메뉴 건너뛰기




Volumn 125, Issue 6, 2009, Pages 1257-1265

A comprehensive catalogue of functional genetic variations in the EGFR pathway: Protein-protein interaction analysis reveals novel genes and polymorphisms important for cancer research

Author keywords

Cancer treatment response and prognosis; EGFR pathway; Network based target selection; Protein protein interactions; SNPs

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN KINASE FYN; PROTEIN KINASE LCK;

EID: 68249142895     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.24535     Document Type: Article
Times cited : (11)

References (80)
  • 1
    • 18844370441 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and signal transduction: Potential targets for anti-cancer therapy
    • Pal SK, Pegram M. Epidermal growth factor receptor and signal transduction: potential targets for anti-cancer therapy. Anticancer Drugs 2005;16:483-94.
    • (2005) Anticancer Drugs , vol.16 , pp. 483-494
    • Pal, S.K.1    Pegram, M.2
  • 2
    • 33749316418 scopus 로고    scopus 로고
    • The epidermal growth factor receptor pathway: A model for targeted therapy
    • Scaltriti M, Baselga J. The epidermal growth factor receptor pathway: a model for targeted therapy. Clin Cancer Res 2006;12: 5268-72.
    • (2006) Clin Cancer Res , vol.12 , pp. 5268-5272
    • Scaltriti, M.1    Baselga, J.2
  • 4
    • 43049158080 scopus 로고    scopus 로고
    • A retrospective on the inhibition of epidermal growth factor receptor as a therapeutic strategy for patients with relapsed metastatic colorectal cancer: Impact on treatment of today's patients
    • Jackson C, Cunningham D. A retrospective on the inhibition of epidermal growth factor receptor as a therapeutic strategy for patients with relapsed metastatic colorectal cancer: impact on treatment of today's patients. Clin Colorectal Cancer 2007;Suppl 1:S8-15.
    • (2007) Clin Colorectal Cancer , Issue.SUPPL. 1
    • Jackson, C.1    Cunningham, D.2
  • 5
    • 47049086333 scopus 로고    scopus 로고
    • Targeting the epidermal growth factor receptor in high-grade astrocytomas
    • Voelzke WR, Petty WJ, Lesser GJ. Targeting the epidermal growth factor receptor in high-grade astrocytomas. Curr Treat Options Oncol 2008;9:23-31.
    • (2008) Curr Treat Options Oncol , vol.9 , pp. 23-31
    • Voelzke, W.R.1    Petty, W.J.2    Lesser, G.J.3
  • 8
    • 46949101939 scopus 로고    scopus 로고
    • EGFR/HER2 in breast cancer: A biological approach for molecular diagnosis and therapy
    • Milanezi F, Carvalho S, Schmitt FC. EGFR/HER2 in breast cancer: a biological approach for molecular diagnosis and therapy. Expert Rev Mol Diagn 2008;8:417-34.
    • (2008) Expert Rev Mol Diagn , vol.8 , pp. 417-434
    • Milanezi, F.1    Carvalho, S.2    Schmitt, F.C.3
  • 12
    • 38149015503 scopus 로고    scopus 로고
    • PI3K/PTEN signaling in tumorigenesis and angiogenesis
    • Jiang BH, Liu LZ. PI3K/PTEN signaling in tumorigenesis and angiogenesis. Biochim Biophys Acta 2008;1784:150-8.
    • (2008) Biochim Biophys Acta , vol.1784 , pp. 150-158
    • Jiang, B.H.1    Liu, L.Z.2
  • 13
    • 34547730818 scopus 로고    scopus 로고
    • Marks JL, McLellan MD, Zakowski MF, Lash AE, Kasai Y, Broderick S, Sarkaria IS, Pham D, Singh B, Miner TL, Fewell GA, Fulton LL, et al. Mutational analysis of EGFR and related signaling pathway genes in lung adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4. PLoS ONE 2007;2:e426.
    • Marks JL, McLellan MD, Zakowski MF, Lash AE, Kasai Y, Broderick S, Sarkaria IS, Pham D, Singh B, Miner TL, Fewell GA, Fulton LL, et al. Mutational analysis of EGFR and related signaling pathway genes in lung adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4. PLoS ONE 2007;2:e426.
