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Volumn 18, Issue 4, 2009, Pages 336-342

The glomerular filter: an imperfect barrier is required for perfect renal function

Author keywords

Albumin retrieval pathway; albuminuria; glomerular charge; proximal tubular cell

Indexed keywords

ALBUMIN; CUBILIN; DYNAMIN; FC RECEPTOR; MEGALIN;

EID: 67849113715     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/MNH.0b013e32832cb96a     Document Type: Review
Times cited : (47)

References (57)
  • 1
    • 42149122041 scopus 로고    scopus 로고
    • Properties of the glomerular barrier and mechanisms of proteinuria
    • The traditional model of glomerular function and albuminuria is presented
    • Haraldsson B, Nyström J, Deen WM. Properties of the glomerular barrier and mechanisms of proteinuria. Physiol Rev 2008; 88:451-487. The traditional model of glomerular function and albuminuria is presented.
    • (2008) Physiol Rev , vol.88 , pp. 451-487
    • Haraldsson, B.1    Nyström, J.2    Deen, W.M.3
  • 2
    • 0026445848 scopus 로고
    • Intrarenal handling of proteins in rats using fractional micropuncture technique
    • Tojo A, Endou H. Intrarenal handling of proteins in rats using fractional micropuncture technique. Am J Physiol 1992; 263:F601-F606.
    • (1992) Am J Physiol , vol.263
    • Tojo, A.1    Endou, H.2
  • 3
    • 57349177609 scopus 로고    scopus 로고
    • Disease-dependent mechanisms of albuminuria
    • A new model of PTC-controlled albuminuria is presented
    • Comper WD, Hilliard LM, Nikolic-Paterson D, Russo LM. Disease-dependent mechanisms of albuminuria. Am J Physiol Renal Physiol 2008; 295:F1589-F1600. A new model of PTC-controlled albuminuria is presented.
    • (2008) Am J Physiol Renal Physiol , vol.295
    • Comper, W.D.1    Hilliard, L.M.2    Nikolic-Paterson, D.3    Russo, L.M.4
  • 4
    • 84882846681 scopus 로고    scopus 로고
    • Renal filtration, transport, and metabolism of albumin and albuminuria
    • Alpern R, Hebert S, editors, San Diego: Elsevier;
    • Comper WD, Osicka TM, Russo LM. Renal filtration, transport, and metabolism of albumin and albuminuria. In: Alpern R, Hebert S, editors. The kidney: physiology, pathophysiology. San Diego: Elsevier; 2007. pp. 2081-2112.
    • (2007) The kidney: Physiology, pathophysiology , pp. 2081-2112
    • Comper, W.D.1    Osicka, T.M.2    Russo, L.M.3
  • 6
    • 47349084411 scopus 로고    scopus 로고
    • Loss of heparan sulfate glycosaminoglycan assembly in podocytes does not lead to proteinuria
    • Knockout mice that have halted heparan sulfate biosynthesis in podocytes do not develop significant albuminuria
    • Chen S, Wassenhove-McCarthy DJ, Yamaguchi Y, et al. Loss of heparan sulfate glycosaminoglycan assembly in podocytes does not lead to proteinuria. Kidney Int 2008; 74:289-299. Knockout mice that have halted heparan sulfate biosynthesis in podocytes do not develop significant albuminuria
    • (2008) Kidney Int , vol.74 , pp. 289-299
    • Chen, S.1    Wassenhove-McCarthy, D.J.2    Yamaguchi, Y.3
  • 7
    • 34547680445 scopus 로고    scopus 로고
    • Disruption of glomerular basement membrane charge through podocyte-specific mutation of agrin does not alter glomerular permselectivity
    • Harvey SJ, Jarad G, Cunningham J, et al. Disruption of glomerular basement membrane charge through podocyte-specific mutation of agrin does not alter glomerular permselectivity. Am J Pathol 2007; 171:139-152.
    • (2007) Am J Pathol , vol.171 , pp. 139-152
    • Harvey, S.J.1    Jarad, G.2    Cunningham, J.3
  • 8
    • 0037439268 scopus 로고    scopus 로고
    • Heparan sulfate chains of perlecan are indispensable in the lens capsule but not the kidney
    • Rossi M, Morita H, Sormunen R, et al. Heparan sulfate chains of perlecan are indispensable in the lens capsule but not the kidney. EMBO J 2003; 22:236-245.
