Synthetic lipopeptide MALP-2 inhibits intracellular growth of mycobacterium bovis BCG in alveolar macrophages-preliminary data

Inflammation

Volumn 32, Issue 4, 2009, Pages 247-251

  Jörgens, Grit ^a   Bange, Franz Christoph ^a   Mühlradt, Peter F ^b   Pabst, Reinhard ^a   Maus, Ulrich A ^a   Tschernig, Thomas ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b Wound Healing Research Group   (Germany)

Author keywords

Alveolar macrophages; IFN ; M. bovis BCG; MALP 2

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 6; MACROPHAGE ACTIVATING LIPOPEPTIDE 2; SYNTHETIC PEPTIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; BACTERIAL GROWTH; COLONY FORMING UNIT; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFICACY; LUNG ALVEOLUS MACROPHAGE; MYCOBACTERIUM BOVIS; NONHUMAN; RAT; SUPERNATANT; TARGET CELL;

ANIMALS; COLONY COUNT, MICROBIAL; CYTOKINES; INTERFERON-GAMMA; LIPOPEPTIDES; LUNG; MACROPHAGES, ALVEOLAR; MYCOBACTERIUM BOVIS; RATS; TUBERCULOSIS;

BACTERIA (MICROORGANISMS); MYCOBACTERIUM BOVIS BCG; RATTUS;

EID: 67651215716     PISSN: 03603997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10753-009-9127-1     Document Type: Article

References (19)

1. R. Brosch V. Vincent 2007 Cutting-edge science and the future of tuberculosis control Bull. World Health Organ. 85 410 412
2. J. L. Flynn J. Chan 2001 Immunology of tuberculosis Annu. Rev. Immunol. 19 93 129
3. A. Raja 2004 Immunology of tuberculosis Indian J. Med. Res. 120 213 232
4. H. L. Collins S. H. Kaufmann 2001 The many faces of host responses to tuberculosis Immunology 103 1 9
5. A. Jeevan C. T. McFarland T. Yoshimura T. Skwor H. Cho T. Lasco D. N. McMurray 2006 Production and characterization of guinea pig recombinant gamma interferon and its effect on macrophage activation Infect. Immun. 74 213 224
6. F. E. Aldwell D. N. Wedlock L. J. Slobbe J. F. Griffin B. M. Buddle G. S. Buchan 2001 In vitro control of Mycobacterium bovis by macrophages Tuberculosis (Edinb). 81 115 123
7. F. E. Aldwell D. N. Wedlock B. M. Buddle 1997 Sequential activation of alveolar macrophages by IFN-gamma and LPS is required for enhanced growth inhibition of virulent Mycobacterium bovis but not M. bovis BCG Immunol. Cell. Biol. 75 161 166
8. I. E. Flesch J. H. Hess I. P. Oswald S. H. Kaufmann 1994 Growth inhibition of Mycobacterium bovis by IFN-gamma stimulated macrophages: regulation by endogenous tumor necrosis factor-alpha and by IL-10 Int. Immunol. 6 693 700
9. O. Takeuchi A. Kaufmann K. Grote T. Kawai K. Hoshino M. Morr P. F. Mühlradt S. Akira 2000 Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway J. Immunol. 15 164 554 557
10. O. Takeuchi T. Kawai P. F. Mühlradt M. Morr J. D. Radolf A. Zychlinsky K. Takeda S. Akira 2001 Discrimination of bacterial lipoproteins by Toll-like receptor 6 Int. Immunol. 13 933 940
11. P. F. Mühlradt M. Kiess H. Meyer R. Süssmuth G. Jung 1997 Isolation, structure elucidation, and synthesis of a macrophage stimulatory lipopeptide from Mycoplasma fermentans acting at picomolar concentration J. Exp. Med. 185 1951 1958
12. K. Liu J. Yu D. G. Russel 2003 pckA-deficient Mycobacterium bovis BCG shows attenuated virulence in mice and in macrophages Microbiology 149 1829 1835
13. M. Denis D. N. Wedlock B. M. Buddle 2005 IFN-γ enhances bovine macrophage responsiveness to Mycobacterium bovis: impact of bacterial replication, cytokine release and macrophage apoptosis Immunol. Cell Biol. 83 643 650
14. A. Lührmann T. Tschernig R. Pabst S. Niewiesk 2005 Improved intranasal immunization with live-attenuated measles virus after co-inoculation of the lipopeptide MALP-2 Vaccine 23 4721 4726
15. A. Lührmann U. Deiters J. Skokowa M. Hanke J. E. Gessner P. F. Mühlradt R. Pabst T. Tschernig 2002 In vivo effects of a synthetic 2-kilodalton macrophage-activating lipopeptide of Mycoplasma fermentans after pulmonary application Infect. Immun. 70 3785 3792
16. M. B. Drennan D. Nicolle V. J. Quesniaux M. Jacobs N. Allie J. Mpagi C. Frémond H. Wagner C. Kirschning B. Ryffel 2004 Toll-like receptor 2-deficient mice succumb to Mycobacterium tuberculosis infection Am. J. Pathol. 164 49 57
17. V. J. Quesniaux D. M. Nicolle D. Torres L. Kremer Y. Guérardel J. Nigou G. Puzo F. Erard B. Ryffel 2004 Toll-like receptor 2 (TLR2)-dependent- positive and TLR2-independent-negative regulation of proinflammatory cytokines by mycobacterial lipomannans J. Immunol. 172 4425 4434
18. M. Gilleron V. F. Quesniaux G. Puzo 2003 Acylation state of the phosphatidylinositol hexamannosides from Mycobacterium bovis bacillus Calmette Guerin and mycobacterium tuberculosis H37Rv and its implication in Toll-like receptor response J. Biol. Chem. 278 29880 29889
19. K. Reppe T. Tschernig A. Lührmann V. van Laak K. Grote M. V. Zemlin B. Gutbier H. C. Müller M. Kursar H. Schütte S. Rosseau R. Pabst N. Suttorp M. Witzenrath 2009 Immunostimulation with macrophage-activating lipopeptide-2 increased survival in murine pneumonia Am. J. Respir. Cell. Mol. Biol. 40 174 181