  • 15
    • 0034658499 scopus 로고    scopus 로고
    • STAT signaling in head and neck cancer
    • Song JI, Grandis JR. STAT signaling in head and neck cancer. Oncogene 2000;19:2489-95.
    • (2000) Oncogene , vol.19 , pp. 2489-2495
    • Song, J.I.1    Grandis, J.R.2
  • 16
    • 36749008023 scopus 로고    scopus 로고
    • The epidermal growth factor receptor: A role in repair of radiation-induced DNA damage
    • Chen DJ, Nirodi CS. The epidermal growth factor receptor: a role in repair of radiation-induced DNA damage. Clin Cancer Res 2007; 13(22 Part 1):6555-60.
    • (2007) Clin Cancer Res , vol.13 , Issue.22 PART 1 , pp. 6555-6560
    • Chen, D.J.1    Nirodi, C.S.2
  • 17
    • 0036235654 scopus 로고    scopus 로고
    • The roles of JNK1 and Stat3 in the response of head and neck cancer cell lines to combined treatment with all-trans-retinoic acid and 5-fluorouracil
    • Masuda M, Toh S, Koike K, Kuratomi Y, Suzui M, Deguchi A, Komiyama S, Weinstein IB. The roles of JNK1 and Stat3 in the response of head and neck cancer cell lines to combined treatment with all-trans-retinoic acid and 5-fluorouracil. Jpn J Cancer Res 2002; 93:329-39.
    • (2002) Jpn J Cancer Res , vol.93 , pp. 329-339
    • Masuda, M.1    Toh, S.2    Koike, K.3    Kuratomi, Y.4    Suzui, M.5    Deguchi, A.6    Komiyama, S.7    Weinstein, I.B.8
  • 18
    • 35548962203 scopus 로고    scopus 로고
    • Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung cancer
    • Mitsudomi T, Yatabe Y. Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung cancer. Cancer Sci 2007;98:1817-24.
    • (2007) Cancer Sci , vol.98 , pp. 1817-1824
    • Mitsudomi, T.1    Yatabe, Y.2
  • 19
    • 40749094856 scopus 로고    scopus 로고
    • Activation of the PI3-K/ AKT pathway and implications for radioresistance mechanisms in head and neck cancer
    • Bussink J, van der Kogel AJ, Kaanders JH. Activation of the PI3-K/ AKT pathway and implications for radioresistance mechanisms in head and neck cancer. Lancet Oncol 2008;9:288-96.
    • (2008) Lancet Oncol , vol.9 , pp. 288-296
    • Bussink, J.1    van der Kogel, A.J.2    Kaanders, J.H.3
  • 21
    • 36549013178 scopus 로고    scopus 로고
    • Activation of the ERK and AKT signalling pathway predicts poor prognosis in hepatocellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection
    • Schmitz KJ, Wohlschlaeger J, Lang H, Sotiropoulos GC, Malago M, Steveling K, Reis H, Cicinnati VR, Schmid KW, Baba HA. Activation of the ERK and AKT signalling pathway predicts poor prognosis in hepatocellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection. J Hepatol 2008;48:83-90.
    • (2008) J Hepatol , vol.48 , pp. 83-90
    • Schmitz, K.J.1    Wohlschlaeger, J.2    Lang, H.3    Sotiropoulos, G.C.4    Malago, M.5    Steveling, K.6    Reis, H.7    Cicinnati, V.R.8    Schmid, K.W.9    Baba, H.A.10
  • 23
    • 84984932946 scopus 로고    scopus 로고
    • Population genetics-making sense out of sequence
    • Chakravarti A. Population genetics-making sense out of sequence. Nat Genet 1999;21(1 Suppl):56-60.
    • (1999) Nat Genet , vol.21 , Issue.1 SUPPL. , pp. 56-60
    • Chakravarti, A.1
  • 24
    • 1642308104 scopus 로고    scopus 로고
    • SNPs in cancer research and treatment
    • Erichsen HC, Chanock SJ. SNPs in cancer research and treatment. Br J Cancer 2004;90:747-51.
    • (2004) Br J Cancer , vol.90 , pp. 747-751
    • Erichsen, H.C.1    Chanock, S.J.2
  • 25
    • 46749126552 scopus 로고    scopus 로고
    • Genetic factors in drug metabolism
    • Belle DJ, Singh H. Genetic factors in drug metabolism. Am Fam Physician 2008;77:1553-60.
