Structure and reactivity of human mitochondrial 2,4-dienoyl-CoA reductase: Enzyme-ligand interactions in a distinctive short-chain reductase active site

Journal of Biological Chemistry

Volumn 280, Issue 4, 2005, Pages 3068-3077

  Alphey, Magnus S ^a   Yu, Wenhua ^b   Byres, Emma ^a   Li, Ding ^b   Hunter, William N ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b CITY UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYST ACTIVITY; CHEMICAL BONDS; COMPLEXATION; CONFORMATIONS; CRYSTAL STRUCTURE; FATTY ACIDS; MUTAGENESIS; OXIDATION; SOLVENTS;

DOUBLE BOND CONFORMATION; MITOCHONDRIA; PEROXISOMES;

ENZYMES;

2,4 DIENOYL COENZYME A REDUCTASE (NADPH); FATTY ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; OXIDOREDUCTASE; TETRAMER;

ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME BINDING; ENZYME REACTIVATION; ENZYME STRUCTURE; GENE OVEREXPRESSION; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; BINDING SITES; CATALYTIC DOMAIN; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; MITOCHONDRIA; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; POLYMERASE CHAIN REACTION; PROTEIN BINDING; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

MAMMALIA;

EID: 13244258549     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M411069200     Document Type: Article

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