메뉴 건너뛰기




Volumn 135, Issue 8, 2009, Pages 969-981

Experimental models of hepatocellular carcinoma: Developments and evolution

Author keywords

Experimental models; Hepatocellular carcinoma; Liver cancer

Indexed keywords

CANCER GROWTH; CARCINOGENESIS; DIAGNOSTIC PROCEDURE; EVOLUTION; EXPERIMENTAL MODEL; GENETIC ENGINEERING; HEPATITIS B VIRUS; HEPATITIS C VIRUS; HEPATITIS VIRUS; HUMAN; LIVER CELL CARCINOMA; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; REVIEW; RISK FACTOR;

EID: 68249083962     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00432-009-0591-7     Document Type: Review
Times cited : (37)

References (125)
  • 2
    • 0018718742 scopus 로고
    • Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line
    • 10.1038/282615a0
    • DP Aden A Fogel S Plotkin I Damjanov BB Knowles 1979 Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line Nature 282 615 616 10.1038/282615a0
    • (1979) Nature , vol.282 , pp. 615-616
    • Aden, D.P.1    Fogel, A.2    Plotkin, S.3    Damjanov, I.4    Knowles, B.B.5
  • 3
    • 27944459717 scopus 로고    scopus 로고
    • SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation
    • 10.1038/sj.onc.1209046
    • D Ahuja MT Saenz-Robles JM Pipas 2005 SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation Oncogene 24 7729 7745 10.1038/sj.onc.1209046
    • (2005) Oncogene , vol.24 , pp. 7729-7745
    • Ahuja, D.1    Saenz-Robles, M.T.2    Pipas, J.M.3
  • 4
    • 38549101261 scopus 로고    scopus 로고
    • Tumor microenvironment, a dangerous society leading to cancer metastasis. from mechanisms to therapy and prevention
    • 10.1007/s10555-007-9102-y
    • A Albini 2008 Tumor microenvironment, a dangerous society leading to cancer metastasis. From mechanisms to therapy and prevention Cancer Metastasis Rev 27 3 4 10.1007/s10555-007-9102-y
    • (2008) Cancer Metastasis Rev , vol.27 , pp. 3-4
    • Albini, A.1
  • 5
    • 0035100475 scopus 로고    scopus 로고
    • Cellular transformation by SV40 large T antigen: Interaction with host proteins
    • 10.1006/scbi.2000.0342
    • SH Ali JA DeCaprio 2001 Cellular transformation by SV40 large T antigen: interaction with host proteins Semin Cancer Biol 11 15 23 10.1006/scbi.2000.0342
    • (2001) Semin Cancer Biol , vol.11 , pp. 15-23
    • Ali, S.H.1    Decaprio, J.A.2
  • 6
    • 28544438991 scopus 로고    scopus 로고
    • Liver cancer: The role of stem cells
    • 10.1111/j.1365-2184.2005.00354.x
    • MR Alison MJ Lovell 2005 Liver cancer: the role of stem cells Cell Prolif 38 407 421 10.1111/j.1365-2184.2005.00354.x
    • (2005) Cell Prolif , vol.38 , pp. 407-421
    • Alison, M.R.1    Lovell, M.J.2
  • 7
    • 1642402228 scopus 로고    scopus 로고
    • Orthotopic implantation of human hepatocellular carcinoma in mice: Analysis of tumor progression and establishment of the BCLC-9 cell line
    • 10.1158/1078-0432.CCR-03-1028
    • C Armengol G Tarafa L Boix M Solé R Queralt D Costa O Bachs J Bruix G Capellá 2004 Orthotopic implantation of human hepatocellular carcinoma in mice: analysis of tumor progression and establishment of the BCLC-9 cell line Clin Cancer Res 10 2150 2157 10.1158/1078-0432.CCR-03-1028
    • (2004) Clin Cancer Res , vol.10 , pp. 2150-2157
    • Armengol, C.1    Tarafa, G.2    Boix, L.3    Solé, M.4    Queralt, R.5    Costa, D.6    Bachs, O.7    Bruix, J.8    Capellá, G.9
  • 8
    • 0022366887 scopus 로고
    • Specific expression of hepatitis B surface antigen (HBsAg) in transgenic mice
    • C Babinet H Farza D Morello M Hadchouel C Pourcel 1985 Specific expression of hepatitis B surface antigen (HBsAg) in transgenic mice Science 230 1160 1163 10.1126/science.3865370 (Pubitemid 16170002)
    • (1985) Science , vol.230 , Issue.4730 , pp. 1160-1163
    • Babinet, C.1    Farza, H.2    Morello, D.3
  • 9
  • 12
    • 0015897384 scopus 로고
    • Aryl hydrocarbon hydroxylase induction in mammalian liver cell culture. IV. Stimulation of the enzyme activity in established cell lines derived from rat or mouse hepatoma and from normal rat liver
    • 10.1016/0006-2952(73)90138-X
    • WF Benedict JE Gielen IS Owens A Niwa DW Bebert 1973 Aryl hydrocarbon hydroxylase induction in mammalian liver cell culture. IV. Stimulation of the enzyme activity in established cell lines derived from rat or mouse hepatoma and from normal rat liver Biochem Pharmacol 22 2766 2769 10.1016/0006-2952(73) 90138-X
    • (1973) Biochem Pharmacol , vol.22 , pp. 2766-2769
    • Benedict, W.F.1    Gielen, J.E.2    Owens, I.S.3    Niwa, A.4    Bebert, D.W.5
  • 13
    • 0018496446 scopus 로고
    • Induction of enzyme activity in cell culture: A rapid screen for detection of planar polychlorinated organic compounds
    • JA Bradlaw JL Casterline Jr 1979 Induction of enzyme activity in cell culture: a rapid screen for detection of planar polychlorinated organic compounds J Assoc Off Anal Chem 62 904 916
    • (1979) J Assoc off Anal Chem , vol.62 , pp. 904-916
    • Bradlaw, J.A.1    Casterline Jr, J.L.2
  • 14
    • 0025681560 scopus 로고
    • Differential regulation of hepatic triglyceride lipase and 3-hydroxy-3-methylglutaryl-CoA reductase gene expression in a human hepatoma cell line, HepG2
    • SJ Busch RL Barnhart GA Martin MA Flanagan RL Jackson 1990 Differential regulation of hepatic triglyceride lipase and 3-hydroxy-3-methylglutaryl-CoA reductase gene expression in a human hepatoma cell line, HepG2 J Biol Chem 265 22474 22479 (Pubitemid 120014325)