    • (2003) EMBO J , vol.22 , pp. 236-245
    • Rossi, M.1    Morita, H.2    Sormunen, R.3
  • 9
    • 33749577192 scopus 로고    scopus 로고
    • No change in glomerular heparan sulfate structure in early human and experimental diabetic nephropathy
    • van den Born J, Pisa B, Bakker MA, et al. No change in glomerular heparan sulfate structure in early human and experimental diabetic nephropathy. J Biol Chem 2006; 281:29606-29613.
    • (2006) J Biol Chem , vol.281 , pp. 29606-29613
    • van den Born, J.1    Pisa, B.2    Bakker, M.A.3
  • 10
    • 38149061339 scopus 로고    scopus 로고
    • Reduction of anionic sites in the glomerular basement membrane by heparanase does not lead to proteinuria
    • Mice overexpressing heparanase resulting in a reduction of glycosaminoglycan anionic sites in the glomerular basement membrane are not albuminuric
    • van den Hoven MJ, Wijnhoven TJ, Li JP, et al. Reduction of anionic sites in the glomerular basement membrane by heparanase does not lead to proteinuria. Kidney Int 2008; 73:278-287. Mice overexpressing heparanase resulting in a reduction of glycosaminoglycan anionic sites in the glomerular basement membrane are not albuminuric.
    • (2008) Kidney Int , vol.73 , pp. 278-287
    • van den Hoven, M.J.1    Wijnhoven, T.J.2    Li, J.P.3
  • 11
    • 67651089928 scopus 로고    scopus 로고
    • Glomerular filtration is normal in the absence of both agrin and perlecan-heparan sulfate from the glomerular basement membrane
    • Epub ahead of print] Mice lacking the heparan sulfate chains of perlecan either alone or in combination with podocyte-specific loss of agrin were not proteinuric
    • Goldberg S, Harvey SJ, Cunningham J, et al. Glomerular filtration is normal in the absence of both agrin and perlecan-heparan sulfate from the glomerular basement membrane. Nephrol Dial Transplant 2009. [Epub ahead of print] Mice lacking the heparan sulfate chains of perlecan either alone or in combination with podocyte-specific loss of agrin were not proteinuric.
    • (2009) Nephrol Dial Transplant
    • Goldberg, S.1    Harvey, S.J.2    Cunningham, J.3
  • 12
    • 0028966777 scopus 로고
    • Albumin interaction with the glomerular capillary wall in vitro
    • Adal Y, Smit MF, Osicka TM, Comper WD. Albumin interaction with the glomerular capillary wall in vitro. Kidney Int 1995; 47:1031-1038.
    • (1995) Kidney Int , vol.47 , pp. 1031-1038
    • Adal, Y.1    Smit, M.F.2    Osicka, T.M.3    Comper, W.D.4
  • 14
    • 36348995969 scopus 로고    scopus 로고
    • Decorin deficiency enhances progressive nephropathy in diabetic mice
    • Williams KJ, Qiu G, Usui HK, et al. Decorin deficiency enhances progressive nephropathy in diabetic mice. Am J Pathol 2007; 171:1441-1450.
    • (2007) Am J Pathol , vol.171 , pp. 1441-1450
    • Williams, K.J.1    Qiu, G.2    Usui, H.K.3
  • 15
    • 0034809350 scopus 로고    scopus 로고
    • Effects of filtration rate on the glomerular barrier and clearance of four differently shaped molecules
    • Ohlson M, Sörensson J, Lindström K, et al. Effects of filtration rate on the glomerular barrier and clearance of four differently shaped molecules. Am J Physiol 2001; 281:F103-F113.
    • (2001) Am J Physiol , vol.281
    • Ohlson, M.1    Sörensson, J.2    Lindström, K.3
  • 16
  • 17
    • 33746747093 scopus 로고    scopus 로고
    • Functional and molecular alterations of the glomerular barrier in long-term diabetes
    • Jeansson M, Granqvist AB, Nyström JS, Haraldsson B. Functional and molecular alterations of the glomerular barrier in long-term diabetes. Diabetologia 2006; 49:2200-2209.
