Regulation of expression of the chorionic gonadotropin/luteinizing hormone receptor gene in the human myometrium: Involvement of specificity protein-1 (Sp1), Sp3,Sp4, Sp-like proteins, and histone deacetylases

Journal of Clinical Endocrinology and Metabolism

Volumn 90, Issue 6, 2005, Pages 3479-3490

  Phillips, Robert J ^a   Tyson Capper, Alison J ^a   Bailey, Jarrod ^a   Robson, Stephen C ^a   Europe Finner, G Nicholas ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; LUCIFERASE; LUTEINIZING HORMONE RECEPTOR; MESSENGER RNA; PROTEIN; SP LIKE PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR SP3; TRANSCRIPTION FACTOR SP4; TRICHOSTATIN A; UNCLASSIFIED DRUG; PREGNANCY SPECIFIC BETA1 GLYCOPROTEIN; PRIMER DNA; SP4 PROTEIN, HUMAN;

ARTICLE; ASSAY; CELL; CELL CULTURE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CODON; CONTROLLED STUDY; DNA BINDING; GENE CONSTRUCT; GENE DELETION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE REPRESSION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MEASUREMENT; MYOMETRIUM; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN FAMILY; PROTEIN FUNCTION; PURIFICATION; RECEPTOR GENE; REGULATORY MECHANISM; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; SEQUENCE ANALYSIS; TRANSCRIPTION REGULATION; WESTERN BLOTTING; CELL NUCLEUS; ENZYMOLOGY; FEMALE; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; REGULATORY SEQUENCE;

BASE SEQUENCE; CELL NUCLEUS; CELLS, CULTURED; CODON; DNA PRIMERS; FEMALE; GENE EXPRESSION REGULATION; GENES, REPORTER; HISTONE DEACETYLASES; HUMANS; LUCIFERASES; MYOMETRIUM; PREGNANCY-SPECIFIC BETA 1-GLYCOPROTEINS; PROMOTER REGIONS (GENETICS); RECEPTORS, LH; REGULATORY SEQUENCES, NUCLEIC ACID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SP4 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 21244481766     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2004-1962     Document Type: Article

References (29)