    • (2008) Am Fam Physician , vol.77 , pp. 1553-1560
    • Belle, D.J.1    Singh, H.2
  • 28
    • 0035474084 scopus 로고    scopus 로고
    • The birth and death of human single-nucleotide polymorphisms: New experimental evidence and implications for human history and medicine
    • Miller RD, Kwok PY. The birth and death of human single-nucleotide polymorphisms: new experimental evidence and implications for human history and medicine. Hum Mol Genet 2001;10:2195-8.
    • (2001) Hum Mol Genet , vol.10 , pp. 2195-2198
    • Miller, R.D.1    Kwok, P.Y.2
  • 29
    • 47849093350 scopus 로고    scopus 로고
    • Discovery and verification of functional single nucleotide polymorphisms in regulatory genomic regions: Current and developing technologies
    • Chorley BN, Wang X, Campbell MR, Pittman GS, Noureddine MA, Bell DA. Discovery and verification of functional single nucleotide polymorphisms in regulatory genomic regions: current and developing technologies. Mutat Res 2008;659:147-57.
    • (2008) Mutat Res , vol.659 , pp. 147-157
    • Chorley, B.N.1    Wang, X.2    Campbell, M.R.3    Pittman, G.S.4    Noureddine, M.A.5    Bell, D.A.6
  • 30
    • 18844421908 scopus 로고    scopus 로고
    • A Graves' disease-associated Kozak sequence single-nucleotide polymorphism enhances the efficiency of CD40 gene translation: A case for translational pathophysiology
    • Jacobson EM, Concepcion E, Oashi T, Tomer Y. A Graves' disease-associated Kozak sequence single-nucleotide polymorphism enhances the efficiency of CD40 gene translation: a case for translational pathophysiology. Endocrinology 2005;146:2684-91.
    • (2005) Endocrinology , vol.146 , pp. 2684-2691
    • Jacobson, E.M.1    Concepcion, E.2    Oashi, T.3    Tomer, Y.4
  • 31
    • 21644459086 scopus 로고    scopus 로고
    • Two haplotypes of 50 untranslated region in L-myc gene with different internal ribosome entry site activity
    • Kumimoto H, Yamane Y, Ishizaki K. Two haplotypes of 50 untranslated region in L-myc gene with different internal ribosome entry site activity. Int J Oncol 2005;26:287-93.
    • (2005) Int J Oncol , vol.26 , pp. 287-293
    • Kumimoto, H.1    Yamane, Y.2    Ishizaki, K.3
  • 32
    • 12344319508 scopus 로고    scopus 로고
    • The role of the AU-rich elements of mRNAs in controlling translation
    • Espel E. The role of the AU-rich elements of mRNAs in controlling translation. Semin Cell Dev Biol 2005;16:59-67.
    • (2005) Semin Cell Dev Biol , vol.16 , pp. 59-67
    • Espel, E.1
  • 33
    • 34547843634 scopus 로고    scopus 로고
    • Aberrant allele frequencies of the SNPs located in microRNA target sites are potentially associated with human cancers
    • Yu Z, Li Z, Jolicoeur N, Zhang L, Fortin Y, Wang E, Wu M, Shen SH. Aberrant allele frequencies of the SNPs located in microRNA target sites are potentially associated with human cancers. Nucleic Acids Res 2007;35:4535-41.
    • (2007) Nucleic Acids Res , vol.35 , pp. 4535-4541
    • Yu, Z.1    Li, Z.2    Jolicoeur, N.3    Zhang, L.4    Fortin, Y.5    Wang, E.6    Wu, M.7    Shen, S.H.8
  • 34
    • 43349090926 scopus 로고    scopus 로고
    • miRNAs: Effectors of environmental influences on gene expression and disease
    • Hudder A, Novak RF. miRNAs: effectors of environmental influences on gene expression and disease. Toxicol Sci 2008;103:228-40.
    • (2008) Toxicol Sci , vol.103 , pp. 228-240
    • Hudder, A.1    Novak, R.F.2
  • 35
    • 33750353461 scopus 로고    scopus 로고
    • Predicting the effects of amino acid substitutions on protein function
    • Ng PC, Henikoff S. Predicting the effects of amino acid substitutions on protein function. Annu Rev Genomics Hum Genet 2006;7:61-80.
