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Volumn 17, Issue 2, 2009, Pages 86-92

Antimutagenic effect of phenethyl isothiocyanate

Author keywords

2 amino 3 methylimidazo 4,5 quinoline; Aflatoxin B1; Ames test; Comet assay; Micronucleus test; N nitroso N methylurea; Phenethyl isothiocyanate

Indexed keywords


EID: 68149083099     PISSN: 12107778     EISSN: None     Source Type: Journal    
DOI: 10.21101/cejph.a3526     Document Type: Article
Times cited : (3)

References (46)
  • 1
    • 0142166328 scopus 로고    scopus 로고
    • Cancer chemoprevention with dietary phytochemicals
    • Oct;
    • Surh YJ. Cancer chemoprevention with dietary phytochemicals. Nat Rev Canc. 2003 Oct; 3(10):768-80.
    • (2003) Nat Rev Canc , vol.3 , Issue.10 , pp. 768-780
    • Surh, Y.J.1
  • 2
    • 33646028804 scopus 로고    scopus 로고
    • Molecular targets of dietary agents for prevention and therapy of cancer
    • May 14;
    • Aggarwal BB, Shishodia S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol. 2006 May 14;71(10):1397-421.
    • (2006) Biochem Pharmacol , vol.71 , Issue.10 , pp. 1397-1421
    • Aggarwal, B.B.1    Shishodia, S.2
  • 3
    • 27844439469 scopus 로고    scopus 로고
    • Overview of mechanisms of cancer chemopreventive agents
    • Dec 11;
    • De Flora S, Ferguson LR. Overview of mechanisms of cancer chemopreventive agents. Mutat Res. 2005 Dec 11;591 (1-2):8-15.
    • (2005) Mutat Res , vol.591 , Issue.1-2 , pp. 8-15
    • De Flora, S.1    Ferguson, L.R.2
  • 4
    • 0033980370 scopus 로고    scopus 로고
    • Progress in cancer chemoprevention: Development of diet-derived chemopreventive agents
    • Feb;
    • Kelloff GJ, Crowell JA, Steele VE, Lubet RA, Malone WA, Boone Ch W, et al. Progress in cancer chemoprevention: development of diet-derived chemopreventive agents. J Nutr. 2000 Feb; 130(2S Suppl):467S-71S.
    • (2000) J Nutr , vol.130 , Issue.2S SUPPL.
    • Kelloff, G.J.1    Crowell, J.A.2    Steele, V.E.3    Lubet, R.A.4    Malone, W.A.5    Boone, C.W.6
  • 5
    • 5644283296 scopus 로고    scopus 로고
    • Role of chemopreventive agents in cancer therapy
    • Nov 25;
    • Dorai T, Aggarwal BB. Role of chemopreventive agents in cancer therapy. Cancer Lett. 2004 Nov 25;215(2): 129-40.
    • (2004) Cancer Lett , vol.215 , Issue.2 , pp. 129-140
    • Dorai, T.1    Aggarwal, B.B.2
  • 11
    • 0030411296 scopus 로고    scopus 로고
    • Vegetables, fruit, and cancer prevention: A review
    • Oct;
    • Steinmetz KA, Potter JD. Vegetables, fruit, and cancer prevention: a review. J Am Diet Assoc. 1996 Oct; 96(10):1027-39.
    • (1996) J Am Diet Assoc , vol.96 , Issue.10 , pp. 1027-1039
    • Steinmetz, K.A.1    Potter, J.D.2
  • 12
    • 0034538640 scopus 로고    scopus 로고
    • Inhibition of carcinogenesis by isothiocyanates
    • Aug-Nov;
    • Hecht SS. Inhibition of carcinogenesis by isothiocyanates. Drug Metab Rev. 2000 Aug-Nov;32(3-4):395-411.
    • (2000) Drug Metab Rev , vol.32 , Issue.3-4 , pp. 395-411
    • Hecht, S.S.1
  • 13
    • 0032980125 scopus 로고    scopus 로고
    • Chemoprevention of cancer by isothiocyanates, modifiers of carcinogen metabolism
    • Mar;
    • Hecht SS. Chemoprevention of cancer by isothiocyanates, modifiers of carcinogen metabolism. J Nutr. 1999 Mar; 129(3):768S-774S.