    • (1990) Journal of Biological Chemistry , vol.265 , Issue.36 , pp. 22474-22479
    • Busch, S.J.1    Barnhart, R.L.2    Martin, G.A.3    Flanagan, M.A.4    Jackson, R.L.5
  • 15
    • 0032473553 scopus 로고    scopus 로고
    • Dietary supplementation with eicosapentaenoic and docosahexaenoic acid inhibits growth of Morris hepatocarcinoma 3924A in rats: Effects on proliferation and apoptosis
    • 10.1002/(SICI)1097-0215(19980302)75:5<699::AID-IJC7>3.0.CO;2-U
    • G Calviello P Palozza E Piccioni N Maggiano A Frattucci P Franceschelli GM Bartoli 1998 Dietary supplementation with eicosapentaenoic and docosahexaenoic acid inhibits growth of Morris hepatocarcinoma 3924A in rats: effects on proliferation and apoptosis Int J Cancer 75 699 705 10.1002/(SICI)1097-0215(19980302)75:5<699::AID-IJC7>3.0.CO;2-U
    • (1998) Int J Cancer , vol.75 , pp. 699-705
    • Calviello, G.1    Palozza, P.2    Piccioni, E.3    Maggiano, N.4    Frattucci, A.5    Franceschelli, P.6    Bartoli, G.M.7
  • 17
  • 18
    • 0033557966 scopus 로고    scopus 로고
    • Mutational inactivation of the xeroderma pigmentosum group C gene confers predisposition to 2-acetylaminofluorene-induced liver and lung cancer and to spontaneous testicular cancer in Trp53(-/-) mice
    • DL Cheo DK Burns LB Meira JF Houle EC Friedberg 1999 Mutational inactivation of the xeroderma pigmentosum group C gene confers predisposition to 2-acetylaminofluorene-induced liver and lung cancer and to spontaneous testicular cancer in Trp53-/- mice Cancer Res 59 4 771 775 (Pubitemid 29086724)
    • (1999) Cancer Research , vol.59 , Issue.4 , pp. 771-775
    • Cheo, D.L.1    Burns, D.K.2    Meira, L.B.3    Houle, J.F.4    Friedberg, E.C.5
  • 19
    • 0022397571 scopus 로고
    • A transgenic mouse model of the chronic hepatitis B surface antigen carrier state
    • FV Chisari CA Pinkert DR Milich P Filippi A McLachlan RD Palmiter RL Brinster 1985 A transgenic mouse model of the chronic hepatitis B surface antigen carrier state Science 230 1157 1160 10.1126/science.3865369 (Pubitemid 16170001)
    • (1985) Science , vol.230 , Issue.4730 , pp. 1157-1160
    • Chisari, F.V.1    Pinkert, C.A.2    Milich, D.R.3
  • 22
    • 32044451776 scopus 로고    scopus 로고
    • HBV induced carcinogenesis
    • 10.1016/S1386-6532(05)80014-9
    • D Cougot C Neuveut MA Buendia 2005 HBV induced carcinogenesis J Clin Virol 34 S75 S78 10.1016/S1386-6532(05)80014-9
    • (2005) J Clin Virol , vol.34
    • Cougot, D.1    Neuveut, C.2    Buendia, M.A.3
  • 23
    • 12544260280 scopus 로고    scopus 로고
    • Tumorigenesis in p27/p53- and p18/p53-double null mice: Functional collaboration between the pRb and p53 pathways
    • 10.1002/mc.20068
    • LA Damo PW Snyder DS Franklin 2005 Tumorigenesis in p27/p53- and p18/p53-double null mice: functional collaboration between the pRb and p53 pathways Mol Carcinog 42 109 120 10.1002/mc.20068
    • (2005) Mol Carcinog , vol.42 , pp. 109-120
    • Damo, L.A.1    Snyder, P.W.2    Franklin, D.S.3
  • 26
    • 0025325248 scopus 로고
    • Transgenic mice containing hepatitis B virus sequences are more susceptible to carcinogen-induced hepatocarcinogenesis
    • TA Dragani G Manenti H Farza G Della Porta P Tiollais C Pourcel 1990 Transgenic mice containing hepatitis B virus sequences are more susceptible to carcinogen-induced hepatocarcinogenesis Carcinogenesis 11 953 956 10.1093/carcin/11.6.953 (Pubitemid 20207348)
    • (1990) Carcinogenesis , vol.11 , Issue.6 , pp. 953-956
    • Dragani, T.A.1    Manenti, G.2    Farza, H.3    Della Porta, G.4    Tiollais, P.5    Pourcel, C.6
  • 27
    • 0025826837 scopus 로고
    • Time-course development of differentiated hepatocarcinoma and lung metastasis in transgenic mice
    • 10.1016/0168-8278(91)90819-W
    • N Dubois M Bennoun I Allemand T Molina G Grimber M Daudet-Monsac R Abelanet P Briand 1991 Time-course development of differentiated hepatocarcinoma and lung metastasis in transgenic mice J Hepatol 13 227 239 10.1016/0168-8278(91)90819-W
    • (1991) J Hepatol , vol.13 , pp. 227-239
    • Dubois, N.1    Bennoun, M.2    Allemand, I.3    Molina, T.4    Grimber, G.5    Daudet-Monsac, M.6    Abelanet, R.7    Briand, P.8
  • 28
    • 0025334672 scopus 로고
    • Hepatocarcinogenesis due to chronic liver cell injury in hepatitis B virus transgenic mice
    • HA Dunsford S Sell FV Chisari 1990 Hepatocarcinogenesis due to chronic liver cell injury in hepatitis B virus transgenic mice Cancer Res 50 3400 3407 (Pubitemid 20190150)
    • (1990) Cancer Research , vol.50 , Issue.11 , pp. 3400-3407
    • Dunsford, H.A.1    Sell, S.2    Chisari, F.V.3
  • 29
    • 77951465721 scopus 로고    scopus 로고
    • Models for liver cancer
    • Wiley, NY
    • Feo F (2007) Models for liver cancer. In: The cancer handbook. Wiley, NY, pp 1-16
    • (2007) The Cancer Handbook , pp. 1-16
    • Feo, F.1
  • 30
    • 0017412603 scopus 로고
    • One hundred and twenty seven cultured human tumor cell lines producing tumors in nude mice
    • J Fogh JM Fogh T Orfeo 1977 One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice J Natl Cancer Inst 59 221 226 (Pubitemid 8144854)
    • (1977) Journal of the National Cancer Institute , vol.59 , Issue.1 , pp. 221-226
    • Fogh, J.1    Fogh, J.M.2    Orfeo, T.3
  • 31
    • 34548217651 scopus 로고    scopus 로고
    • Maximizing mouse cancer models
    • 10.1038/nrc2192