    • (2006) Annu Rev Genomics Hum Genet , vol.7 , pp. 61-80
    • Ng, P.C.1    Henikoff, S.2
  • 36
    • 2942604293 scopus 로고    scopus 로고
    • Identifying functional genetic variants in DNA repair pathway using protein conservation analysis
    • Savas S, Kim DY, Ahmad MF, Shariff M, Ozcelik H. Identifying functional genetic variants in DNA repair pathway using protein conservation analysis. Cancer Epidemiol Biomarkers Prev 2004;13:801-7.
    • (2004) Cancer Epidemiol Biomarkers Prev , vol.13 , pp. 801-807
    • Savas, S.1    Kim, D.Y.2    Ahmad, M.F.3    Shariff, M.4    Ozcelik, H.5
  • 37
    • 34247884268 scopus 로고    scopus 로고
    • Functional nonsynonymous single nucleotide polymorphisms from the TGF-beta protein interaction network
    • Savas S, Taylor IW, Wrana JL, Ozcelik H. Functional nonsynonymous single nucleotide polymorphisms from the TGF-beta protein interaction network. Physiol Genomics 2007;29:109-17.
    • (2007) Physiol Genomics , vol.29 , pp. 109-117
    • Savas, S.1    Taylor, I.W.2    Wrana, J.L.3    Ozcelik, H.4
  • 39
    • 33645217304 scopus 로고    scopus 로고
    • Human SNPs resulting in premature stop codons and protein truncation
    • Savas S, Tuzmen S, Ozcelik H. Human SNPs resulting in premature stop codons and protein truncation. Hum Genomics 2006; 2:274-86.
    • (2006) Hum Genomics , vol.2 , pp. 274-286
    • Savas, S.1    Tuzmen, S.2    Ozcelik, H.3
  • 40
    • 33746889808 scopus 로고    scopus 로고
    • A comprehensive pathway map of epidermal growth factor receptor signaling
    • Oda K, Matsuoka Y, Funahashi A, Kitano H. A comprehensive pathway map of epidermal growth factor receptor signaling. Mol Syst Biol 2005;1:2005 0010.
    • (2005) Mol Syst Biol 2005 , vol.1 , pp. 0010
    • Oda, K.1    Matsuoka, Y.2    Funahashi, A.3    Kitano, H.4
  • 41
    • 33745714456 scopus 로고    scopus 로고
    • ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors
    • Ohtsu H, Dempsey PJ, Eguchi S. ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors. Am J Physiol Cell Physiol 2006;291:C1-10.
    • (2006) Am J Physiol Cell Physiol , vol.291
    • Ohtsu, H.1    Dempsey, P.J.2    Eguchi, S.3
  • 42
    • 34250727017 scopus 로고    scopus 로고
    • A dual role of EGFR protein tyrosine kinase signaling in ubiquitination of AAV2 capsids and viral second-strand DNA synthesis
    • Zhong L, Zhao W, Wu J, Li B, Zolotukhin S, Govindasamy L, Agbandje-McKenna M, Srivastava A. A dual role of EGFR protein tyrosine kinase signaling in ubiquitination of AAV2 capsids and viral second-strand DNA synthesis. Mol Ther 2007;15:1323-30.
    • (2007) Mol Ther , vol.15 , pp. 1323-1330
    • Zhong, L.1    Zhao, W.2    Wu, J.3    Li, B.4    Zolotukhin, S.5    Govindasamy, L.6    Agbandje-McKenna, M.7    Srivastava, A.8
  • 43
    • 68249151390 scopus 로고    scopus 로고
    • Available at
    • Conpath EGFR1 signaling pathway. Available at: http://conpath.dnachip. co.jp/search/pathway-detail.php/CNPTH010009.
    • Conpath EGFR1 signaling pathway
  • 44
    • 68249145070 scopus 로고    scopus 로고
    • Available at
    • Sigma Aldrich EGFR pathway. Available at: http://www.sigmaaldrich. com/Area-of-Interest/Life-Science/Cell-Signaling/Scientific-Resources/ Pathway-Slides---Charts/EGF-Receptor-Signal-Transduction-Pathway. html.
    • Sigma Aldrich EGFR pathway
  • 45
    • 84874019148 scopus 로고    scopus 로고
    • Available at
    • Cancer cell map. Available at: http://cancer.cellmap.org/cellmap/ record.do?id5356.
