ischemia/reperfusion injury and blunts cardioprotective effect of GIK Am J Physiol Endocrinol Metab 293 E629 E635 10.1152/ajpendo.00221. 2007 (Pubitemid 47358973)
23. AK Jonassen MN Sack OD Mjos DM Yellon 2001 Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling Circ Res 89 1191 1198 10.1161/hh2401. 101385
24. S Xydas AR Kherani JS Chang S Klotz I Hay CJ Mutrie 2006 Beta(2)-adrenergic stimulation attenuates left ventricular remodeling, decreases apoptosis, and improves calcium homeostasis in a rodent model of ischemic cardiomyopathy J Pharmacol Exp Ther 317 553 561 10.1124/jpet.105.099432
25. XB Xu JJ Pang JM Cao C Ni RK Xu XZ Peng 2005 GH-releasing peptides improve cardiac dysfunction and cachexia and suppress stress-related hormones and cardiomyocyte apoptosis in rats with heart failure Am J Physiol Heart Circ Physiol 289 H1643 H1651
26. R Shibata Y Izumiya K Sato K Papanicolaou S Kihara WS Colucci 2007 Adiponectin protects against the development of systolic dysfunction following myocardial infarction J Mol Cell Cardiol 42 1065 1074 10.1016/j.yjmcc.2007.03. 808 (Pubitemid 46829193)
27. RM Schneider KG Morris A Chu KB Roberts RE Coleman FR Cobb 1987 Relation between myocardial perfusion and left ventricular function following acute coronary occlusion: disproportionate effects of anterior vs. inferior ischemia Circ Res 60 60 71
28. A Chaudhuri D Janicke MF Wilson D Tripathy R Garg A Bandyopadhyay 2004 Anti-inflammatory and profibrinolytic effect of insulin in acute ST-segment-elevation myocardial infarction Circulation 109 849 854 10.1161/01.CIR.0000116762.77804.FC (Pubitemid 38252736)
29. P Dandona A Chaudhuri H Ghanim P Mohanty 2006 Anti-inflammatory effects of insulin and pro-inflammatory effects of glucose: relevance to the management of acute myocardial infarction and other acute coronary syndromes Rev Cardiovasc Med 7 Suppl 2 S25 S34
30. J Li H Zhang F Wu Y Nan H Ma W Guo 2008 Insulin inhibits tumor necrosis factor-alpha induction in myocardial ischemia/reperfusion: role of Akt and endothelial nitric oxide synthase phosphorylation Crit Care Med 36 1551 1558 10.1097/CCM.0b013e3181782335 (Pubitemid 351620675)
31. R Aikawa M Nawano Y Gu H Katagiri T Asano W Zhu 2000 Insulin prevents cardiomyocytes from oxidative stress-induced apoptosis through activation of PI3 kinase/Akt Circulation 102 2873 2879
32. H Ma HF Zhang L Yu QJ Zhang J Li JH Huo 2006 Vasculoprotective effect of insulin in the ischemic/reperfused canine heart: role of Akt-stimulated NO production Cardiovasc Res 69 57 65 10.1016/j.cardiores.2005.08.019 (Pubitemid 41814811)
33. AK Sinha S Bhattacharya K Acharya S Mazumder 1999 Stimulation of nitric oxide synthesis and protective role of insulin in acute thrombosis in vivo Life Sci 65 2687 2696 10.1016/S0024-3205(99)00537-8
34. MA Pfeffer 1995 Left ventricular remodeling after acute myocardial infarction Annu Rev Med 46 455 466 10.1146/annurev.med.46.1.455
35. G Olivetti R Abbi F Quaini J Kajstura W Cheng JA Nitahara 1997 Apoptosis in the failing human heart N Engl J Med 336 1131 1141
36. J Narula N Haider R Virmani TG DiSalvo FD Kolodgie RJ Hajjar 1996 Apoptosis in myocytes in end-stage heart failure N Engl J Med 335 1182 1189
37. Z Li OH Bing X Long KG Robinson EG Lakatta 1997 Increased cardiomyocyte apoptosis during the transition to heart failure in the spontaneously hypertensive rat Am J Physiol 272 H2313 H2319
38. E Teiger VD Than L Richard C Wisnewsky BS Tea L Gaboury 1996 Apoptosis in pressure overload-induced heart hypertrophy in the rat J Clin Invest 97 2891 2897 10.1172/JCI118747
39. A Saraste K Pulkki M Kallajoki P Heikkila P Laine S Mattila 1999 Cardiomyocyte apoptosis and progression of heart failure to transplantation Eur J Clin Invest 29 380 386 10.1046/j.1365-2362.1999.00481