    • KK Frese DA Tuveson 2007 Maximizing mouse cancer models Nat Rev Cancer 7 645 658 10.1038/nrc2192
    • (2007) Nat Rev Cancer , vol.7 , pp. 645-658
    • Frese, K.K.1    Tuveson, D.A.2
  • 32
    • 0020322252 scopus 로고
    • Spontaneous hepatocellular neoplasms and hepatic hemangiosarcomas in several strains of mice
    • CH Frith L Wiley 1982 Spontaneous hepatocellular neoplasms and hepatic hemangiosarcomas in several strains of mice Lab Anim Sci 32 157 162 (Pubitemid 12091581)
    • (1982) Laboratory Animal Science , vol.32 , Issue.2 , pp. 157-162
    • Frith, C.H.1    Wiley, L.2
  • 34
    • 0025941884 scopus 로고
    • Target organs in chronic bioassays of 533 chemical carcinogens
    • 10.2307/3431194
    • LS Gold TH Slone NB Manley L Bernstein 1991 Target organs in chronic bioassays of 533 chemical carcinogens Environ Health Perspect 93 233 246 10.2307/3431194
    • (1991) Environ Health Perspect , vol.93 , pp. 233-246
    • Gold, L.S.1    Slone, T.H.2    Manley, N.B.3    Bernstein, L.4
  • 36
    • 0015918809 scopus 로고
    • Phenylalanine hydroxylase in cultured hepatoxytes. I. Hormonal control of enzyme levels
    • DF Haggerty PL Young G Popják WH Carnes 1973 Phenylalanine hydroxylase in cultured hepatoxytes. I. Hormonal control of enzyme levels J Biol Chem 248 223 232
    • (1973) J Biol Chem , vol.248 , pp. 223-232
    • Haggerty, D.F.1    Young, P.L.2    Popják, G.3    Carnes, W.H.4
  • 37
  • 39
    • 0033500248 scopus 로고    scopus 로고
    • Orthotopic metastatic mouse models for anticancer drug discovery and evaluation: A bridge to the clinic
    • 10.1023/A:1006326203858
    • RM Hoffman 1999 Orthotopic metastatic mouse models for anticancer drug discovery and evaluation: a bridge to the clinic Invest New Drugs 17 343 359 10.1023/A:1006326203858
    • (1999) Invest New Drugs , vol.17 , pp. 343-359
    • Hoffman, R.M.1
  • 40
    • 20544467225 scopus 로고    scopus 로고
    • Orthotopic metastatic (MetaMouse) models for discovery and development of novel chemotherapy
    • RM Hoffman 2005 Orthotopic metastatic (MetaMouse) models for discovery and development of novel chemotherapy Methods Mol Med 111 297 322
    • (2005) Methods Mol Med , vol.111 , pp. 297-322
    • Hoffman, R.M.1
  • 42
    • 1842480063 scopus 로고    scopus 로고
    • Integration of woodchuck hepatitis and N-myc rearrangement determine size and histologic grade of hepatic tumors
    • 10.1002/hep.20106
    • JR Jacob A Sterczer IA Toshkov 2004 Integration of woodchuck hepatitis and N-myc rearrangement determine size and histologic grade of hepatic tumors Hepatology 39 1008 1016 10.1002/hep.20106
    • (2004) Hepatology , vol.39 , pp. 1008-1016
    • Jacob, J.R.1    Sterczer, A.2    Toshkov, I.A.3
  • 43
    • 0242298109 scopus 로고    scopus 로고
    • Contributions of lung tissue extracts to invasion and migration of human hepatocellular carcinoma cells with various metastatic potentials
    • 10.1007/s00432-003-0475-1
    • XN Ji SL Ye Y Li B Tian J Chen DM Gao J Chen WH Bao YK Liu ZY Tang 2003 Contributions of lung tissue extracts to invasion and migration of human hepatocellular carcinoma cells with various metastatic potentials J Cancer Res Clin Oncol 129 556 564 10.1007/s00432-003-0475-1
    • (2003) J Cancer Res Clin Oncol , vol.129 , pp. 556-564
    • Ji, X.N.1    Ye, S.L.2    Li, Y.3    Tian, B.4    Chen, J.5    Gao, D.M.6    Chen, J.7    Bao, W.H.8    Liu, Y.K.9    Tang, Z.Y.10
  • 44
    • 0037033693 scopus 로고    scopus 로고
    • Inverse correlation between E-cadherin and Snail expression in hepatocellular carcinoma cell lines in vitro and in vivo
    • 10.1038/sj.bjc.6600017
    • W Jiao K Miyazaki Y Kitajima 2002 Inverse correlation between E-cadherin and Snail expression in hepatocellular carcinoma cell lines in vitro and in vivo Br J Cancer 86 98 101 10.1038/sj.bjc.6600017
    • (2002) Br J Cancer , vol.86 , pp. 98-101
    • Jiao, W.1    Miyazaki, K.2    Kitajima, Y.3
  • 46
    • 1542436704 scopus 로고    scopus 로고
    • Human tumor xenografts as predictive preclinical models for anticancer drug activity in humans: Better than commonly perceived-but they can be improved
    • RS Kerbel 2003 Human tumor xenografts as predictive preclinical models for anticancer drug activity in humans: better than commonly perceived-but they can be improved Cancer Biol Ther 2 S134 S139
    • (2003) Cancer Biol Ther , vol.2
    • Kerbel, R.S.1
  • 47
    • 0032410157 scopus 로고    scopus 로고
    • Orthotopic models are necessary to predict therapy of transplantable tumors in mice
    • 10.1023/A:1006140513233
    • JJ Killion R Radinsky IJ Fidler 1998-1999 Orthotopic models are necessary to predict therapy of transplantable tumors in mice Cancer Metastasis Rev 17 279 284 10.1023/A:1006140513233
    • (1998) Cancer Metastasis Rev , vol.17 , pp. 279-284
    • Killion, J.J.1    Radinsky, R.2    Fidler, I.J.3
  • 48
    • 0025907983 scopus 로고
    • HBx gene of hepatitis B virus induces liver cancer in transgenic mice
    • CM Kim K Koike I Saito T Miyamura G Jay 1991 HBx gene of hepatitis B virus induces liver cancer in transgenic mice Nature 351 317 320 10.1038/351317a0 (Pubitemid 21896589)
    • (1991) Nature , vol.351 , Issue.6324 , pp. 317-320
    • Kim, C.-M.1    Koike, K.2    Saito, I.3    Miyamura, T.4    Jay, G.5
  • 50
    • 0029586749 scopus 로고
    • Hepatitis B virus HBx gene and hepatocarcinogenesis
    • K Koike 1995 Hepatitis B virus HBx gene and hepatocarcinogenesis Intervirology 38 134 142 (Pubitemid 26009384)
