Interplay between polypyrimidine tract binding protein-associated splicing factor and human myometrial progesterone receptors

Journal of Molecular Endocrinology

Volumn 43, Issue 1, 2009, Pages 29-41

  Tyson Capper, A J ^a   Shiells, E A ^a   Robson, S C ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; GLUCOCORTICOID RECEPTOR; HISTONE DEACETYLASE 2; POLYPYRIMIDINE TRACT BINDING PROTEIN ASSOCIATED SPLICING FACTOR; PROGESTERONE RECEPTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL LYSATE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA BINDING; FEMALE; GENE EXPRESSION REGULATION; GENE TARGETING; GENETIC TRANSFECTION; HORMONE RESPONSE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; LABOR; MOLECULAR INTERACTION; MYOMETRIUM; NUCLEOTIDE SEQUENCE; PREGNANCY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; UTERUS;

DNA; FEMALE; HUMANS; LABOR, OBSTETRIC; MYOMETRIUM; PREGNANCY; PROTEIN BINDING; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, PROGESTERONE; RESPONSE ELEMENTS; RNA-BINDING PROTEINS;

EID: 67849106717     PISSN: 09525041     EISSN: 14796813     Source Type: Journal    
DOI: 10.1677/JME-09-0001     Document Type: Article

References (56)

