3D-QSAR with the aid of pharmacophore search and docking-based alignments for farnesyltransferase inhibitors

European Journal of Medicinal Chemistry

Volumn 44, Issue 10, 2009, Pages 4070-4082

  Vaidya, Madhura ^a   Weigt, Mathias ^a   Wiese, Michael ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

3D QSAR; CoMFA; CoMSIA; Farnesyltransferase inhibitors

Indexed keywords

PROTEIN FARNESYLTRANSFERASE INHIBITOR;

ARTICLE; COMPARATIVE MOLECULAR FIELD ANALYSIS; COMPARATIVE MOLECULAR SIMILARITY INDICES ANALYSIS; DRUG ACTIVITY; DRUG STRUCTURE; ENZYME INHIBITION; MOLECULAR DOCKING; PHARMACOPHORE; PREDICTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

COMPUTER SIMULATION; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 67651159319     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.04.045     Document Type: Article

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