메뉴 건너뛰기




Volumn 125, Issue 6, 2009, Pages 1464-1472

Biscoclaurine alkaloid cepharanthine inhibits the growth of primary effusion lymphoma in vitro and in vivo and induces apoptosis via suppression of the NF-κB pathway

Author keywords

Animal model; Cepharanthine; NF B; Primary effusion lymphoma

Indexed keywords

CEPHARANTHINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

EID: 68249154790     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.24521     Document Type: Article
Times cited : (40)

References (58)
  • 1
    • 0029974841 scopus 로고    scopus 로고
    • Primary effusion lymphoma: A distinct clinicopathologic entity associated with the Kaposi's sarcoma-associated herpes virus
    • Nador RG, Cesarman E, Chadburn A, Dawson DB, Ansari MQ, Sald J, Knowles DM. Primary effusion lymphoma: a distinct clinicopathologic entity associated with the Kaposi's sarcoma-associated herpes virus. Blood 1996;88:645-56.
    • (1996) Blood , vol.88 , pp. 645-656
    • Nador, R.G.1    Cesarman, E.2    Chadburn, A.3    Dawson, D.B.4    Ansari, M.Q.5    Sald, J.6    Knowles, D.M.7
  • 3
    • 0029069445 scopus 로고
    • Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas
    • Cesarman E, Chang Y, Moore PS, Said JW, Knowles DM. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N Engl J Med 1995;332:1186-91.
    • (1995) N Engl J Med , vol.332 , pp. 1186-1191
    • Cesarman, E.1    Chang, Y.2    Moore, P.S.3    Said, J.W.4    Knowles, D.M.5
  • 4
    • 0037441888 scopus 로고    scopus 로고
    • Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma
    • Aoki Y, Feldman GM, Tosato G. Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma. Blood 2003;101:1535-42.
    • (2003) Blood , vol.101 , pp. 1535-1542
    • Aoki, Y.1    Feldman, G.M.2    Tosato, G.3
  • 5
    • 0034287445 scopus 로고    scopus 로고
    • Inhibition of NF-κB induces apoptosis of KSHV-infected primary effusion lymphoma cells
    • Keller SA, Schattner EJ, Cesarman E. Inhibition of NF-κB induces apoptosis of KSHV-infected primary effusion lymphoma cells. Blood 2000;96:2537-42.
    • (2000) Blood , vol.96 , pp. 2537-2542
    • Keller, S.A.1    Schattner, E.J.2    Cesarman, E.3
  • 7
    • 0037369240 scopus 로고    scopus 로고
    • The human herpes virus 8-encoded viral FLICE inhibitory protein protects against growth factor withdrawal-induced apoptosis via NF-j B activation
    • Sun Q, Matta H, Chaudhary PM. The human herpes virus 8-encoded viral FLICE inhibitory protein protects against growth factor withdrawal-induced apoptosis via NF-j B activation. Blood 2003;101: 1956-61.
    • (2003) Blood , vol.101 , pp. 1956-1961
    • Sun, Q.1    Matta, H.2    Chaudhary, P.M.3
  • 8
    • 33746818715 scopus 로고    scopus 로고
    • Cell signaling pathways engaged by KSHV
    • Jarviluoma A, Ojala PM. Cell signaling pathways engaged by KSHV. Biochim Biophys Acta 2006;1766:140-58.
    • (2006) Biochim Biophys Acta , vol.1766 , pp. 140-158
    • Jarviluoma, A.1    Ojala, P.M.2
  • 9
    • 33947586159 scopus 로고    scopus 로고
    • Aberrant NF-jB signaling in lymphoma: Mechanisms, consequences, and therapeutic implications
    • Jost PJ, Ruland J. Aberrant NF-jB signaling in lymphoma: mechanisms, consequences, and therapeutic implications. Blood 2007;109: 2700-7.
    • (2007) Blood , vol.109 , pp. 2700-2707
    • Jost, P.J.1    Ruland, J.2
  • 10
    • 0037134478 scopus 로고    scopus 로고
    • The human herpes virus 8-encoded viral FLICE inhibitory protein physically associates with and persistently activates the Ikappa B kinase complex
    • Liu L, Eby MT, Rathore N, Sinha SK, Kumar A, Chaudhary PM. The human herpes virus 8-encoded viral FLICE inhibitory protein physically associates with and persistently activates the Ikappa B kinase complex. J Biol Chem 2002;277:13745-51.
