Reevaluation of glomerular charge selective protein-sieving function

Pediatric Nephrology

Volumn 24, Issue 3, 2009, Pages 609-612

  Saito, Hiroshi ^a   Takahashi, Shori ^a   Nagata, Michio ^b   Tsuchiya, Tatsuyuki ^a   Mugishima, Hideo ^a   Yan, Kunimasa ^c   Kondo, Yoshiaki ^d   Matsuyama, Takeshi ^e   Sekine, Takashi ^f   Igarashi, Takashi ^f  

^a NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c KYORIN UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e Fussa Hospital   (Japan)

^f UNIVERSITY OF TOKYO   (Japan)

Author keywords

Charge barrier; Charge selectivity index; Glomerular basement membrane; Protein filtration; Urinary protein

Indexed keywords

CORTICOSTEROID; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G;

ARTICLE; CHRONIC GLOMERULONEPHRITIS; CONTROLLED STUDY; DISEASE COURSE; FUNCTIONAL ASSESSMENT; GLOMERULOPATHY; GLOMERULUS BASEMENT MEMBRANE; GLOMERULUS FILTRATION; HUMAN; KIDNEY CLEARANCE; KIDNEY FUNCTION TEST; MAJOR CLINICAL STUDY; NEPHROTIC SYNDROME; PATHOPHYSIOLOGY; PODOCYTE; PRIORITY JOURNAL; PROTEINURIA; REFERENCE VALUE;

GLOMERULAR BASEMENT MEMBRANE; GLOMERULONEPHRITIS; HUMANS; PERMEABILITY; PODOCYTES; PROTEINURIA;

EID: 59849086065     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00467-008-1013-9     Document Type: Article

References (15)

1. Brenner BM, Hostetter TH, Humes HD (1978) Molecular basis of proteinuria of glomerular origin. N Engl J Med 298:826-833
2. Kestilä M, Lenkkeri U, Männikkö M, Lamerdin J, McCready P, Putaala H, Ruotsalainen V, Morita T, Nissinen M, Herva R, Kashtan CE, Peltonen L, Holmberg C, Olsen A, Tryggvason K (1998) Positionally cloned gene for a novel glomerular protein-nephrin-is mutated in congenital nephrotic syndrome. Mol Cell 1:575-582
3. Ruotsalainen V, Ljungberg P, Wartiovaara J, Lenkkeri U, Kestilä M, Jalanko H, Holmberg C, Tryggvason K (1999) Nephrin is specifically located at the slit diaphragm of glomerular podocytes. Proc Natl Acad Sci U S A 96:7962-7967
4. Sako M, Nakanishi K, Obana M, Yata N, Hoshii S, Takahashi S, Wada N, Takahashi Y, Kaku Y, Satomura K, Ikeda M, Honda M, Iijima K, Yoshikawa N (2005) Analysis of NPHS1, NPHS2, ACTN4, and WT1 in Japanese patients with congenital nephrotic syndrome. Kidney Int 67:1248-1255
5. Takahashi S, Kitamura T, Murakami H, Hashimoto K, Nagata M, Harada K (2005) Acute interstitial nephritis predisposed a six-year-old girl to minimal change nephrotic syndrome. Pediatr Nephrol 20:1168-1170
6. Takahashi S, Watanabe S, Wada N, Murakami H, Funaki S, Yan K, Kondo Y, Harada K, Nagata M (2006) Charge selective function in childhood glomerular diseases. Pediatr Res 59:336-340
7. Norden AG, Lapsley M, Lee PJ, Pusey CD, Scheinman SJ, Tam FW, Thakker RV, Unwin RJ, Wrong O (2001) Glomerular protein sieving and implications for renal failure in Fanconi syndrome. Kidney Int 60:1885-1892
8. Sörensson J, Björnson A, Ohlson M, Ballermann BJ, Haraldsson B (2003) Synthesis of sulfated proteoglycans by bovine glomerular endothelial cells in culture. Am J Physiol Renal Physiol 284:F373-380
9. Smithies O (2003) Why the kidney glomerulus does not clog: A gel permeation/diffusion hypothesis of renal function. Proc Natl Acad Sci U S A 100:4108-4113
10. Ohlson M, Sörensson J, Haraldsson B (2001) A gel-membrane model of glomerular charge and size selectivity in series. Am J Physiol Renal Physiol 280:F396-405
11. Takahashi S, Wada N, Harada K, Nagata M (2004) Cationic charge-preferential IgG reabsorption in the renal proximal tubules. Kidney Int 66:1556-1560
12. Wada N, Ueda Y, Iidaka K, Inage Z, Kikkawa Y, Kitagawa T (1990) Portions of basement membrane with decreased negative charge in various glomerulonephritis. Clin Nephrol 34:9-16
13. Sakagami Y, Nakajima M, Takagawa K, Ueda T, Akazawa H, Maruhashi Y, Shimoyama H, Kamitsuji H, Yoshioka A (2004) Analysis of glomerular anionic charge status in children with IgA nephropathy using confocal laser scanning microscopy. Nephron Clin Pract 96:c96-104
14. Lee HS, Choi Y, Lee JS, Yu BH, Koh HI (1989) Ultrastructural changes in IgA nephropathy in relation to histologic and clinical data. Kidney Int 35:880-886
15. Nomura Y, Ohya N, Shimada M (1989) A histopathological study on the prognosis of childhood IgA nephropathy and glomerular basement membrane lesions. Pediatr Nephrol 3:242-247