Synthesis and antinociceptive properties of new structurally planned imidazo[1,2-a]pyridine 3-acylarylhydrazone derivatives

European Journal of Medicinal Chemistry

Volumn 33, Issue 3, 1998, Pages 225-235

  Ribeiro, Izabella G ^a   Da Silva, Kelly Christine M ^a   Parrini, Sergio C ^a   De Miranda, Ana Luisa P ^a   Fraga, Carlos A M ^a   Barreiro, Eliezer J ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

2 methyl imidazo 1,2 a pyridine; 3 acylarylhydrazone derivative; Acylarylhydrazone; Analgesic activity; Anti inflammatory activity; Imidazo 1,2 a pyridine

Indexed keywords

ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; DRUG CARRIER; HYDRAZONE DERIVATIVE; IMIDAZO[1,2 A]PYRIDINE 3 ACYLARYLHYDRAZONE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARACHIDONIC ACID METABOLISM; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

EID: 0032033406     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(98)80012-3     Document Type: Article

References (23)

1. [1] Davier P., Bailey P.J., Goldenberg M., Ford-Hutchinson, A.W., Ann. Rev. Immunol. 2 (1984) 335.
2. [2] Vane J.R., Nature New Biology 231 (1971) 232.
3. [3] Higgs A.G., Vane J.R., Br. Med. Bull. 39 (1983) 265.
4. [4] Dray A., Urban L., Dickenson A., Trends Pharmacol. Sci. 15 (1994) 190.
5. [5] Soler O., M.Sc. Thesis, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil, 1994.
6. [6] Matheus M.E., Oliveira L.F., Freitas A.C.C., Carvalho A.M.A.S.P., Barrciro E.J., Braz. J. Med. Biol. Res. 24 (1991) 1219.
7. [7] Dias L.R.S., Alvim M.J.F., Freitas A.C.C., Barreiro E.J., Miranda A.L.P., Pharm. Acta Helv. 69 (1994) 163.
8. [8] Gaston M.J., Dias L.R.S., Freitas A.C.C., Barreiro E.J., Miranda A.L.P., Pharm. Acta Helv. 71 (1996) 213.
9. [9] Patari G.A., LaVoie E.J., Chem. Rev. 96 (1996) 3147.
10. [10] Albuquerque M.G., M.Sc. Thesis, Instituto de Química/LASSBio Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil, 1994.
11. [11] Ifas D., Alencastro R.B., Barreiro E.J., unpublished results.
12. [12] Elliott A.J., Guzik H., Soler J.R., J. Heterocyclic Chem. 19 (1982) 1437.
13. [13] Kaminski J.J., Bristol J.A., Puchalski C., Lovey R.G., Elliott A.J., Guzik H., Solomon D.M., Conn D.J., Domalsky M.S., Wong S.-C., Gold E.H., Long J.F., Chiu P.J.S., Steinberg M., McPhail A.T., J. Med. Chem. 28 (1985) 876.
14. [14] Kaminski J.J., Hilbert J.M., Pramanik B.N., Solomon D.M., Conn D.J., Rizvi R.K., Elliott A.J., Guzik H., Lovey R.G., Domalsky M.S., Wong S-C., Puchalski C., Gold E.H., Long J.F., Chiu P.J.S., McPhail A.T., J. Med. Chem. 30 (1987) 2031.
15. [15] Kaminski J.J., Puchalski C., Solomon D.M., Rizvi R.K., Conn D.J., Elliott A.J., Lovey R.G., Guzik H., Chiu P.J.S., Long J.F., McPhail A.T., J. Med. Chem. 32 (1989) 1686.
16. [16] Karabatsos G.J., Graham J.D., Vanne F.M., J. Am. Chem. Soc. 84 (1962) 753.
17. [17] Karabatsos G.J., Taller R.A., J. Am. Chem. Soc. 85 (1963) 3624.
18. [18] Karabatsos G.J., Shapiro B.L., Vanne F.M., Fleming J.S., Ratka J.S., J. Am. Chem. Soc. 85 (1963) 2785.
19. [19] Whittle B.A., Brit. J. Pharmacol. Chemother. 22 (1964) 246.
20. [20] Ferreira S.H., J. Pharm. Pharmacol. 31 (1979) 648.
21. [21] Bodor N., Trends Pharmacol. Sci. 3 (1982) 53.
22. [22] For an example of the metabolism of aromatic amine drugs, see: Maurich V., De Amici M., De Micheli C., Rossato P., Eur. J. Med. Chem. 30 (1995) 757.
23. [23] For an example of the metabolism studies in para-substituted hydrazone derivatives, see: Komurcu S.G., Rollas S., Ulgen M., Gorrod J.W., Cevikbas A., Boll. Chim. Farm. 134 (1995) 375.