Non-requirement of a regulatory subunit of Protein Phosphatase 2A, PP2A-B′, for activation of Sex comb reduced activity in Drosophila melanogaster

Mechanisms of Development

Volumn 126, Issue 8-9, 2009, Pages 605-610

  Moazzen, Hoda ^a   Rosenfeld, Robyn ^a   Percival Smith, Anthony ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

HOX; Phosphatase; Phosphorylation; PP2A; Regulatory subunit

Indexed keywords

HOX PROTEIN; PHOSPHOPROTEIN PHOSPHATASE 2A; TRANSCRIPTION FACTOR SEX COMB; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; ENZYME ACTIVITY; ENZYME SUBUNIT; GENE MUTATION; GENETIC RECOMBINATION; HOMOZYGOTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SALIVARY GLAND;

ANIMALS; CELL NUCLEUS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HOMEODOMAIN PROTEINS; HOMOZYGOTE; MALE; MODELS, GENETIC; MUTATION; PHENOTYPE; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; PROTEIN STRUCTURE, TERTIARY; SALIVARY GLANDS; TRANSCRIPTION FACTORS;

DROSOPHILA MELANOGASTER;

EID: 68349116071     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mod.2009.06.1084     Document Type: Article

References (42)

1. Adachi M., and Lewis E.J. The paired-like homeodomain protein, arix, mediates protein kinase A-stimulated dopamine beta-hydroylase gene transcription through its phosphorylation status. J. Biol. Chem. 277 (2002) 22915-22924
2. Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., et al. The genome sequence of Drosophila melanogaster. Science 287 (2000) 2185-2195
3. Andrews J., Bouffard G.G., Cheadle C., Lu J., Becker K.G., and Oliver B. Gene discovery using computational and microarray analysis of transcription in the Drosophila melanogaster testis. Genome Res. 10 (2000) 2030-2043
4. Berry M., and Gehring W.J. Phosphorylation status of the SCR homeodomain determines its functional activity: essential role for protein phosphatase 2A-B′. EMBO J. 19 (2000) 2946-2957
5. Chen F., Archambault V., Kar A., Lio P., D'Avino P.P., Sinka R., et al. Multiple protein phosphatases are required for mitosis in Drosophila. Curr. Biol. 17 (2007) 293-303
6. Chen S., Ji M., Paris M., Hullinger R.L., and Andrisani O.M. The cAMP pathway regulates both transcription and activity of the paired homeobox transcription factor Phoxa2 required for development of neural crest-derived and central nervous system-derived catecholaminergic neurons. J. Biol. Chem. 280 (2005) 41025-41036
7. Cohen P.T.W. Overview of protein serine/threonine phosphatases. In: Arino J., and Alexander D.R. (Eds). Topics in Current Genetics. Protein Phosphatases vol. 5 (2004), Springer-Verlag, Berlin Heidelberg 1-20
8. Dong J., and Krause H.M. Tissue-specific requirements for a phosphorylation site in the Fushi tarazu homeodomain. Genes Dev. Evol. 209 (1999) 427-431
9. Dura J.M., and Ingham P. Tissue- and stage-specific control of homeotic and segmentation gene expression in Drosophila embryos by the polyhomeotic gene. Development 103 (1988) 733-741
10. Furukubo-Tokunaga K., Flister S., and Gehring W.J. Functional specificity of the Antennapedia homeodomain. Proc. Natl. Acad. Sci. USA 90 (1993) 6363-6364
11. Giot L., Bader J.S., Brouwer C., Chaudhuri A., Kuang B., Li Y., et al. A protein interaction map of Drosophila melanogaster. Science 302 (2003) 1727-1736
12. Hannus M., Feiguin F., Heisenberg C.P., and Eaton S. Planar cell polarization requires Widerborst, a B′ regulatory subunit of protein phosphatase 2A. Development 129 (2002) 3493-3503
13. Himmelbach A., Hoffman T., Leube M., and Grill E. Homeodomain protein ATHB6 is a target of the protein phosphatase ABI1 and regulates hormone responses in Arabidopsis. EMBO J. 21 (2002) 3029-3038
14. Hueber S.D., Bezdan D., Henz S.R., Blank M., Wu H., and Lohmann I. Comparative analysis of HOX downstream genes. Development 134 (2007) 381-392
15. Jaffe L., Ryoo H.-D., and Mann R.S. A role for phosphorylation by casein kinase II in modulating Antennapedia activity in Drosophila. Genes Dev. 11 (1997) 1327-1340
16. Janssens V., and Goris J. Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. J. Biochem. 353 (2001) 417-439
17. Joshi R., Passner J.M., Rohs R., Jain R., Sosinsky A., Crickmore M.A., et al. Functional specificity of a Hox protein mediated by the recognition of minor groove structure. Cell 131 (2007) 343-530
18. Junttila M.R., Puustinen P., Niemela M., Alola R., Arnold H., Bottzauw T., et al. CIP2A inhibits PP2A in human malignancies. Cell 130 (2007) 51-62
19. Kulkarni M.M., Booker M., Silver S.J., Friedman A., Hong P., Perrimon N., and Mathey-Prevot B. Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assay. Nat. Methods 3 (2006) 833-838
