Identification of Mycobacterium tuberculosis-specific genomic regions encoding antigens inducing protective cellular immune responses

Indian Journal of Experimental Biology

Volumn 47, Issue 6 SPEC. ISS., 2009, Pages 498-504

  Mustafa, Abu Salim ^a   Al Attiyah, Rajaa ^a  

^a KUWAIT UNIVERSITY   (Kuwait)

Author keywords

IFN ; IL 10; Mycobacterium tuberculosis; PBMCs; RD antigens

Indexed keywords

MYCOBACTERIUM TUBERCULOSIS;

BACTERIAL ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10;

ARTICLE; BACTERIAL GENOME; GENETICS; HUMAN; IMMUNITY; IMMUNOLOGY; MONONUCLEAR CELL; MYCOBACTERIUM TUBERCULOSIS; PHYSIOLOGY; TUBERCULOSIS;

ANTIGENS, BACTERIAL; GENOME, BACTERIAL; HUMANS; IMMUNE SYSTEM PROCESSES; INTERFERON-GAMMA; INTERLEUKIN-10; LEUKOCYTES, MONONUCLEAR; MYCOBACTERIUM TUBERCULOSIS; TUBERCULOSIS;

EID: 68249153823     PISSN: 00195189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Lönnroth K & Raviglione M, Global epidemiology of tuberculosis: Prospects for control, Semin Respir Crit Care Med, 29 (2008) 481.
2. (Pubitemid 38087953) Flynn J, Immunology of tuberculosis and implications in vaccine development, Tuberculosis, 4 (2004) 93.
3. Mustafa A S, Progress towards the development of new antituberculosis vaccines, in Focus on Tuberculosis Research, edited by Lucy T Smithe (Nova Science Publishers Inc, NY, USA) 2005, 47.
4. (Pubitemid 37289749) Al-Attiyah R, Mustafa A S, Abal A T, Madi N M & Andersen P, Restoration of mycobacterial antigen-induced proliferation and interferon-gamma responses in peripheral blood mononuclear cells of tuberculosis patients upon effective chemotherapy, FEMS Immunol Med Microbiol, 38 (2003) 249.
5. (Pubitemid 43881745) Al-Attiyah R, Madi N, El-Shamy A S, Herald W, Andersen P & Mustafa A S, Cytokine profiles in tuberculosis patients and healthy subjects in response to complex and single antigens of Mycobacterium tuberculosis, FEMS Immunol Med Microbiol, 47 (2006) 254.
6. (Pubitemid 44252495) Al-Attiyah R, El-Shazly A & Mustafa A S, Assessment of in vitro immunity to Mycobacterium tuberculosis in a human peripheral blood infection model using a luciferase reporter construct of M tuberculosis H37Rv, Clin Exp Immunol, 145 (2006) 520.
7. (Pubitemid 39451904) Bai, X, Wilson S E, Chmura K, Feldman N E & Chan E D, Morphometric analysis of Th (1) and Th (2) cytokine expression in human pulmonary tuberculosis, Tuberculosis, 84 (2004) 375.
8. (Pubitemid 351967075) Beamer G L, Flaherty D K, Vesosky B & Turner J, Peripheral blood gamma interferon release assay predict lung responses and Mycobacterium tuberculosis disease outcome in mice, Clin Vaccine Immunol, 15 (2008) 474.
9. (Pubitemid 36903482) Turner J, Gonzalez-Juarrero M, Ellis D L, Basarba R J, A. Kipnis A, Orme I M & Cooper A M, In vivo IL-10 production reactivates chronic pulmonary tuberculosis in C57BL/6 mice, J Immunol, 169 (2002) 6343.
10. Beamer G L, Flaherty D K, Assogba B D, Stromberg P, Gonzalez-Juarrero M, de Waal Malefyt R, Vesosky B & Turner J, Interleukin-10 promotes Mycobacterium tuberculosis disease progression in CBA/J mice, J Immunol, 181 (2008) 5545.
11. Sai Priya V H, Anuradha B, Latha Gaddam S, Hasnain S E, Murthy K J & Valluri V L, In vitro levels of interleukins IL-10 and IL-12 in response to Mycobacterium bovis BCG r32kDa antigen after treatment for tuberculosis, Clin Vaccine Immunol, 16 (2009) 111.
12. Murray P J & Young R A, Increased antimycobacterial immunity in interleukin-10 deficient mice, Infect Immun, 67 (1999) 3087.
13. Mustafa A S, Biotechnology in the development of new vaccines and diagnostic reagents against tuberculosis, Curr Pharm Biotechnol, 2 (2001) 157.
14. (Pubitemid 129524431) Behr M A, Wilson M A, Gill W P, Salamon H, Schoolnik G K, Rane S & Small P M, Comparative genomics of BCG vaccines by whole-genome DNA microarray, Science, 284 (1999) 1520.