    • (1999) J Nutr , vol.129 , Issue.3
    • Hecht, S.S.1
  • 14
    • 5144230473 scopus 로고    scopus 로고
    • Cancer-preventive isothiocyanates: Measurement of human exposure and mechanism of action
    • Nov 2;
    • Zhang Y. Cancer-preventive isothiocyanates: measurement of human exposure and mechanism of action. Mutat Res. 2004 Nov 2;555(1-2): 173-90.
    • (2004) Mutat Res , vol.555 , Issue.1-2 , pp. 173-190
    • Zhang, Y.1
  • 15
    • 68149154310 scopus 로고    scopus 로고
    • Chemopreventive potential of compounds in cruciferous vegetables
    • Baer-Dubowska W, Bartoszek AB, Gianti DM, editors, Boca Raton: CRC Taylor&Francis group;
    • Vang O. Chemopreventive potential of compounds in cruciferous vegetables. In: Baer-Dubowska W, Bartoszek AB, Gianti DM, editors. Carcinogenic and anticarcinogenic food components. Boca Raton: CRC Taylor&Francis group; 2006. p. 303-28.
    • (2006) Carcinogenic and anticarcinogenic food components , pp. 303-328
    • Vang, O.1
  • 16
    • 33645303201 scopus 로고    scopus 로고
    • Effects of benzyl and phenethyl isothiocyanate on P450s 2A6 and 2A13: Potential for chemoprevention in smokers
    • Apr;
    • Von Weymarn LB, Chun JA, Hollenberg PR Effects of benzyl and phenethyl isothiocyanate on P450s 2A6 and 2A13: potential for chemoprevention in smokers. Carcinogenesis. 2006 Apr; 27(4):782-90.
    • (2006) Carcinogenesis , vol.27 , Issue.4 , pp. 782-790
    • Von Weymarn, L.B.1    Chun, J.A.2    Hollenberg, P.R.3
  • 17
    • 0035076706 scopus 로고    scopus 로고
    • Chemoprevention of lung cancer by isothiocyanates and their conjugates in A/J mouse
    • Apr-May;
    • Chung FL. Chemoprevention of lung cancer by isothiocyanates and their conjugates in A/J mouse. Exp Lung Res. 2001 Apr-May;27(3):319-30.
    • (2001) Exp Lung Res , vol.27 , Issue.3 , pp. 319-330
    • Chung, F.L.1
  • 18
    • 24944480252 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice
    • Sep 15;
    • Conaway CC, Wang CX, Pittman B, Yang YM, Schwartz JE, Tian D, et al. Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice. Cancer Res. 2005 Sep 15;65(18):8548-57.
    • (2005) Cancer Res , vol.65 , Issue.18 , pp. 8548-8557
    • Conaway, C.C.1    Wang, C.X.2    Pittman, B.3    Yang, Y.M.4    Schwartz, J.E.5    Tian, D.6
  • 19
    • 0345303968 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate inhibits nitrosamine carcinogenesis in a model study of oral cancer
    • Dec 30;
    • Solt DB, Chang K, Helenowski I, Rademaker AW. Phenethyl isothiocyanate inhibits nitrosamine carcinogenesis in a model study of oral cancer. Cancer Lett. 2003 Dec 30;202(2):147-52.
    • (2003) Cancer Lett , vol.202 , Issue.2 , pp. 147-152
    • Solt, D.B.1    Chang, K.2    Helenowski, I.3    Rademaker, A.W.4
  • 21
    • 33750448018 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of the mitochondrial membrane potential
    • Nov;
    • Xiao D, Lew KL, Zeng Y, Xiao H, Marynowski SW, Dhir R, et al. Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of the mitochondrial membrane potential. Carcinogenesis. 2006 Nov; 27(11):2223-34.