    • (2006) Diabetologia , vol.49 , pp. 2200-2209
    • Jeansson, M.1    Granqvist, A.B.2    Nyström, J.S.3    Haraldsson, B.4
  • 18
    • 33644806727 scopus 로고    scopus 로고
    • Morphological and functional evidence for an important role of the endothelial cell glycocalyx in the glomerular barrier
    • Jeansson M, Haraldsson B. Morphological and functional evidence for an important role of the endothelial cell glycocalyx in the glomerular barrier. Am J Physiol Renal Physiol 2006; 290:F111-F116.
    • (2006) Am J Physiol Renal Physiol , vol.290
    • Jeansson, M.1    Haraldsson, B.2
  • 19
    • 0037609543 scopus 로고    scopus 로고
    • Glomerular filtration rate dependence of sieving of albumin and some neutral proteins in rat kidneys
    • Lund U, Rippe A, Venturoli D, et al. Glomerular filtration rate dependence of sieving of albumin and some neutral proteins in rat kidneys. Am J Physiol Renal Physiol 2003; 284:F1226-F1234.
    • (2003) Am J Physiol Renal Physiol , vol.284
    • Lund, U.1    Rippe, A.2    Venturoli, D.3
  • 20
    • 36049006561 scopus 로고    scopus 로고
    • Size and charge selectivity of the glomerular filter in early experimental diabetes in rats
    • Rippe C, Rippe A, Torffvit O, Rippe B. Size and charge selectivity of the glomerular filter in early experimental diabetes in rats. Am J Physiol Renal Physiol 2007; 293:F1533-F1538.
    • (2007) Am J Physiol Renal Physiol , vol.293
    • Rippe, C.1    Rippe, A.2    Torffvit, O.3    Rippe, B.4
  • 21
    • 33646150223 scopus 로고    scopus 로고
    • Effects of glomerular filtration rate on Ficoll sieving coefficients in rats
    • Rippe C, Asgeirsson D, Venturoli D, et al. Effects of glomerular filtration rate on Ficoll sieving coefficients in rats. Kidney Int 2006; 69:1326-1332.
    • (2006) Kidney Int , vol.69 , pp. 1326-1332
    • Rippe, C.1    Asgeirsson, D.2    Venturoli, D.3
  • 22
    • 15044362503 scopus 로고    scopus 로고
    • Ficoll and dextran vs. globular proteins as probes for testing glomerular permselectivity: Effects of molecular size, shape, charge, and deformability
    • Venturoli D, Rippe B. Ficoll and dextran vs. globular proteins as probes for testing glomerular permselectivity: effects of molecular size, shape, charge, and deformability. Am J Physiol Renal Physiol 2005; 288:F605-F613.
    • (2005) Am J Physiol Renal Physiol , vol.288
    • Venturoli, D.1    Rippe, B.2
  • 24
    • 0013479129 scopus 로고    scopus 로고
    • Conformational dependence of the fractional clearance of dextran and Ficoll
    • Smit MF, Pratt LM, Comper WD. Conformational dependence of the fractional clearance of dextran and Ficoll. Nephrology 1996; 2:355-360.
    • (1996) Nephrology , vol.2 , pp. 355-360
    • Smit, M.F.1    Pratt, L.M.2    Comper, W.D.3
  • 25
    • 15744387865 scopus 로고    scopus 로고
    • Mechanism of hypoalbuminemia in rodents
    • Koltun M, Nikolovski J, Strong K, et al. Mechanism of hypoalbuminemia in rodents. Am J Physiol 2005; 288:H1604-H1610.
    • (2005) Am J Physiol , vol.288
    • Koltun, M.1    Nikolovski, J.2    Strong, K.3
  • 26
    • 59849086065 scopus 로고    scopus 로고
    • Reevaluation of glomerular charge selective protein-sieving function
    • Saito H, Takahashi S, Nagata M, et al. Reevaluation of glomerular charge selective protein-sieving function. Pediatr Nephrol 2009; 24:609-612.