    • Cancer cell map
  • 46
    • 38549092091 scopus 로고    scopus 로고
    • Wheeler DL, Barrett T, Benson DA, Bryant SH, Canese K, Chetvernin V, Church DM, Dicuccio M, Edgar R, Federhen S, Feolo M, Geer LY, et al. Database resources of the National Center for Biotechnology Information. Nucleic Acids Res 2008;36(Database issue): D13-21.
    • Wheeler DL, Barrett T, Benson DA, Bryant SH, Canese K, Chetvernin V, Church DM, Dicuccio M, Edgar R, Federhen S, Feolo M, Geer LY, et al. Database resources of the National Center for Biotechnology Information. Nucleic Acids Res 2008;36(Database issue): D13-21.
  • 47
    • 38549117309 scopus 로고    scopus 로고
    • Bruford EA, Lush MJ, Wright MW, Sneddon TP, Povey S, Birney E. The HGNC database in 2008: a resource for the human genome. Nucleic Acids Res 2008;36(Database issue):D445-8.
    • Bruford EA, Lush MJ, Wright MW, Sneddon TP, Povey S, Birney E. The HGNC database in 2008: a resource for the human genome. Nucleic Acids Res 2008;36(Database issue):D445-8.
  • 49
    • 84871979029 scopus 로고    scopus 로고
    • SNP@ Promoter: A database of human SNPs (single nucleotide polymorphisms) within the putative promoter regions
    • Kim BC, Kim WY, Park D, Chung WH, Shin KS, Bhak J. SNP@ Promoter: a database of human SNPs (single nucleotide polymorphisms) within the putative promoter regions. BMC Bioinformatics 2008;Suppl 1:S2.
    • (2008) BMC Bioinformatics , Issue.SUPPL. 1
    • Kim, B.C.1    Kim, W.Y.2    Park, D.3    Chung, W.H.4    Shin, K.S.5    Bhak, J.6
  • 50
    • 33846118697 scopus 로고    scopus 로고
    • Bao L, Zhou M, Wu L, Lu L, Goldowitz D, Williams RW, Cui Y. PolymiRTS database: linking polymorphisms in microRNA target sites with complex traits. Nucleic Acids Res 2007;35(Database issue): D51-4.
    • Bao L, Zhou M, Wu L, Lu L, Goldowitz D, Williams RW, Cui Y. PolymiRTS database: linking polymorphisms in microRNA target sites with complex traits. Nucleic Acids Res 2007;35(Database issue): D51-4.
  • 51
    • 0036713510 scopus 로고    scopus 로고
    • Human non-synonymous SNPs: Server and survey
    • Ramensky V, Bork P, Sunyaev S. Human non-synonymous SNPs: server and survey. Nucleic Acids Res 2002;30:3894-900.
    • (2002) Nucleic Acids Res , vol.30 , pp. 3894-3900
    • Ramensky, V.1    Bork, P.2    Sunyaev, S.3
  • 52
    • 36549003965 scopus 로고    scopus 로고
    • InterPro and InterProScan: Tools for protein sequence classification and comparison
    • Mulder N, Apweiler R. InterPro and InterProScan: tools for protein sequence classification and comparison. Methods Mol Biol 2007;396: 59-70.
    • (2007) Methods Mol Biol , vol.396 , pp. 59-70
    • Mulder, N.1    Apweiler, R.2
  • 53
    • 13444301473 scopus 로고    scopus 로고
    • Mignone F, Grillo G, Licciulli F, Iacono M, Liuni S, Kersey PJ, Duarte J, Saccone C, Pesole G. UTRdb and UTRsite: a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs. Nucleic Acids Res 2005;33(Database issue): D141-6.
    • Mignone F, Grillo G, Licciulli F, Iacono M, Liuni S, Kersey PJ, Duarte J, Saccone C, Pesole G. UTRdb and UTRsite: a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs. Nucleic Acids Res 2005;33(Database issue): D141-6.
  • 54
    • 18744376914 scopus 로고    scopus 로고
    • Online predicted human interaction database
    • Brown KR, Jurisica I. Online predicted human interaction database. Bioinformatics 2005;21:2076-82.
    • (2005) Bioinformatics , vol.21 , pp. 2076-2082
    • Brown, K.R.1    Jurisica, I.2
  • 55
    • 84860126939 scopus 로고    scopus 로고
    • Available at
    • NAVIGaTOR. Available at:http://ophid.utoronto.ca/navigator.
