Stress affects a gastrin-releasing peptide system in the spinal cord that mediates sexual function: Implications for psychogenic erectile dysfunction

PLoS ONE

Volumn 4, Issue 1, 2009, Pages

  Sakamoto, Hirotaka ^a   Matsuda, Ken Ichi ^a   Zuloaga, Damian G ^b   Nishiura, Nobuko ^a   Takanami, Keiko ^a   Jordan, Cynthia L ^b   Breedlove, S Marc ^b   Kawata, Mitsuhiro ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; GASTRIN RELEASING PEPTIDE; TESTOSTERONE;

ACUTE STRESS; ADULT ANIMAL; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EJACULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ERECTILE DYSFUNCTION; IN VIVO STUDY; LUMBAR SPINE; MALE; NERVE FIBER; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; RAT; REFLEX; SEXUAL FUNCTION; SPINAL CORD; TESTOSTERONE BLOOD LEVEL; WESTERN BLOTTING; ANIMAL; BLOOD; DISEASE MODEL; DOSE RESPONSE; MENTAL STRESS; METABOLISM; POSTTRAUMATIC STRESS DISORDER; PSYCHOSEXUAL DISORDER; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EJACULATION; ERECTILE DYSFUNCTION; GASTRIN-RELEASING PEPTIDE; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ANDROGEN; SEXUAL DYSFUNCTIONS, PSYCHOLOGICAL; SPINAL CORD; STRESS DISORDERS, POST-TRAUMATIC; STRESS, PSYCHOLOGICAL; TESTOSTERONE;

EID: 59249100476     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0004276     Document Type: Article

References (39)

