Loss of steroid receptor co-activator-3 attenuates carbon tetrachloride-induced murine hepatic injury and fibrosis

Laboratory Investigation

Volumn 89, Issue 8, 2009, Pages 903-914

  Ma, Xinran ^a   Xu, Lingyan ^a   Wang, Shu ^a   Chen, Haoyan ^b   Xu, Jianming ^a   Li, Xiaoying ^a   Ning, Guang ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Chronic hepatic fibrosis; Issue microarray; Mad2 3; Ransforming growth factor beta; 1; Teroid receptor co activator 3

Indexed keywords

CARBON TETRACHLORIDE; SMAD ANCHOR FOR RECEPTOR ACTIVATION; STEROID RECEPTOR COACTIVATOR 3; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; FIBROGENESIS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER FIBROSIS; LIVER INJURY; LIVER PROTECTION; MALE; MOUSE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ACUTE DISEASE; ANIMALS; APOPTOSIS; CARBON TETRACHLORIDE; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; COLLAGEN; FIBROSIS; HEPATIC STELLATE CELLS; HEPATITIS, VIRAL, HUMAN; HEPATOCYTES; HISTONE ACETYLTRANSFERASES; HUMANS; LIVER; LIVER CIRRHOSIS, EXPERIMENTAL; LIVER NEOPLASMS; MICE; MICE, KNOCKOUT; NECROSIS; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; TISSUE ARRAY ANALYSIS; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 68149182609     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2009.51     Document Type: Article

References (45)