    • (1995) Intervirology , vol.38 , Issue.3-4 , pp. 134-142
    • Koike, K.1
  • 51
    • 0028230728 scopus 로고
    • High-level expression of hepatitis B virus HBx gene and hepatocarcinogenesis in transgenic mice
    • DOI 10.1016/0270-9139(94)90277-1
    • K Koike K Moriya S Iino H Yotsuyanagi Y Endo T Miyamura K Kurokawa 1994 High-level expression of hepatitis B virus HBx gene and hepatocarcinogenesis in transgenic mice Hepatology 19 810 819 (Pubitemid 24109339)
    • (1994) Hepatology , vol.19 , Issue.4 , pp. 810-819
    • Koike, K.1    Moriya, K.2    Iino, S.3    Yotsuyanagi, H.4    Endo, Y.5    Miyamura, T.6    Kurokawa, K.7
  • 52
    • 0036097130 scopus 로고    scopus 로고
    • Role of hepatitis C virus in the development of hepatocellular carcinoma: Transgenic approach to viral hepatocarcinogenesis
    • 10.1046/j.1440-1746.2002.02763.x
    • K Koike K Moriya S Kimura 2002 Role of hepatitis C virus in the development of hepatocellular carcinoma: transgenic approach to viral hepatocarcinogenesis J Gastroenterol Hepatol 17 394 400 10.1046/j.1440-1746. 2002.02763.x
    • (2002) J Gastroenterol Hepatol , vol.17 , pp. 394-400
    • Koike, K.1    Moriya, K.2    Kimura, S.3
  • 54
    • 0030021432 scopus 로고    scopus 로고
    • The transmembrane protein-tyrosine phosphatase LAR modulates signaling by multiple receptor tyrosine kinases
    • 10.1074/jbc.271.2.748
    • DT Kulas BJ Goldstein RA Mooney 1996 The transmembrane protein-tyrosine phosphatase LAR modulates signaling by multiple receptor tyrosine kinases J Biol Chem 271 748 754 10.1074/jbc.271.2.748
    • (1996) J Biol Chem , vol.271 , pp. 748-754
    • Kulas, D.T.1    Goldstein, B.J.2    Mooney, R.A.3
  • 55
    • 0023404551 scopus 로고
    • Establishment and characterization of a diethylnitrosamine-initiated woodchuck hepatocyte cell line
    • 10.1002/hep.1840070524
    • H Lee T Kawaguchi K Nomura T Kitagawa 1987 Establishment and characterization of a diethylnitrosamine-initiated woodchuck hepatocyte cell line Hepatology 7 937 940 10.1002/hep.1840070524
    • (1987) Hepatology , vol.7 , pp. 937-940
    • Lee, H.1    Kawaguchi, T.2    Nomura, K.3    Kitagawa, T.4
  • 56
    • 0025222293 scopus 로고
    • Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice
    • TH Lee MJ Finegold RF Shen JL DeMayo SL Woo JS Butel 1990 Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice J Virol 64 5939 5947
    • (1990) J Virol , vol.64 , pp. 5939-5947
    • Lee, T.H.1    Finegold, M.J.2    Shen, R.F.3    Demayo, J.L.4    Woo, S.L.5    Butel, J.S.6
  • 57
    • 0001723767 scopus 로고    scopus 로고
    • Establishment and characterization of four human hepatocellular carcinoma cell lines containing hepatitis B virus DNA
    • JH Lee JL Ku YJ Park KU Lee WH Kim JG Park 1999 Establishment and characterization of four human hepatocellular carcinoma cell lines containing hepatitis B virus DNA World J Gastroenterol 5 289 295
    • (1999) World J Gastroenterol , vol.5 , pp. 289-295
    • Lee, J.H.1    Ku, J.L.2    Park, Y.J.3    Lee, K.U.4    Kim, W.H.5    Park, J.G.6
  • 58
    • 63449084376 scopus 로고    scopus 로고
    • Mouse models in liver cancer research: A review of current literature
    • 10.3748/wjg.14.6915
    • MW Leenders MW Nijkamp IH Borel Rinkes 2008 Mouse models in liver cancer research: A review of current literature World J Gastroenterol 14 6915 6923 10.3748/wjg.14.6915
    • (2008) World J Gastroenterol , vol.14 , pp. 6915-6923
    • Leenders, M.W.1    Nijkamp, M.W.2    Borel Rinkes, I.H.3
  • 60
    • 33745527481 scopus 로고    scopus 로고
    • Viral hepatitis and liver cancer: The case of hepatitis C
    • 10.1038/sj.onc.1209562
    • M Levrero 2006 Viral hepatitis and liver cancer: the case of hepatitis C Oncogene 25 3834 3847 10.1038/sj.onc.1209562
    • (2006) Oncogene , vol.25 , pp. 3834-3847
    • Levrero, M.1
  • 61
    • 0032241157 scopus 로고    scopus 로고
    • Establishment of a lymph node metastatic model of mouse hepatocellular carcinoma hca-F cells in C3H/Hej mice
    • HF Li MY Ling Y Xie H Xie 1998 Establishment of a lymph node metastatic model of mouse hepatocellular carcinoma Hca-F cells in C3H/Hej mice Oncol Res 10 569 573 (Pubitemid 128740445)
    • (1998) Oncology Research , vol.10 , Issue.11-12 , pp. 569-573
    • Li, H.-F.1    Ling, M.-Y.2    Xie, Y.3    Xie, H.4
  • 63
    • 0037250193 scopus 로고    scopus 로고
    • Establishment of a hepatocellular carcinoma cell line with unique metastatic characteristics through in vivo selection and screening for metastasis-related genes through cDNA microarray
    • 10.1007/s00432-003-0493-z
    • Y Li Y Tang L Ye B Liu K Liu J Chen Q Xue 2003 Establishment of a hepatocellular carcinoma cell line with unique metastatic characteristics through in vivo selection and screening for metastasis-related genes through cDNA microarray J Cancer Res Clin Oncol 129 43 51 10.1007/s00432-003-0493-z
    • (2003) J Cancer Res Clin Oncol , vol.129 , pp. 43-51
    • Li, Y.1    Tang, Y.2    Ye, L.3    Liu, B.4    Liu, K.5    Chen, J.6    Xue, Q.7
  • 64
    • 4344589523 scopus 로고    scopus 로고
    • Stepwise metastatic human hepatocellular carcinoma cell model system with multiple metastatic potentials established through consecutive in vivo selection and studies on metastatic characteristics