20. LeMotte P., Kuroiwa A., Fessler L.I., and Gehring W.J. The homeotic gene Sex combs reduced of Drosophila: gene structure and embryonic expression. EMBO J. 8 (1989) 219-227
21. Lewis R.A., Kaufman T.C., Denell R.E., and Tallerico P. Genetic analysis of the Antennapedia gene complex (Ant-C) and adjacent chromosomal regions of Drosophila melanogaster. I. Polytene chromosome segments 84B-D. Genetics 95 (1980) 367-381
22. Lewis R.A., Wakimoto B.T., Denell R.E., and Kaufman T.C. Genetic analysis of the Antennapedia gene complex (Ant-C) and adjacent chromosomal regions of Drosophila melanogaster. II. Polytene chromosome segments 84A-84B1, 2. Genetics 95 (1980) 383-397
23. Li X., Scuderi A., Letsou A., and Virshup D.M. B56-associated protein phosphatase 2A is required for survival and protects from apoptosis in Drosophila melanogaster. Mol. Cell. Biol. 22 (2002) 3674-3684
24. Liu W., Silverstein A.M., Shu H., Martinez B., and Mumby M.C. A functional genomics analysis of the B56 isoforms of Drosophila protein phosphatase 2A. Mol. Cell. Proteomics 6 (2007) 319-332
25. Ma Y., Creanga A., Lum L., and Beachy P.A. Prevalence of off-target effects in Drosophila RNA interference screens. Nature 443 (2006) 359-363
26. Mahaffey J.W., and Kaufman T.C. Distribution of the Sex combs reduced gene products in Drosophila melanogaster. Genetics 117 (1987) 51-60
27. Mayer-Jaekel R.E., Baumgartner S., Bible G., Ohkura H., Glover D.M., and Hemmings B.A. Molecular cloning and developmental expression of the catalytic and 65-kDa regulatory subunits of protein phosphatase 2A in Drosophila. Mol. Biol. Cell 3 (1992) 287-298
28. Panzer S., Weigel D., and Beckendorf S.K. Organogenesis in Drosophila melanogaster: embryonic salivary gland determination is controlled by homeotic and dorsoventral patterning genes. Development 114 (1992) 49-57
29. Parks A.L., Cook K.R., Belvin M., Dompe N.A., Fawcett R., et al. Systematic generation of high resolution deletion coverage of the Drosophila genome. Nat. Genet. 36 (2004) 288-292
30. Pattatucci A.M., and Kaufman T.C. The homeotic gene Sex combs reduced of Drosophila melanogaster is differentially regulated in the embryonic and imaginal stages of development. Genetics 129 (1991) 443-461
31. Percival-Smith A., Müller M., Affolter M., and Gehring W.J. The interaction with DNA of wild-type and mutant fushi tarazu homeodomains. EMBO J. 9 (1990) 3967-3974
32. Sathyanarayanan S., Zheng X., Xiao R., and Sehgal A. Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A. Cell 116 (2004) 603-615
33. Sivanantharajah L., and Percival-Smith A. Analysis of the sequence and phenotype of Drosophila Sex combs reduced alleles reveals potential functions of conserved protein motifs of the Sex combs reduced protein. Genetics 182 (2009) 191-203
34. Snaith H.A., Armstrong C.G., Guo Y., Kaiser K., and Cohen P.T.W. Deficiency of protein phosphatase 2A uncouples the nuclear and centrosome cycles and prevents attachment of microtubules to the kinetochore in Drosophila microtubule star (mts) embryos. J. Cell Sci. 109 (1996) 3001-3012
35. Struhl G. Genes controlling segmental specification in the Drosophila thorax. Proc. Natl. Acad. Sci. USA 79 (1982) 7380-7384
36. Taghli-Lamallem O., Hsia C., Ronshaugen M., and McGinnis W. Context-dependent regulation of Hox protein function by CK2 phosphorylation sites. Dev. Genes Evol. 218 (2008) 321-332
37. Tayyab I., Hallahan H.M., and Percival-Smith A. Analysis of Drosophila proboscipedia mutant alleles. Genome 47 (2004) 600-609
38. Tweedie S., Ashburner M., Falls K., Leyland P., McQuilton P., Marygold S., et al. FlyBase: enhancing Drosophila gene ontology annotations. Nucleic Acids Res. 37 (2009) D555-D559
39. Uemura T., Shiomi K., Togashi S., and Takeichi M. Mutation of twins encoding a regulator of protein Phosphatase 2A leads to pattern duplication in Drosophila imaginal discs. Genes Dev. 7 (1993) 429-440
40. Vijapurkar U., Fischbach N., Shen W.F., Brandts C., Stokoe D., Lawrence H.J., and Largman C. Protein kinase C-mediated phosphorylation of the leukemia-associated HOXA9 protein impairs its DNA binding ability and induces myeloid differentiation. Mol. Cell. Biol. 24 (2004) 3827-3837
41. Wieschaus E., and Nüsslein-Volhard C. Looking at embryos. In: Roberts D.B. (Ed). Drosophila: A practical Approach (1986), IRL, Oxford 199-228
42. Zeng W., Andrew D.J., Mathies L.D., Horner M.A., and Scott M.P. Ectopic expression and function of the Antp and Scr homeotic genes: the N terminus of the homeodomain is critical to functional specificity. Development 118 (1993) 339-352