Insights into the anthrax lethal factor-substrate interaction and selectivity using docking and molecular dynamics simulations

Protein Science

Volumn 18, Issue 8, 2009, Pages 1774-1785

  Dalkas, Georgios A ^a   Papakyriakou, Athanasios ^a   Vlamis Gardikas, Alexios ^b   Spyroulias, Georgios A ^a  

^a UNIVERSITY OF PATRAS   (Greece)

^b BIOMEDICAL RESEARCH FOUNDATION   (Greece)

Author keywords

Anthrax lethal factor; Docking; Enzyme substrate interactions; MEK; MKK; Molecular dynamics; Protein plasticity

Indexed keywords

ANTHRAX LETHAL FACTOR; ANTHRAX TOXIN; BACTERIAL PROTEIN; METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG; ZINC;

AMINO TERMINAL SEQUENCE; ARTICLE; BACILLUS ANTHRACIS; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME INACTIVATION; ENZYME SUBSTRATE COMPLEX; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN FAMILY; SIGNAL TRANSDUCTION; SIMULATION; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANTIGENS, BACTERIAL; BACILLUS ANTHRACIS; BACTERIAL TOXINS; BINDING SITES; CATALYTIC DOMAIN; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DATABASES, PROTEIN; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; ZINC;

BACILLUS ANTHRACIS; BACTERIA (MICROORGANISMS);

EID: 67749122089     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.169     Document Type: Article

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