    • (2006) Carcinogenesis , vol.27 , Issue.11 , pp. 2223-2234
    • Xiao, D.1    Lew, K.L.2    Zeng, Y.3    Xiao, H.4    Marynowski, S.W.5    Dhir, R.6
  • 22
    • 1942451371 scopus 로고    scopus 로고
    • Selected isothiocyanates rapidly induce growth inhibition of cancer cells
    • Oct;
    • Zhang Y, Tang L, Gonzalez V. Selected isothiocyanates rapidly induce growth inhibition of cancer cells. Mol Cancer Ther. 2003 Oct; 2(10):1045-52.
    • (2003) Mol Cancer Ther , vol.2 , Issue.10 , pp. 1045-1052
    • Zhang, Y.1    Tang, L.2    Gonzalez, V.3
  • 23
    • 4444231754 scopus 로고    scopus 로고
    • Dietary organic isothiocyanates are cytotoxic in human breast cancer MCF-7 and mammary epithelial MCF-12A cell lines
    • Sep;
    • Tseng E, Scott-Ramsay EA, Morris ME. Dietary organic isothiocyanates are cytotoxic in human breast cancer MCF-7 and mammary epithelial MCF-12A cell lines. Exp Biol Med. 2004 Sep; 229(8):835-42.
    • (2004) Exp Biol Med , vol.229 , Issue.8 , pp. 835-842
    • Tseng, E.1    Scott-Ramsay, E.A.2    Morris, M.E.3
  • 25
    • 33947244444 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate inhibits angiogenesis in vitro and ex vivo
    • Mar 1;
    • Xiao D, Singh SV. Phenethyl isothiocyanate inhibits angiogenesis in vitro and ex vivo. Cancer Res. 2007 Mar 1; 67(5):2239-46.
    • (2007) Cancer Res , vol.67 , Issue.5 , pp. 2239-2246
    • Xiao, D.1    Singh, S.V.2
  • 26
    • 33846217828 scopus 로고    scopus 로고
    • Dual action on promoter demethylation and chromatin by an isothiocyanate restored GSTP1 silenced in prostate cancer
    • Jan;
    • Wang LG, Beklemisheva A, Liu XM, Ferrari AC, Feng J, Chiao JW. Dual action on promoter demethylation and chromatin by an isothiocyanate restored GSTP1 silenced in prostate cancer. Mol Carcinog. 2007 Jan; 46(1):24-31.
    • (2007) Mol Carcinog , vol.46 , Issue.1 , pp. 24-31
    • Wang, L.G.1    Beklemisheva, A.2    Liu, X.M.3    Ferrari, A.C.4    Feng, J.5    Chiao, J.W.6
  • 27
  • 28
    • 0030060455 scopus 로고    scopus 로고
    • Effects of phenethyl isothiocyanate on metabolism and on genotoxicity of dimethylnitrosamine and 2-amino-l-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP)
    • Feb 19;
    • Knasmüller S, Friesen MD, Holme JA, Alexander J, Sanyal R, Kassie F, et al. Effects of phenethyl isothiocyanate on metabolism and on genotoxicity of dimethylnitrosamine and 2-amino-l-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP). Mutat Res. 1996 Feb 19;350(1):93-102.
    • (1996) Mutat Res , vol.350 , Issue.1 , pp. 93-102
    • Knasmüller, S.1    Friesen, M.D.2    Holme, J.A.3    Alexander, J.4    Sanyal, R.5    Kassie, F.6
  • 29
    • 0030519429 scopus 로고    scopus 로고
    • Effects of isothiocyanates on cytochrome P450 1A1 and 1A2 activity and on the mutagenicity of heterocyclic amines
    • Nov-Dec;
    • Hamilton SM, Teel RW. Effects of isothiocyanates on cytochrome P450 1A1 and 1A2 activity and on the mutagenicity of heterocyclic amines. Anticancer Res. 1996 Nov-Dec;16(6B):3597-602.