    • Y Li B Tian J Yang L Zhao X Wu SL Ye YK Liu ZY Tang 2004 Stepwise metastatic human hepatocellular carcinoma cell model system with multiple metastatic potentials established through consecutive in vivo selection and studies on metastatic characteristics J Cancer Res Clin Oncol 130 460 468 10.1007/s00432-004-0564-9 (Pubitemid 39119289)
    • (2004) Journal of Cancer Research and Clinical Oncology , vol.130 , Issue.8 , pp. 460-468
    • Li, Y.1    Tian, B.2    Yang, J.3    Zhao, L.4    Wu, X.5    Ye, S.-L.6    Liu, Y.-K.7    Tang, Z.-Y.8
  • 65
    • 33748529363 scopus 로고    scopus 로고
    • Growth arrest and apoptosis of the human hepatocellular carcinoma cell line BEL-7402 induced by melittin
    • 10.1159/000094711
    • B Li W Gu C Zhang KQ Han CQ Ling 2006 Growth arrest and apoptosis of the human hepatocellular carcinoma cell line BEL-7402 induced by melittin Onkologie 29 367 371 10.1159/000094711
    • (2006) Onkologie , vol.29 , pp. 367-371
    • Li, B.1    Gu, W.2    Zhang, C.3    Han, K.Q.4    Ling, C.Q.5
  • 66
    • 33745297957 scopus 로고    scopus 로고
    • Serum CYFRA 21-1 level reflects hepatocellular carcinoma metastasis: Study in nude mice model and clinical patients
    • 10.1007/s00432-006-0098-4
    • Y Li ZY Tang B Tian SL Ye LX Qin Q Xue RX Sun 2006 Serum CYFRA 21-1 level reflects hepatocellular carcinoma metastasis: study in nude mice model and clinical patients J Cancer Res Clin Oncol 132 515 520 10.1007/s00432-006-0098-4
    • (2006) J Cancer Res Clin Oncol , vol.132 , pp. 515-520
    • Li, Y.1    Tang, Z.Y.2    Tian, B.3    Ye, S.L.4    Qin, L.X.5    Xue, Q.6    Sun, R.X.7
  • 67
    • 0033801953 scopus 로고    scopus 로고
    • In vitro and in vivo suppression of growth of rat liver epithelial tumor cells by antisense oligonucleotide against protein kinase C-alpha
    • 10.1034/j.1600-0641.2000.033004601.x
    • SB Lin LC Wu SL Huang HL Hsu SH Hsieh CW Chi LC Au 2000 In vitro and in vivo suppression of growth of rat liver epithelial tumor cells by antisense oligonucleotide against protein kinase C-alpha J Hepatol 33 601 608 10.1034/j.1600-0641.2000.033004601.x
    • (2000) J Hepatol , vol.33 , pp. 601-608
    • Lin, S.B.1    Wu, L.C.2    Huang, S.L.3    Hsu, H.L.4    Hsieh, S.H.5    Chi, C.W.6    Au, L.C.7
  • 68
    • 12344288378 scopus 로고    scopus 로고
    • Inhibitory effect of recombinant adenovirus carrying melittin gene on hepatocellular carcinoma
    • 10.1093/annonc/mdi019
    • CQ Ling B Li C Zhang DZ Zhu XQ Huang W Gu SX Li 2005 Inhibitory effect of recombinant adenovirus carrying melittin gene on hepatocellular carcinoma Ann Oncol 16 109 115 10.1093/annonc/mdi019
    • (2005) Ann Oncol , vol.16 , pp. 109-115
    • Ling, C.Q.1    Li, B.2    Zhang, C.3    Zhu, D.Z.4    Huang, X.Q.5    Gu, W.6    Li, S.X.7
  • 70
    • 51049090381 scopus 로고    scopus 로고
    • Hepatitis B virus genotype and mutants: Risk factors for hepatocellular carcinoma
    • 10.1093/jnci/djn261
    • JM Llovet A Lok 2008 Hepatitis B virus genotype and mutants: risk factors for hepatocellular carcinoma J Natl Cancer Inst 100 1121 1123 10.1093/jnci/djn261
    • (2008) J Natl Cancer Inst , vol.100 , pp. 1121-1123
    • Llovet, J.M.1    Lok, A.2
  • 72
    • 40749150740 scopus 로고    scopus 로고
    • CD133 + HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway
    • 10.1038/sj.onc.1210811
    • S Ma TK Lee BJ Zheng KW Chan XY Guan 2008 CD133 + HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway Oncogene 27 1749 1758 10.1038/sj.onc.1210811
    • (2008) Oncogene , vol.27 , pp. 1749-1758
    • Ma, S.1    Lee, T.K.2    Zheng, B.J.3    Chan, K.W.4    Guan, X.Y.5
  • 74
    • 0037471081 scopus 로고    scopus 로고
    • Medicine. Building better mouse models for studying cancer
    • 10.1126/science.299.5615.1972
    • J Marx 2003 Medicine. Building better mouse models for studying cancer Science 299 1972 1975 10.1126/science.299.5615.1972
    • (2003) Science , vol.299 , pp. 1972-1975
    • Marx, J.1
  • 75
    • 12644319367 scopus 로고
    • A preliminary report on tumors found in wild rats
    • GW McCoy 1909 A preliminary report on tumors found in wild rats J Med Res 21 285 296
    • (1909) J Med Res , vol.21 , pp. 285-296
    • McCoy, G.W.1
  • 76
    • 0034053296 scopus 로고    scopus 로고
    • Properties of the hepatitis C virus core protein: A structural protein that modulates cellular processes
    • 10.1046/j.1365-2893.2000.00201.x
    • J McLauchlan 2000 Properties of the hepatitis C virus core protein: a structural protein that modulates cellular processes J Viral Hepat 7 2 14 10.1046/j.1365-2893.2000.00201.x
    • (2000) J Viral Hepat , vol.7 , pp. 2-14
    • McLauchlan, J.1
  • 77
    • 0028295478 scopus 로고
    • Extrathymic expression of the intracellular hepatitis B core antigen results in T cell tolerance in transgenic mice
    • DR Milich JE Jones JL Hughes T Maruyama J Price I Melhado F Jirik 1994 Extrathymic expression of the intracellular hepatitis B core antigen results in T cell tolerance in transgenic mice J Immunol 152 455 466 (Pubitemid 24072949)
    • (1994) Journal of Immunology , vol.152 , Issue.2 , pp. 455-466
    • Milich, D.R.1    Jones, J.E.2    Hughes, J.L.3    Maruyama, T.4    Price, J.5    Melhado, I.6    Jirik, F.7
  • 78
    • 0018778961 scopus 로고
    • Polypeptide profile of HBSAg excreted by a human hepatoma cell line
    • 10.1016/0042-6822(79)90123-5
    • J Monjardino E Crawford 1979 Polypeptide profile of HBSAg excreted by a human hepatoma cell line Virology 96 652 655 10.1016/0042-6822(79)90123-5
