The role of noninvasive cellular imaging in developing cell-based therapies for neurodegenerative disorders

Neurodegenerative Diseases

Volumn 4, Issue 4, 2007, Pages 306-313

  Walczak, Piotr ^a,c   Bulte, Jeff W M ^a,b,c,d  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b Johns Hopkins University   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bioluminescence; Contrast agents; Magnetic resonance imaging; Molecular imaging; Stem cells, transplantation

Indexed keywords

BIOLUMINESCENCE; BIOTECHNOLOGICAL PROCEDURES; BRAIN DYSFUNCTION; BRAIN ISCHEMIA; BRAIN TISSUE; CELL MIGRATION; CELL THERAPY; CELL TRANSPLANTATION; DEGENERATIVE DISEASE; HUMAN; IN VIVO STUDY; MOLECULAR IMAGING; MULTIPHOTON MICROSCOPY; NERVOUS SYSTEM; NEUROIMAGING; NON INVASIVE PROCEDURE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PARKINSON DISEASE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REVIEW; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SPINAL CORD INJURY; STEM CELL TRANSPLANTATION; THERAPY EFFECT;

ANIMALS; CONTRAST MEDIA; HUMANS; MAGNETIC RESONANCE IMAGING; NEURODEGENERATIVE DISEASES; STEM CELL TRANSPLANTATION;

EID: 34347389929     PISSN: 16602854     EISSN: 16602862     Source Type: Journal    
DOI: 10.1159/000101887     Document Type: Review

References (55)