15. (Pubitemid 351799083) Mustafa A S, Development of new vaccines and diagnostic reagents against tuberculosis, Mol Immunol, 39 (2002) 113.
16. (Pubitemid 351966995) Mustafa A S, Recombinant and synthetic peptides to identify Mycobacterium tuberculosis antigens and epitopes of diagnostic and vaccine relevance, Tuberculosis (Edinb), 85 (2005) 367.
17. (Pubitemid 30434544) Mustafa A S, Mycobacterial gene cloning and expression, comparative genomics, bioinformatics and proteomics in relation to the development of new vaccines and diagnostic reagents, Med Princ Pract, 14 Suppl 1 (2005) 27.
18. (Pubitemid 39279976) Al-Attiyah R & Mustafa A S, Characterization of human cellular immune responses to novel Mycobacterium tuberculosis antigens encoded by genomic regions absent in Mycobacterium bovis BCG, Infect Immun, 76 (2008) 4190.
19. (Pubitemid 28505680) Mustafa A S, Abal A T, Shaban F, El-Shamy A M & Amoudy H A, HLA-DR binding prediction and experimental evaluation of mycolyltransferase (Ag85B), a major secreted antigen of Mycobacterium tuberculosis, Med Princ Pract, 14 (2005) 140.
20. Mustafa A S & Shaban F A, Propred analysis and experimental evaluation of promiscuous Th1 cell epitopes of three major secreted antigens of Mycobacterium tuberculosis, Tuberculosis (Edinb), 86 (2006) 115.
21. (Pubitemid 36368728) Mustafa A S, El-Shamy A M, Madi N M, Amoudy H A & Al-Attiyah R, Cell-mediated immune responses to complex and single mycobacterial antigens in tuberculosis patients with diabetes, Med Princ Pract, 17 (2008) 325.
22. (Pubitemid 32250406) Mustafa A S, Th1-cell reactivity and HLA-DR binding prediction for promiscuous recognition of MPT63 (Rv1926c), a major secreted protein of Mycobacterium tuberculosis, Scand J Immunol, 69 (2009) 213.
23. (Pubitemid 36232879) Hanif S N M, El-Shamy A M, Al-Attiyah R & Mustafa A S, Whole blood assays to identify Th1 cell antigens and peptides encoded by Mycobacterium tuberculosis-specific RD1 genes, Med Princ Pract, 17 (2008) 244.
24. (Pubitemid 44157243) Mustafa A S, Al-Attiyah R, Hanif S N M & Shaban F A, Efficient testing of large pools of Mycobacterium tuberculosis RD1 peptides and identification of major antigens and immunodominant peptides recognized by human Th1 cells, Clin Vaccine Immunol, 15 (2008) 916.
25. Mustafa A S, Shaban F A, Abal A T, Al-Attiyah R, Wiker HG, Lundin K E A, Oftung F & Huygen K, Identification and HLA restriction of naturally derived Th1-cell epitopes from the secreted Mycobacterium tuberculosis antigen 85B recognized by antigen-specific human CD4+ T cell lines, Infect Immun, 68 (2000) 3933.
26. Al-Attiyah R, Mustafa A S, Abal A T, El-Shamy A M, Dalemans W & Skeiky Y A W, In vitro cellular immune responses to complex and newly defined recombinant antigens of Mycobacterium tuberculosis, Clin Exp Immunol, 138 (2004) 139.
27. Mustafa A S, Amoudy H A, Wiker H G, Abal A T, Ravn P, Oftung F & Andersen P, Comparison of antigen-specific T- cell responses of tuberculosis patients using complex or single antigens of Mycobacterium tuberculosis, Scand J Immunol, 48 (1998) 535.
28. Al-Attiyah R, Shaban F A, Wiker H G, Oftung F & Mustafa A S, Synthetic peptides identify promiscuous human Th1 cell epitopes of the secreted mycobacterial antigen MPB70, Infect Immun, 71 (2003) 1953.
29. Mustafa A S, Oftung F, Amoudy H A, Madi N M, Abal A T, Shaban F, Rosen Krands I & Andersen P, Multiple epitopes from the Mycobacterium tuberculosis ESAT-6 antigen are recognized by antigen-specific human T cell lines, Clin Infect Dis, 30 Suppl 3 (2000) S201.
30. Mustafa A S, Cockle P J, Shaban F, Hewinson R G & Vordermeier H M, Immunogenicity of Mycobacterium tuberculosis RD1 region gene products in infected cattle, Clin Exp Immunol, 130 (2002) 37.