1. López Bernal A, Watson SP, Phaneuf S, Europe-Finner GN 1993 Biochemistry and physiology of preterm labour and delivery. Baillieres Clin Obstet Gynaecol 7:523-552
2. Brody S, Carlstrom G 1965 Human chorionic gonadotrophin pattern and its relation to the sex of the fetus. J Clin Endocrinol 25:792-797
3. Zuo J, Lei ZM, Rao CV 1994 Human myometrial chorionic gonadotropin/ luteinizing hormone receptors in preterm and term deliveries. J Clin Endocrinol Metab 79:907-911
4. Eta E, Ambrus G, Rao CV 1994 Direct regulation of human myometrial contractions by human chorionic-gonadotropin. J Clin Endocrinol Metab 79:1582-1586
5. Slattery MM, Brennan C, O'Leary, MJ, Morrison JJ 2001 Human chorionic gonadotrophin inhibition of pregnant human myometrial contractility. Br J Obstet Gynaecol 108:704-708
6. Kurtzman JT, Spinnato JA, Goldsmith LJ, Zimmerman MJ, Klem M, Lei ZM, Rao CV 1999 Human chorionic gonadotropin exhibits potent inhibition of preterm delivery in a small animal model. Am J Obstet Gynecol 181:853-857
7. Ali FM, Fateen B, Ezzet A, Badawy H, Ramadan A, El-tobge A 2000 Treatment of preterm labor with human chorionic gonadotropin: a new modality. Obstet Gynecol 95:104
8. sn pregnancy. Endocrinology 132:2484-2490
9. s in human myometrium in term and preterm labor: a mechanism for parturition. J Clin Endocrinol Metab 79:1835-1839
10. López Bernal A, Europe-Finner GN, Phaneuf S, Watson SP 1995 Preterm labour: a pharmacological challenge. Trends Pharmacol Sci 16:129-133
11. s in the human myometrium during pregnancy and labor involves transcriptional regulation by cyclic AMP and binding of phosphorylated nuclear proteins to multipleGCboxes within the promoter. J Clin Endocrinol Metabl 87:5675-5685
12. Atger M, Misrahi M, Sar S, Le Flem L, Dessen P, Milgrom E 1995 Structure of the human luteinizing hormone-choriogonadotropin receptor gene: unusual promoter and 5′ non-coding regions. Mol Cell Endocrinol 111:113-123
13. Tsai-Morris CH, Geng Y, Buczko E, Dufau ML 1998 A novel human luteinizing hormone receptor gene. J Clin Endocrinol Metab 83:288-291
14. Tsai-Morris CH, Buczko E, Wang W, Dufau ML 1990 Intronic nature of the rat luteinising hormone receptor gene defines a soluble receptor subspecies with hormone binding activity. J Biol Chem 265:19385-19388
15. Tsai-Morris CH, Buczko E, Wang W, Xie, XZ, Dufau, ML 1991 Structural organization of the rat luteinising hormone (LH) receptor gene. J Biol Chem 266:11355-11359
16. Koo YB, Li LI, Ji TH 1994 Characterization of different sizes of rat luteinizing/chorionic gonadotropin receptor messenger ribonucleic acids. Endocrinology 134:19-26
17. Huhtaniemi IT, Esskola V, Pakarinen P, Matikainen T, Sprengel R 1992 The murine luteinising hormone and follicle-stimulating hormone receptor genes: transcription initiation sites. Mol Cell Endocrinol 88:55-66
18. Tsai-Morris CH, Xie XZ, Wang W, Buczko E, Dufau ML 1993 Promoter and regulatory regions of the rat luteinising hormone receptor gene. J Biol Chem 268:4447-4452
19. Tsai-Morris CH, Geng Y, Buczko E, Dufau ML 1995 Characterisation of diverse functional elements in the upstream Sp1 domain of the rat luteinising hormone receptor gene promoter. J Biol Chem 270:7487-7494
20. Geng Y, Tsai-Morris CH, Zhang Y, Dufau ML 1999 The human luteinising hormone receptor gene promoter: activation by Sp1 and Sp3 and inhibitory regulation. Biochem Biophys Res Commun 263:366-371
21. Rohlff C, Ahmad S, Borellini F, Lei J, Glazer RI 1997 Modulation of transcription factor Sp1 by cAMP dependent protein kinase. J Biol Chem 272:21137-21141
22. Tsai-Morris CH, Geng Y, Xie XZ, Buczko E, Dufau ML 1994 Transcriptional protein binding domains governing basal expression of the rat luteinising hormone receptor gene. J Biol Chem 269:15868-15875
23. Zhang Y, Dufau ML 2002 Silencing of transcription of the human luteinising hormone receptor gene by histone deacetylase-mSin3A complex. J Biol Chem 277:33431-33448
24. Zhang Y, Dufau ML 2003 Dual mechanisms of regulation of transcription of luteinising hormone receptor gene by nuclear orphan receptors and histone deacetylase. J Steroid Biochem Mol Biol 85:401-414
25. Zhang Y, Dufau ML 2001 EAR2 and EAR3/COUP-TFI regulate transcription of the rat LH receptor. Mol Endocrinol 15:1891-1905
26. Zhang Y, Dufau ML 2000 Nuclear orphan receptors regulate transcription of the gene for human luteinising hormone receptor. J Biol Chem 275:2763-2770
27. Phaneuf S, Europe-Finner GN, Varney M, MacKenzie IZ, Watson SP, López Bernal A 1993 Oxytocin-stimulated phosphoinositide hydrolysis in human myometrial cells: involvement of pertussis toxin sensitive and insensitive G proteins. J Endocrinol 136:497-509
28. Hu YL, Lei ZM, Rao ChV 1996 Cis-acting elements and trans-acting proteins in the transcription of chorionic gonadotropin/luteinizing hormone receptor gene in human choriocarcinoma cells and placenta. Endocrinology 137:3897-3905
29. Condon JC, Jeyasuria P, Faust JM, Wilson JW, Mendelson CR 2003 A decline in the levels of progesterone receptor coactivators in the pregnant uterus at term may antagonize progesterone receptor function and contribute to the initiation of parturition. Proc Natl Acad Sci USA 100:9518-9523