Protective effects of isothiocyanates alone or in combination with vitamin C towards N-nitrosodibutylamine or N-nitrosopiperidine-induced oxidative DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay

Journal of Applied Toxicology

Volumn 28, Issue 2, 2008, Pages 196-204

  García, Almudena ^a   Haza, Ana I ^a   Arranz, Nuria ^a   Rafter, Joseph ^b   Morales, Paloma ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Comet assay; Isothiocyanates compounds; NDBA; NPIP; Vitamin C

Indexed keywords

1 NITROSOPIPERIDINE; 3 INDOLEMETHANOL; 4 NITROPHENOL; ASCORBIC ACID; COUMARIN; CYTOCHROME P450; DIBUTYLNITROSAMINE; DNA FORMAMIDOPYRIMIDINE GLYCOSYLASE; ISOTHIOCYANIC ACID DERIVATIVE; OXYGENASE;

APURINIC SITE; APYRIMIDINIC SITE; ARTICLE; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND; DRUG INHIBITION; ENZYME ACTIVITY; GENOTOXICITY; HUMAN; HUMAN CELL; HYDROXYLATION; LIPID OXIDATION; PRIORITY JOURNAL;

ANTICARCINOGENIC AGENTS; ARYL HYDROCARBON HYDROXYLASES; ASCORBIC ACID; CARCINOGENS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; COMET ASSAY; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP2E1; DNA BREAKS; DNA-FORMAMIDOPYRIMIDINE GLYCOSYLASE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; INDOLES; ISOTHIOCYANATES; LIVER NEOPLASMS; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; NITROSAMINES; OXIDATIVE STRESS;

EID: 41149086283     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1270     Document Type: Article

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