Genetic screen identifies serpin5 as a regulator of the toll pathway and CHMP2B toxicity associated with frontotemporal dementia

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 29, 2009, Pages 12168-12173

  Tariq Ahmad, S ^a   Sweeney, Sean T ^b   Lee, Jin A ^a   Sweeney, Neal T ^a,c,d   Gaoa, Fen Biao ^a,c  

^a GLADSTONE INSTITUTE OF NEUROLOGICAL DISEASE   (United States)

^b UNIVERSITY OF YORK   (United Kingdom)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d YALE UNIVERSITY   (United States)

Author keywords

Drosophila; Endosomal sorting complex required for transport (ESCRT); Modifier screen; Neurodegeneration

Indexed keywords

GENE PRODUCT; LIGAND; MUTANT PROTEIN; PROTEIN CHMP2B; REGULATOR PROTEIN; SERPIN 5; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHMP2B GENE; CHROMOSOME 3; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; ENDOSOME; FRONTOTEMPORAL DEMENTIA; GENE; GENE INTERACTION; GENE LOCUS; GENE MUTATION; GENETIC LINKAGE; GENETIC SCREENING; GENOME; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION;

ANIMALS; BIOLOGICAL TRANSPORT; DEMENTIA; DISEASE MODELS, ANIMAL; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; ENDOSOMES; EXTRACELLULAR SPACE; EYE; GENES, DOMINANT; GENES, INSECT; GENETIC SCREENING; INTRONS; MUTANT PROTEINS; PHENOTYPE; SERPINS; SIGNAL TRANSDUCTION; SUPPRESSION, GENETIC; TOLL-LIKE RECEPTORS; VESICULAR TRANSPORT PROTEINS;

ANIMALIA;

EID: 67749145743     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0903134106     Document Type: Article

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