Mitochondrial 2,4-dienoyl-CoA reductase deficiency in mice results in severe hypoglycemia with stress intolerance and unimpaired ketogenesis

PLoS Genetics

Volumn 5, Issue 7, 2009, Pages

  Miinalainen, Ilkka J ^a   Schmitz, Werner ^b   Huotari, Anne ^c   Autio, Kaija J ^a   Soininen, Raija ^a   Van Themaat, Emiel Ver Loren ^d   Baes, Myriam ^e   Herzig, Karl Heinz ^a,c,f   Conzelmann, Ernst ^b   Hiltunen, J Kalervo ^a  

^a UNIVERSITY OF OULU   (Finland)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

^d ACADEMIC MEDICAL CENTER   (Netherlands)

^e UNIVERSITY OF LEUVEN   (Belgium)

^f Department of Internal Medicine ^*  (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIENOYL COENZYME A REDUCTASE (NADPH); ACYLCARNITINE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DECADIENOYLCARNITINE; DICARBOXYLIC ACID; GLYCEROL; LINOLEIC ACID; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; UNCLASSIFIED DRUG; UNSATURATED FATTY ACID; 2,4-DIENOYL-COA REDUCTASE; GLUCOSE; KETONE BODY; OXIDOREDUCTASE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL BOND; COLD EXPOSURE; CONTROLLED STUDY; ENZYME DEFICIENCY; FATTY LIVER; FEMALE; GLUCONEOGENESIS; GLYCOGEN ANALYSIS; HYPOGLYCEMIA; KETOGENESIS; MALE; MOUSE; NONHUMAN; OXIDATION; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; THERMOGENESIS; URINARY EXCRETION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; ENZYMOLOGY; GENETICS; METABOLISM; MITOCHONDRION; MOUSE MUTANT; OXIDATION REDUCTION REACTION; PATHOPHYSIOLOGY; PHYSIOLOGICAL STRESS;

MAMMALIA; MUS;

ANIMALS; FATTY ACIDS, UNSATURATED; FEMALE; GLUCOSE; HYPOGLYCEMIA; KETONE BODIES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; OXIDATION-REDUCTION; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; STRESS, PHYSIOLOGICAL; TRIGLYCERIDES;

EID: 68249131913     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1000543     Document Type: Article

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