1. Aoyagi S & Archer TK 2007 Dynamic histone acetylation/deacetylation with progesterone receptor-mediated transcription. Molecular Endocrinology 21 843-856.
2. Appleby SB, Ristimaki A, Neilson K, Narko K & Hla T 1994 Structure of the human cyclo-oxygenase-2 gene. Biochemical Journal 302 723-727.
3. Astle S, Slater DM & Thornton S 2003 The involvement of progesterone in the onset of human labour. European Journal of Obstetrics, Gynecology, and Reproductive Biology 108 177-181.
4. Auboeuf D, Honig A, Berget SM & O'Malley BW 2002 Coordinate regulation of transcription and splicing by steroid receptor coregulators. Science 298 416-419.
5. Auboeuf D, Dowhan DH, Kang YK, Larkin K, Lee JW, Berget SM & O'Malley BW 2004 Differential recruitment of nuclear receptor coactivators may determine alternative RNA splice site choice in target genes. PNAS 101 2270-2274.
6. Challis JRG, Matthews SG, Gibb W & Lye SJ 2000 Endocrine and paracrine regulation of birth at term and preterm. Endocrine Reviews 21 514-550.
7. Condon JC, Jeyasuria P, Faust JM, Wilson JW & Mendelson CR 2003 A decline in the levels of progesterone receptor coactivators in the pregnant uterus at term may antagonize progesterone receptor function and contribute to the initiation of parturition. PNAS 100 9518-9523.
8. Condon JC, Hardy DB, Kovaric K & Mendelson CR 2006 Up-regulation of the progesterone receptor (PR)-C isoform in laboring myometrium by activation of nuclear factor-kappaB may contribute to the onset of labor through inhibition of PR function. Molecular Endocrinology 20 764-775.
9. Dai D, Wolf DM, Litman ES, White MJ & Leslie KK 2002 Progesterone inhibits human endometrial cancer cell growth and invasiveness: down-regulation of cellular adhesion molecules through progesterone B receptors. Cancer Research 62 881-886.
10. Davies S, Dai D, Pickett G & Leslie KK 2006 Gene regulation profiles by progesterone and dexamethasone in human endometrial cancer Ishikawa H cells. Gynecologic Oncology 101 62-70.
11. Dong X, Shylnova O, Challis JR & Lye SJ 2005 Identification and characterization of the protein-associated splicing factor as a negative co-regulator of the progesterone receptor. Journal of Biological Chemistry 280 13329-13340.
12. Dong X, Sweet J, Challis JR, Brown T & Lye SJ 2007 Transcriptional activity of androgen receptor is modulated by two RNA splicing factors, PSF and p54nrb. Molecular and Cellular Biology 27 4863-4875.
13. Druckmann R & Druckmann MA 2005 Progesterone and the immunology of pregnancy. Journal of Steroid Biochemistry and Molecular Biology 97 389-396.
14. Dye BT & Patton JG 2001 An RNA recognition motif (RRM) is required for the localization of PTB-associated splicing factor (PSF) to subnuclear speckles. Experimental Cell Research 263 131-144.
15. Guillouf C, Gallais I & Moreau-Gachelin F 2006 Spi-1/PU.1 oncoprotein affects splicing decisions in a promoter bindingdependent manner. Journal of Biological Chemistry 281 19145-19155.
16. Hall-Pogar T, Liang S, Hague LK & Lutz CS 2007 Specific trans-acting proteins interact with auxiliary RNA polyadenylation elements in the COX-2 3′-UTR. RNA 13 1103-1115.
17. Han A, He J, Wu Y, Liu JO & Chen L 2005 Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2. Journal of Molecular Biology 345 91-102.
18. Harper KA, Robson SC, Europe-Finner GN & Tyson-Capper AJ 2007 Characterisation of class 1 and class 11 HDACs in the human myometrium in pregnancy. Reproductive Sciences 14 A9.
19. Horie-Inoue K, Takayama K, Bono HU, Ouchi Y, Okazaki Y & Inoue S 2006 Identification of novel steroid target genes through the combination of bioinformatics and functional analysis of hormone response elements. Biochemical and Biophysical Research Communications 339 99-106.
20. Karteris E, Zervou S, Pang Y, Dong J, Hillhouse EW, Randeva HS & Thomas P 2006 Progesterone signaling in human myometrium through two novel membrane G protein-coupled receptors: potential role in functional progesterone withdrawal at term. Molecular Endocrinology 20 1519-1534.
21. Kastner P, Krust A, Turcotte B, Stropp U, Tora L, Gronemeyer H & Chambon P 1990 Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO Journal 9 1603-1614.
22. Leonhardt SA, Boonyaratanakornkit V & Edwards DP 2003 Progesterone receptor transcription and non-transcription signaling mechanisms. Steroids 68 761-770.
23. Li X, Wong J, Tsai SY, Tsai MJ & O'Malley BW 2003 Progesterone and glucocorticoid receptors recruit distinct coactivator complexes and promote distinct patterns of local chromatin modification. Molecular and Cellular Biology 23 3763-3773.
24. Ma K, Chan JK, Zhu G & Wu Z 2005 Myocyte enhancer factor 2 acetylation by p300 enhances its DNA binding activity, transcriptional activity, and myogenic differentiation. Molecular and Cellular Biology 25 3575-3582.
25. Mathur M, Tucker PW & Samuels HH 2001 PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors. Molecular and Cellular Biology 21 2298-2311.
26. McKenna NJ, Lanz RB & O'Malley BW 1999 Nuclear receptor coregulators: cellular and molecular biology. Endocrine Reviews 20 321-344.
27. McKinsey TA, Zhang CL & Olson EN 2002 MEF2: a calcium-dependent regulator of cell division, differentiation and death. Trends in Biochemical Sciences 27 40-47.
28. Merlino AA, Welsh TN, Tan H, Yi LJ, Cannon V, Mercer BM & Mesiano S 2007 Nuclear progesterone receptors in the human pregnancy myometrium: evidence that parturition involves functional progesterone withdrawal mediated by increased expression of progesterone receptor-A. Journal of Clinical Endocrinology and Metabolism 92 1927-1933.
29. Mesiano S & Welsh TN 2007 Steroid hormone control of myometrial contractility and parturition. Seminars in Cell and Developmental Biology 18 321-331.
30. Mitchell CM, Johnson RF, Giles W & Zakar T 2007 Glucocorticoid receptor: pCREB and CBP binding to the prostaglandin endoperoxide H synthase (PGHS-2) promoter in term amnion in vivo. Reproductive Sciences 14 A538.