    • (2002) J Biol Chem , vol.277 , pp. 13745-13751
    • Liu, L.1    Eby, M.T.2    Rathore, N.3    Sinha, S.K.4    Kumar, A.5    Chaudhary, P.M.6
  • 12
    • 33846940700 scopus 로고    scopus 로고
    • The effects of biscoclaurine alkaloid cepharanthine on mammalian cells: Implications for cancer, shock, and inflammatory diseases
    • Furusawa S, Wu J. The effects of biscoclaurine alkaloid cepharanthine on mammalian cells: implications for cancer, shock, and inflammatory diseases. Life Sci 2007;80:1073-9.
    • (2007) Life Sci , vol.80 , pp. 1073-1079
    • Furusawa, S.1    Wu, J.2
  • 14
    • 8644235762 scopus 로고    scopus 로고
    • Cepharanthine, an anti-inflammatory drug, suppresses mitochondrial membrane permeability transition
    • Nagano M, Kanno T, Fujita H, Muranaka S, Fujiwara T, Utsumi K. Cepharanthine, an anti-inflammatory drug, suppresses mitochondrial membrane permeability transition. Physiol Chem Phys Med NMR 2003;35:131-43.
    • (2003) Physiol Chem Phys Med NMR , vol.35 , pp. 131-143
    • Nagano, M.1    Kanno, T.2    Fujita, H.3    Muranaka, S.4    Fujiwara, T.5    Utsumi, K.6
  • 15
    • 0026670777 scopus 로고
    • Selective inhibition of T-cell-dependent immune responses by bisbenzylisoquinoline alkaloids in vivo
    • Kondo Y, Imai Y, Hojo H, Hashimoto Y, Nozoe S. Selective inhibition of T-cell-dependent immune responses by bisbenzylisoquinoline alkaloids in vivo. Int J Immunopharmacol 1992;14:1181-6.
    • (1992) Int J Immunopharmacol , vol.14 , pp. 1181-1186
    • Kondo, Y.1    Imai, Y.2    Hojo, H.3    Hashimoto, Y.4    Nozoe, S.5
  • 16
    • 0025824159 scopus 로고
    • Cepharanthine (biscoclaurine alkaloid) treatment in endotoxic shock of suckling rats
    • Goto M, Zeller WP, Hurley RM. Cepharanthine (biscoclaurine alkaloid) treatment in endotoxic shock of suckling rats. J Pharm Pharmacol 1991;43:589-91.
    • (1991) J Pharm Pharmacol , vol.43 , pp. 589-591
    • Goto, M.1    Zeller, W.P.2    Hurley, R.M.3
  • 19
    • 0034804592 scopus 로고    scopus 로고
    • Characteristics of antitumour activity of cepharanthin against a human adenosquamous cell carcinoma cell line
    • Harada K, Bando T, Yoshida H, Sato M. Characteristics of antitumour activity of cepharanthin against a human adenosquamous cell carcinoma cell line. Oral Oncol 2001;37:643-51.
    • (2001) Oral Oncol , vol.37 , pp. 643-651
    • Harada, K.1    Bando, T.2    Yoshida, H.3    Sato, M.4
  • 20
    • 0036204777 scopus 로고    scopus 로고
    • Effects of combination chemotherapy with biscoclaurine-derived alkaloid (Cepharanthine) and nimustine hydrochloride on malignant glioma cell lines
    • Kono K, Takahashi JA, Ueba T, Mori H, Hashimoto N, Fukumoto M. Effects of combination chemotherapy with biscoclaurine-derived alkaloid (Cepharanthine) and nimustine hydrochloride on malignant glioma cell lines. J Neurooncol 2002;56:101-8.
    • (2002) J Neurooncol , vol.56 , pp. 101-108
    • Kono, K.1    Takahashi, J.A.2    Ueba, T.3    Mori, H.4    Hashimoto, N.5    Fukumoto, M.6
  • 21
    • 30644476699 scopus 로고    scopus 로고
    • Cepharanthine triggers apoptosis in a human hepatocellular carcinoma cell line (HuH-7) through the activation of JNK1/2 and the downregulation of Akt
    • Biswas KK, Tancharoen S, Sarker KP, Kawahara K, Hashiguchi T, Maruyama I. Cepharanthine triggers apoptosis in a human hepatocellular carcinoma cell line (HuH-7) through the activation of JNK1/2 and the downregulation of Akt. FEBS Lett 2006;580:703-10.
    • (2006) FEBS Lett , vol.580 , pp. 703-710
    • Biswas, K.K.1    Tancharoen, S.2    Sarker, K.P.3    Kawahara, K.4    Hashiguchi, T.5    Maruyama, I.6
  • 22
    • 0032552469 scopus 로고    scopus 로고
    • Potent inhibition of HIV type 1 replication by an antiinflammatory alkaloid, cepharanthine, in chronically infected monocytic cells
    • Okamoto M, Ono M, Baba M. Potent inhibition of HIV type 1 replication by an antiinflammatory alkaloid, cepharanthine, in chronically infected monocytic cells. AIDS Res Hum Retroviruses 1998;14: 1239-45.