    • NAVIGaTOR
  • 57
    • 12944281622 scopus 로고    scopus 로고
    • Candidate nsSNPs that can affect the functions and interactions of cell cycle proteins
    • Savas S, Ahmad MF, Shariff M, Kim DY, Ozcelik H. Candidate nsSNPs that can affect the functions and interactions of cell cycle proteins. Proteins 2005;58:697-705.
    • (2005) Proteins , vol.58 , pp. 697-705
    • Savas, S.1    Ahmad, M.F.2    Shariff, M.3    Kim, D.Y.4    Ozcelik, H.5
  • 58
    • 33749057696 scopus 로고    scopus 로고
    • Nonsense-mediated mRNA decay modulates clinical outcome of genetic disease
    • Khajavi M, Inoue K, Lupski JR. Nonsense-mediated mRNA decay modulates clinical outcome of genetic disease. Eur J Hum Genet 2006;14:1074-81.
    • (2006) Eur J Hum Genet , vol.14 , pp. 1074-1081
    • Khajavi, M.1    Inoue, K.2    Lupski, J.R.3
  • 59
    • 53749106666 scopus 로고    scopus 로고
    • Impact of EGFR gene polymorphisms on anticancer drug cytotoxicity in vitro
    • Puyo S, Le Morvan V, Robert J. Impact of EGFR gene polymorphisms on anticancer drug cytotoxicity in vitro. Mol Diagn Ther 2008; 12:225-34.
    • (2008) Mol Diagn Ther , vol.12 , pp. 225-234
    • Puyo, S.1    Le Morvan, V.2    Robert, J.3
  • 62
    • 21044442984 scopus 로고    scopus 로고
    • A single nucleotide polymorphism in the 50 untranslated region of the EGF gene is associated with occurrence and malignant progression of gastric cancer
    • Hamai Y. Matsumura S, Matsusaki K, Kitadai Y, Yoshida K, Yamaguchi Y, Imai K, Nakachi K, Toge T, Yasui W. A single nucleotide polymorphism in the 50 untranslated region of the EGF gene is associated with occurrence and malignant progression of gastric cancer. Pathobiology 2005;72:133-8.
    • (2005) Pathobiology , vol.72 , pp. 133-138
    • Hamai, Y.1    Matsumura, S.2    Matsusaki, K.3    Kitadai, Y.4    Yoshida, K.5    Yamaguchi, Y.6    Imai, K.7    Nakachi, K.8    Toge, T.9    Yasui, W.10
  • 64
    • 0028201735 scopus 로고
    • Translation of 15-lipoxygenase mRNA is inhibited by a protein that binds to a repeated sequence in the 3′ untranslated region
    • Ostareck-Lederer A, Ostareck DH, Standart N, Thiele BJ. Translation of 15-lipoxygenase mRNA is inhibited by a protein that binds to a repeated sequence in the 3′ untranslated region. EMBO J 1994;13: 1476-81.
    • (1994) EMBO J , vol.13 , pp. 1476-1481
    • Ostareck-Lederer, A.1    Ostareck, D.H.2    Standart, N.3    Thiele, B.J.4
  • 66
    • 33749254585 scopus 로고    scopus 로고
    • Applications of computational algorithm tools to identify functional SNPs in cytokine genes
    • Shen J, Deininger PL, Zhao H. Applications of computational algorithm tools to identify functional SNPs in cytokine genes. Cytokine 2006;35:62-6.
    • (2006) Cytokine , vol.35 , pp. 62-66
    • Shen, J.1    Deininger, P.L.2    Zhao, H.3
  • 67
    • 0032837376 scopus 로고    scopus 로고
    • Nonsense-mediated mRNA decay in health and disease
    • Frischmeyer PA, Dietz HC. Nonsense-mediated mRNA decay in health and disease. Hum Mol Genet 1999;8:1893-900.
    • (1999) Hum Mol Genet , vol.8 , pp. 1893-1900
    • Frischmeyer, P.A.1    Dietz, H.C.2
  • 68
    • 0035893581 scopus 로고    scopus 로고
    • The Phox homology (PX) domain, a new player in phosphoinositide signalling
    • Xu Y, Seet LF, Hanson B, Hong W. The Phox homology (PX) domain, a new player in phosphoinositide signalling. Biochem J 2001;360 (Part 3):513-30.