    • (1996) Anticancer Res , vol.16 , Issue.6 B , pp. 3597-3602
    • Hamilton, S.M.1    Teel, R.W.2
  • 30
    • 0030596125 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate modulates clastogenicity of mitomycin C and cyclophosphamide in vivo
    • Dec 20;
    • Sen S, Mukherjee A, Agarwal K, Sharma A. Phenethyl isothiocyanate modulates clastogenicity of mitomycin C and cyclophosphamide in vivo. Mutat Res. 1996 Dec 20;37(3-4): 159-64.
    • (1996) Mutat Res , vol.37 , Issue.3-4 , pp. 159-164
    • Sen, S.1    Mukherjee, A.2    Agarwal, K.3    Sharma, A.4
  • 31
    • 33748761674 scopus 로고    scopus 로고
    • Protective effects of isothiocyanates towards N-nitrosamine-induced DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay
    • Nov-Dec;
    • Arranz N, Haza AI, Garcia A, Möller L, Rafter J, Morales P. Protective effects of isothiocyanates towards N-nitrosamine-induced DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay. J Appl Toxicol. 2006 Nov-Dec;26(6):493-9.
    • (2006) J Appl Toxicol , vol.26 , Issue.6 , pp. 493-499
    • Arranz, N.1    Haza, A.I.2    Garcia, A.3    Möller, L.4    Rafter, J.5    Morales, P.6
  • 32
    • 0016685233 scopus 로고
    • Methods for detection of carcinogens and mutagens with Salmonella/mammalian-microsome mutagenicity test
    • Dec;
    • Ames BN, McCann J, Yamasaki E. Methods for detection of carcinogens and mutagens with Salmonella/mammalian-microsome mutagenicity test. Mutat Res. 1975 Dec; 31(6):347-64.
    • (1975) Mutat Res , vol.31 , Issue.6 , pp. 347-364
    • Ames, B.N.1    McCann, J.2    Yamasaki, E.3
  • 33
    • 0020533372 scopus 로고
    • Revised methods for the Salmonella mutagenicity test
    • May;
    • Maron DM, Ames BN. Revised methods for the Salmonella mutagenicity test. Mutat Res. 1983 May; 113(3-4):173-215.
    • (1983) Mutat Res , vol.113 , Issue.3-4 , pp. 173-215
    • Maron, D.M.1    Ames, B.N.2
  • 34
    • 0004958237 scopus 로고
    • The Ames method. V: Methods for the biological monitoring ot the genotoxic effects of environmental factors - standard methodology
    • In Czech
    • Černá M, Dobiáš L, Hájek V. The Ames method. V: Methods for the biological monitoring ot the genotoxic effects of environmental factors - standard methodology. Acta Hyg Epidemiol Microbiol. 1989; Suppl 20:33-56. (In Czech.)
    • (1989) Acta Hyg Epidemiol Microbiol , Issue.SUPPL. 20 , pp. 33-56
    • Černá, M.1    Dobiáš, L.2    Hájek, V.3
  • 35
    • 0016437314 scopus 로고
    • The micronucleus test
    • Feb;
    • Schmid W. The micronucleus test. Mutat Res. 1975 Feb; 31(1):9-15.
    • (1975) Mutat Res , vol.31 , Issue.1 , pp. 9-15
    • Schmid, W.1
  • 36
    • 0023919963 scopus 로고
    • A simple technique for quantitation of low levels of DNA damage in individual cells
    • Mar;
    • Singh NP, McCoy MT, Tice RR, Schneider EL. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res. 1988 Mar; 175(1): 184-91.
    • (1988) Exp Cell Res , vol.175 , Issue.1 , pp. 184-191
    • Singh, N.P.1    McCoy, M.T.2    Tice, R.R.3    Schneider, E.L.4
  • 39
    • 0343517520 scopus 로고    scopus 로고
    • Genotoxic effects of allyl isothiocyanate (AITC) and phenethyl isothiocyanate (PEITC)
    • Jul 3;
    • Kassie F, Knasmuller S. Genotoxic effects of allyl isothiocyanate (AITC) and phenethyl isothiocyanate (PEITC). Chem Biol Interact. 2000 Jul 3;127(2):163-80.