1. Ramón y Cajal S, May RM: Degeneration and Regeneration of the Nervous System. Oxford, Oxford University Press, 1928.
2. Altman J, Das GD: Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J Comp Neurol 1965;124:319-335.
3. Alvarez-Buylla A, Herrera DG, Wichterle H: The subventricular zone: source of neuronal precursors for brain repair. Prog Brain Res 2000;127:1-11.
4. Bjorklund LM, Sanchez-Pernaute R, Chung S, Andersson T, Chen IY, McNaught KS, Brownell AL, Jenkins BG, Wahlestedt C, Kim KS, Isacson O: Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc Natl Acad Sci USA 2002;99:2344-2349.
5. Willing AE, Vendrame M, Mallery J, Cassady CJ, Davis CD, Sanchez-Ramos J, Sanberg PR: Mobilized peripheral blood cells administered intravenously produce functional recovery in stroke. Cell Transplant 2003;12:449-454.
6. Bernstein-Goral H, Bregman BS: Axotomized rubrospinal neurons rescued by fetal spinal cord transplants maintain axon collaterals to rostral CNS targets. Exp Neurol 1997;148:13-25.
7. Blakemore WF, Gilson JM, Crang AJ: Transplanted glial cells migrate over a greater distance and remyelinate demyelinated lesions more rapidly than endogenous remyelinating cells. J Neurosci Res 2000;61:288-294.
8. Magavi SS, Macklis JD: Manipulation of neural precursors in situ: induction of neurogenesis in the neocortex of adult mice. Neuropsychopharmacology 2001;25:816-835.
9. Scheffler B, Edenhofer F, Brustle O: Merging fields: stem cells in neurogenesis, transplantation, and disease modeling. Brain Pathol 2006;16:155-168.
10. Walczak P, Chen N, Hudson JE, Willing AE, Garbuzova-Davis SN, Song S, Sanberg PR, Sanchez-Ramos J, Bickford PC, Zigova T: Do hematopoietic cells exposed to a neurogenic environment mimic properties of endogenous neural precursors? J Neurosci Res 2004;76:244-254.
11. McDonald JW, Liu XZ, Qu Y, Liu S, Mickey SK, Turetsky D, Gottlieb DI, Choi DW: Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord. Nat Med 1999;5:1410-1412.
12. Kim JH, Auerbach JM, Rodriguez-Gomez JA, Velasco I, Gavin D, Lumelsky N, Lee SH, Nguyen J, Sanchez-Pernaute R, Bankiewicz K, McKay R: Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease. Nature 2002;418:50-56.
13. Klug MG, Soonpaa MH, Koh GY, Field LJ: Genetically selected cardiomyocytes from differentiating embryonic stem cells form stable intracardiac grafts. J Clin Invest 1996;98:216-224.
14. Cao F, Lin S, Xie X, Ray P, Patel M, Zhang X, Drukker M, Dylla SJ, Connolly AJ, Chen X, Weissman IL, Gambhir SS, Wu JC: In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery. Circulation 2006;113:1005-1014.
15. Fujikawa T, Oh SH, Pi L, Hatch HM, Shupe T, Petersen BE: Teratoma formation leads to failure of treatment for type I diabetes using embryonic stem cell-derived insulin-producing cells. Am J Pathol 2005;166:1781-1791.
16. Lepore AC, Walczak P, Rao MS, Fischer I, Bulte JW: MR imaging of lineage-restricted neural precursors following transplantation into the adult spinal cord. Exp Neurol 2006;201:49-59.
17. Gritti A, Parati EA, Cova L, Frolichsthal P, Galli R, Wanke E, Faravelli L, Morassutti DJ, Roisen F, Nickel DD, Vescovi AL: Multipotential stem cells from the adult mouse brain proliferate and self-renew in response to basic fibroblast growth factor. J Neurosci 1996;16:1091-1100.
18. Shen LH, Li Y, Chen J, Zacharek A, Gao Q, Kapke A, Lu M, Raginski K, Vanguri P, Smith A, Chopp M: Therapeutic benefit of bone marrow stromal cells administered 1 month after stroke. J Cereb Blood Flow Metab 2007;27:6-13.
19. Shyu WC, Lin SZ, Chiang MF, Su CY, Li H: Intracerebral peripheral blood stem cell (CD34+) implantation induces neuroplasticity by enhancing beta1 integrin-mediated angiogenesis in chronic stroke rats. J Neurosci 2006;26:3444-3453.