    • (2001) Biochem J , vol.360 , Issue.PART 3 , pp. 513-530
    • Xu, Y.1    Seet, L.F.2    Hanson, B.3    Hong, W.4
  • 69
    • 10944230901 scopus 로고    scopus 로고
    • The phox homology (PX) domain protein interaction network in yeast
    • Vollert CS, Uetz P. The phox homology (PX) domain protein interaction network in yeast. Mol Cell Proteomics 2004;3:1053-64.
    • (2004) Mol Cell Proteomics , vol.3 , pp. 1053-1064
    • Vollert, C.S.1    Uetz, P.2
  • 70
    • 33745007067 scopus 로고    scopus 로고
    • The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis
    • Lee CS, Kim IS, Park JB, Lee MN, Lee HY, Suh PG, Ryu SH. The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis. Nat Cell Biol 2006;8:477-84.
    • (2006) Nat Cell Biol , vol.8 , pp. 477-484
    • Lee, C.S.1    Kim, I.S.2    Park, J.B.3    Lee, M.N.4    Lee, H.Y.5    Suh, P.G.6    Ryu, S.H.7
  • 71
    • 0027333330 scopus 로고
    • Hundreds of ankyrin-like repeats in functionally diverse proteins: Mobile modules that cross phyla horizontally?
    • Bork P. Hundreds of ankyrin-like repeats in functionally diverse proteins: mobile modules that cross phyla horizontally? Proteins 1993; 17:363-74.
    • (1993) Proteins , vol.17 , pp. 363-374
    • Bork, P.1
  • 72
    • 0345411335 scopus 로고    scopus 로고
    • The ubiquitous nature of epistasis in determining susceptibility to common human diseases
    • Moore JH. The ubiquitous nature of epistasis in determining susceptibility to common human diseases. Hum Hered 2003;56:73-82.
    • (2003) Hum Hered , vol.56 , pp. 73-82
    • Moore, J.H.1
  • 73
    • 26944444679 scopus 로고    scopus 로고
    • BRCA1 in hormonal carcinogenesis: Basic and clinical research
    • Rosen EM, Fan S, Isaacs C. BRCA1 in hormonal carcinogenesis: basic and clinical research. Endocr Relat Cancer 2005;12:533-48.
    • (2005) Endocr Relat Cancer , vol.12 , pp. 533-548
    • Rosen, E.M.1    Fan, S.2    Isaacs, C.3
  • 74
    • 33646428682 scopus 로고    scopus 로고
    • The basal phenotype of BRCA1-related breast cancer: Past, present and future
    • Tischkowitz MD, Foulkes WD. The basal phenotype of BRCA1-related breast cancer: past, present and future. Cell Cycle 2006;5:963-7.
    • (2006) Cell Cycle , vol.5 , pp. 963-967
    • Tischkowitz, M.D.1    Foulkes, W.D.2
  • 75
    • 52049098991 scopus 로고    scopus 로고
    • Targeted therapies in breast cancer: Established drugs and recent developments
    • Fischgrabe J, Wulfing P. Targeted therapies in breast cancer: established drugs and recent developments. Curr Clin Pharmacol 2008;3: 85-98.
    • (2008) Curr Clin Pharmacol , vol.3 , pp. 85-98
    • Fischgrabe, J.1    Wulfing, P.2
  • 78
    • 16844369571 scopus 로고    scopus 로고
    • The need for a systematic approach to complex pathways in molecular epidemiology
    • Thomas DC. The need for a systematic approach to complex pathways in molecular epidemiology. Cancer Epidemiol Biomarkers Prev 2005;14:557-9.
    • (2005) Cancer Epidemiol Biomarkers Prev , vol.14 , pp. 557-559
    • Thomas, D.C.1
  • 80
    • 45449095236 scopus 로고    scopus 로고
    • Genome-wide prediction of functional gene-gene interactions inferred from patterns of genetic differentiation in mice and men
    • Bochdanovits Z, Sondervan D, Perillous S, van Beijsterveldt T, Boomsma D, Heutink P. Genome-wide prediction of functional gene-gene interactions inferred from patterns of genetic differentiation in mice and men. PLoS ONE 2008;3:e1593.
    • (2008) PLoS ONE , vol.3
    • Bochdanovits, Z.1    Sondervan, D.2    Perillous, S.3    van Beijsterveldt, T.4    Boomsma, D.5    Heutink, P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.