    • (1979) Virology , vol.96 , pp. 652-655
    • Monjardino, J.1    Crawford, E.2
  • 80
    • 0015950733 scopus 로고
    • Induction and some characteristics of "minimal Deviation" and other transplantable rat hepatomas
    • HP Morris DR Meranze 1974 Induction and some characteristics of "Minimal Deviation" and other transplantable rat hepatomas Recent Results Cancer Res 44 103 114
    • (1974) Recent Results Cancer Res , vol.44 , pp. 103-114
    • Morris, H.P.1    Meranze, D.R.2
  • 81
    • 0027245446 scopus 로고
    • Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumorigenesis: Interaction of c-myc and transforming growth factor α in hepatic oncogenesis
    • H Murakami ND Sanderson P Nagy PA Marino G Merlino SS Thorgeirsson 1993 Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumorigenesis: interaction of c-myc and transforming growth factor alpha in hepatic oncogenesis Cancer Res 53 1719 1723 (Pubitemid 23127090)
    • (1993) Cancer Research , vol.53 , Issue.8 , pp. 1719-1723
    • Murakami, H.1    Sanderson, N.D.2    Nagy, P.3    Marino, P.A.4    Merlino, G.5    Thorgeirsson, S.S.6
  • 83
    • 41249102034 scopus 로고    scopus 로고
    • Experimental models of hepatocellular carcinoma
    • 10.1016/j.jhep.2008.01.008
    • P Newell A Villanueva SL Friedman K Koike JM Llovet 2008 Experimental models of hepatocellular carcinoma J Hepatol 48 858 879 10.1016/j.jhep.2008.01. 008
    • (2008) J Hepatol , vol.48 , pp. 858-879
    • Newell, P.1    Villanueva, A.2    Friedman, S.L.3    Koike, K.4    Llovet, J.M.5
  • 84
    • 0020993233 scopus 로고
    • Establishment of two rat hepatoma cell strains produced by a carcinogen initiation, phenobarbital promotion protocol
    • DL Novicki RL Jirtle G Michalopoulos 1983 Establishment of two rat hepatoma cell strains produced by a carcinogen initiation, phenobarbital promotion protocol In Vitro 19 191 202 10.1007/BF02618059 (Pubitemid 15217079)
    • (1983) In Vitro , vol.19 , Issue.3 I , pp. 191-202
    • Novicki, D.L.1    Jirtle, R.L.2    Michalopoulos, G.3
  • 85
    • 0035869694 scopus 로고    scopus 로고
    • Establishment of rat hepatocellular carcinoma cell lines with differing metastatic potential in nude mice
    • 10.1002/1097-0215(200002)9999:9999<::AID-IJC1140>3.0.CO;2-#
    • K Ogawa H Nakanishi F Takeshita M Futakuchi M Asamoto K Imaida M Tatematsu T Shirai 2001 Establishment of rat hepatocellular carcinoma cell lines with differing metastatic potential in nude mice Int J Cancer 91 797 802 10.1002/1097-0215(200002)9999:9999<::AID-IJC1140>3.0.CO;2-#
    • (2001) Int J Cancer , vol.91 , pp. 797-802
    • Ogawa, K.1    Nakanishi, H.2    Takeshita, F.3    Futakuchi, M.4    Asamoto, M.5    Imaida, K.6    Tatematsu, M.7    Shirai, T.8
  • 89
    • 0034643920 scopus 로고    scopus 로고
    • Mutations in the p53 tumor suppressor gene in tree shrew hepatocellular carcinoma associated with hepatitis B virus infection and intake of aflatoxin B1
    • 10.1016/S0378-1119(00)00183-9
    • US Park JJ Su KC Ban L Qin EH Lee YI Lee 2000 Mutations in the p53 tumor suppressor gene in tree shrew hepatocellular carcinoma associated with hepatitis B virus infection and intake of aflatoxin B1 Gene 251 73 80 10.1016/S0378-1119(00)00183-9
    • (2000) Gene , vol.251 , pp. 73-80
    • Park, U.S.1    Su, J.J.2    Ban, K.C.3    Qin, L.4    Lee, E.H.5    Lee, Y.I.6
  • 90
    • 0024457750 scopus 로고
    • Animal models of human disease. Pathology and molecular biology of spontaneous neoplasms occurring in transgenic mice carrying and expressing activated cellular oncogenes
    • PK Pattengale TA Stewart A Leder E Sinn W Muller I Tepler E Schmidt P Leder 1989 Animal models of human disease. Pathology and molecular biology of spontaneous neoplasms occurring in transgenic mice carrying and expressing activated cellular oncogenes Am J Pathol 135 39 61 (Pubitemid 19228990)
    • (1989) American Journal of Pathology , vol.135 , Issue.1 , pp. 39-61
    • Pattengale, P.K.1    Stewart, T.A.2    Leder, A.3    Sinn, E.4    Muller, W.5    Tepler, I.6    Schmidt, E.7    Leder, P.8
  • 91
    • 8944262349 scopus 로고    scopus 로고
    • Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype
    • RB Ray LM Lagging K Meyer R Ray 1996 Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype J Virol 70 4438 4443 (Pubitemid 26187445)
    • (1996) Journal of Virology , vol.70 , Issue.7 , pp. 4438-4443
    • Ray, R.B.1    Martin Lagging, L.2    Meyer, K.3    Ray, R.4
  • 92
    • 0030589563 scopus 로고    scopus 로고
    • Suppression of apoptotic cell death by hepatitis C virus core protein
    • 10.1006/viro.1996.0644
    • RB Ray K Meyer R Ray 1996 Suppression of apoptotic cell death by hepatitis C virus core protein Virology 226 176 182 10.1006/viro.1996.0644
    • (1996) Virology , vol.226 , pp. 176-182
    • Ray, R.B.1    Meyer, K.2    Ray, R.3
  • 93
    • 0035499267 scopus 로고    scopus 로고
    • Stem cells, cancer, and cancer stem cells
    • 10.1038/35102167
    • T Reya SJ Morrison MF Clarke IL Weissman 2001 Stem cells, cancer, and cancer stem cells Nature 414 105 111 10.1038/35102167
    • (2001) Nature , vol.414 , pp. 105-111
    • Reya, T.1    Morrison, S.J.2    Clarke, M.F.3    Weissman, I.L.4
  • 94
    • 0021233716 scopus 로고
    • Regulation and expression of carbamyl phosphate synthetase I mRNA in developing rat liver and Morris hepatoma 5123D