31. Mustafa A S, Shaban F A, Al-Attiyah R, Abal A T, El-Shamy A M, Andersen P & Oftung F, Human Th1 cell lines recognize the Mycobacterium tuberculosis ESAT-6 antigen and its peptides in association with frequently expressed HLA class II molecules, Scand J Immunol, 57 (2003) 125.
32. Mustafa A S, Skeiky Y A, Al-Attiyah R, Alderson M R, Hewinson R G & Vordermeier H M, Immunogenicity of Mycobacterium tuberculosis antigens in Mycobacterium bovis BCG-vaccinated and M bovis-infected cattle, Infect Immun, 74 (2006) 4566.
33. (Pubitemid 29243124) Ahmad S, Amoudy H A, Thole J E, Young D B & Mustafa A S, Identification of a novel protein antigen encoded by a Mycobacterium tuberculosis-specific RD1 region gene, Scand J Immunol, 49 (1999) 515.
34. (Pubitemid 29503457) Ahmad S, Akbar P K, Wiker H G, Harboe M & Mustafa A S, Cloning, expression and immunological reactivity of two mammalian cell entry proteins encoded by the mcel operon of Mycobacterium tuberculosis, Scand J Immunol, 50 (1999) 510.
35. (Pubitemid 36720246) Ahmad S, Ali M M & Mustafa A S, Construction of a modified vector for efficient purification of recombinant Mycobacterium tuberculosis proteins expressed in Escherichia coli, Protein Exp Purif, 29 (2003) 167.
36. (Pubitemid 39331494) Ahmad S, El-Shazly S, Mustafa A S & Al-Attiyah R, Mammalian cell-entry proteins encoded by the mce3 operon of Mycobacterium tuberculosis are expressed during natural infection in humans, Scand J Immunol, 60 (2004) 382.
37. (Pubitemid 41025874) Ahmad S, El-Shazly S, Mustafa A S & Al-Attiyah R, The six mammalian cell entry proteins (Mce3A-F) encoded by the mce3 operon are expressed during in vitro growth of Mycobacterium tuberculosis, Scand J Immunol, 62 (2005) 16.
38. Amoudy H A, Al-Turab M B & Mustafa A S, Identification of transcriptionally active open reading frames within the RD1 genomic segment of Mycobacterium tuberculosis, Med Princ Pract, 15 (2006) 137.
39. Amoudy H A & Mustafa A S, Amplification of six putative RD1 genes of Mycobacterium tuberculosis for cloning and expression in Escherichia coli and purification of expressed proteins, Med Princ Pract, 17 (2008) 378.
40. Mustafa A S, HLA-restricted immune response to mycobacterial antigens: Relevance to vaccine design, Hum Immunol, 61 (2000) 166.
41. (Pubitemid 47609697) Fan X, Gao Q & Fu R, DNA vaccine encoding ESAT-6 enhances the protective efficacy of BCG against Mycobacterium tuberculosis infection in mice, Scand J Immunol, 66 (2007) 523.
42. (Pubitemid 47562899) Kalra M, Grover A, Mehta N, Singh J, Kaur J, Sable S B, Behera D, Sharma P, Verma I & Khuller G K, Supplementation with RD antigens enhances the protective efficacy of BCG in tuberculous mice, Clin Immunol, 125 (2007) 173.
43. (Pubitemid 351656162) Wu Y, Woodworth J S, Shin D S, Morris S & Behar S M, Vaccine-elicited 10-kilodalton culture filtrate protein-specific CD8+ T cells are sufficient to mediate protection against Mycobacterium tuberculosis infection, Infect Immun, 76 (2008) 2249.
44. (Pubitemid 36597098) Pym A S, Brodin P, Majlessi L, Brosch R, Demangel C, Williams A, Griffiths K E, Marchal G, Leclerc C & Cole S T, Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis, Nat Med, 9 (2003) 533.
45. (Pubitemid 38858411) Brodin P, Majlessi L, Brosch R, Smith D, Bancroft G, Clark S, Williams A, Leclerc C & Cole S T, Enhanced protection against tuberculosis by vaccination with recombinant Mycobacterium microti vaccine that induces T cell immunity against region of difference 1 antigens, J Infect Dis, 190 (2004) 115.
46. Ganguly N, Siddiqui I & Sharma P, Role of M. tuberculosis RD-1 region encoded secretory proteins in protective response and virulence, Tuberculosis (Edinb), 88 (2008) 510.
47. (Pubitemid 35365606) Pym A S, Brodin P, Brosch R, Huerre M & Cole S T, Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti, Mol Microbiol, 46 (2002) 709.