    • (2009) Pediatr Nephrol , vol.24 , pp. 609-612
    • Saito, H.1    Takahashi, S.2    Nagata, M.3
  • 27
    • 33947181051 scopus 로고    scopus 로고
    • The normal kidney filters nephrotic levels of albumin that is retrieved by the proximal tubule cell: Retrieval is disrupted in nephrotic states
    • Russo LM, Sandoval RM, McKee M, et al. The normal kidney filters nephrotic levels of albumin that is retrieved by the proximal tubule cell: retrieval is disrupted in nephrotic states. Kidney Int 2007; 71:504-513.
    • (2007) Kidney Int , vol.71 , pp. 504-513
    • Russo, L.M.1    Sandoval, R.M.2    McKee, M.3
  • 28
    • 33947183451 scopus 로고    scopus 로고
    • Renal albumin handling: A look at the dark side of the filter
    • Gekle M. Renal albumin handling: a look at the dark side of the filter. Kidney Int 2007; 71:479-481.
    • (2007) Kidney Int , vol.71 , pp. 479-481
    • Gekle, M.1
  • 29
    • 62149122940 scopus 로고    scopus 로고
    • Albuminuria in diabetes is due to dysfunction of proximal tubular cell processing and not changes in albumin filtration
    • Glomerular permeability measured directly by two-photon microscopy in the diabetic rat remains unaltered
    • Russo LM, Sandoval RM, McKee M, et al. Albuminuria in diabetes is due to dysfunction of proximal tubular cell processing and not changes in albumin filtration. J Am Soc Nephrol 2009; 20:489-494. Glomerular permeability measured directly by two-photon microscopy in the diabetic rat remains unaltered.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 489-494
    • Russo, L.M.1    Sandoval, R.M.2    McKee, M.3
  • 30
    • 35348878790 scopus 로고    scopus 로고
    • Glomerular sieving of three neutral polysaccharides, polyethylene oxide and bikunin in rat. Effects of molecular size and conformation
    • Asgeirsson D, Venturoli D, Fries E, et al. Glomerular sieving of three neutral polysaccharides, polyethylene oxide and bikunin in rat. Effects of molecular size and conformation. Acta Physiol 2007; 191:237-246.
    • (2007) Acta Physiol , vol.191 , pp. 237-246
    • Asgeirsson, D.1    Venturoli, D.2    Fries, E.3
  • 31
    • 85133383861 scopus 로고    scopus 로고
    • Tanner GA. Glomerular sieving coefficient of serum albumin in the rat: a two- photon microscopy study. Am J Physiol Renal Physiol 2009. [Epub ahead of print] The methodological problems are exemplified by the following major discrepancy in the Tanner et al. data. Originally, Tanner et al. found GSCs for albumin in the Necturus of 0.03 (Tanner et al. J Am Soc Nephrol 2004; 15:211A). They then published another paper (Tanner et al, Am J Physiol Renal Physiol 2009 [Epub ahead of print]) stating that GSCs were originally too high due to possible contaminants and they obtained low GSCs. The high GSC data were then eliminated. Yet in this publication, Tanner demonstrated that the albumin preparations used in the Necturus study had no contaminants.
    • Tanner GA. Glomerular sieving coefficient of serum albumin in the rat: a two- photon microscopy study. Am J Physiol Renal Physiol 2009. [Epub ahead of print] The methodological problems are exemplified by the following major discrepancy in the Tanner et al. data. Originally, Tanner et al. found GSCs for albumin in the Necturus of 0.03 (Tanner et al. J Am Soc Nephrol 2004; 15:211A). They then published another paper (Tanner et al, Am J Physiol Renal Physiol 2009 [Epub ahead of print]) stating that GSCs were originally too high due to possible contaminants and they obtained low GSCs. The high GSC data were then eliminated. Yet in this publication, Tanner demonstrated that the albumin preparations used in the Necturus study had no contaminants.
  • 32
    • 0017293323 scopus 로고
    • Distribution of endogenous albumin in the rat glomerulus: Role of hemodynamic factors in glomerular barrier function
    • Ryan GB, Karnovsky MJ. Distribution of endogenous albumin in the rat glomerulus: role of hemodynamic factors in glomerular barrier function. Kidney Int 1976; 9:36-45.
