Magnetic Resonance Imaging of Mesenchymal Stem Cells Labeled with Dual (MR and Fluorescence) Agents in Rat Spinal Cord Injury

Academic Radiology

Volumn 16, Issue 9, 2009, Pages 1142-1154

  Shen, Jun ^a   Zhong, Xiao Mei ^a   Duan, Xiao Hui ^a   Cheng, Li Na ^a   Hong, Guo bing ^a   Bi, Xiao Bing ^a   Liu, Yu ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

cell labeling; magnetic resonance imaging; Mesenchymal stem cells; spinal cord injury

Indexed keywords

FLUORESCENT DYE; GADOLINIUM PENTETATE; PHOSPHATE BUFFERED SALINE; POLYETHYLENEIMINE; RHODAMINE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL LABELING; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CONVALESCENCE; FLUORESCENCE MICROSCOPY; LOCOMOTION; MALE; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PRIORITY JOURNAL; RAT; SPINAL CORD INJURY;

ANIMALS; CELLS, CULTURED; IMAGE ENHANCEMENT; MAGNETIC RESONANCE IMAGING; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MICROSCOPY, FLUORESCENCE; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD INJURIES; STAINING AND LABELING; SURGERY, COMPUTER-ASSISTED;

EID: 68049095241     PISSN: 10766332     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.acra.2009.03.016     Document Type: Article

References (34)