    • (2000) Chem Biol Interact , vol.127 , Issue.2 , pp. 163-180
    • Kassie, F.1    Knasmuller, S.2
  • 40
    • 0028326168 scopus 로고
    • Anticarcinogenic activities of organic isothiocyanates: Chemistry and mechanisms
    • Apr 1;
    • Zhang Y, Talalay P. Anticarcinogenic activities of organic isothiocyanates: chemistry and mechanisms. Cancer Res. 1994 Apr 1;54(7 Suppl): 1976S-1981S.
    • (1994) Cancer Res , vol.54 , Issue.7 SUPPL.
    • Zhang, Y.1    Talalay, P.2
  • 41
    • 0032530999 scopus 로고    scopus 로고
    • Essential role of p53 in phenethyl isothiocyanate-induced apoptosis
    • Sep 15;
    • Huang C, Ma WY, Li J, Hecht SS, Dong Z. Essential role of p53 in phenethyl isothiocyanate-induced apoptosis. Cancer Res. 1998 Sep 15;58(18):4102-6.
    • (1998) Cancer Res , vol.58 , Issue.18 , pp. 4102-4106
    • Huang, C.1    Ma, W.Y.2    Li, J.3    Hecht, S.S.4    Dong, Z.5
  • 42
    • 4344649449 scopus 로고    scopus 로고
    • Ingestion of an isothiocyanate metabolite from cruciferous vegetables inhibits growth of human prostate cancer cell
    • Aug;
    • Chiao JW, Wu H, Ramaswamy G, Conaway CC, Chung FL, Wang L, et al. Ingestion of an isothiocyanate metabolite from cruciferous vegetables inhibits growth of human prostate cancer cell. Carcinogenesis. 2004 Aug; 25(8): 1403-8.
    • (2004) Carcinogenesis , vol.25 , Issue.8 , pp. 1403-1408
    • Chiao, J.W.1    Wu, H.2    Ramaswamy, G.3    Conaway, C.C.4    Chung, F.L.5    Wang, L.6
  • 43
    • 0034040868 scopus 로고    scopus 로고
    • Antibacterial mechanism of allyl isothiocyanate
    • Jun;
    • Lin CM, Preston JF, Wei CI. Antibacterial mechanism of allyl isothiocyanate. J Food Prot. 2000 Jun; 63(6):727-34.
    • (2000) J Food Prot , vol.63 , Issue.6 , pp. 727-734
    • Lin, C.M.1    Preston, J.F.2    Wei, C.I.3
  • 44
    • 41149086283 scopus 로고    scopus 로고
    • Protective effects of isothiocyanates alone or in combination with vitamin C towards N-nitrosodibutylamine or N-nitrosopiperidine-induced oxidative DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay
    • Mar;
    • Garcia A, Haza AI, Arranz N, Rafter J, Morales P. Protective effects of isothiocyanates alone or in combination with vitamin C towards N-nitrosodibutylamine or N-nitrosopiperidine-induced oxidative DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay. J Appl Toxicol. 2008 Mar; 28(2):196-204.
    • (2008) J Appl Toxicol , vol.28 , Issue.2 , pp. 196-204
    • Garcia, A.1    Haza, A.I.2    Arranz, N.3    Rafter, J.4    Morales, P.5
  • 45
    • 0036235637 scopus 로고    scopus 로고
    • Isothiocyanates: Mechanism of cancer chemopreventive action
    • Apr;
    • Thornalley PJ. Isothiocyanates: mechanism of cancer chemopreventive action. Anticancer Drugs. 2002 Apr; 13(4):331-8.
    • (2002) Anticancer Drugs , vol.13 , Issue.4 , pp. 331-338
    • Thornalley, P.J.1
  • 46
    • 5144230473 scopus 로고    scopus 로고
    • Cancer-preventive isothiocyanates: Measurement of human exposure and mechanism of action
    • Nov 2;
    • Zhang Y. Cancer-preventive isothiocyanates: measurement of human exposure and mechanism of action. Mutat Res. 2004 Nov 2;555(1-2): 173-190.
    • (2004) Mutat Res , vol.555 , Issue.1-2 , pp. 173-190
    • Zhang, Y.1


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