Cerebellar deficits in schizophrenia are associated with executive dysfuntion

NeuroReport

Volumn 19, Issue 15, 2008, Pages 1513-1517

  Segarra, Nuria ^a,b,c   Bernardo, Miguel ^a,b,c,d   Valdes, Manuel ^b,c,d   Caldu, Xavier ^d   Falcón, Carlos ^b,c,d   Rami, Lorena ^b,c   Bargallo, Nuria ^b,c,d   Parramon, Genma ^b   Junque, Carme ^c,d  

^a Programme Schizophrenia Clinic   (Spain)

^b HOSPITAL CLÍNIC   (Spain)

^c INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^d UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Cerebellum; Executive function; Grey matter volume; MRI; Voxel based morphometry; White matter volume

Indexed keywords

ADULT; ARTICLE; BRAIN DYSFUNCTION; CEREBELLUM DISEASE; CEREBELLUM VERMIS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GRAY MATTER; HUMAN; MALE; MEMORY DISORDER; NEUROPATHOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SCHIZOPHRENIA; WHITE MATTER; WORKING MEMORY;

ADOLESCENT; ADULT; BRAIN; BRIEF PSYCHIATRIC RATING SCALE; CEREBELLUM; DOMINANCE, CEREBRAL; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; NEUROPSYCHOLOGICAL TESTS; SCHIZOPHRENIA;

EID: 53549129727     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNR.0b013e3283108bd8     Document Type: Article

References (25)

1. Kelly RM, Strick PL. Cerebellar loops with motor cortex and prefrontal cortex of a nonhuman primate. J Neurosci 2003; 23:8432-3444.
2. Middleton FA, Strick PL. Anatomical evidence for cerebellar and basal ganglia involvement in higher cognitive function. Science 1994; 266: 458-461.
3. Schmahmann JD, Sherman JC. The cerebellar cognitive affective syndrome. Brain 1998; 121(Pt 4)561-579.
4. Weinberger DR, Kleinman JE, Luchins DJ, Bigelow LB, Wyatt RJ. Cerebellar pathology in schizophrenia: a controlled postmortem study. Am J Psychiatry 1980; 137:359-361.
5. Bottmer C, Bachmann S, Pantel J, Essig M, Amann M, Schad LR, et al. Reduced cerebellar volume and neurological soft signs in first-episode schizophrenia. Psychiatry Res 2005; 140:239-250.
6. Joyal CC, Pennanen C, Tiihonen E, Laakso MP, Tiihonen J, Aronen HJ. MRI volumetry of the vermis and the cerebellar hemispheres in men with schizophrenia. Psychiatry Res 2004; 131:115-124.
7. Lee KH, Farrow TF, Parks RW, Newton LD, Mir NU, Egleston PN, et al. Increased cerebellar vermis white-matter volume in men with schizophrenia. J Psychiatr Res 2006; 41:645-651.
8. Staal WG, Hulshoff Pol HE, Schnack HG, Hoogendoorn ML, Jellema K, Kahn RS. Structural brain abnormalities in patients with schizophrenia and their healthy siblings. Am J Psychiatry 2000; 157:416-421.
9. Nopoulos PC, Ceilley JW, Gailis EA, Andreasen NC. An MRI study of cerebellar vermis morphology in patients with schizophrenia: evidence in support of the cognitive dysmetria concept. Biol Psychiatry 1999; 46:703-711.
10. Levitt JJ, McCarley RW, Nestor PG, Petrescu C, Donnino R, Hirayasu Y, et al. Quantitative volumetric MRI study of the cerebellum and vermis in schizophrenia: clinical and cognitive correlates. Am J Psychiatry 1999; 156:1105-1107.
11. Ashburner J, Friston KJ. Voxel-based morphometry-the methods. Neuroimage 2000; 11:805-821.
12. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV Axis I Disorders-Clinical Version. Washington: Am Psychiat Press; 1997.
13. Kay SR, Fiszbein A, Vital-Herne M, Fuentes LS. The Positive and Negative Syndrome Scale-Spanish adaptation. J Nerv Ment Dis 1990; 178:510-517.
14. Oldfield. The assessment and analysis of handedness. The Edinburgh Inventory. Neuropsychologia 1971; 9:97-114.
15. Wechsler D. Escala de inteligencia de Wechsler para adultos-WAIS III, Spanish version. Madrid: TEA Ediciones; 1999.
16. Reitan RM, Wolfson D. The Halstead-Reitan Neuropsychological test battery: theory and clinical interpretation. Neuropsychol Press 1985.
17. Borkowski JG, Benton AL, Spreen O. Word fluency and brain damage. Neuropsychologia 1967; 5:135-140.
18. Heaton RK. A Manual for the Wisconsin Card Sorting Test. Odessa: Psychological Assessment Res; 1981.
19. Chua SE, Cheung C, Cheung V, Tsang JT, Chen EY, Wong JC, et al. Cerebral grey, white matter and csf in never-medicated, first-episode schizophrenia. Schizophr Res 2007; 89:12-21.
20. Okugawa G, Nobuhara K, Minami T, Takase K, Sugimoto T, Saito Y, et al. Neural disorganization in the superior cerebellar peduncle and cognitive abnormality in patients with schizophrenia: a diffusion tensor imaging study. Prog Neuropsychopharmacol Biol Psychiatry 2006; 30:1408-1412.
21. Haroutunian V, Davis KL. Introduction to the special section: myelin and oligodendrocyte abnormalities in schizophrenia. Int J Neuropsychopharmacol 2007; 10:499-502.
22. Ross CA, Margolis RL, Reading SA, Pletnikov M, Coyle JT. Neurobiology of schizophrenia. Neuron 2006; 52:139-153.
23. Desmond JE, Chen SH, DeRosa E, Pryor MR, Pfefferbaum A, Sullivan EV. Increased frontocerebellar activation in alcoholics during verbal working memory: an fMRI study. Neuroimage 2003; 19:1510-1520.
24. Bellebaum C, Daum I. Cerebellar involvement in executive control. Cerebellum 2007; 6:184-192.
25. Andreasen NC, Pierson R. The role of the cerebellum in schizophrenia. Biol Psychiatry 2008; 64:81-88.