20. Bulte JW, Zhang S, van Gelderen P, Herynek V, Jordan EK, Duncan ID, Frank JA: Neurotransplantation of magnetically labeled oligodendrocyte progenitors: magnetic resonance tracking of cell migration and myelination. Proc Natl Acad Sci USA 1999;96:15256-15261.
21. Tang Y, Shah K, Messerli SM, Snyder E, Breakefield X, Weissleder R: In vivo tracking of neural progenitor cell migration to glioblastomas. Hum Gene Ther 2003;14:1247-1254.
22. Haydar TF, Ang E Jr, Rakic P: Mitotic spindle rotation and mode of cell division in the developing telencephalon. Proc Natl Acad Sci USA 2003;100:2890-2895.
23. Adonai N, Nguyen KN, Walsh J, Iyer M, Toyokuni T, Phelps ME, McCarthy T, McCarthy DW, Gambhir SS: Ex vivo cell labeling with 64Cu-pyruvaldehyde-bis(N4- methylthiosemicarbazone) for imaging cell trafficking in mice with positron-emission tomography. Proc Natl Acad Sci USA 2002;99:3030-3035.
24. De Vries IJ, Lesterhuis WJ, Barentsz JO, Verdijk P, van Krieken JH, Boerman OC, Oyen WJ, Bonenkamp JJ, Boezeman JB, Adema GJ, Bulte JW, Scheenen TW, Punt CJ, Heerschap A, Figdor CG: Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy. Nat Biotechnol 2005;23:1407-1413.
25. Frank JA, Miller BR, Arbab AS, Zywicke HA, Jordan EK, Lewis BK, Bryant LH Jr, Bulte JW: Clinically applicable labeling of mammalian and stem cells by combining superparamagnetic iron oxides and transfection agents. Radiology 2003;228:480-487.
26. Walczak P, Kedziorek DA, Gilad AA, Lin S, Bulte JW: Instant MR labeling of stem cells using magnetoelectroporation. Magn Reson Med 2005;54:769-774.
27. Shapiro EM, Sharer K, Skrtic S, Koretsky AP: In vivo detection of single cells by MRI. Magn Reson Med 2006;55:242-249.
28. Ben-Hur T, van Heeswijk R, Einstein O, Aharonovitch M, Xue R, Frost EE, Mori S, Reubinoff B, Bulte JWM: In vivo MR tracking of magnetically labeled neural spheres transplanted in chronic EAE mice: relation between cell migration and inflammation. Magn Reson Med 2007;57:164-171.
29. Hoehn M, Kustermann E, Blunk J, Wiedermann D, Trapp T, Wecker S, Focking M, Arnold H, Hescheler J, Fleischmann BK, Schwindt W, Buhrle C: Monitoring of implanted stem cell migration in vivo: a highly resolved in vivo magnetic resonance imaging investigation of experimental stroke in rat. Proc Natl Acad Sci USA 2002;99:16267-16272.
30. Zhang ZG, Jiang Q, Zhang R, Zhang L, Wang L, Zhang L, Arniego P, Ho KL, Chopp M: Magnetic resonance imaging and neurosphere therapy of stroke in rat. Ann Neurol 2003;53:259-263.
31. Modo M, Mellodew K, Cash D, Fraser SE, Meade TJ, Price J, Williams SC: Mapping transplanted stem cell migration after a stroke: a serial, in vivo magnetic resonance imaging study. Neuroimage 2004;21:311-317.
32. Jendelova P, Herynek V, Urdzikova L, Glogarova K, Kroupova J, Andersson B, Bryja V, Burian M, Hajek M, Sykova E: Magnetic resonance tracking of transplanted bone marrow and embryonic stem cells labeled by iron oxide nanoparticles in rat brain and spinal cord. J Neurosci Res 2004;76:232-243.
33. Lee IH, Bulte JW, Schweinhardt P, Douglas T, Trifunovski A, Hofstetter C, Olson L, Spenger C: In vivo magnetic resonance tracking of olfactory ensheathing glia grafted into the rat spinal cord. Exp Neurol 2004;187:509-516.
34. Bulte JW, Douglas T, Witwer B, Zhang SC, Strable E, Lewis BK, Zywicke H, Miller B, van Gelderen P, Moskowitz BM, Duncan ID, Frank JA: Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells. Nat Biotechnol 2001;19:1141-1147.
35. Bulte JW, Ben-Hur T, Miller BR, Mizrachi-Kol R, Einstein O, Reinhartz E, Zywicke HA, Douglas T, Frank JA: MR microscopy of magnetically labeled neurospheres transplanted into the Lewis EAE rat brain. Magn Reson Med 2003;50:201-205.
36. Zhang Z, Jiang Q, Jiang F, Ding G, Zhang R, Wang L, Zhang L, Robin AM, Katakowski M, Chopp M: In vivo magnetic resonance imaging tracks adult neural progenitor cell targeting of brain tumor. Neuroimage 2004;23:281-287.