    • J Ryall RA Rachubinski M Nguyen R Rozen KE Broglie GC Shore 1984 Regulation and expression of carbamyl phosphate synthetase I mRNA in developing rat liver and Morris hepatoma 5123D J Biol Chem 259 9172 9176 (Pubitemid 14098901)
    • (1984) Journal of Biological Chemistry , vol.259 , Issue.14 , pp. 9172-9176
    • Ryall, J.1    Rachubinski, R.A.2    Nguyen, M.3
  • 95
    • 0030036244 scopus 로고    scopus 로고
    • Evolution of neoplastic development in the liver of transgenic mice co- expressing c-myc and transforming growth factor-α
    • E Santoni-Rugiu P Nagy MR Jensen VM Factor SS Thorgeirsson 1996 Evolution of neoplastic development in the liver of transgenic mice co-expressing c-myc and transforming growth factor-alpha Am J Pathol 149 407 428 (Pubitemid 26256330)
    • (1996) American Journal of Pathology , vol.149 , Issue.2 , pp. 407-428
    • Santoni-Rugiu, E.1    Nagy, P.2    Jensen, M.R.3    Factor, V.M.4    Thorgeirsson, S.S.5
  • 96
    • 84982596373 scopus 로고
    • Specific inhibition of cell proliferation in the mouse intestine by an aqueous extract of rabbit small intestine
    • P Sassier M Bergeron 1977 Specific inhibition of cell proliferation in the mouse intestine by an aqueous extract of rabbit small intestine Cell Tissue Kinet 10 223 231 (Pubitemid 8083127)
    • (1977) Cell and Tissue Kinetics , vol.10 , Issue.3 , pp. 223-231
    • Sassier, P.1    Bergeron, M.2
  • 98
    • 0345275881 scopus 로고    scopus 로고
    • Mouse Models to Study the Interaction of Risk Factors for Human Liver Cancer
    • S Sell 2003 Mouse models to study the interaction of risk factors for human liver cancer Cancer Res 63 7553 7562 (Pubitemid 37466672)
    • (2003) Cancer Research , vol.63 , Issue.22 , pp. 7553-7562
    • Sell, S.1
  • 99
    • 45549084904 scopus 로고    scopus 로고
    • Liver cancer stem cells
    • 10.1200/JCO.2007.15.5945
    • S Sell HL Leffert 2008 Liver cancer stem cells J Clin Oncol 26 2800 2805 10.1200/JCO.2007.15.5945
    • (2008) J Clin Oncol , vol.26 , pp. 2800-2805
    • Sell, S.1    Leffert, H.L.2
  • 100
    • 0030048790 scopus 로고    scopus 로고
    • Transgenic animals
    • 10.1056/NEJM199603073341009
    • AR Shuldiner 1996 Transgenic animals N Engl J Med 334 653 655 10.1056/NEJM199603073341009
    • (1996) N Engl J Med , vol.334 , pp. 653-655
    • Shuldiner, A.R.1
  • 101
    • 0038780018 scopus 로고    scopus 로고
    • Transgenic mouse models of hepatitis B virus-associated hepatocellular carcinoma
    • 10.1002/rmv.392
    • M Singh V Kumar 2003 Transgenic mouse models of hepatitis B virus-associated hepatocellular carcinoma Rev Med Virol 13 243 253 10.1002/rmv.392
    • (2003) Rev Med Virol , vol.13 , pp. 243-253
    • Singh, M.1    Kumar, V.2
  • 102
    • 0018696805 scopus 로고
    • Hepatitis B surface antigen produced by a human hepatoma cell line
    • 10.1038/282617a0
    • J Skelly JA Copeland CR Howard AJ Zuckerman 1979 Hepatitis B surface antigen produced by a human hepatoma cell line Nature 282 617 618 10.1038/282617a0
    • (1979) Nature , vol.282 , pp. 617-618
    • Skelly, J.1    Copeland, J.A.2    Howard, C.R.3    Zuckerman, A.J.4
  • 103
    • 0029870749 scopus 로고    scopus 로고
    • Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virus X gene
    • 10.1002/(SICI)1098-2744(199604)15:4<261::AID-MC3>3.0.CO;2-J
    • BL Slagle TH Lee D Medina MJ Finegold JS Butel 1996 Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virus X gene Mol Carcinog 15 261 269 10.1002/(SICI)1098-2744(199604) 15:4<261::AID-MC3>3.0.CO;2-J
    • (1996) Mol Carcinog , vol.15 , pp. 261-269
    • Slagle, B.L.1    Lee, T.H.2    Medina, D.3    Finegold, M.J.4    Butel, J.S.5
  • 104
    • 0029956889 scopus 로고    scopus 로고
    • Metastatic models of human liver cancer in nude mice orthotopically constructed by using histologically intact patient specimens
    • 10.1007/BF01212878
    • FX Sun ZY Tang KD Liu Q Xue DM Gao YQ Yu XD Zhou ZC Ma 1996 Metastatic models of human liver cancer in nude mice orthotopically constructed by using histologically intact patient specimens J Cancer Res Clin Oncol 122 397 402 10.1007/BF01212878
    • (1996) J Cancer Res Clin Oncol , vol.122 , pp. 397-402
    • Sun, F.X.1    Tang, Z.Y.2    Liu, K.D.3    Xue, Q.4    Gao, D.M.5    Yu, Y.Q.6    Zhou, X.D.7    Ma, Z.C.8
  • 105
    • 1942536204 scopus 로고    scopus 로고
    • Similarities and Differences in Hepatitis B and C Virus Induced Hepatocarcinogenesis
    • E Szabó C Páska P Kaposi Novák Z Schaff A Kiss 2004 Similarities and differences in hepatitis B and C virus induced hepatocarcinogenesis Pathol Oncol Res 10 5 11 10.1007/BF02893401 (Pubitemid 38506605)
    • (2004) Pathology Oncology Research , vol.10 , Issue.1 , pp. 5-11
    • Szabo, E.1    Paska, C.2    Kaposi Novak, P.3    Schaff, Z.4    Kiss, A.5
  • 107
    • 34247876272 scopus 로고    scopus 로고
    • Murine models to evaluate novel and conventional therapeutic strategies for cancer
    • 10.2353/ajpath.2007.060929
    • JE Talmadge RK Singh IJ Fidler A Raz 2007 Murine models to evaluate novel and conventional therapeutic strategies for cancer Am J Pathol 170 793 804 10.2353/ajpath.2007.060929
    • (2007) Am J Pathol , vol.170 , pp. 793-804
    • Talmadge, J.E.1    Singh, R.K.2    Fidler, I.J.3    Raz, A.4
  • 108
    • 0028132948 scopus 로고
    • Rapid development of hepatic tumors in transforming growth factor alpha transgenic mice associated with increased cell proliferation in precancerous hepatocellular lesions initiated by N-nitrosodiethylamine and promoted by phenobarbital
