The structural integrity exerted by N-terminal pyroglutamate is crucial for the cytotoxicity of frog ribonuclease from Rana pipiens

Nucleic Acids Research

Volumn 31, Issue 18, 2003, Pages 5247-5255

  Liao, You Di ^a   Wang, Sui Chi ^a   Leu, Ying Jen ^a,b   Wang, Chiu Feng ^a   Chang, Shu Ting ^a   Hong, Yu Ting ^a   Pan, Yun Ru ^a   Chen, Chinpan ^a  

^a INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^b NATIONAL TSING HUA UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; GENOMIC DNA; GLUTAMIC ACID; GUANINE; HYDROGEN; LYSINE; METHIONYL AMINOPEPTIDASE; PHOSPHATE; PYROGLUTAMIC ACID; RANPIRNASE; RECOMBINANT ENZYME; RIBONUCLEASE; SIGNAL PEPTIDE; THREONINE; URIDINE; VALINE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANTIGENICITY; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ESCHERICHIA COLI; FROG; GENE EXPRESSION; HYDROGEN BOND; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN VARIANT; RNA STRUCTURE; THERMOSTABILITY; WILD TYPE;

ANIMALS; CATALYSIS; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; CIRCULAR DICHROISM; CLONING, MOLECULAR; DNA; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EPITOPES; ESCHERICHIA COLI; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; K562 CELLS; KINETICS; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; MUTATION; PYRROLIDONECARBOXYLIC ACID; RANA PIPIENS; RECOMBINANT PROTEINS; RIBONUCLEASES; SEQUENCE ANALYSIS, DNA; SUBSTRATE SPECIFICITY;

ANIMALIA; ANURA; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; RANA PIPIENS;

EID: 0345306332     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkg746     Document Type: Article

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