Androgen regulates the sexually dimorphic gastrin-releasing peptide system in the lumbar spinal cord that mediates male sexual function

Endocrinology

Volumn 150, Issue 8, 2009, Pages 3672-3679

  Sakamoto, Hirotaka ^a,c   Takanami, Keiko ^a   Zuloaga, Damian G ^b   Matsuda, Ken Ichi ^a   Jordan, Cynthia L ^b   Breedlove, S Marc ^b   Kawata, Mitsuhiro ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c OKAYAMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; GASTRIN RELEASING PEPTIDE; MESSENGER RNA; TESTOSTERONE; TESTOSTERONE PROPIONATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CASTRATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME REGULATION; GENE FREQUENCY; LUMBAR SPINAL CORD; MALE; MALE SEXUAL DYSFUNCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SEX DIFFERENCE; SIGNAL TRANSDUCTION; TESTICULAR FEMINIZATION;

ANDROGEN-INSENSITIVITY SYNDROME; ANDROGENS; ANIMALS; BLOTTING, WESTERN; CASTRATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GASTRIN-RELEASING PEPTIDE; IMMUNOHISTOCHEMISTRY; MALE; POLYMERASE CHAIN REACTION; RATS; RATS, LONG-EVANS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ANDROGEN; RECEPTORS, BOMBESIN; SEXUAL DEVELOPMENT; SPINAL CORD; TESTOSTERONE;

EID: 67651180805     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2008-1791     Document Type: Article

References (38)

