Novel indoline-based acyl-CoA: cholesterol acyltransferase inhibitor: Effects of introducing a methanesulfonamide group on physicochemical properties and biological activities

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 16, 2009, Pages 6020-6031

  Shoji, Yoshimichi ^a   Takahashi, Kenji ^a   Ohta, Masaru ^a   Kasai, Masayasu ^a   Kunishiro, Kazuyoshi ^a   Kanda, Mamoru ^a   Yogai, Satoko ^a   Takeuchi, Yasuo ^b   Shirahase, Hiroaki ^a  

^a Research Laboratories   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

Author keywords

ACAT inhibitor; Anti foam cell formation; Lipophilicity; Methanesulfonamide derivatives; Pactimibe

Indexed keywords

CHOLESTEROL; CHOLESTEROL ACYLTRANSFERASE; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; METHANESULFONAMIDE DERIVATIVE; N (1 ETHYL 5 METHANESULFONYLAMINO 4,6 DIMETHYLINDOLIN 7 YL) 2,2 DIMETHYLPROPANAMIDE; PACTIMIBE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; BIOLOGICAL ACTIVITY; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; FOAM CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPERLIPIDEMIA; LIPOPHILICITY; LIVER MICROSOME; MALE; MASS SPECTROMETRY; NONHUMAN; PHYSICAL CHEMISTRY; PROTON NUCLEAR MAGNETIC RESONANCE; RABBIT; RAT;

AMIDES; ANIMALS; ANTICHOLESTEREMIC AGENTS; CELL LINE, TUMOR; ENZYME INHIBITORS; HUMANS; INDOLEACETIC ACIDS; INDOLES; MALE; MICE; RATS; RATS, SPRAGUE-DAWLEY; STEROL O-ACYLTRANSFERASE; SULFONAMIDES;

MUS; RATTUS;

EID: 68149110226     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.06.047     Document Type: Article

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