1. Kim B.G., Hwang D.H., Lee S.I., et al. Stem cell-based cell therapy for spinal cord injury. Cell Transplant 16 (2007) 355-364
2. McDonald J.W., Liu X.Z., Qu Y., et al. Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord. Nat Med 5 (1999) 1410-1412
3. Parr A.M., Kulbatski I., Wang X.H., et al. Fate of transplanted adult neural stem/progenitor cells and bone marrow-derived mesenchymal stromal cells in the injured adult rat spinal cord and impact on functional recovery. Surg Neurol 70 (2008) 600-607
4. Syková E., and Jendelová P. Magnetic resonance tracking of implanted adult and embryonic stem cells in injured brain and spinal cord. Ann NY Acad Sci 1049 (2005) 146-160
5. Kraitchman D.L., Gilson W.D., and Lorenz C.H. Stem cell therapy: MRI guidance and monitoring. J Magn Reson Imaging 27 (2008) 299-310
6. Bulte J.W., Douglas T., Witwer B., et al. Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells. Nat Biotechnol 19 (2001) 1141-1147
7. Crichton R.R., Wilmet S., Legssyer R., et al. Molecular and cellular mechanisms of iron homeostasis and toxicity in mammalian cells. J Inorg Biochem 91 (2002) 9-18
8. Wilhelm C., Cebers A., Bacri J.C., et al. Deformation of intracellular endosomes under a magnetic field. Eur Biophys J 32 (2003) 655-660
9. Modo M., Cash D., Mellodew K., et al. Tracking transplanted stem cells migration using bifunctional contrast agent-enhanced, magnetic resonance imaging. NeuroImage 17 (2002) 803-811
10. Boussif O.F., Lezoualc'h M.A., Zanta M.D., et al. Versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci U S A 92 (1995) 7297-7301
11. Politi L.S. MR-based imaging of neural stem cells. Neuroradiology 49 (2007) 523-534
12. Allen A.R., and MacPhail R.C. Surgery of experimental lesion of spinal cord equivalent to crush injury of fractured is location of spinal column. Pharmacol Biochem Behav 57 (1911) 878-880
13. Nagaya N., Fujii T., Iwase T., et al. Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis. Am J Physiol Heart Circ Physiol 287 (2004) H2670-H2676
14. Denizot F., and Lang R. Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Methods 89 (1986) 271-277
15. In den Kleef J.J.E., and Cuppen J.J.M. RLSQ: T1, T2 and rho calculations, combining ratios and least squares. Magn Reson Med 5 (1987) 513-524
16. Basso D.M., Beattie M.S., and Bresnahan J.C. A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 12 (1995) 1-21
17. Eftekharpour E., Karimi-Abdolrezaee S., and Fehlings M.G. Current status of experimental cell replacement approaches to spinal cord injury. Neurosurgical FOCUS 24 3-4 (2008) E18
18. Himes B.T., Neuhuber B., Coleman C., et al. Recovery of function following grafting of human bone marrow-derived stromal cells into the injured spinal cord. Neurorehabil Neural Repair 20 (2006) 278-296
19. Syková E., Jendelová P., Urdzíková L., et al. Bone marrow stem cells and polymer hydrogels-two strategies for spinal cord injury repair. Cell Mol Neurobiol 26 (2006) 1113-1129
20. Miyanji F., Furlan J.C., Aarabi B., et al. Acute cervical traumatic spinal cord injury: MR imaging findings correlated with neurologic outcome-prospective study with 100 consecutive patients. Radiology 243 (2007) 820-827
21. Walczak P., and Bulte J.W. The role of noninvasive cellular imaging in developing cell-based therapies for neurodegenerative disorders. Neurodegenerative Dis 4 (2007) 306-313
22. Bulte J.W., Duncan I.D., and Frank J.A. In vivo magnetic resonance tracking of magnetically labeled cells after transplantation. J Cereb Blood Flow Metab 22 (2002) 899-907
23. Budde M.D., and Frank J.A. Magnetic tagging of therapeutic cells for MRI. J Nucl Med 50 (2009) 171-174
24. Lee I.H., Bulte J.W., Schweinhardt P., et al. In vivo magnetic resonance tracking of olfactory ensheathing glia grafted into the rat spinal cord. Exp Neurol 187 (2004) 509-516
25. Urdzikova L., Jendelova P., Glogarova K., et al. Transplantation of bone marrow stem cells as well as mobilization by granulocyte-colony stimulating factor promotes recovery after spinal cord injury in rats. J Neurotrauma 23 (2006) 1379-1391
26. Jendelová P., Herynek V., Urdzíková L., et al. MR tracking of transplanted bone marrow and embryonic stem cells labeled by iron oxide nanoparticles in rat brain and spinal cord. J Neurosci Res 76 (2004) 232-243
27. Shyu W.C., Chen C.P., Lin S.Z., et al. Efficient Tracking of non-iron-labeled mesenchymal stem cells with serial MRI in chronic stroke rats. Stroke 38 (2007) 367-374
28. Giesel F.L., Stroick M., Griebe M., et al. Gadofluorine M uptake in stem cells as a new magnetic resonance imaging tracking method: an in vitro and in vivo study. Invest Radiol 41 (2006) 868-873
29. Anderson S.A., Lee K.K., and Frank J.A. Gadolinium-fullerenol as a paramagnetic contrast agent for cellular imaging. Invest Radiol 41 (2006) 332-338
30. Daldrup-Link H.E., Rudelius M., Oostendorp R.A., et al. Targeting of hematopoietic progenitor cells with MR contrast agents. Radiology 228 (2003) 760-767
31. Parac-Vogt T.N., Vander Elst L., Kimpe K., et al. Pharmacokinetic and in vivo evaluation of a self-assembled gadolinium(III)-iron(II) contrast agent with high relaxivity. Contrast Media Mol Imaging 1 (2006) 267-278
32. Crich S.G., Biancone L., Cantaluppi V., et al. Improved route for the visualization of stem cells labeled with a Gd-/Eu-chelate as dual (MRI and fluorescence) agent. Magn Reson Med 51 (2004) 938-944
33. Ludemann L., Wurm R., and Zimmer C. Pharmacokinetic modeling of GD-DTPA extravasation in brain tumors. Invest Radiol 37 (2002) 562-570
34. Walczak P., Kedziorek D.A., Gilad A.A., et al. Applicability and limitations of MR tracking of neural stem cells with asymmetric cell division and rapid turnover: the case of the shiverer dysmyelinated mouse brain. Magn Reson Med 58 (2007) 261-269