1. Morris JA, Jordan CL, Breedlove SM 2004 Sexual differentiation of the vertebrate nervous system. Nat Neurosci 7:1034-1039
2. Matsuda K, Sakamoto H, Kawata M 2008 Androgen action in the brain and spinal cord for the regulation of male sexual behaviors. Curr Opin Pharmacol 8:747-751
3. Phoenix CH, Goy RW, Gerall AA, Young WC 1959 Organizing action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig. Endocrinology 65:369-382
4. Sachs BD 1982 Role of striated penile muscles in penile reflexes, copulation, and induction of pregnancy in the rat. J Reprod Fertil 66:433-443
5. Hart BL 1973 Effects of testosterone propionate and dihydrotestosterone on penile morphology and sexual reflexes of spinal male rats. Horm Behav 4:239-246
6. Hart BL 1979 Activation of sexual reflexes of male rats by dihydrotestosterone but not estrogen. Physiol Behav 23:107-109
7. Breedlove SM, Arnold AP 1983 Hormonal control of a developing neuromuscular system. I. Complete memasculinization of the male rat spinal nucleus of the bulbocavernosus using the anti-androgen flutamide. J Neurosci 3:417-423
8. Breedlove SM, Arnold AP 1983 Hormonal control of a developing neuromuscular system. II. Sensitive periods for the androgen-induced masculinization of the rat spinal nucleus of the bulbocavernosus. J Neurosci 3:424-432
9. Forger NG, Fishman RB, Breedlove SM 1992 Differential effects of testosterone metabolites upon the size of sexually dimorphic motoneurons in adulthood. Horm Behav 26:204-213
10. Hart BL, Haugen CM 1968 Activation of sexual reflexes in male rats by spinal implantation of testosterone. Physiol Behav 3:735-738
11. Anastasi A, Erspamer V, Bucci M 1971 Isolation and structure of bombesin and alytesin, 2 analogous active peptides from the skin of the European amphibians Bombina and Alytes. Experientia 27:166-167
12. McDonald TJ, Jörnvall H, Nilsson G, Vagne M, Ghatei M, Bloom SR, Mutt V 1979 Characterization of a gastrin releasing peptide from porcine non-antral gastric tissue. Biochem Biophys Res Commun 90:227-233
13. Panula P, Nieminen O, Falkenberg M, Auvinen S 1988 Localization and development of bombesin/GRP-like immunoreactivity in the rat central nervous system. Ann NY Acad Sci 547:54-69
14. Ladenheim EE, Taylor JE, Coy DH, Moore KA, Moran TH 1996 Hindbrain GRP receptor blockade antagonizes feeding suppression by peripherally administered GRP. Am J Physiol 271:R180-R184
15. Shinohara K, Tominaga K, Isobe Y, Inouye ST 1993 Photic regulation of peptides located in the ventrolateral subdivision of the suprachiasmatic nucleus of the rat: daily variations of vasoactive intestinal polypeptide, gastrinreleasing peptide, and neuropeptide Y. J Neurosci 13:793-800
16. Sun YG, Chen ZF 2007 A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord. Nature 448:700-703
17. Merali Z, Bédard T, Andrews N, Davis B, McKnight AT, Gonzalez MI, Pritchard M, Kent P, Anisman H 2006 Bombesin receptors as a novel anti-anxiety therapeutic target: BB1 receptor actions on anxiety through alterations of serotonin activity. J Neurosci 26:10387-10396
18. Truitt WA, Coolen LM 2002 Identification of a potential ejaculation generator in the spinal cord. Science 297:1566-1569
19. Sakamoto H, Matsuda K, Zuloaga DG, Hongu H, Wada E, Wada K, Jordan CL, Breedlove SM, Kawata M 2008 Sexually dimorphic gastrin releasing peptide system in the spinal cord controls male reproductive functions. Nat Neurosci 11:634-636
20. Bardin CW, Bullock L, Blackburn WR, Sherins RJ, Vanha-Perttula T 1971 Testosterone metabolism in the androgen-insensitive rat: a model for testicular feminization. Birth Defects Orig Artic Ser 7:185-192
21. Beach FA, Buehler MG 1977 Male rats with inherited insensitivity to androgen show reduced sexual behavior. Endocrinology 100:197-200
22. Krey LC, Lieberburg I, MacLusky NJ, Davis PG, Robbins R 1982 Testosterone increases cell nuclear estrogen receptor levels in the brain of the Stanley-Gumbreck pseudohermaphrodite male rat: implications for testosterone modulation of neuroendocrine activity. Endocrinology 110:2168-2176
23. Griffin JE, Leshin M, Wilson JD 1982 Androgen resistance syndromes. Am J Physiol 243:E81-E87
24. Yarbrough WG, Quarmby VE, Simental JA, Joseph DR, Sar M, Lubahn DB, Olsen KL, French FS, Wilson EM 1990 A single base mutation in the androgen receptor gene causes androgen insensitivity in the testicular feminized rat. J Biol Chem 265:8893-8900
25. Cui H, Sakamoto H, Higashi S, Kawata M 2008 Effects of single-prolonged stress on neurons and their afferent inputs in the amygdala. Neuroscience 152:703-712
26. Sakamoto H, Matsuda K, Hosokawa K, Nishi M, Morris JF, Prossnitz ER, Kawata M 2007 Expression of G protein-coupled receptor-30, a G protein-coupled membrane estrogen receptor, in oxytocin neurons of the rat paraventricular and supraoptic nuclei. Endocrinology 148:5842-5850
27. Sakamoto H, Matsuda K, Zuloaga DG, Nishiura N, Takanami K, Jordan CL, Breedlove SM, Kawata M 2009 Stress affects a gastrin-releasing peptide system in the spinal cord that mediates sexual function: Implications for psychogenic erectile dysfunction. PLoS ONE 4:e4276
28. Sakamoto H, Mezaki Y, Shikimi H, Ukena K, Tsutsui K 2003 Dendritic growth and spine formation in response to estrogen in the developing Purkinje cell. Endocrinology 144:4466-4477
29. Zuloaga DG, Puts DA, Jordan CL, Breedlove SM 2008 The role of androgen receptors in the masculinization of brain and behavior: what we've learned from the testicular feminization mutation. Horm Behav 53:613-626
30. Sachs BD 1996 Penile erection in response to remote cues from females: albino rats severely impaired relative to pigmented strains. Physiol Behav 60:803-808
31. Newton BW 1992 A sexually dimorphic population of galanin-like neurons in the rat lumbar spinal cord: functional implications. Neurosci Lett 137:119-122
32. Phan DC, Newton BW 1999 Cholecystokinin-8-like immunoreactivity is sexually dimorphic in a midline population of rat lumbar neurons. Neurosci Lett 276:165-168
33. Nicholas AP, Zhang X, Hökfelt T 1999 An immunohistochemical investigation of the opioid cell column in lamina X of the male rat lumbosacral spinal cord. Neurosci Lett 270:9-12
34. Ju G, Melander T, Ceccatelli S, Hökfelt T, Frey P 1987 Immunohistochemical evidence for a spinothalamic pathway co-containing cholecystokinin- and galanin-like immunoreactivities in the rat. Neuroscience 20:439-456
35. Truitt WA, Shipley MT, Veening JG, Coolen LM 2003 Activation of a subset of lumbar spinothalamic neurons after copulatory behavior in male but not female rats. J Neurosci 23:325-331
36. Newton BW, Phan DC 2006 Androgens regulate the sexually dimorphic production of co-contained galanin and cholecystokinin in lumbar laminae VII and X neurons. Brain Res 1099:88-96
37. Evrard HC 2006 Estrogen synthesis in the spinal dorsal horn: a new central mechanism for the hormonal regulation of pain. Am J Physiol Regul Integr Comp Physiol 291:R291-R299
38. Evrard HC, Balthazart J 2003 Aromatase (estrogen synthase) activity in the dorsal horn of the spinal cord: functional implications. Ann NY Acad Sci 1007:263-271