    • (1976) Kidney Int , vol.9 , pp. 36-45
    • Ryan, G.B.1    Karnovsky, M.J.2
  • 33
    • 62149142105 scopus 로고    scopus 로고
    • Albuminuria, wherefore art thou?
    • Jarad G, Miner JH. Albuminuria, wherefore art thou? J Am Soc Nephrol 2009; 20:455-457.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 455-457
    • Jarad, G.1    Miner, J.H.2
  • 34
    • 31544451031 scopus 로고    scopus 로고
    • Renal albumin absorption in physiology and pathology
    • Birn H, Christensen EI. Renal albumin absorption in physiology and pathology. Kidney Int 2006; 69:440-449.
    • (2006) Kidney Int , vol.69 , pp. 440-449
    • Birn, H.1    Christensen, E.I.2
  • 35
    • 0032895573 scopus 로고    scopus 로고
    • The return of glomerular filtered albumin to the rat renal vein
    • Eppel GA, Osicka TM, Pratt LM, et al. The return of glomerular filtered albumin to the rat renal vein. Kidney Int 1999; 55:1861-1870.
    • (1999) Kidney Int , vol.55 , pp. 1861-1870
    • Eppel, G.A.1    Osicka, T.M.2    Pratt, L.M.3
  • 36
    • 31344450192 scopus 로고    scopus 로고
    • Characterisation of the urinary albumin degradation pathway in the isolated perfused rat kidney
    • Hilliard LM, Osicka TM, Clavant S, et al. Characterisation of the urinary albumin degradation pathway in the isolated perfused rat kidney. J Lab Clin Med 2006; 147:36-44.
    • (2006) J Lab Clin Med , vol.147 , pp. 36-44
    • Hilliard, L.M.1    Osicka, T.M.2    Clavant, S.3
  • 37
    • 34247103999 scopus 로고    scopus 로고
    • Insights into the relationship between hypertension and albuminuria
    • Hilliard LM, Russo LM, Comper WD. Insights into the relationship between hypertension and albuminuria. Curr Hypertens Rev 2007; 3:29-37.
    • (2007) Curr Hypertens Rev , vol.3 , pp. 29-37
    • Hilliard, L.M.1    Russo, L.M.2    Comper, W.D.3
  • 38
    • 56349170391 scopus 로고    scopus 로고
    • Albuminuria in cardiovascular disease is associated with reduced lysosomal activity in the kidney and the heart
    • This paper describes a plausible relationship of why cardiovascular disease is associated with albuminuria
    • Hilliard LM, Russo LM, Comper WD. Albuminuria in cardiovascular disease is associated with reduced lysosomal activity in the kidney and the heart. Am J Nephrol 2009; 29:454-464. This paper describes a plausible relationship of why cardiovascular disease is associated with albuminuria.
    • (2009) Am J Nephrol , vol.29 , pp. 454-464
    • Hilliard, L.M.1    Russo, L.M.2    Comper, W.D.3
  • 39
    • 0021328801 scopus 로고
    • Albumin absorption and catabolism by isolated perfused proximal convoluted tubules of the rabbit
    • Park CH, Maack T. Albumin absorption and catabolism by isolated perfused proximal convoluted tubules of the rabbit. J Clin Invest 1984; 73:767-777.
    • (1984) J Clin Invest , vol.73 , pp. 767-777
    • Park, C.H.1    Maack, T.2
  • 40
    • 0347132276 scopus 로고    scopus 로고
    • Urinary clearance of albumin is critically determined by its tertiary structure
    • Clavant SP, Comper WD. Urinary clearance of albumin is critically determined by its tertiary structure. J Lab Clin Med 2003; 142:372-384.
    • (2003) J Lab Clin Med , vol.142 , pp. 372-384
    • Clavant, S.P.1    Comper, W.D.2
  • 41
    • 0000729650 scopus 로고    scopus 로고
    • Glomerular capillary wall permeability to albumin and horseradish peroxidase
    • Osicka TM, Pratt LM, Comper WD. Glomerular capillary wall permeability to albumin and horseradish peroxidase. Nephrology 1996; 2:199-212.