    • 10.1093/carcin/15.9.1791
    • S Tamano GT Merlino JM Ward 1994 Rapid development of hepatic tumors in transforming growth factor alpha transgenic mice associated with increased cell proliferation in precancerous hepatocellular lesions initiated by N-nitrosodiethylamine and promoted by phenobarbital Carcinogenesis 15 1791 1798 10.1093/carcin/15.9.1791
    • (1994) Carcinogenesis , vol.15 , pp. 1791-1798
    • Tamano, S.1    Merlino, G.T.2    Ward, J.M.3
  • 109
    • 36749083957 scopus 로고    scopus 로고
    • Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: Implications for HCV-associated hepatocarcinogenesis
    • 10.1002/ijc.23056
    • N Tanaka K Moriya K Kiyosawa K Koike T Aoyama 2008 Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: implications for HCV-associated hepatocarcinogenesis Int J Cancer 122 124 131 10.1002/ijc.23056
    • (2008) Int J Cancer , vol.122 , pp. 124-131
    • Tanaka, N.1    Moriya, K.2    Kiyosawa, K.3    Koike, K.4    Aoyama, T.5
  • 112
    • 0036345943 scopus 로고    scopus 로고
    • Interaction between hepatitis C virus proteins and host cell factors
    • 10.1016/S1369-5274(02)00341-7
    • TL Tellinghuisen CM Rice 2002 Interaction between hepatitis C virus proteins and host cell factors Curr Opin Microbiol 5 419 427 10.1016/S1369-5274(02)00341-7
    • (2002) Curr Opin Microbiol , vol.5 , pp. 419-427
    • Tellinghuisen, T.L.1    Rice, C.M.2
  • 113
    • 0032742269 scopus 로고    scopus 로고
    • New human hepatocellular carcinoma (HCC) cell line with highly metastatic potential (MHCC97) and its expressions of the factors associated with metastasis
    • 10.1038/sj.bjc.6690769
    • J Tian ZY Tang SL Ye YK Liu ZY Lin J Chen Q Xue 1999 New human hepatocellular carcinoma (HCC) cell line with highly metastatic potential (MHCC97) and its expressions of the factors associated with metastasis Br J Cancer 81 814 821 10.1038/sj.bjc.6690769
    • (1999) Br J Cancer , vol.81 , pp. 814-821
    • Tian, J.1    Tang, Z.Y.2    Ye, S.L.3    Liu, Y.K.4    Lin, Z.Y.5    Chen, J.6    Xue, Q.7
  • 114
    • 0027939369 scopus 로고
    • Hepatic preneoplasia in hepatitis B virus transgenic mice
    • DOI 10.1016/0270-9139(94)90752-8
    • I Toshkov FV Chisari P Bannasch 1994 Hepatic preneoplasia in hepatitis B virus transgenic mice Hepatology 20 1162 1172 (Pubitemid 24323561)
    • (1994) Hepatology , vol.20 , Issue.5 , pp. 1162-1172
    • Toshkov, I.1    Chisari, F.V.2    Bannasch, P.3
  • 117
    • 0034954939 scopus 로고    scopus 로고
    • Antihepatoma effect of alpha-fetoprotein antisense phosphorothioate oligodeoxyribonucleotides in vitro and in mice
    • XW Wang JH Yuan RG Zhang LX Guo Y Xie H Xie 2001 Antihepatoma effect of alpha-fetoprotein antisense phosphorothioate oligodeoxyribonucleotides in vitro and in mice World J Gastroenterol 7 345 351 (Pubitemid 32586518)
    • (2001) World Journal of Gastroenterology , vol.7 , Issue.3 , pp. 345-351
    • Wang, X.W.1    Yuan, J.H.2    Zhang, R.G.3    Guo, L.X.4    Xie, Y.5    Xie, H.6
  • 121
    • 11144355421 scopus 로고    scopus 로고
    • LFIRE-1/HFREP-1, a liver-specific gene, is frequently downregulated and has growth suppressor activity in hepatocellular carcinoma
    • 10.1038/sj.onc.1207306
    • J Yan Y Yu N Wang Y Chang H Ying W Liu J He S Li W Jiang Y Li H Liu H Wang Y Xu 2004 LFIRE-1/HFREP-1, a liver-specific gene, is frequently downregulated and has growth suppressor activity in hepatocellular carcinoma Oncogene 23 1939 1949 10.1038/sj.onc.1207306
    • (2004) Oncogene , vol.23 , pp. 1939-1949
    • Yan, J.1    Yu, Y.2    Wang, N.3    Chang, Y.4    Ying, H.5    Liu, W.6    He, J.7    Li, S.8    Jiang, W.9    Li, Y.10    Liu, H.11    Wang, H.12    Xu, Y.13
  • 122
    • 27744576829 scopus 로고    scopus 로고
    • Modification of an in vivo lung metastasis model of hepatocellular carcinomaby low dose N-nitrosomorpholine and diethylnitrosamine
    • 10.1007/s10585-005-2807-9
    • H Yoshino M Futakuchi YM Cho K Ogawa F Takeshita N Imai S Tamano T Shirai 2005 Modification of an in vivo lung metastasis model of hepatocellular carcinomaby low dose N-nitrosomorpholine and diethylnitrosamine Clin Exp Metastasis 22 441 447 10.1007/s10585-005-2807-9
    • (2005) Clin Exp Metastasis , vol.22 , pp. 441-447
    • Yoshino, H.1    Futakuchi, M.2    Cho, Y.M.3    Ogawa, K.4    Takeshita, F.5    Imai, N.6    Tamano, S.7    Shirai, T.8
  • 124
    • 0019813096 scopus 로고
    • Characterization of the major apolipoproteins secreted by two human hepatoma cell lines
    • VI Zannis JL Breslow TR SanGiacomo DP Aden BB Knowles 1981 Characterization of the major apolipoproteins secreted by two human hepatoma cell lines Biochemistry 20 7089 7096 10.1021/bi00528a006 (Pubitemid 12188872)
    • (1981) Biochemistry , vol.20 , Issue.25 , pp. 7089-7096
    • Zannis, V.I.1    Breslow, J.L.2    San Giacomo, T.R.3
  • 125
    • 33846432330 scopus 로고    scopus 로고
    • Hepatitis B virus promotes hepatocarcinogenesis in transgenic mice
    • 10.1002/hep.21445
    • Y Zheng WL Chen SG Louie TS Yen JH Ou 2007 Hepatitis B virus promotes hepatocarcinogenesis in transgenic mice Hepatology 45 16 21 10.1002/hep.21445
    • (2007) Hepatology , vol.45 , pp. 16-21
    • Zheng, Y.1    Chen, W.L.2    Louie, S.G.3    Yen, T.S.4    Ou, J.H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.