Abnormal patterns of regional cerebral blood flow in schizophrenia with primary negative symptoms during an effortful auditory recognition task

American Journal of Psychiatry

Volumn 158, Issue 11, 2001, Pages 1797-1808

  Lahti, A C ^a   Holcomb, H H ^a   Medoff, D R ^a   Weiler, M A ^a   Tamminga, C A ^a   Carpenter W T , Jr ^a  

^a MARYLAND PSYCHIATRIC RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; AUDITORY DISCRIMINATION; BRAIN BLOOD FLOW; BRAIN METABOLISM; CLINICAL ARTICLE; DECISION MAKING; FEMALE; FRONTAL CORTEX; HUMAN; MALE; PARIETAL LOBE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SCHIZOPHRENIA; SENSORIMOTOR FUNCTION; TASK PERFORMANCE;

ADULT; ANTIPSYCHOTIC AGENTS; AUDITORY PERCEPTION; CEREBROVASCULAR CIRCULATION; FEMALE; FRONTAL LOBE; HUMANS; MALE; PARIETAL LOBE; PSYCHOMOTOR PERFORMANCE; REACTION TIME; RECOGNITION (PSYCHOLOGY); SCHIZOPHRENIA; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0035155660     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/appi.ajp.158.11.1797     Document Type: Article

References (75)

1. Schizophrenia
2. Neuropsychiatric aspects of schizophrenia
3. Lifestyle and Age of Schizophrenics: A Catamnestic Long-Term Study Into Old Age
4. European long-term followup studies of schizophrenia
5. Course types in schizophrenia: An analysis of European and American studies
6. Longitudinal studies of schizophrenic patients
7. A selective review of recent North American long-term followup studies of schizophrenia
8. The diagnosis and understanding of schizophrenia, part III: Speculations on the processes that underlie schizophrenic symptoms and signs
9. Negative v positive schizophrenia: Definition and validation
10. Neuropsychological impairments in deficit vs nondeficit forms of schizophrenia
11. Domains of psychopathology relevant to the study of etiology and treatment in schizophrenia
12. Evidence of dysfunction of a prefrontal-limbic network in schizophrenia: A magnetic resonance imaging and regional cerebral blood flow study of discordant monozygotic twins
13. Strong inference, theory testing, and the neuroanatomy of schizophrenia
14. The two-syndrome concept: Origins and current status
15. A unitary model of schizophrenia: Bleuler's "fragmented phrene" as schizencephaly
16. Family history and deficit form in schizophrenia
17. Sibling correlation of deficit syndrome in the Irish Study of High-Density Schizophrenia Families
18. Risk factors for the deficit syndrome of schizophrenia
19. Association of abnormal smooth pursuit eye movements with the deficit syndrome in schizophrenic patients
20. Eye tracking disorder in schizophrenia is characterized by specific ocular motor defects and is associated with the deficit syndrome
21. A comparison of plasma homovanillic acid in the deficit and nondeficit subtypes of schizophrenia
22. Plasma 3-methoxy-4-hydroxyphenylglycol and homovanillic acid measurements in deficit and nondeficit forms of schizophrenia
23. Limbic system abnormalities identified in schizophrenia using positron emission tomography with fluorodeoxyglucose and neocortical alterations with deficit syndrome
24. Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia
25. Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia
26. Patterns of cerebral blood flow in schizophrenia
27. Regional brain activity in chronic schizophrenic patients during the performance of a verbal fluency task
28. Resting cerebral glucose metabolism in first-episode and previously treated patients with schizophrenia relates to clinical features
29. A functional neuroanatomy of hallucinations in schizophrenia
30. Schizophrenia and cognitive dysmetria: A positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry
31. Auditory attentional deficits in patients with schizophrenia: A positron emission tomography study
32. 2O PET study during single-trial Stroop task performance
33. Functional hypofrontality and working memory dysfunction in schizophrenia
34. Brain activations in schizophrenia during a graded memory task studied with functional neuroimaging
35. Hypofrontality in neuroleptic-naive patients and in patients with chronic schizophrenia: Assessment with xenon 133 single-photon emission computed tomography and the Tower of London
36. Functional imaging of memory retrieval in deficit vs nondeficit schizophrenia
37. Brain activation patterns in schizophrenic and comparison volunteers during a matched-performance auditory recognition task
38. The Schedule for the Deficit Syndrome: An instrument for research in schizophrenia
39. The Brief Psychiatric Rating Scale
40. 15O, II: Implementation and validation
41. Detecting activations in PET and fMRI: Levels of inference and power
42. A three-dimensional statistical analysis for CBF activation studies in human brain
43. Cerebral blood flow relationships associated with a difficult tone recognition task in trained normal volunteers
44. Persistence of haloperidol in human brain tissue
45. Persistent increase in striatal dopamine stimulated adenylate cyclase activity persists for more than 6 months but disappears after 1 year following withdrawal from 18 months cis-flupenthixol intake
46. Negative symptoms and hypofrontality in chronic schizophrenia
47. Three clinical syndromes of schizophrenia in untreated subjects: Relation to brain glucose activity measured by positron emission tomography
48. Regional cerebral blood flow and negative/positive symptoms in 24 drug-naive schizophrenics
49. Positive and negative symptoms and regional cerebral perfusion in antipsychotic-naive schizophrenic patients: A high-resolution SPECT study
50. Clinical symptoms and regional cerebral blood flow in schizophrenia
51. Regional cerebral blood flow in patients with schizophrenia: Relevance to symptom structures
52. Functional sites of neuroleptic drug action in the human brain: PET/FDG studies with and without haloperidol
53. Frontal-subcortical circuits and human behavior
54. Frontal lobe and frontal-striatal substrates for different forms of human cognitive flexibility
55. Experimental neuropsychological studies of frontal lobe functions
56. Neuroimaging and activation of the frontal lobes
57. Components of performance
58. Deficits of visual attention and saccadic eye movements after lesions of parieto-occipital cortex in monkeys
59. The representation of visuomotor space in the parietal lobe of the monkey
60. Electrocortical substrates of visual selective attention
61. Dissociation of object and spatial visual processing pathways in human extrastriate cortex
62. A PET study of visuospatial attention
63. PET studies of parietal involvement in spatial attention: Comparison of different task types
64. High resolution evoked potential imaging of the cortical dynamics of human working memory
65. Impairments on neuropsychologic tests of temporohippocampal and frontohippocampal functions and word fluency in remitting schizophrenia and affective disorders
66. Higher cortical functions in normals and in schizophrenia: A selective review
67. Auditory working memory and Wisconsin Card Sorting Test performance in schizophrenia
68. Attentional impairments in deficit and nondeficit forms of schizophrenia
69. Interstitial cells of the white matter in the inferior parietal cortex in schizophrenia: An unbiased cell-counting study
70. Ionotropic glutamate receptors and expression of N-methylaspartate receptor subunits in subregions of human hippocampus: Effects of schizophrenia
71. What are the functional consequences of neurocognitive deficits in schizophrenia?
72. Two-year outcome in first-episode schizophrenia: Predictive value of symptoms for quality of life