    • (1998) AIDS Res Hum Retroviruses , vol.14 , pp. 1239-1245
    • Okamoto, M.1    Ono, M.2    Baba, M.3
  • 23
    • 35848957914 scopus 로고    scopus 로고
    • Cepharanthin-enhanced radiosensitivity through the inhibition of radiation-induced nuclear factor-κB activity in human oral squamous cell carcinoma cells
    • Tamatani T, Azuma M, Motegi K, Takamaru N, Kawashima Y, Bando T. Cepharanthin-enhanced radiosensitivity through the inhibition of radiation-induced nuclear factor-κB activity in human oral squamous cell carcinoma cells. Int J Oncol 2007;31:761-8.
    • (2007) Int J Oncol , vol.31 , pp. 761-768
    • Tamatani, T.1    Azuma, M.2    Motegi, K.3    Takamaru, N.4    Kawashima, Y.5    Bando, T.6
  • 24
    • 0029876473 scopus 로고    scopus 로고
    • Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture
    • Renne R, Zhong W, Herndier B, McGrath M, Abbey N, Kedes D, Ganem D. Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture. Nat Med 1996;2:342-6.
    • (1996) Nat Med , vol.2 , pp. 342-346
    • Renne, R.1    Zhong, W.2    Herndier, B.3    McGrath, M.4    Abbey, N.5    Kedes, D.6    Ganem, D.7
  • 27
    • 0034489187 scopus 로고    scopus 로고
    • Naturally occurring and synthetic inhibitors of NF-jB functions
    • Umezawa K, Ariga A, Matsumoto N. Naturally occurring and synthetic inhibitors of NF-jB functions. Anticancer Drug Des 2000;15: 239-44.
    • (2000) Anticancer Drug Des , vol.15 , pp. 239-244
    • Umezawa, K.1    Ariga, A.2    Matsumoto, N.3
  • 28
    • 0025726216 scopus 로고
    • A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
    • Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 1991;139:271-9.
    • (1991) J Immunol Methods , vol.139 , pp. 271-279
    • Nicoletti, I.1    Migliorati, G.2    Pagliacci, M.C.3    Grignani, F.4    Riccardi, C.5
  • 29
    • 0034608386 scopus 로고    scopus 로고
    • Assessment of caspase activities in intact apoptotic thymocytes using cellpermeable fluorogenic caspase substrates
    • Komoriya A, Packard BZ, Brown MJ, Wu ML, Henkart PA. Assessment of caspase activities in intact apoptotic thymocytes using cellpermeable fluorogenic caspase substrates. J Exp Med 2000;191:1819-28.
    • (2000) J Exp Med , vol.191 , pp. 1819-1828
    • Komoriya, A.1    Packard, B.Z.2    Brown, M.J.3    Wu, M.L.4    Henkart, P.A.5
  • 31
    • 27844514746 scopus 로고    scopus 로고
    • In vitro and in vivo antitumor activity of the NF-kappaB inhibitor DHMEQ in the human T-cell leukemia virus type I-infected cell line. HUT-102
    • Ohsugi T, Kumasaka T, Ishida A, Ishida T, Horie R, Watanabe T, Umezawa K, Yamaguchi K. In vitro and in vivo antitumor activity of the NF-kappaB inhibitor DHMEQ in the human T-cell leukemia virus type I-infected cell line. HUT-102. Leuk Res 2006;30:90-7.
    • (2006) Leuk Res , vol.30 , pp. 90-97
    • Ohsugi, T.1    Kumasaka, T.2    Ishida, A.3    Ishida, T.4    Horie, R.5    Watanabe, T.6    Umezawa, K.7    Yamaguchi, K.8
  • 33
    • 64249164929 scopus 로고    scopus 로고
    • Okada S, Harada H, Ito T, Saito T, Suzu S. Early development of human hematopoietic and acquired immune systems in new born NOD/Scid/Jak3(null) mice intrahepatic engrafted with cord bloodderived CD34 (1) cells. Int J Hematol 2008;88:476-82. 34. Katano H, Sato Y, Kurata T, Mori S, Sata T. High expression of HHV-8-encoded ORF73 protein in spindle-shaped cells of Kaposi's sarcoma. Am J Pathol 1999;155:47-52.