    • (1996) Nephrology , vol.2 , pp. 199-212
    • Osicka, T.M.1    Pratt, L.M.2    Comper, W.D.3
  • 42
    • 33645914780 scopus 로고    scopus 로고
    • Albumin binding to FcRn: Distinct from the FcRn-IgG interaction
    • Chaudhury C, Brooks CL, Carter DC, et al. Albumin binding to FcRn: distinct from the FcRn-IgG interaction. Biochemistry 2006; 45:4983-4990.
    • (2006) Biochemistry , vol.45 , pp. 4983-4990
    • Chaudhury, C.1    Brooks, C.L.2    Carter, D.C.3
  • 43
    • 0037415556 scopus 로고    scopus 로고
    • The major histocompatibility complex-related Fcreceptor for IgG (FcRn) binds albumin and prolongs its lifespan
    • Chaudhury C, Mehnaz S, Robinson JM, et al. The major histocompatibility complex-related Fcreceptor for IgG (FcRn) binds albumin and prolongs its lifespan. J Exp Med 2003; 197:315-322.
    • (2003) J Exp Med , vol.197 , pp. 315-322
    • Chaudhury, C.1    Mehnaz, S.2    Robinson, J.M.3
  • 44
    • 67849109216 scopus 로고    scopus 로고
    • The handling of albumin and IgG by FcRn is distinct in renal and extrarenal sites
    • This intriguing paper suggests that the retrieval pathway is associated with the FcRn receptor in the PTC, in press
    • Sarav M, Wang Y, Hack BK, et al. The handling of albumin and IgG by FcRn is distinct in renal and extrarenal sites. J Am Soc Nephrol (in press). This intriguing paper suggests that the retrieval pathway is associated with the FcRn receptor in the PTC.
    • J Am Soc Nephrol
    • Sarav, M.1    Wang, Y.2    Hack, B.K.3
  • 45
    • 52949110519 scopus 로고    scopus 로고
    • FcRn-mediated antibody transport across epithelial cells revealed by electron tomography
    • Transcellular transport of proteins in epithelial cells is observed in this study
    • He W, Ladinsky MS, Huey-Tubman KE, et al. FcRn-mediated antibody transport across epithelial cells revealed by electron tomography. Nature 2008; 455:542-546. Transcellular transport of proteins in epithelial cells is observed in this study.
    • (2008) Nature , vol.455 , pp. 542-546
    • He, W.1    Ladinsky, M.S.2    Huey-Tubman, K.E.3
  • 46
    • 34547549299 scopus 로고    scopus 로고
    • Mutations in LRP2, which encodes the multiligand receptor megalin, cause Donnai-Barrow and facio-oculo-acoustico-renal syndromes
    • Kantarci S, Al-Gazali L, Hill RS, et al. Mutations in LRP2, which encodes the multiligand receptor megalin, cause Donnai-Barrow and facio-oculo-acoustico-renal syndromes. Nat Gen 2007; 39:957-959.
    • (2007) Nat Gen , vol.39 , pp. 957-959
    • Kantarci, S.1    Al-Gazali, L.2    Hill, R.S.3
  • 47
    • 0037313753 scopus 로고    scopus 로고
    • Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect
    • Leheste JR, Melsen F, Wellner M, et al. Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect. FASEB J 2003; 17:247-249.
    • (2003) FASEB J , vol.17 , pp. 247-249
    • Leheste, J.R.1    Melsen, F.2    Wellner, M.3
  • 48
    • 0034073250 scopus 로고    scopus 로고
    • Cubilin is an albumin binding protein important for renal tubular reabsorption
    • Birn H, Fyfe JC, Jacobsen C, et al. Cubilin is an albumin binding protein important for renal tubular reabsorption. J Clin Invest 2000; 105:1354-1361.
    • (2000) J Clin Invest , vol.105 , pp. 1354-1361
    • Birn, H.1    Fyfe, J.C.2    Jacobsen, C.3
  • 49
    • 0020059230 scopus 로고
    • Mechanisms of proteinuria in diabetic nephropathy: A study of glomerular barrier function
    • Myers BD, Winetz JA, Chui F, Michaels AS. Mechanisms of proteinuria in diabetic nephropathy: a study of glomerular barrier function. Kidney Int 1982; 21:633-641.