31. Nishimori T, Inoue H & Hirata Y 2004 Involvement of the 3′-untranslated region of cyclooxygenase-2 gene in its posttranscriptional regulation through the glucocorticoid receptor. Life Sciences 74 2505-2513.
32. O'Malley B 2008 The year in basic science: nuclear receptors and coregulators. Molecular Endocrinology 22 2751-2758.
33. Patton JG, Porro EB, Galceran J, Tempst P & Nadal-Ginard B 1993 Cloning and characterization of PSF, a novel pre-mRNA splicing factor. Genes and Development 7 393-406.
34. Petz LN, Ziegler YS, Schultz JR, Kim H, Kemper JK & Nardulli AM 2004 Differential regulation of the human progesterone receptor gene through an estrogen response element half site and Sp1 sites. Journal of Steroid Biochemistry and Molecular Biology 88 113-122.
35. Phaneuf S, Asboth G, Carrasco MP, Europe-Finner GN, Saji F, Kimura T, Harris A & Lopez Bernal A 1997 The desensitization of oxytocin receptors in human myometrial cells is accompanied by down-regulation of oxytocin receptor messenger RNA. Journal of Endocrinology 154 7-18.
36. Phillips RJ, Tyson-Capper (Née Pollard) AJ, Bailey J, Robson SC & Europe-Finner GN 2005 Regulation of expression of the chorionic gonadotropin/luteinizing hormone receptor gene in the human myometrium: involvement of specificity protein-1 (Sp1), Sp3, Sp4, Sp-like proteins, and histone deacetylases. Journal of Clinical Endocrinology and Metabolism 90 3479-3490.
37. Pieber D, Allport VC, Hills F, Johnson M & Bennett PR 2001 Interactions between progesterone receptor isoforms in myometrial cells in human labour. Molecular Human Reproduction 7 875-879.
38. Pollard AJ, Sparey C, Robson SC, Krainer AR & Europe-Finner GN 2000 Spatio-temporal expression of the trans-acting splicing factors SF2/ASF and heterogeneous ribonuclear proteins A1/A1B in the myometrium of the pregnant human uterus: a molecular mechanism for regulating regional protein isoform expression in vivo. Journal of Clinical Endocrinology and Metabolism 85 1928-1936.
39. Pollard AJ, Krainer AR, Robson SC & Europe-Finner GN 2002 Alternative splicing of the adenylyl cyclase stimulatory G-protein G alpha(s) is regulated by SF2/ASF and heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) and involves the use of an unusual TG 3′-splice Site. Journal of Biological Chemistry 277 15241-15251.
40. Qiu Y, Zhao Y, Becker M, John S, Parekh BS, Huang S, Hendarwanto A, Martinez ED, Chen Y, Lu H et al. 2006 HDAC1 acetylation is linked to progressive modulation of steroid receptor-induced gene transcription. Molecular Cell 22 669-679.
41. Ristimaki A, Narko K & Hla T 1996 Down-regulation of cytokine-induced cyclo-oxygenase-2 transcript isoforms by dexamethasone: evidence for post-transcriptional regulation. Biochemical Journal 318 325-331.
42. Rosonina E, Ip JY, Calarco JA, Bakowski MA, Emili A, McCracken S, Tucker P, Ingles CJ & Blencowe BJ 2005 Role for PSF in mediating transcriptional activator-dependent stimulation of pre-mRNA processing in vivo. Molecular and Cellular Biology 25 6734-6746.
43. Samalecos A & Gellersen B 2008 Systematic expression analysis and antibody screening do not support the existence of naturally occurring PR-C, PR-M or other truncated progesterone receptor isoforms. Endocrinology 149 5872-5887.
44. Shav-Tal Y, Cohen M, Lapter S, Dye B, Patton JG, Vandekerckhove J & Zipori D 2001 Nuclear relocalization of the pre-mRNA splicing factor PSF during apoptosis involves hyperphosphorylation, masking of antigenic epitopes, and changes in protein interactions. Molecular Biology of the Cell 12 2328-2340.
45. Slater DM, Dennes WJ, Campa JS, Poston L & Bennett PR 1999 Expression of cyclo-oxygenase types-1 and -2 in human myometrium throughout pregnancy. Molecular Human Reproduction 5 880-884.
46. Szekeres-Bartho J, Barakonyi A, Par G, Polgar B, Palkovics T & Szereday L 2001 Progesterone as an immunomodulatory molecule. International Immunopharmacology 1 1037-1048.
47. Tyson-Capper A & Robson SC 2007 PSF and the regulation of the progesterone receptor gene in the human myometrium during pregnancy. Reproductive Sciences 14 A541.
48. Tyson-Capper AJ & Robson SC 2008 The ambiguity of myometrial progesterone receptor expression in pregnancy and labour. Human Reproduction 15 A621.
49. Tyson-Capper AJ, Bailey J, Krainer AR, Robson SC & Europe-Finner GN 2005 The switch in alternative splicing of cyclic AMP-response element modulator protein CREM{tau}2{alpha} (activator) to CREM{alpha} (repressor) in human myometrial cells is mediated by SRp40. Journal of Biological Chemistry 280 34521-34529.
50. Urban RJ & Bodenburg Y 2002 PTB-associated splicing factor regulates growth factor-stimulated gene expression in mammalian cells. American Journal of Physiology. Endocrinology and Metabolism 283 E794-E798.
51. 2 terminus of PTB-associated splicing factor binds to the porcine P450scc IGF-I response element. American Journal of Physiology. Endocrinology and Metabolism 283 E423-E427.
52. Vegeto E, Shahbaz MM, Wen DX, Goldman ME, O'Malley BW & McDonnell DP 1993 Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function. Molecular Endocrinology 7 1244-1255.
53. Vienonen A, Miettinen S, Blauer M, Martikainen PM, Tomas E, Heinonen PK & Ylikomi T 2004 Expression of nuclear receptors and cofactors in human endometrium and myometrium. Journal of the Society for Gynecologic Investigation 11 104-112.
54. Wang JC, Derynck MK, Nonaka DF, Khodabakhsh DB, Haqq C & Yamamoto KR 2004 Chromatin immunoprecipitation (ChIP) scanning identifies primary glucocorticoid receptor target genes. PNAS 101 15603-15608.
55. Yudt MR, Berrodin TJ, Jelinsky SA, Hanna LA, Brown EL, Chippari S, Bhat RA, Winneker RC & Zhang Z 2006 Selective and opposing actions of progesterone receptor isoforms in human endometrial stromal cells. Molecular and Cellular Endocrinology 247 116-126.
56. Zhang Y & Dufau ML 2002 Silencing of transcription of the human luteinizing hormone receptor gene by histone deacetylase-mSin3A complex. Journal of Biological Chemistry 277 33431-33438.