    • Okada S, Harada H, Ito T, Saito T, Suzu S. Early development of human hematopoietic and acquired immune systems in new born NOD/Scid/Jak3(null) mice intrahepatic engrafted with cord bloodderived CD34 (1) cells. Int J Hematol 2008;88:476-82. 34. Katano H, Sato Y, Kurata T, Mori S, Sata T. High expression of HHV-8-encoded ORF73 protein in spindle-shaped cells of Kaposi's sarcoma. Am J Pathol 1999;155:47-52.
  • 34
    • 0034099221 scopus 로고    scopus 로고
    • Quantitation of cell-free and cell-associated Kaposi's sarcoma-associated herpesvirus DNA by real-time PCR
    • White IE, Campbell TB. Quantitation of cell-free and cell-associated Kaposi's sarcoma-associated herpesvirus DNA by real-time PCR. J Clin Microbiol 2000;38:1992-5.
    • (2000) J Clin Microbiol , vol.38 , pp. 1992-1995
    • White, I.E.1    Campbell, T.B.2
  • 35
    • 0029043888 scopus 로고    scopus 로고
    • Vermes I, Haanen C, Steffens-Nakken H, Reutelingsperger C. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled. Annexin. V. J Immunol Methods 1995;184:39-51.
    • Vermes I, Haanen C, Steffens-Nakken H, Reutelingsperger C. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled. Annexin. V. J Immunol Methods 1995;184:39-51.
  • 36
    • 0032520778 scopus 로고    scopus 로고
    • A physiologic role of Bcl-xL induced in activated macrophages
    • Okada S, Zhang H, Hatano M, Tokuhisa T. A physiologic role of Bcl-xL induced in activated macrophages. J Immunol 1998;160: 2590-6.
    • (1998) J Immunol , vol.160 , pp. 2590-2596
    • Okada, S.1    Zhang, H.2    Hatano, M.3    Tokuhisa, T.4
  • 37
    • 1842631466 scopus 로고    scopus 로고
    • KSHV vFLIP is essential for the survival of infected lymphoma cells
    • Guasparri I, Keller SA, Cesarman E. KSHV vFLIP is essential for the survival of infected lymphoma cells. J Exp Med 2004;199:993-1003.
    • (2004) J Exp Med , vol.199 , pp. 993-1003
    • Guasparri, I.1    Keller, S.A.2    Cesarman, E.3
  • 39
    • 0029839239 scopus 로고    scopus 로고
    • Severe combined immunodeficient mouse models of human leukemia
    • Uckun FM. Severe combined immunodeficient mouse models of human leukemia. Blood 1996;88:1135-46.
    • (1996) Blood , vol.88 , pp. 1135-1146
    • Uckun, F.M.1
  • 41
    • 0030221263 scopus 로고    scopus 로고
    • and leukemic human stem cells assayed in SCID mice
    • Dick JE. Normal and leukemic human stem cells assayed in SCID mice. Semin Immunol 1996;8:197-206.
    • (1996) Semin Immunol , vol.8 , pp. 197-206
    • Normal, D.J.E.1
  • 42
    • 33846630040 scopus 로고    scopus 로고
    • Humanized mice in translational biomedical research
    • Shultz LD, Ishikawa F, Greiner DL. Humanized mice in translational biomedical research. Nat Rev Immunol 2007;7:118-30.
    • (2007) Nat Rev Immunol , vol.7 , pp. 118-130
    • Shultz, L.D.1    Ishikawa, F.2    Greiner, D.L.3
  • 45
    • 0346101776 scopus 로고    scopus 로고
    • The human herpes virus 8-encoded viral FLICE-inhibitory protein induces cellular transformation via NF-jB activation
    • Sun Q, Zachariah S, Chaudhary PM. The human herpes virus 8-encoded viral FLICE-inhibitory protein induces cellular transformation via NF-jB activation. J Biol Chem 2003;278:52437-45.
    • (2003) J Biol Chem , vol.278 , pp. 52437-52445
    • Sun, Q.1    Zachariah, S.2    Chaudhary, P.M.3
  • 46
    • 25844459154 scopus 로고    scopus 로고
    • NF-κB: Linking inflammation and immunity to cancer development and progression
    • Karin M, Greten FR. NF-κB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 2005;5:749-59.
    • (2005) Nat Rev Immunol , vol.5 , pp. 749-759
    • Karin, M.1    Greten, F.R.2
  • 47
    • 33846685017 scopus 로고    scopus 로고
    • NF-κB activation in development and progression of cancer
    • Inoue J, Gohda J, Akiyama T, Semba K. NF-κB activation in development and progression of cancer. Cancer Sci 2007;98:268-74.