1. Friedman SL. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 2000;275:2247-2250.
2. Iredale JP. Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ. J Clin Invest 2007;117: 539-548.
3. Wallace K, Burt AD, Wright MC. Liver fibrosis. Biochem J 2008;411:1-18.
4. Gressner AM, Weiskirchen R. Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-β as major players and therapeutic targets. J Cell Mol Med 2006;10:76-99.
5. Ghosh AK. Factors involved in the regulation of type I collagen gene expression: implication in fibrosis. Exp Biol Med 2002;227:301-314.
6. Ghosh AK, Varga J. The transcriptional coactivator and acetyltransferase p300 in fibroblast biology and fibrosis. J Cell Physiol 2007;213:663-671.
7. Itoh S, Ericsson J, Nishikawa J, et al. The transcriptional co-activator P/CAF potentiates TGF-β/Smad signaling. Nucleic Acids Res 2000;28:4291-4298.
8. Dennler S, Pendaries V, Tacheau C, et al. The steroid receptor co-activator-1 (SRC-1) potentiates TGF-b/Smad signaling: role of p300/CBP. Oncogene 2005;24:1936-1945.
9. Xu J, Li Q. Review of the in vivo functions of the p160 steroid receptor coactivator family. Mol Endocrinol 2003;17:1681-1692.
10. Naeem H, Cheng D, Zhao Q, et al. The activity and stability of the transcriptional coactivator p/CIP/SRC-3 are regulated by CARM1-dependent methylation. Mol Cell Biol 2007;27:120-134.
11. Shi YH, Ding WX, Zhou J, et al. Expression of X-linked inhibitor-of-apoptosis protein in hepatocellular carcinoma promotes metastasis and tumor recurrence. Hepatology 2008;48:497-507.
12. Xu W, Hellerbrand C, Köhler UA, et al. The Nrf2 transcription factor protects from toxin-induced liver injury and fibrosis. Lab Invest 2008;88:1068-1078.
13. Schuster N, Krieglstein K. Mechanisms of TGF-β-mediated apoptosis. Cell Tissue Res 2002;307:1-14.
14. Nguyen LN, Furuya MH, Wolfraim LA, et al. Transforming growth factor-beta differentially regulates oval cell and hepatocyte proliferation. Hepatology 2007;45:31-41.
15. Hemmann S, Graf J, Roderfeld M, et al. Expression of MMPs and TIMPs in liver fibrosis: a systematic review with special emphasis on anti-fibrotic strategies. J Hepatol 2007;46:955-975.
16. Parsons CJ, Takashima M, Rippe RA. Molecular mechanisms of hepatic fibrogenesis. J Gastroenterol Hepatol 2007;22(Suppl 1):S79-S84.
17. Wang Y, Wu MC, Sham JS, et al. Prognostic significance of c-myc and AIB1 amplification in hepatocellular carcinoma: a broad survey using high-throughput tissue microarray. Cancer 2002;95:2346-2352.
18. Bravo R. Synthesis of the nuclear protein cyclin (PCNA) and its relationship with DNA replication. Exp Cell Res 1986;163:287-293.
19. Yu C, York B, Wang S, et al. An essential function of the SRC-3 coactivator in suppression of cytokine mRNA translation and inflammatory response. Mol Cell 2007;25:765-778.
20. Watanabe A, Hashmi A, Gomes DA, et al. Apoptotic hepatocyte DNA inhibits hepatic stellate cell chemotaxis via toll-like receptor 9. Hepatology 2007;46:1509-1518.
21. Strongin AY, Collier I, Bannikov G, et al. Mechanism of cell surface activation of 72-kDa type IV collagenase. Isolation of the activated form of the membrane metalloprotease. J Biol Chem 1995;270:5331-5338.
22. Zhou X, Hovell CJ, Pawley S, et al. Expression of matrix metalloproteinase-2 and -14 persists during early resolution of experimental liver fibrosis and might contribute to fibrolysis. Liver Int 2004;24:492-501.
23. Parsons CJ, Bradford BU, Pan CQ, et al. Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats. Hepatology 2004;40:1106-1115.
24. Watanabe T, Niioka M, Ishikawa A, et al. Dynamic change of cells expressing MMP-2 mRNA and MT1-MMP mRNA in the recovery from liver fibrosis in the rat. J Hepatol 2001;35:465-473.
25. Knittel T, Mehde M, Kobold D, et al. Expression patterns of matrix metalloproteinases and their inhibitors in parenchymal and non-parenchymal cells of rat liver: regulation by TNF-alpha and TGF-beta1. J Hepatol 1999;30:48-60.
26. Ikeda K, Wakahara T, Wang YQ, et al. In vitro migratory potential of rat quiescent hepatic stellate cells and its augmentation by cell activation. Hepatology 1999;29:1760-1767.
27. Zhou X, Hovell CJ, Pawley S, et al. Expression of matrix metalloproteinase-2 and -14 persists during early resolution of experimental liver fibrosis and might contribute to fibrolysis. Liver Int 2004;24:492-501.
28. Yu Q, Stamenkovic I. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes Dev 2000;14:163-176.
29. Cao Q, Mak KM, Lieber CS. Dilinoleoylphosphatidylcholine prevents transforming growth factor-beta1-mediated collagen accumulation in cultured rat hepatic stellate cells. J Lab Clin Med 2002;139:202-210.
30. Han YP, Zhou L, Wang J, et al. Essential role of matrix metalloproteinases in interleukin-1-induced myofibroblastic activation of hepatic stellate cell in collagen. J Biol Chem 2004;279:4820-4828.
31. Watanabe T, Niioka M, Hozawa S, et al. Gene expression of interstitial collagenase in both progressive and recovery phase of rat liver fibrosis induced by carbon tetrachloride. J Hepatol 2000;33:224-235.
32. Yan S, Chen GM, Yu CH, et al. Expression pattern of matrix metalloproteinases-13 in a rat model of alcoholic liver fibrosis. Hepatobiliary Pancreat Dis Int 2005;4:569-572.
33. Benyon RC, Arthur MJ. Extracellular matrix degradation and the role of hepatic stellate cells. Semin Liver Dis 2001;21:373-384.
34. Issa R, Zhou X, Trim N, et al. Mutation in collagen-1 that confers resistance to the action of collagenase results in failure of recovery from CCl4-induced liver fibrosis, persistence of activated hepatic stellate cells, and diminished hepatocyte regeneration. FASEB J 2003;17:47-49.
35. Preaux AM, D'ortho MP, Bralet MP, et al. Apoptosis of human hepatic myofibroblasts promotes activation of matrix metalloproteinase-2. Hepatology 2002;36:615-622.
36. Roderfeld M, Weiskirchen R, Wagner S, et al. Inhibition of hepatic fibrogenesis by matrix metalloproteinase-9 mutants in mice. FASEB J 2006;20:444-454.
37. Yan J, Erdem H, Li R, et al. Steroid receptor coactivator-3/AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expression. Cancer Res 2008;68:5460-5468.
38. Wynn TA. Cellular and molecular mechanisms of fibrosis. J Pathol 2008;214:199-210.
39. Ueda S, Yamanoi A, Hishikawa Y, et al. Transforming growth factor-beta1 released from the spleen exerts a growth inhibitory effect on liver regeneration in rats. Lab Invest 2003;83:1595-1603.
40. Samson CM, Schrum LW, Bird MA, et al. Hepatocyte apoptosis: is transforming growth factor-B1 the kiss of death? Hepatology 1993;18:1536-1537.
41. Samson CM, Schrum LW, Bird MA, et al. Transforming growth factor-beta1 induces hepatocyte apoptosis by a c-Jun independent mechanism. Surgery 2002;132:441-449.
42. Gressner AM, Weiskirchen R, Breitkopf K, et al. Roles of TGF-beta in hepatic fibrosis. Front Biosci 2002;7:793-807.
43. Cocolakis E, Dai M, Drevet L, et al. Smad signaling antagonizes STAT5-mediated gene transcription and mammary epithelial cell differentiation. J Biol Chem 2008;283:1293-1307.
44. Jungert K, Buck A, Buchholz M, et al. Smad-Sp1 complexes mediate TGFb-induced early transcription of oncogenic Smad7 in pancreatic cancer cells. Carcinogenesis 2006;27:2392-2401.
45. Mithani SK, Balch GC, Shiou SR, et al. Smad3 has a critical role in TGF-γ-mediated growth inhibition and apoptosis in colonic epithelial cells. J Surg Res 2004;117:296-305.