    • (1982) Kidney Int , vol.21 , pp. 633-641
    • Myers, B.D.1    Winetz, J.A.2    Chui, F.3    Michaels, A.S.4
  • 50
    • 0026480167 scopus 로고
    • Glomerular permselectivity in healthy and nephrotic humans
    • Scandling JD, Black VM, Deen WM, Myers BD. Glomerular permselectivity in healthy and nephrotic humans. Adv Nephrol 1992; 21:159-176.
    • (1992) Adv Nephrol , vol.21 , pp. 159-176
    • Scandling, J.D.1    Black, V.M.2    Deen, W.M.3    Myers, B.D.4
  • 51
    • 0034843154 scopus 로고    scopus 로고
    • Glomerular perm- selectivity factors are not responsible for the increase in fractional clearance of albumin in rat glomerulonephritis
    • Greive KA, Nikolic-Paterson DJ, Guimarães MAM, et al. Glomerular perm- selectivity factors are not responsible for the increase in fractional clearance of albumin in rat glomerulonephritis. Am J Pathol 2001; 159:1159-1170.
    • (2001) Am J Pathol , vol.159 , pp. 1159-1170
    • Greive, K.A.1    Nikolic-Paterson, D.J.2    Guimarães, M.A.M.3
  • 52
    • 51349162919 scopus 로고    scopus 로고
    • The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A
    • Faul C, Donnelly M, Merscher-Gomez S, et al. The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A. Nature Med 2008; 14:931-938.
    • (2008) Nature Med , vol.14 , pp. 931-938
    • Faul, C.1    Donnelly, M.2    Merscher-Gomez, S.3
  • 53
    • 38049032013 scopus 로고    scopus 로고
    • Modification of kidney barrier function by the urokinase receptor
    • Wei C, Möller C, Altintas MM, et al. Modification of kidney barrier function by the urokinase receptor. Nat Med 2008; 14:55-62.
    • (2008) Nat Med , vol.14 , pp. 55-62
    • Wei, C.1    Möller, C.2    Altintas, M.M.3
  • 54
    • 59649117855 scopus 로고    scopus 로고
    • Is the LPS-mediated proteinuria mouse model relevant to human kidney disease?
    • Comper WD. Is the LPS-mediated proteinuria mouse model relevant to human kidney disease? Nat Med 2009; 15:133.
    • (2009) Nat Med , vol.15 , pp. 133
    • Comper, W.D.1
  • 55
    • 33847011714 scopus 로고    scopus 로고
    • Evidence for a role of transforming growth factor (TGF)-b1 in the induction of postglomerular albuminuria in diabetic nephropathy
    • Russo LM, del Re E, Brown D, Lin HY. Evidence for a role of transforming growth factor (TGF)-b1 in the induction of postglomerular albuminuria in diabetic nephropathy. Diabetes 2007; 56:380-388.
    • (2007) Diabetes , vol.56 , pp. 380-388
    • Russo, L.M.1    del Re, E.2    Brown, D.3    Lin, H.Y.4
  • 56
    • 33645403170 scopus 로고    scopus 로고
    • Hereditary proteinuria syndromes and mechanisms of proteinuria
    • Tryggvason K, Patrakka J, Wartiovaara J. Hereditary proteinuria syndromes and mechanisms of proteinuria. N Engl J Med 2006; 354:1387-1401.
    • (2006) N Engl J Med , vol.354 , pp. 1387-1401
    • Tryggvason, K.1    Patrakka, J.2    Wartiovaara, J.3
  • 57
    • 10244266416 scopus 로고    scopus 로고
    • Retention of albumin in the circulation is governed by saturable renal cell-mediated processes
    • Koltun M, Comper WD. Retention of albumin in the circulation is governed by saturable renal cell-mediated processes. Microcirculation 2004; 11:351-360.
    • (2004) Microcirculation , vol.11 , pp. 351-360
    • Koltun, M.1    Comper, W.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.