    • (2007) Cancer Sci , vol.98 , pp. 268-274
    • Inoue, J.1    Gohda, J.2    Akiyama, T.3    Semba, K.4
  • 48
    • 33645999706 scopus 로고    scopus 로고
    • NF-κB and IKK as therapeutic targets in cancer
    • Kim HJ, Hawke N, Baldwin AS. NF-κB and IKK as therapeutic targets in cancer. Cell Death Differ 2006;13:738-47.
    • (2006) Cell Death Differ , vol.13 , pp. 738-747
    • Kim, H.J.1    Hawke, N.2    Baldwin, A.S.3
  • 49
    • 33748311907 scopus 로고    scopus 로고
    • Inhibition of tumor growth by NF-κB inhibitors
    • Umezawa K. Inhibition of tumor growth by NF-κB inhibitors. Cancer Sci 2006;97:990-5.
    • (2006) Cancer Sci , vol.97 , pp. 990-995
    • Umezawa, K.1
  • 50
    • 0036272696 scopus 로고    scopus 로고
    • Suppression of tumor necrosis factor α-induced matrix metalloproteinase 9 production in human salivary gland acinar cells by cepharanthine occurs via down-regulation of nuclear factor κB: A possible therapeutic agent for preventing the destruction of the acinar structure in the salivary glands of Sjogren's syndrome patients
    • Azuma M, Aota K, Tamatani T, Motegi K, Yamashita T, Ashida Y, Hayashi Y, Sato M. Suppression of tumor necrosis factor α-induced matrix metalloproteinase 9 production in human salivary gland acinar cells by cepharanthine occurs via down-regulation of nuclear factor κB: a possible therapeutic agent for preventing the destruction of the acinar structure in the salivary glands of Sjogren's syndrome patients. Arthritis Rheum 2002;46:1585-94.
    • (2002) Arthritis Rheum , vol.46 , pp. 1585-1594
    • Azuma, M.1    Aota, K.2    Tamatani, T.3    Motegi, K.4    Yamashita, T.5    Ashida, Y.6    Hayashi, Y.7    Sato, M.8
  • 52
    • 42549096557 scopus 로고    scopus 로고
    • Biscoclaurine alkaloid cepharanthine protects DNA in TK6 lymphoblastoid cells from constitutive oxidative damage
    • Halicka D, Ita M, Tanaka T, Kurose A, Darzynkiewicz Z. Biscoclaurine alkaloid cepharanthine protects DNA in TK6 lymphoblastoid cells from constitutive oxidative damage. Pharmacol Rep 2008;60:93-100.
    • (2008) Pharmacol Rep , vol.60 , pp. 93-100
    • Halicka, D.1    Ita, M.2    Tanaka, T.3    Kurose, A.4    Darzynkiewicz, Z.5
  • 54
    • 0030027978 scopus 로고    scopus 로고
    • High-dose biscoclaurine alkaloids together with prednisolone raise platelet counts in chronic idiopathic thrombocytopenic purpura
    • Saito N, Takemori N, Hirai K, Onodera R, Watanabe S, Kohgo Y. High-dose biscoclaurine alkaloids together with prednisolone raise platelet counts in chronic idiopathic thrombocytopenic purpura. Am J Hematol 1996;51:173-4.
    • (1996) Am J Hematol , vol.51 , pp. 173-174
    • Saito, N.1    Takemori, N.2    Hirai, K.3    Onodera, R.4    Watanabe, S.5    Kohgo, Y.6
  • 56
    • 0024853140 scopus 로고
    • Pharmacokinetic disposition of cepharanthine following single and multiple intravenous doses in healthy subjects
    • Yasuda K, Moro M, Akasu M, Ohnishi A. Pharmacokinetic disposition of cepharanthine following single and multiple intravenous doses in healthy subjects. Jpn J Clin Pharmacol Ther 1989;20:741-9.
    • (1989) Jpn J Clin Pharmacol Ther , vol.20 , pp. 741-749
    • Yasuda, K.1    Moro, M.2    Akasu, M.3    Ohnishi, A.4
  • 58
    • 0037900693 scopus 로고    scopus 로고
    • Cepharanthine exerts antitumor activity on oral squamous cell carcinoma cell lines by induction of p27Kip1
    • Harada K, Supriatno , Yamamoto S, Kawaguchi S, Yoshida H, Sato M. Cepharanthine exerts antitumor activity on oral squamous cell carcinoma cell lines by induction of p27Kip1. Anticancer Res 2003; 23:1441-8.
    • (2003) Anticancer Res , vol.23 , pp. 1441-1448
    • Harada, K.1    Supriatno2    Yamamoto, S.3    Kawaguchi, S.4    Yoshida, H.5    Sato, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.