1. Pitman RK (1997) Overview of biological themes in PTSD. Ann N Y Acad Sci 821: 1-9.
2. Cosgrove DJ, Gordon Z, Bernie JE, Hami S, Montoya D, et al. (2002) Sexual dysfunction in combat veterans with post-traumatic stress disorder. Urology 60: 881-884.
3. Kaplan HS (1989) Post-traumatic stress syndrome and sexual dysfunction. J Sex Marital Ther 15: 74-77.
4. Kaplan HS (1988) Anxiety and sexual dysfunction. J Clin Psychiatry 49 Suppl. pp 21-25.
5. Letourneau EJ, Schewe PA, Frueh BC (1997) Preliminary evaluation of sexual problems in combat veterans with PTSD. J Trauma Stress 10: 125-132.
6. Rajfer J (2000) Relationship between testosterone and erectile dysfunction. Rev Urol 2: 122-128.
7. Retana-Marquez S, Bonilla-Jaime H, Vazquez-Palacios G, Martinez-Garcia R, Velazquez-Moctezuma J (2003) Changes in masculine sexual behavior, corticosterone and testosterone in response to acute and chronic stress in male rats. Horm Behav 44: 327-337.
8. Mason JW, Giller EL, Kosten TR (1988) Serum testosterone differences between patients with schizophrenia and those with affective disorder. Biol Psychiatry 23: 357-366.
9. Kreuz LE, Rose RM, Jennings JR (1972) Suppression of plasma testosterone levels and psychological stress. A longitudinal study of young men in Officer Candidate School. Arch Gen Psychiatry 26: 479-482.
10. Mulchahey JJ, Ekhator NN, Zhang H, Kasckow JW, Baker DG, et al. (2001) Cerebrospinal fluid and plasma testosterone levels in post-traumatic stress disorder and tobacco dependence. Psychoneuroendocrinology 26: 273-285.
11. Bauer M, Priebe S, Graf KJ, Kurten I, Baumgartner A (1994) Psychological and endocrine abnormalities in refugees from East Germany: Part II. Serum levels of cortisol, prolactin, luteinizing hormone, follicle stimulating hormone, and testosterone. Psychiatry Res 51: 75-85.
12. Anastasi A, Erspamer V, Bucci M (1971) Isolation and structure of bombesin and alytesin, 2 analogous active peptides from the skin of the European amphibians Bombina and Alytes. Experientia 27: 166-167.
13. McDonald TJ, Jornvall H, Nilsson G, Vagne M, Ghatei M, et al. (1979) Characterization of a gastrin releasing peptide from porcine non-antral gastric tissue. Biochem Biophys Res Commun 90: 227-233.
14. Panula P, Nieminen O, Falkenberg M, Auvinen S (1988) Localization and development of bombesin/GRP-like immunoreactivity in the rat central nervous system. Ann N Y Acad Sci 547: 54-69.
15. Sun YG, Chen ZF (2007) A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord. Nature 448: 700-703.
16. Shinohara K, Tominaga K, Isobe Y, Inouye ST (1993) Photic regulation of peptides located in the ventrolateral subdivision of the suprachiasmatic nucleus of the rat: daily variations of vasoactive intestinal polypeptide, gastrin-releasing peptide, and neuropeptide Y. J Neurosci 13: 793-800.
17. Ladenheim EE, Taylor JE, Coy DH, Moore KA, Moran TH (1996) Hindbrain GRP receptor blockade antagonizes feeding suppression by peripherally administered GRP. Am J Physiol 271: R180-184.
18. Merali Z, Bedard T, Andrews N, Davis B, McKnight AT, et al. (2006) Bombesin receptors as a novel anti-anxiety therapeutic target: BB1 receptor actions on anxiety through alterations of serotonin activity. J Neurosci 26: 10387-10396.
19. Truitt WA, Coolen LM (2002) Identification of a potential ejaculation generator in the spinal cord. Science 297: 1566-1569.
20. Sakamoto H, Matsuda K-I, Zuloaga DG, Hongu H, Wada E, et al. (2008) Sexually dimorphic gastrin releasing peptide system in the spinal cord controls male reproductive functions. Nat Neurosci 11: 634-636.
21. Liberzon I, Krstov M, Young EA (1997) Stress-restress: effects on ACTH and fast feedback. Psychoneuroendocrinology 22: 443-453.
22. Sachs BD (1982) Role of striated penile muscles in penile reflexes, copulation, and induction of pregnancy in the rat. J Reprod Fertil 66: 433-443.
23. Khan S, Liberzon I (2004) Topiramate attenuates exaggerated acoustic startle in an animal model of PTSD. Psychopharmacology (Berl) 172: 225-229.
24. Kohda K, Harada K, Kato K, Hoshino A, Motohashi J, et al. (2007) Glucocorticoid receptor activation is involved in producing abnormal phenotypes of single-prolonged stress rats: a putative post-traumatic stress disorder model. Neuroscience 148: 22-33.
25. Iwamoto Y, Morinobu S, Takahashi T, Yamawaki S (2007) Single prolonged stress increases contextual freezing and the expression of glycine transporter 1 and vesicle-associated membrane protein 2 mRNA in the hippocampus of rats. Prog Neuropsychopharmacol Biol Psychiatry 31: 642-651.
26. Kang J, Ishola TA, Baregamian N, Mourot JM, Rychahou PG, et al. (2007) Bombesin induces angiogenesis and neuroblastoma growth. Cancer Lett 253: 273-281.
27. Levine L, Lucci JA 3rd, Pazdrak B, Cheng JZ, Guo YS, et al. (2003) Bombesin stimulates nuclear factor kappa B activation and expression of proangiogenic factors in prostate cancer cells. Cancer Res 63: 3495-3502.
28. Yesavage JA, Davidson J, Widrow L, Berger PA (1985) Plasma testosterone levels, depression, sexuality, and age. Biol Psychiatry 20: 222-225.
29. Matsumoto A (2005) Testosterone prevents synaptic loss in the perineal motoneuron pool in the spinal cord in male rats exposed to chronic stress. Stress 8: 133-140.
30. Chrousos GP, Kino T (2007) Glucocorticoid action networks and complex psychiatric and/or somatic disorders. Stress 10: 213-219.
31. Holsboer F, Grasser A, Friess E, Wiedemann K (1994) Steroid effects on central neurons and implications for psychiatric and neurological disorders. Ann N Y Acad Sci 746: 345-361.
32. Yehuda R (1997) Sensitization of the hypothalamic-pituitary-adrenal axis in posttraumatic stress disorder. Ann N Y Acad Sci 821: 57-75.
33. Yehuda R (2002) Post-traumatic stress disorder. N Engl J Med 346: 108-114.
34. Cui H, Sakamoto H, Higashi S, Kawata M (2008) Effects of single-prolonged stress on neurons and their afferent inputs in the amygdala. Neuroscience 152: 703-712.
35. Yoshii T, Sakamoto H, Kawasaki M, Ozawa H, Ueta Y, et al. (2008) The single-prolonged stress paradigm alters both the morphology and stress response of magnocellular vasopressin neurons. Neuroscience 156: 466-474.
36. Sakamoto H, Matsuda K-I, Hosokawa K, Nishi M, Morris JF, et al. (2007) Expression of G protein-coupled receptor-30, a G protein-coupled membrane estrogen receptor, in oxytocin neurons of the rat paraventricular and supraoptic nuclei. Endocrinology 148: 5842-5850.
37. Monaghan EP, Breedlove SM (1992) The role of the bulbocavernosus in penile reflex behavior in rats. Brain Res 587: 178-180.
38. Chen CD, Welsbie DS, Tran C, Baek SH, Chen R, et al. (2004) Molecular determinants of resistance to antiandrogen therapy. Nat Med 10: 33-39.
39. Cheng G, Weihua Z, Warner M, Gustafsson JA (2004) Estrogen receptors ER alpha and ER beta in proliferation in the rodent mammary gland. Proc Natl Acad Sci U S A 101: 3739-3746.