37. Urdzikova L, Jendelova P, Glogarova K, Burian M, Hajek M, Sykova E: Transplantation of bone marrow stem cells as well as mobilization by granulocyte-colony stimulating factor promotes recovery after spinal cord injury in rats. J Neurotrauma 2006;23:1379-1391.
38. Heyn C, Ronald JA, Mackenzie LT, MacDonald IC, Chambers AF, Rutt BK, Foster PJ: In vivo magnetic resonance imaging of single cells in mouse brain with optical validation. Magn Reson Med 2006;55:23-29.
39. Genove G, DeMarco U, Xu H, Goins WF, Ahrens ET: A new transgene reporter for in vivo magnetic resonance imaging. Nat Med 2005;11:450-454.
40. Weissleder R, Moore A, Mahmood U, Bhorade R, Benveniste H, Chiocca EA, Basilion JP: In vivo magnetic resonance imaging of transgene expression. Nat Med 2000;6:351-355.
41. Gilad AA, McMahon MT, Walczak P, Winnard PT Jr, Raman V, Skoglund CM, Bulte JWM, van Zijl PCM: Artificial reporter gene providing MRI contrast based on proton exchange. Nat Biotechnol 2007;25:217-219.
42. Kraitchman DL, Tatsumi M, Gilson WD, Ishimori T, Kedziorek D, Walczak P, Segars WP, Chen HH, Fritzges D, Izbudak I, Young RG, Marcelino M, Pittenger MF, Solaiyappan M, Boston RC, Tsui BM, Wahl RL, Bulte JW: Dynamic imaging of allogeneic mesenchymal stem cells trafficking to myocardial infarction. Circulation 2005;112:1451-1461.
43. Acton PD, Zhou R: Imaging reporter genes for cell tracking with PET and SPECT. Q J Nucl Med Mol Imaging 2005;49:349-360.
44. Yaghoubi S, Barrio JR, Dahlbom M, Iyer M, Namavari M, Satyamurthy N, Goldman R, Herschman HR, Phelps ME, Gambhir SS: Human pharmacokinetic and dosimetry studies of [(18)F]FHBG: a reporter probe for imaging herpes simplex virus type-1 thymidine kinase reporter gene expression. J Nucl Med 2001;42:1225-1234.
45. Pogarell O, Koch W, Gildehaus FJ, Kupsch A, Lindvall O, Oertel WH, Tatsch K: Long-term assessment of striatal dopamine transporters in Parkinsonian patients with intrastriatal embryonic mesencephalic grafts. Eur J Nucl Med Mol Imaging 2006;33:407-411.
46. Engebrecht J, Silverman M: Identification of genes and gene products necessary for bacterial bioluminescence. Proc Natl Acad Sci USA 1984;81:4154-4158.
47. Chaudhari AJ, Darvas F, Bading JR, Moats RA, Conti PS, Smith DJ, Cherry SR, Leahy RM: Hyperspectral and multispectral bioluminescence optical tomography for small animal imaging. Phys Med Biol 2005;50:5421-5441.
48. Okada S, Ishii K, Yamane J, Iwanami A, Ikegami T, Katoh H, Iwamoto Y, Nakamura M, Miyoshi H, Okano HJ, Contag CH, Toyama Y, Okano H: In vivo imaging of engrafted neural stem cells: its application in evaluating the optimal timing of transplantation for spinal cord injury. FASEB J 2005;19:1839-1841.
49. Kim DE, Schellingerhout D, Ishii K, Shah K, Weissleder R: Imaging of stem cell recruitment to ischemic infarcts in a murine model. Stroke 2004;35:952-957.
50. Helmchen F, Denk W: Deep tissue two-photon microscopy. Nat Methods 2005;2:932-940.
51. Mizrahi A, Lu J, Irving R, Feng G, Katz LC: In vivo imaging of juxtaglomerular neuron turnover in the mouse olfactory bulb. Proc Natl Acad Sci USA 2006;103:1912-1917.
52. Sdrulla AD, Linden DJ: Dynamic imaging of cerebellar Purkinje cells reveals a population of filopodia which cross-link dendrites during early postnatal development. Cerebellum 2006;5:105-115.
53. Saporta S, Borlongan CV, Sanberg PR: Neural transplantation of human neuroteratocarcinoma (hNT) neurons into ischemic rats: a quantitative dose-response analysis of cell survival and behavioral recovery. Neuroscience 1999;91:519-525.
54. Kondziolka D, Wechsler L, Goldstein S, Meltzer C, Thulborn KR, Gebel J, Jannetta P, DeCesare S, Elder EM, McGrogan M, Reitman MA, Bynum L: Transplantation of cultured human neuronal cells for patients with stroke. Neurology 2000;55:565-569.
55. Bang OY, Lee JS, Lee PH, Lee G: Autologous mesenchymal stem cell transplantation in stroke patients. Ann Neurol 2005;57:874-882.