In vitro antileishmanial effects of antibacterial diterpenes from two Ethiopian Premna species: P. schimperi and P. oligotricha

BMC Pharmacology

Volumn 3, Issue , 2003, Pages

  Habtemariam, Solomon ^a  

^a UNIVERSITY OF GREENWICH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

12 OXO ENT 3,13(16) CLERODIEN 15 OIC ACID; 12 OXOLABDA 8,13(16) DIEN 15 OIC ACID; 16 HYDROXY CLEROD 3,13(14) DIENE 15,16 OLIDE; ANDROGRAPHOLIDE; ANTILEISHMANIAL AGENT; CLERODANE DERIVATIVE; DITERPENE; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; PREMMA OLIGOTRICHA EXTRACT; PREMMA SCHIMPERI EXTRACT; UNCLASSIFIED DRUG;

AMASTIGOTE; ANTIBACTERIAL ACTIVITY; ARTICLE; CELL LINE; CELL VIABILITY; CONTROLLED STUDY; DRUG ISOLATION; DRUG POTENCY; ETHIOPIA; HOST CELL; HUMAN; IN VITRO STUDY; MEDICINAL PLANT; NONHUMAN; PREMMA OLIGOTRICHA; PREMMA SCHIMPERI; SKIN LEISHMANIASIS; STRUCTURE ACTIVITY RELATION; VERBENACEAE;

EID: 2642529526     PISSN: 14712210     EISSN: None     Source Type: Journal    
DOI: 10.1186/1471-2210-3-6     Document Type: Article

References (31)

1. Handman E: Cell biology of leishmania In: Advancec in Parasitology Volume 44. Edited by: Baker, JR, Muller R, Rollinson, D. London, Academic Press; 20002-27.
2. WHO (World Health Organisation): Communicable disease surveillance and response [http://www.who.int/emc/diseases/leish/leisdisl.html].
3. WHO: The leishmaniasis and leishmania/HIV co-infection: Fact Sheets [http://www.who.int/inf-fs/en/fact116.html].
4. Berman JD: Human leishmaniasis: clinical, diagnostic and chemotherapeutic Developments in the last 10 years Clin Infect Dis 1997, 24:684-703.
5. Boelaert M, Le-Ray D and Van-Der SP: How better drugs could change kala-azar control. Lessons from a cost-effectiveness analysis Trop Med Int Health 2002, 7:955-959.
6. Ephros M, Waldman E and Zilberstein D: Pentostam induces resistance to antimony and the preservative chlorocresol in Leishmania donovani promastigotes and axenically grown amastigotes Antimicrob Agents Chemother 1997, 41:1064-1068.
7. Lira R, Sundar S, Makharia A, Kenney R, Gam A, Saraiva E and Sacks D: Evidence that the high incidence of treatment failures in Indian kala-azar is due to the emergence of antimony-resistant strains of Leishmania donovani J Infect Dis 1999, 180:564-567.
8. Gulland A: Deadly parasitic disease grips southern Sudan BMJ 2002, 325:1133.
9. Mikus J and Steverding D: A simple colorimetric method to screen drug cytotoxicity against leishmania using the dye Alamar Blue Parasitol International 2000, 48:265-269.
10. 3 (edelfosine) and amphotericin B Acta Tropica 2002, 81:151-157.
11. Habtemariam S: Cytotoxicity of diterpenes from Premna schimperi and Premna oligotricha Planta Medica 1995, 61:368-369.
12. Zhao G, Jung JH, Smith DL, Wood KV and McLaughlin JL: Cytotoxic clerodane diterpenes from Polyalthia longifolia Planta Medica 1991, 57:380-383.
13. Habtemariam S, Gray AI, Halbert GW and Waterman PG: A novel antibacterial diterpene from Premna schimperi. Planta Medica 1990, 56:187-189.
14. Habtemariam S, Gray AI and Waterman PG: Antibacterial diterpenes from the aerial parts of Premna oligotricha. Planta Medica 1992, 58:109-110.
15. Habtemariam S, Gray AI, Lavaud C, Massiot G, Skelton BW, Waterman PG and White AH: ent-12-Oxolabda-8,13(16)-dien-15-oic acid and ent-8β,12α-epidioxy-12β-hydroxylabda-9(11 ,13-dien-15-oic acid γ-lactone: Two new diterpenes from the aerial parts of Premna oligotricha J Chem Soc Perkin Trans I 1991:893-896.
16. Habtemariam S, Gray AI and Waterman PG: Flavonoids from three Ethiopian species of Premna Z Naturforsch 1991, 47b:144-147.
17. Habtemariam S, Gray AI and Waterman PG: A novel antibacterial sesquiterpene from Premna oligotricha J Nat Prod 56:140-143.
18. Matsuda T, Kuroyanagi M, Sugiyama S, Umehara K, Ueno A and Nishi K: Cell differentiation inducing diterpenes from Andrographis paniculata Nees Chem Pharm Bull 1994, 42:1216-1225.
19. Amroyan E, Gabrielian E, Panossian A, Wikman G and Wagner H: Inhibitory effect of andrographolide from Andrographis paniculata on PAF-induced platelet aggregation Phytomedicine 1999, 6:27-31.
20. Habtemariam S: Andrographolide inhibits the tumour necrosis factor-α induced upregulation of ICAM-1 expression and endothelial-monocyte adhesion Phytotherapy Res 1998, 12:37-40.
21. Kapil A, Koul IB, Banerjee SK and Gupta BD: Antihepatotoxic effects of major diterpenoid constituents of Andrographis paniculata Biochem Pharmacol 1993, 46:182-185.
22. Sinha J, Mukhopadhyay S, Das N and Basu MK: Targeting of liposomal andrographolide to L. donovani-infected macrophages in vivo Drug Deliv 2000, 7:209-213.
23. Richomme P, Godet CM, Fousard F, Toupet L, Sevenet T and Bruneton J: A novel antileishmanial labdane from Polyathia macropoda Planta Medica 1991, 57:552-554.
24. Tan N, Kaloga M, Radtke OA, Kiderlen AF, Öksüz S, Ulubelen A and Kolodziej H: Abietane diterpenoids and triterpenoic acids from Salvia cilicica and their antileishmanial activities Phytochemistry 2002, 61:881-884.
25. Gupta N, Goyal N and Rastogi AK: In vitro cultivation and characterization of axenic amastigotes of Leishmania Trends Parasitol 2001, 17:150-153.
26. Assefa D, Worku Y and Skoglund G: Protein kinase activities in Leishmania aethiopica: control by growth, transformation and inhibitors Biochim Biophys Acta (B) - Mol Basis Dis 1995, 1270:157-162.
27. Leon LL, Temporal RM, Soares MJ and Jr-Grimaldi G: Proteinase activities during temperature-induced stage differentiation of species complexes of Leishmania Acta Tropica 1994, 56:289-298.
28. Saar Y, Ransford A., Waldman E, Mazareb S, Amin-Spector S, Plumblee J, Turco SJ and Zilberstein D: Characterization of developmentally-regulated activities in axenic amastigotes of Leishmania donovani Mol Biochem Parasitol 1998, 95:9-20.
29. Somanna A, Mundodi V and Gedamu L: In vitro cultivation and characterization of Leishmania chagasi amastigote-like forms Acta Tropica 2002, 83:37-42.
30. Cohen BE: Amphotericin B toxicity and lethality: a tale of two channels Int J Pharmaceutics 1998, 162:95-106.
31. Sawaya BP, Briggs JP and Schnermann J: Amphotericin B nephrotoxicity: the adverse consequences of altered membrane properties J Am Soc Nephrol 1995, 6:154-164.